Combination of weekly streptozocin and oral S-1 treatment for patients of unresectable or metastatic pancreatic neuroendocrine neoplasms.

abstract：PURPOSE:This study aimed to establish new criteria for limited resection of non-small cell lung cancer (NSCLC) based on computed tomography findings and maximum standardized uptake value (SUVmax). METHODS:Between December 2007 and December 2015, 611 patients underwent lung cancer surgery; of these, 70 with cT1aN0M0 wh...

journal_title：Journal of cancer research and clinical oncology

authors： Aragaki M,Hida Y,Kato T,Fujiwara-Kuroda A,Kaga K,Wakasa S

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (LncRNAs) have been demonstrated as playing important roles in diverse biological processes including tumorigenesis. However, the clinical significance and biological function of LncRNA nuclear-enriched abundant transcript 1 (NEAT1) in gastric cancer are still unknown. The aim of this stu...

journal_title：Journal of cancer research and clinical oncology

authors： Fu JW,Kong Y,Sun X

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:(1) To test whether in genomewide expression profiling differentially expressed genes were also distinct on the protein level including KIT and PDGFRA (2) to correlate the expression with clinicopathological parameters (3) to identify activating mutations that might be eligible for tyrosine kinase inhibitor the...

journal_title：Journal of cancer research and clinical oncology

authors： Knösel T,Chen Y,Altendorf-Hofmann A,Danielczok C,Freesmeyer M,Settmacher U,Wurst C,Schulz S,Yang LL,Petersen I

更新日期：2012-03-01 00:00:00

abstract：:To study whether fluorescent lighting at work might increase carcinogenesis, hairless mice were exposed to a bank of six 36 W standard fluorescent lamps (neutral-white) every workday for 8 h at an illuminance level of 1,000 lx. For comparison, other mice were exposed to UVB radiation or to simulated solar radiation. I...

journal_title：Journal of cancer research and clinical oncology

authors： Wiskemann A,Sturm E,Klehr NW

更新日期：1986-01-01 00:00:00

abstract：AIM:To examine the expressions of focal adhesion kinase (FAK) and its clinical significance in hepatocellular carcinoma (HCC). METHODS:We determined the expression levels of FAK on both steady-state mRNA and protein levels in 50 HCC samples by quantitative real-time PCR and immunohistochemistry, respectively. The corr...

journal_title：Journal of cancer research and clinical oncology

authors： Yuan Z,Zheng Q,Fan J,Ai KX,Chen J,Huang XY

更新日期：2010-10-01 00:00:00

abstract：:Antiproliferative effects of free retinoic acid (RA) and liposome-encapsulated RA (RAlp) were compared in a squamous carcinoma system using both monolayer cells and multicellular tumor spheroids (MTS), an in-vivo-like model with three-dimensional histological structure. Initial studies examined the effect of lipid com...

journal_title：Journal of cancer research and clinical oncology

authors： Sacks PG,Oke V,Mehta K

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To explore the value of Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2) for predicting prostate biopsy results in patients with prostate specific antigen (PSA) levels of 4-10 ng/ml. METHODS:We retrospectively reviewed multi-parameter magnetic resonance images from 528 patients with PSA levels...

journal_title：Journal of cancer research and clinical oncology

authors： Xu N,Wu YP,Chen DN,Ke ZB,Cai H,Wei Y,Zheng QS,Huang JB,Li XD,Xue XY

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:To study the interplay of drugs and energy metabolism of tumor cells, metabolic changes induced by chloroacetaldehyde and cytochalasin B were analyzed in colon carcinoma cells LS174T. METHODS:O(2)-consumption and extracellular acidification were recorded using a bioelectronic sensor-chip system, which monitors...

journal_title：Journal of cancer research and clinical oncology

authors： Motrescu ER,Otto AM,Brischwein M,Zahler S,Wolf B

更新日期：2005-10-01 00:00:00

abstract：:A series of 191 female breast carcinomas (with long-term follow-up) were analysed immunohistochemically (with a monoclonal MIB1 antibody) for Ki-67 (a proliferation marker) expression with special reference to well-established prognostic factors and patient survival. Expression of Ki-67 was directly related to the S-p...

journal_title：Journal of cancer research and clinical oncology

authors： Pietiläinen T,Lipponen P,Aaltomaa S,Eskelinen M,Kosma VM,Syrjänen K

更新日期：1996-01-01 00:00:00

abstract：:Antibody-toxin conjugates, termed immunotoxins, are currently being evaluated as potential new anticancer agents. The monoclonal antibodies that recognize antigens on the surface of tumor cells should deliver the toxins or the catalytic subunits of toxins to cancer cells. The catalytically active parts of the immunoto...

