Current strategies in systemic treatment of gastric cancer and cancer of the gastroesophageal junction.

abstract：:Reversal of natural resistance to bouvardin (NSC 259968) has been attained in vitro and in vivo, by the calcium influx blocker verapamil in sarcoma 180 cells insensitive to bouvardin. Verapamil increased the in vitro lethality of the tumor cells following exposure with cells for 1 and 3 h as a result of the cytotoxic ...

journal_title：Journal of cancer research and clinical oncology

authors： Chitnis MP,Menon RS,Basrur VS,Adwankar MK,Satyamoorthy K

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The appearance of the cervical mucosa is regulated by different factors including retinoic acid. Hormone-dependent alteration of the cervix uteri mucosa is accompanied by a decrease or increase of cytoplasmatic retinoic-acid-binding protein (CRABP). To elucidate whether this hormone-dependent alteration of CRAB...

journal_title：Journal of cancer research and clinical oncology

authors： Volz-Köster S,Volz J,Kiefer A,Biesalski HK

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:Triple (ER-, PR-, HER2-) negative breast carcinoma lack targeted therapies, making this group of tumors difficult to treat. By definition, the lack of HER2 expression means a case scoring 0 or 1+ after immunophenotypical analysis and makes the patients avoiding therapeutical chances with anti-HER2 inhibitors. W...

journal_title：Journal of cancer research and clinical oncology

authors： Brunello E,Bogina G,Bria E,Vergine M,Zamboni G,Pedron S,Daniele I,Furlanetto J,Carbognin L,Marconi M,Manfrin E,Ibrahim M,Miller K,Tortora G,Molino A,Jasani B,Beccari S,Bonetti F,Chilosi M,Martignoni G,Brunelli M

更新日期：2013-09-01 00:00:00

abstract：:Carboplatin therapy has a more favorable toxicity profile than cisplatin and, given in appropriate doses, is equivalent in efficacy to cisplatin for suboptimal ovarian cancer. However myelosuppression frequently curtails therapy with carboplatin. Diethyldithiocarbamate (DDTC) is a thiol compound and heavy-metal-chelat...

journal_title：Journal of cancer research and clinical oncology

authors： Francis P,Markman M,Hakes T,Reichman B,Rubin S,Jones W,Lewis JL Jr,Curtin J,Barakat R,Phillips M

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Streptozocin (STZ) administration with or without other cytotoxic drugs remains a crucial chemotherapy for patients with advanced pancreatic neuroendocrine neoplasms (Pan-NENs). However, the therapeutic effects of combination treatment with weekly STZ and oral S-1 therapy (STS1) remain unknown. Therefore, th...

journal_title：Journal of cancer research and clinical oncology

authors： Ono H,Kudo A,Akahoshi K,Ogura T,Ogawa K,Ban D,Tanaka S,Tanabe M

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Cancer is a serious public health problem worldwide, and difficulty in early diagnosis has been the chief obstacle to improve the prognosis of patients. Recently, microRNAs (miRNAs) were widely studied to be potential biomarkers for cancer detection. miR-16 is a prevalent but sophisticated one. In the curren...

journal_title：Journal of cancer research and clinical oncology

authors： Huang Z,Chen W,Du Y,Guo Q,Mao Y,Zhou X,Hua D

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Due to PSA screening and increased awareness, prostate cancer (PCa) is identified earlier resulting in smaller diagnostic samples on prostate needle biopsy. Because Gleason grading plays a critical role in treatment planning, we undertook a controlled study to evaluate interobserver variability among German ...

journal_title：Journal of cancer research and clinical oncology

authors： Burchardt M,Engers R,Müller M,Burchardt T,Willers R,Epstein JI,Ackermann R,Gabbert HE,de la Taille A,Rubin MA

更新日期：2008-10-01 00:00:00

abstract：:Antinucleolar antisera were raised in rabbits, goats and sheep to nucleoli isolated from three human tumor cell lines. The antisera were shown to cross-react by immunofluorescence with human tumor cell lines originating from different organs and with frozen sections from a wide variety of human malignant and non-malig...

journal_title：Journal of cancer research and clinical oncology

authors： Greenfield RS,Lamon MO,Olech LJ,Grattan JA

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Our primary goal was to determine whether increased expression of the transmembrane carbonic anhydrase (CA) isozymes in renal cell carcinoma (RCC) is regulated by the von Hippel-Lindau (VHL) gene. METHODS:We studied mRNA expression of all three transmembrane CAs - CA IX, XII, and XIV - in 17 RCC cell lines, tr...

journal_title：Journal of cancer research and clinical oncology

authors： Ashida S,Nishimori I,Tanimura M,Onishi S,Shuin T

更新日期：2002-10-01 00:00:00

abstract：:A total of 45 cases of bone tumors and tumor-like lesions were studied in order to determine the expression of an HLA-DR antigen by the monoclonal antibody 910-D-7, and its possible correlation with histology, using the indirect immunoperoxidase method on frozen sections. The pattern of antigen expression was nearly c...

