Non-myelotoxic antitumour effects of L-dopa, buthionine sulphoximine and tamoxifen on neuroblastoma cells in vitro and in vivo.

abstract：PURPOSE:To investigate the genomic alterations in larynx carcinomas (LaCa) tissues and its prognostics values in predicting survival. METHODS:To analyse the aberrations in the genome of LaCa patients, we used array comparative genomic hybridization in 19 human laryngeal tumour samples. DNA samples were also subjected ...

journal_title：Journal of cancer research and clinical oncology

authors： Peralta R,Baudis M,Vazquez G,Juárez S,Ortiz R,Decanini H,Hernandez D,Gallegos F,Valdivia A,Piña P,Salcedo M

更新日期：2010-06-01 00:00:00

abstract：:The carcinogenicity of long-term feeding of masheri extract to animals in a vitamin-A-sufficient (SLO+) and deficient (SLO-) state was studied in Sprague Dawley rats by feeding daily dose of 3 mg extract over a period of 21 months. The phase I activating enzymes, the glutathione (GSH)/glutathione S-transferase (GST) d...

journal_title：Journal of cancer research and clinical oncology

authors： Ammigan N,Nair UJ,Lalitha VS,Bhide SV

更新日期：1991-01-01 00:00:00

abstract：:The isolation of deoxyguanosine-resistant 10T1/2 mouse cell lines following stepwise selection in the presence of increasing concentrations of drug led to the identification of a highly metastatic line, as measured by the ability to form secondary tumors in syngenic mice after intravenous injection. This metastatic de...

journal_title：Journal of cancer research and clinical oncology

authors： Damen JE,Spearman MA,Greenberg AH,Wright JA

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:A growing body of evidence has shown the possible relevance of survivin -31G>C (rs9904341) promoter polymorphism to the genetic susceptibility of cancer. Because of the lack of available conclusive data, we performed a meta-analysis of all relevant available studies to derive a more precise estimation of the re...

journal_title：Journal of cancer research and clinical oncology

authors： Qin Q,Zhang C,Zhu H,Yang X,Xu L,Liu J,Lu J,Zhan L,Cheng H,Sun X

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:Long-term human papillomavirus (HPV) infection is a prerequisite for cervical cancer. IL-1beta and IL-1Ra expression levels play an important role in cervical carcinogenesis. Several functional genetic variants in IL1B and IL-RN have been reported to be associated with IL-1beta expression and cancer susceptibil...

journal_title：Journal of cancer research and clinical oncology

authors： Qian N,Chen X,Han S,Qiang F,Jin G,Zhou X,Dong J,Wang X,Shen H,Hu Z

更新日期：2010-05-01 00:00:00

abstract：:E-cadherin mainly mediated the epithelial cell-cell adhesion, and integrin signaling can modulate the signaling pathway of E-cadherin in the different levels. Up to now, however, it is still unclear that whether E-cadherin could interfere with cell-matrix interaction, a typical adhesion through integrins. In this stud...

journal_title：Journal of cancer research and clinical oncology

authors： Wu H,Liang YL,Li Z,Jin J,Zhang W,Duan L,Zha X

更新日期：2006-12-01 00:00:00

abstract：:Expression of the glutathione S-transferase (GST) subclasses alpha, mu and pi was investigated immunohistochemically in 20 normal or hyperplastic mesothelium and in 57 malignant mesothelioma cases. These results were correlated with survival and also with P-170 glycoprotein expression. Nearly all the non-neoplastic me...

journal_title：Journal of cancer research and clinical oncology

authors： Segers K,Kumar-Singh S,Weyler J,Bogers J,Ramael M,Van Meerbeeck J,Van Marck E

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:This retrospective study evaluated the diagnostic value of integrated whole-body (18)F-fluorodeoxyglucose positron-emission tomography and computed tomography ((18)F-FDG-PET/CT) in early detection of second primary malignancies in cancer patients. MATERIALS AND METHODS:From June 2007 to October 2008, 677 cance...

journal_title：Journal of cancer research and clinical oncology

authors： Xu H,Zhang M,Zhai G,Li B

更新日期：2010-08-01 00:00:00

abstract：:As currently recognized, the essential aspects of ovarian carcinoma surgery are: (1) the search for occult metastases in tumors located in the lower pelvis, (2) the maximum tumor removal ("tumor-reductive surgery") in advanced ovarian carcinoma and (3) the exploratory laparotomy to confirm a complete clinical remissio...

journal_title：Journal of cancer research and clinical oncology

authors： Almendral AC

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of a novel low dose chemotherapy as a remission induction regimen for elderly de novo AML patients ineligible for intensive chemotherapy. METHOD:Fifty consecutive patients, aged 60 to 85, with untreated de novo AML were enrolled. Patients with poor PS or defined non-hematolo...