journal_title：Journal of cancer research and clinical oncology

authors： Pirker R

更新日期：1988-01-01 00:00:00

abstract：:Modulation of 5-fluorouracil (5-FU) is currently being investigated in advanced colorectal cancer. In an attempt to improve the results obtainable for the association of 5-FU and leucovorin, we decided to add cisplatin to 5-FU and (6S)-leucovorin (S-LV) after disease progression. The hypothesis was that a pharmacologi...

journal_title：Journal of cancer research and clinical oncology

authors： Cassano A,Pozzo C,Corsi DC,Fontana T,Noviello MR,Astone A,Barone C

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:In 2008, we reported that 10 Japanese-size cups of green tea daily, supplemented with tablets of green tea extract (GTE), reduced the recurrence of colorectal adenoma by 51.6% in patients after polypectomy. Based on these results, we paid special attention to Japanese cancer patients, who consume green tea ever...

journal_title：Journal of cancer research and clinical oncology

authors： Fujiki H,Sueoka E,Watanabe T,Suganuma M

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To evaluate through retrospective analysis the efficacy and toxicity of combination chemotherapy with etoposide, vincristine, doxorubin and dexamethasone (EVAD) as second-line therapy in patients with advanced AIDS-related Kaposi's sarcoma (AIDS-KS) after failure of first-line chemotherapy. METHODS:Eighty-ei...

journal_title：Journal of cancer research and clinical oncology

authors： Zhong DT,Shi CM,Chen Q,Huang JZ,Liang JG,Lin D

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Hand-foot syndrome (HFS) is a common adverse event that can be induced by capecitabine. It is hypothesized that capecitabine (Hoffmann-La Roche Inc.) based chemotherapy can cause overexpression of COX-2 in tumor and healthy tissue, which finally induced HFS in hands and feet. Based on this, we believed that a s...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang RX,Wu XJ,Lu SX,Pan ZZ,Wan DS,Chen G

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:E- and P-selectins, expressed on vascular endothelium, and their sialyl-Lewis(x )(sLe(x))- and/or sialyl-Lewis(a) (sLe(a))-containing ligands have a crucial role in extravasation and metastasis of circulating cells. We wanted to analyse the role of selectins and their ligands in head and neck tumours. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Renkonen J,Mäkitie A,Paavonen T,Renkonen R

更新日期：1999-10-01 00:00:00

abstract：:Human breast carcinomas were evaluated for estrogen and progesterone receptors by immunohistochemistry using monoclonal anti-receptor antibodies (n = 267) and by cytosol steroid-binding assays (n = 212). The estrogen and progesterone receptor contents of the tumors correlated with histological features of differentiat...

journal_title：Journal of cancer research and clinical oncology

authors： Helle M,Helin M,Isola J,Helin H

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:The oncogenic roles of sphingosine kinase 1 (SphK1) in various cancers, including thyroid cancer, have been well demonstrated. However, the microRNAs (miRNAs) associated with the oncogenic roles of SphK1 remain largely unknown. METHODS:Global gene and miRNA expression in TPC1-Vector and TPC1-SphK1 cells was an...

journal_title：Journal of cancer research and clinical oncology

authors： Liang W,Xie Z,Cui W,Guo Y,Xu L,Wu J,Guan H

更新日期：2017-04-01 00:00:00

abstract：:Induction of gene transcription in response to extracellular stimuli constitutes an essential aspect of host defense mechanisms. Interferons (IFN) are families of cytokines that have been discovered and extensively characterized in the context of host defense against viral infections. In elucidating the mechanism of t...

journal_title：Journal of cancer research and clinical oncology

authors： Taniguchi T,Harada H,Lamphier M

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:Non-adherence to anti-hormonal therapy is a major problem in gynecologic oncology. Reasons reported are side effects and lack of support. The aim of our study was an analysis of influence of experiences of patients with endocrine therapy and communication and information on this topic and their influence o...

journal_title：Journal of cancer research and clinical oncology

authors： Wuensch P,Hahne A,Haidinger R,Meißler K,Tenter B,Stoll C,Senf B,Huebner J

更新日期：2015-01-01 00:00:00

abstract：:Altered and deregulated cellular oncogenes were found in many human solid tumors. Except for a few types of tumors that consistently exhibited specific altered proto-oncogenes, the majority of tumors are associated with a number of transcriptionally activated cellular oncogenes. In the heterologous group of non-small-...