journal_title：Journal of cancer research and clinical oncology

authors： Petzsch M,Vassallo J,Roessner A,Zwadlo G,Sorg C,Vollmer E,Grundmann E

更新日期：1986-01-01 00:00:00

abstract：:Seventy-three evaluable patients with advanced measurable solid tumors were given cisdichlorodiammineplatinum (II) (DDP) at a dose of 20 mg/M2 IV for 1-5 days every 3 weeks, and 19 patients who failed on this low dose DDP protocol received a single high dose of 100 mg/M2 IV once every 3 weeks. Forty-six patients had r...

journal_title：Journal of cancer research and clinical oncology

authors： Schilcher RB,Wessels M,Niederle N,Seeber S,Schmidt CG

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:To determine the potential involvement of ANXA1 in oral squamous-cell carcinoma (OSCC), we evaluated the ANXA1 protein expression in oral premalignant lesions (OPLs) and OSCCs and correlated the results with clinicopathologic variables. METHODS:Matched normal and tumour specimens of 44 primary OSCCs and 28 OPL...

journal_title：Journal of cancer research and clinical oncology

authors： Nomura H,Uzawa K,Yamano Y,Fushimi K,Nakashima D,Kouzu Y,Kasamatsu A,Ogawara K,Shiiba M,Bukawa H,Yokoe H,Tanzawa H

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:Clinical trials have reported conflicting results as to whether taxane-based doublet improves outcome over single-agent taxane in patients with advanced breast cancer. METHODS:We performed a meta-analysis comparing primary and secondary end points of taxane-based doublet with single-agent taxane chemotherapy i...

journal_title：Journal of cancer research and clinical oncology

authors： Xu HB,Xu Q,Li L

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:To discover new molecular targets for cancer therapy and diagnosis, we surveyed signal transducers and activators of transcription 3 (Stat3)-regulated genes, because constitutive activation of Stat3 is associated with a wide variety of human malignancies. METHODS:We investigated the Stat3-regulated genes in 29...

journal_title：Journal of cancer research and clinical oncology

authors： Tomida M,Ohtake H,Yokota T,Kobayashi Y,Kurosumi M

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Recent advances in sequencing technologies supported the development of molecularly targeted therapy in cancer patients. Thus, genomic analyses are becoming a routine part in clinical practice and accurate detection of actionable mutations is essential to assist diagnosis and therapy choice. However, this is...

journal_title：Journal of cancer research and clinical oncology

authors： Ofner R,Ritter C,Ugurel S,Cerroni L,Stiller M,Bogenrieder T,Solca F,Schrama D,Becker JC

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:Alzheimer disease (AD) and cancer are seemingly two opposite ends of one spectrum. Studies have suggested that patients with AD showed a reduced risk of cancer and vice versa. However, available evidences are not conclusive. So we conducted a meta-analysis using published literatures to systematically examine c...

journal_title：Journal of cancer research and clinical oncology

authors： Shi HB,Tang B,Liu YW,Wang XF,Chen GJ

更新日期：2015-03-01 00:00:00

abstract：:159 "poor risk" patients with previously untreated small cell lung cancer were entered into a randomised study of intravenous bolus versus continuous infusion chemotherapy with doxorubicin on weeks 1, 3, 5 and ifosfamide with mesna on weeks 2, 4, 6. Oral etoposide was given on days 1-5, 15-19, and 29-33. There was no ...

journal_title：Journal of cancer research and clinical oncology

authors： Anderson H,Prendiville J,Thatcher N,Radford JA,Swindell R

更新日期：1991-01-01 00:00:00

abstract：:Ftorafur (FT), a 2-tetrahydrofuryl derivative of 5-fluorouracil (5-FU) was introduced into cancer chemotherapy with the hope to obtain a therapeutic effect comparable to 5-FU with a smaller dose and less side effects. A comparison of the effect of FT and 5-FU on the proliferation of L 1210 ascites tumor cells in the p...

journal_title：Journal of cancer research and clinical oncology

authors： Schultze B,Jellinghaus W,Weis G,Müller V,Maurer W

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:beta-1,4-Galactosyltransferase (beta-1,4-GalT) I, II, and V are the enzymes responsible for the biosynthesis of N-acetyllactosamine on N-glycans by transferring UDP-galactose to the terminal N-acetylglucosamine (N-GlcNAc) residues with the formation of a beta-1,4-linkage. Neoplasms undergo various changes in th...

journal_title：Journal of cancer research and clinical oncology

authors： Xu S,Zhu X,Zhang S,Yin S,Zhou L,Chen C,Gu J

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:To study an association between IL-6 signaling and resistance to radiotherapy of prostate cancer (PCa) and explore the molecular mechanisms involved. METHODS:IL-6 expressing C4-2 and CWR22Rv1 (C4-2IL-6/CWRIL-6) and vector control (C4-2vec/CWRvec) cell lines were developed. Radiation-sensitivities of these cell...

journal_title：Journal of cancer research and clinical oncology

authors： Chen X,Chen F,Ren Y,Weng G,Xu L,Xue X,Keng PC,Lee SO,Chen Y

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Signalling through the insulin-like growth factor 1 receptor (IGF-1R) is implicated in carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. The purpose of this study was to investigate the prognostic role of IGF-1R expression in surgically resected non-small-cell lung cancer (NSCLC), and re...