journal_title：Journal of cancer research and clinical oncology

authors： Tsurumi H,Kanemura N,Hara T,Kasahara S,Yamada T,Sawada M,Oyama M,Moriwaki H

更新日期：2007-08-01 00:00:00

abstract：:Differentiation of the rat myelomonocytic leukemia cell line (c-WRT-7) was investigated, by co-culture with a rat embryonic bone marrow preadipose cell line (REC A16). Co-cultivation with REC A16, or with conditioned medium from REC A16 cultures (REC-CM), induced differentiation of c-WRT-7 cells to macrophages. A solu...

journal_title：Journal of cancer research and clinical oncology

authors： Tanaka T,Okamura S,Yasumoto S,Takeichi N,Kobayashi H,Niho Y

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to summarize the accuracy of preoperative vascular invasion with endoscopic ultrasound (EUS) and computed tomography (CT) test performance in pancreatic cancer with meta-analysis METHOD:Two reviewers searched MEDLINE database to identify relevant studies. The reference lists o...

journal_title：Journal of cancer research and clinical oncology

authors： Yang R,Lu M,Qian X,Chen J,Li L,Wang J,Zhang Y

更新日期：2014-12-01 00:00:00

abstract：:The long-term prognosis of surgery for hepatocellular carcinoma (HCC) is not yet satisfactory, the main reason being the high recurrence rate. The authors report the results of a long-term follow-up of 308 patients with HCC who became alpha-fetoprotein-(AFP)-negative after resection between 1975 and 1991. By March 199...

journal_title：Journal of cancer research and clinical oncology

authors： Zhou XD,Tang ZY,Yu YQ,Yang BH,Lu JZ,Lin ZY,Ma ZC,Zhang BH

更新日期：1994-01-01 00:00:00

abstract：:Antinucleolar antisera were raised in rabbits, goats and sheep to nucleoli isolated from three human tumor cell lines. The antisera were shown to cross-react by immunofluorescence with human tumor cell lines originating from different organs and with frozen sections from a wide variety of human malignant and non-malig...

journal_title：Journal of cancer research and clinical oncology

authors： Greenfield RS,Lamon MO,Olech LJ,Grattan JA

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To study the surgical outcomes of patients with a second primary lung cancer after the extrapulmonary malignancy. MATERIALS AND METHODS:Patients who underwent surgical resection for lung cancers between January 2005 and December 2014 were reviewed. Clinical data, imaging characteristics of tumors, surgical a...

journal_title：Journal of cancer research and clinical oncology

authors： Ko KH,Huang HK,Chen YI,Chang H,Tsai WC,Huang TW

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Pancreatic cancer is commonly detected at advanced stages when the tumor is no longer amenable to surgical resection. Therefore, finding biomarkers for early stage disease is urgent. Here, we show that high-definition mass spectrometry (HDMS(E)) can be used to identify serum protein alterations associated with ...

journal_title：Journal of cancer research and clinical oncology

authors： Ansari D,Andersson R,Bauden MP,Andersson B,Connolly JB,Welinder C,Sasor A,Marko-Varga G

更新日期：2015-02-01 00:00:00

abstract：:Bleomycin was injected i.p. in rats, and the amount of expired ethane which indicates lipid peroxidation was followed up for 78 h. Compared to controls neither 1 x 30 mg/kg and 2 x 30 mg/kg nor 1 x 70 mg/kg bleomycin led to increased ethane expiration, although body weight loss indicated toxicity. That pulmonary toxic...

journal_title：Journal of cancer research and clinical oncology

authors： Muliawan H,Burkhardt A,Scheulen ME,Kappus H

更新日期：1982-01-01 00:00:00

abstract：:The extent of ethylation of guanine in 7 N and O 6 position in rat liver DNA was studied after chronic feeding with unlabelled nitrosodiethylamine followed by a single application of the 14C labelled drug. Disulfiram inhibits the alkylation of rat liver DNA. It was also shown that a discontinuous dosage of disulfiram ...

journal_title：Journal of cancer research and clinical oncology

authors： Frank N,Hadjiolov D,Bertram B,Wiessler M

更新日期：1980-01-01 00:00:00

abstract：:The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300,000 IU daily for 12 months) or standard follow-up, and are now evaluable after a median observation ...