journal_title：Journal of cancer research and clinical oncology

authors： Kiefer PE,Wegmann B,Bacher M,Erbil C,Heidtmann H,Havemann K

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To associate the global gene expression of B7/CD28 family transcripts with pathologic features of colon cancer, we determined the B7/CD28 family transcripts in peripheral blood mononuclear cells (PBMCs) from normal subjects and patients with adenomatous polyps and colon cancer, and correlated the results with p...

journal_title：Journal of cancer research and clinical oncology

authors： Lee H,Kim JH,Yang SY,Kong J,Oh M,Jeong DH,Chung JI,Bae KB,Shin JY,Hong KH,Choi I

更新日期：2010-09-01 00:00:00

abstract：:The Harvey ras locus was examined for restriction fragment polymorphism and loss of allelic heterozygosity in 62 oral cancer patients. Southern blot analysis on BamHI digests of the tumour tissue DNA, revealed 23 patients with H-ras-1 heterozygosity. The probes used to study the polymorphism were the BamHI 6.6-kb frag...

journal_title：Journal of cancer research and clinical oncology

authors： Saranath D,Bhoite LT,Mehta AR,Sanghavi V,Deo MG

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Explore patient-reported outcomes (PROs), including health-related quality of life (HRQoL), satisfaction with therapy, impact of the therapy on work and daily life, and concerns related to the therapy and identify variables associated with PROs in persons with chronic myeloid leukemia (CML) receiving tyrosine k...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang Q,Wang HB,Yu L,Gale RP

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:No study has evaluated the prognostic impact of the age-adjusted Charlson comorbidity index (AACI) in those with renal cell carcinoma (RCC). This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC). METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Kang HW,Kim SM,Kim WT,Yun SJ,Lee SC,Kim WJ,Hwang EC,Kang SH,Hong SH,Chung J,Kwon TG,Kim HH,Kwak C,Byun SS,Kim YJ,KORCC (KOrean Renal Cell Carcinoma) Group.

更新日期：2020-01-01 00:00:00

abstract：:Stereological point-counting methods were used to determine the volumetric alterations in collagen from the lamina propria immediately beneath the epithelial-connective tissue junction in hamster check-pouch mucosa treated with the chemical carcinogen DMBA. In addition, a non-neoplastic inflammatory control was evalua...

journal_title：Journal of cancer research and clinical oncology

authors： Tarpey SG,White FH

更新日期：1984-01-01 00:00:00

abstract：:After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50). This change of the organ-specific carcinogenic effect is not observed in exper...

journal_title：Journal of cancer research and clinical oncology

authors： Schweinsberg F,Kouros M,Manncke K

更新日期：1979-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the frequency of second primary non-breast cancer after breast cancer diagnosis and treatment, and its correlation with clinicopathological features. METHODS:Data from 21,527 patients with primary breast cancer were collected retrospectively in a single cancer centre; 4.1% o...

journal_title：Journal of cancer research and clinical oncology

authors： Corso G,Veronesi P,Santomauro GI,Maisonneuve P,Morigi C,Peruzzotti G,Intra M,Sacchini V,Galimberti V

更新日期：2018-05-01 00:00:00

abstract：:The effects of alpha-difluoromethylornithine (DFMO), radiation and the therapy of their combination were investigated in rats bearing G-XII glioma. DFMO treatment as well as radiation therapy prolonged the survival period when compared to the results in non-treated control rats. The combination therapy showed a greate...

journal_title：Journal of cancer research and clinical oncology

authors： Tsukahara T,Tamura M,Yamazaki H,Kurihara H,Matsuzaki S

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Insulin-like growth factor 1 (IGF-1) stimulates mitosis and inhibits apoptosis. High circulating IGF-1 levels are linked with an increased risk of colorectal and breast cancer. Recently, IGF-1 single nucleotide polymorphisms (SNPs), especially variant rs2946834, have been associated with poor clinical outcome i...

journal_title：Journal of cancer research and clinical oncology

authors： Muendlein A,Lang AH,Geller-Rhomberg S,Winder T,Gasser K,Drexel H,Decker T,Mueller-Holzner E,Chamson M,Marth C,Hubalek M

更新日期：2013-03-01 00:00:00

abstract：:P-glycoprotein (P-gp), a cell membrane protein, has been found in multidrug-resistant cancer cells. A total of 104 smears from patients with breast-cancer-associated pleural effusions and ovarian-cancer-related peritoneal effusions were studied for P-gp with the antibody C-219 and the avidin-biotin-immunoperoxidase me...

journal_title：Journal of cancer research and clinical oncology

authors： Athanassiadou P,Athanassiades P,Petrakakou E,Zerva C,Mavrikakis M

更新日期：1997-01-01 00:00:00