journal_title：Journal of cancer research and clinical oncology

authors： Agulló-Ortuño MT,Díaz-García CV,Agudo-López A,Pérez C,Cortijo A,Paz-Ares L,López-Ríos F,Pozo F,de Castro J,Cortés-Funes H,López Martín JA

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Recent studies indicated undisputed contribution of connective tissue growth factor (CTGF) in the development of many cancers, including non-small cell lung cancer (NSCLC). However, the functional role and regulation of CTGF expression during tumorigenesis remain elusive. Our goal was to determine CTGF transcri...

journal_title：Journal of cancer research and clinical oncology

authors： Drzewiecka H,Gałęcki B,Jarmołowska-Jurczyszyn D,Kluk A,Dyszkiewicz W,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:The present study was undertaken to examine the amplification and expression status of Cks1 in breast cancer and its significance. METHODS:The amplification and expression status of Cks1 gene was examined by FISH, real-time PCR and immunohistochemistry, respectively. RNA interference was used to detect the eff...

journal_title：Journal of cancer research and clinical oncology

authors： Wang XC,Tian LL,Tian J,Wu HL,Meng AM

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:PARP inhibitors (PARPi) are used in a wide range of human solid tumours but a limited evidence is reported in rhabdomyosarcoma (RMS), the most frequent childhood soft-tissue sarcoma. The cellular and molecular effects of Olaparib, a specific PARP1/2 inhibitor, and AZD2461, a newly synthesized PARP1/2/3 inhibito...

journal_title：Journal of cancer research and clinical oncology

authors： Camero S,Ceccarelli S,De Felice F,Marampon F,Mannarino O,Camicia L,Vescarelli E,Pontecorvi P,Pizer B,Shukla R,Schiavetti A,Mollace MG,Pizzuti A,Tombolini V,Marchese C,Megiorni F,Dominici C

更新日期：2019-01-01 00:00:00

abstract：:The role of DNA adducts in the initiation of cancer is scrutinized in this presentation. Work on the activation of oncogenes, particularly on ras, has provided new evidence to link DNA adducts and tumour formation. Polycyclic hydrocarbons and nitroso compounds can cause activation of ras oncogenes through a defined po...

journal_title：Journal of cancer research and clinical oncology

authors： Hemminki K,Försti A,Mustonen R,Savela K

更新日期：1986-01-01 00:00:00

abstract：:To investigate further the presence of an autocrine proliferative loop involving gastrin in colorectal carcinomas and to clarify the receptor responsible, 102 human colorectal carcinomas and 10 hepatic metastases were investigated for the expression of the genes encoding gastrin, the gastrin/CCK-B receptor and the gas...

journal_title：Journal of cancer research and clinical oncology

authors： Imdahl A,Mantamadiotis T,Eggstein S,Farthmann EH,Baldwin GS

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Triple negative breast cancer (TNBC) harbors a heterogeneous group of carcinomas with poor prognosis and high genetic variability. As a potential aim for targeted therapy, genetic mutations leading to an activation of the phosphoinositide 3-kinase pathway in a catalytic subunit (PIK3CA) in breast cancer have...

journal_title：Journal of cancer research and clinical oncology

authors： Elfgen C,Reeve K,Moskovszky L,Güth U,Bjelic-Radisic V,Fleisch M,Tausch C,Varga Z

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:To compare the efficacy and safety of a biweekly CHOP regimen consisting of cyclophosphamide (CPA), doxorubicin (DOX), vincristine (VCR), and prednisolone (PSL) and those of a biweekly THP-COP regimen containing pirarubicin (THP), an anthracyclin with less cardiotoxicity than DOX. METHODS:A prospective, random...

journal_title：Journal of cancer research and clinical oncology

authors： Tsurumi H,Yamada T,Sawada M,Kasahara S,Kanemura N,Kojima Y,Fukuno K,Hara T,Saio M,Takahashi T,Oyama M,Ozawa K,Takami T,Moriwaki H

更新日期：2004-02-01 00:00:00

abstract：:Metastatic interstitial cell tumor of the testis is one of the rarest human neoplasms. This is the nineteenth case to be reported. While most of these tumors are combined with hormonal dysfunction, the present tumor, apart from its uncommon hormonal profile, is remarkable because of its capacity of producing and secre...

journal_title：Journal of cancer research and clinical oncology

authors： Higi M,Niederle N,Scheulen ME,Richter HJ

更新日期：1979-07-27 00:00:00

abstract：:Extracts from mistletoe (Viscum album L.) are assumed to exert an antineoplastic activity through their toxicity at high doses or by immunomodulation by nanogram quantities of a lectin. They are used as an unconventional therapy modality in the management of a wide range of cancer diseases, although no anticancer pote...

journal_title：Journal of cancer research and clinical oncology

authors： Kunze E,Schulz H,Gabius HJ

更新日期：1998-01-01 00:00:00