journal_title：Journal of cancer research and clinical oncology

authors： Infante M,Pastorino U,Chiesa G,Bera E,Pisani P,Valente M,Ravasi G

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Aim of the present study was to identify the genetic heterogeneity, prevalence and frequency of germline mutations of BRCA2 gene in Hereditary Breast/Ovarian cancer patients from Kerala, South India. METHODS:We analyzed 102 Breast/Ovarian cancer patients from 96 breast and/ovarian cancer families for BRCA2 gen...

journal_title：Journal of cancer research and clinical oncology

authors： Syamala V,Sreeja L,Syamala VS,Vinodkumar B,Raveendran PB,Sreedharan H,Kuttappan R,Balakrishnan L,Ankathil R

更新日期：2007-11-01 00:00:00

abstract：:Genetic predisposition is responsible for 5% 10% of all breast cancer cases. Therefore, the inherited susceptibility to breast cancer has been intensively investigated during the last 10 years. In particular, the identification of the breast cancer susceptibility genes BRCA1 (breast cancer gene 1) and BRCA2 and the cu...

journal_title：Journal of cancer research and clinical oncology

authors： Hofmann W,Schlag PM

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:Two large, randomized, placebo-controlled trials (IRESSA NSCLC Trial Assessing Combination Therapy; INTACT 1 and 2) in non-small-cell lung cancer (NSCLC) failed to show survival benefit for gefitinib (IRESSA) in combination with first-line platinum-based chemotherapy. Epidermal growth factor receptor (EGFR) sta...

journal_title：Journal of cancer research and clinical oncology

authors： Giaccone G,Iacona RB,Fandi A,Janas M,Ochs JS,Herbst RS,Johnson DH

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Streptozocin (STZ) administration with or without other cytotoxic drugs remains a crucial chemotherapy for patients with advanced pancreatic neuroendocrine neoplasms (Pan-NENs). However, the therapeutic effects of combination treatment with weekly STZ and oral S-1 therapy (STS1) remain unknown. Therefore, th...

journal_title：Journal of cancer research and clinical oncology

authors： Ono H,Kudo A,Akahoshi K,Ogura T,Ogawa K,Ban D,Tanaka S,Tanabe M

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:There was no standard treatment for hepatocellular carcinoma with portal vein tumour thrombosis (PVTT). This prospective, randomised, two-arm clinical trial aims to investigate the feasibility, safety and effectiveness of transarterial chemoembolisation (TACE) combined with the endovascular implantation of an i...

journal_title：Journal of cancer research and clinical oncology

authors： Yang M,Fang Z,Yan Z,Luo J,Liu L,Zhang W,Wu L,Ma J,Yang Q,Liu Q

更新日期：2014-02-01 00:00:00

abstract：:Nitrosodiphenylamine was tested for induction of DNA single strand breaks in rat hepatocytes and Chinese hamster V 79 cells with the alkaline filter elution assay. While in rat hepatocytes DNA damage was observed, negative results were obtained in V 79 cells. In view of the metabolic capacity of hepatocytes and the ch...

journal_title：Journal of cancer research and clinical oncology

authors： Appel KE,Görsdorf S,Scheper T,Ruf HH,Rühl CS,Hildebrandt AG

更新日期：1987-01-01 00:00:00

abstract：INTRODUCTION:Mitochondrial DNA alterations have widely been reported in many age-related degenerative diseases and tumors, including colorectal cancer. In the past few years, the discovery of inter-genomic crosstalk between nucleus and mitochondria has reinforced the role of mitochondrial DNA variants in perturbing thi...

journal_title：Journal of cancer research and clinical oncology

authors： Errichiello E,Venesio T

更新日期：2017-10-01 00:00:00

abstract：:Gastric cancer is a major health issue and a leading cause of death worldwide. The results of standard therapy remain unsatisfactory mainly because of diagnosis at the late stage of disease. Innovative strategies such as neoadjuvant chemotherapy in locally advanced cancer have improved the outcome even in operable cas...

journal_title：Journal of cancer research and clinical oncology

authors： Menges M,Hoehler T

更新日期：2009-01-01 00:00:00

abstract：:Targeted therapy refers to anticancer treatment which specifically targets key molecules of cancer cells and/or neovascular cells, aiming to thus interfere with processes of tumorigenesis, cancer progression and metastasis. The epidermal growth factor receptor (EGFR) was the first receptor to be proposed for targeted ...

journal_title：Journal of cancer research and clinical oncology

authors： Zahorowska B,Crowe PJ,Yang JL

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Metastases are a common event in breast cancer. The expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) is essential for therapy and prognosis, and their conversion during disease progression potentially affects the treatment regimen. The aim was...

journal_title：Journal of cancer research and clinical oncology

authors： Nauroth A,Kalder M,Rössler M,Wichmann G,Dietz A,Wiegand S

更新日期：2017-09-01 00:00:00