Ultrastructural morphometry of collagen from lamina propria during experimental oral carcinogenesis and chronic inflammation.

abstract：:To study whether fluorescent lighting at work might increase carcinogenesis, hairless mice were exposed to a bank of six 36 W standard fluorescent lamps (neutral-white) every workday for 8 h at an illuminance level of 1,000 lx. For comparison, other mice were exposed to UVB radiation or to simulated solar radiation. I...

journal_title：Journal of cancer research and clinical oncology

authors： Wiskemann A,Sturm E,Klehr NW

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:In selected patients with rectal cancer, laparoscopic surgery is as safe as open surgery, with similar resection margins and completeness of resection. In addition, recovery is faster after laparoscopic surgery. We analyzed long-term outcomes in a group of patients with locally advanced rectal cancer (LARC) ...

journal_title：Journal of cancer research and clinical oncology

authors： Calvo FA,Sole CV,Serrano J,Rodriguez M,Marcos F,Muñoz-Calero A,Zorrilla J,Lopez-Baena JA,Diaz-Zorita B,García-Sabrido JL,del Valle E

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:PIK3CA mutation appears to predict a lack of response to anti-EGFR monoclonal antibody (mAb) treatment in patients with metastatic colorectal cancer (mCRC). However, the predictive value of PIK3CA mutations for survival remains inconclusive. Here, we pooled the data from published studies to estimate the associ...

journal_title：Journal of cancer research and clinical oncology

authors： Wu S,Gan Y,Wang X,Liu J,Li M,Tang Y

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:Explore molecular monitoring patterns of patients with chronic myeloid leukemia (CML) on tyrosine kinase inhibitors therapy in China and identify variables associated with monitoring patterns. METHODS:Non-interventional, cross-sectional study using questionnaires distributed to persons with CML and answered an...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang Q,Gale RP

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Matrix metalloproteinases (MMPs) are a family of structurally related zinc-dependent endopeptidases that are able to degrade extracellular matrix components. MMPs play a role in tumor invasion and tumor metastasis. MMP-2 (also known as gelatinase A) is expressed in human melanoma cells. METHODS:In this study, ...

journal_title：Journal of cancer research and clinical oncology

authors： Wollina U,Hipler UC,Knöll B,Graefe T,Kaatz M,Kirsch K

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:The incidence and mortality of gastric and colorectal cancers are among the highest malignant tumors in China. The aim of this study is to investigate whether variations of the human oxoguanine glycosylase 1 (hOGG1) gene are related to the risk of gastric and colorectal cancers in the Chinese population. METHO...

journal_title：Journal of cancer research and clinical oncology

authors： Liu X,Xiao N,Guo W,Wu Y,Cai Z,He Q,Zhang L,Chen X,Sun C,Wang J,Zhu C,Jin H,Wang Y

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:The oncogenic roles of sphingosine kinase 1 (SphK1) in various cancers, including thyroid cancer, have been well demonstrated. However, the microRNAs (miRNAs) associated with the oncogenic roles of SphK1 remain largely unknown. METHODS:Global gene and miRNA expression in TPC1-Vector and TPC1-SphK1 cells was an...

journal_title：Journal of cancer research and clinical oncology

authors： Liang W,Xie Z,Cui W,Guo Y,Xu L,Wu J,Guan H

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The PI3K pathway controls diverse cellular processes including growth, survival, metabolism, and apoptosis. Nuclear FOXO factors were observed in cancers that harbor constitutively active PI3K pathway output and stem signatures. FOXO1 and FOXO3 were previously published to induce stem genes such as OCT4 in e...

journal_title：Journal of cancer research and clinical oncology

authors： Martinez E,Vazquez N,Lopez A,Fanniel V,Sanchez L,Marks R,Hinojosa L,Cuello V,Cuevas M,Rodriguez A,Tomson C,Salinas A,Abad M,Holguin M,Garza N,Arenas A,Abraham K,Maldonado L,Rojas V,Basdeo A,Schuenzel E,Persans M

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:Tumor necrosis (TN) is one of the unfavorable prognostic factors in renal cell carcinoma (RCC). We identified two patterns of TN according to their morphology: dirty necrosis and ghost necrosis. We aimed to elucidate the morphological features and unfavorable prognostic impact of dirty necrosis in RCC. METHODS...

journal_title：Journal of cancer research and clinical oncology

authors： Kuroe T,Watanabe R,Kojima M,Morisue R,Sugano M,Kuwata T,Masuda H,Kusuhara S,Matsubara N,Oda S,Ushiku T,Ishii G

更新日期：2021-01-21 00:00:00

abstract：:The laboratory findings in patients receiving high-dose vitamin A as adjuvant treatment for stage I lung cancer are here reported. A group of 283 patients were randomized to either treatment with retinyl palmitate (300,000 IU daily for 12 months) or standard follow-up, and are now evaluable after a median observation ...

journal_title：Journal of cancer research and clinical oncology

authors： Infante M,Pastorino U,Chiesa G,Bera E,Pisani P,Valente M,Ravasi G

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Natural killer (NK) cells can kill transformed cells and represent anti-tumor activities for improving the immunotherapy of cancer. In previous works, we established human interleukin-15 (hIL-15) gene-modified NKL cells (NKL-IL15) and demonstrated their efficiency against human hepatocarcinoma cells (HCCs) in v...

journal_title：Journal of cancer research and clinical oncology

authors： Jiang W,Zhang C,Tian Z,Zhang J

更新日期：2018-07-01 00:00:00

abstract：:A series of 191 female breast carcinomas (with long-term follow-up) were analysed immunohistochemically (with a monoclonal MIB1 antibody) for Ki-67 (a proliferation marker) expression with special reference to well-established prognostic factors and patient survival. Expression of Ki-67 was directly related to the S-p...

journal_title：Journal of cancer research and clinical oncology

authors： Pietiläinen T,Lipponen P,Aaltomaa S,Eskelinen M,Kosma VM,Syrjänen K

更新日期：1996-01-01 00:00:00

abstract：:The standard definition of platinum-resistant ovarian cancer or primary peritoneal carcinoma commonly includes patients whose disease initially responded to a platinum-based combination regimen, but recurred less than 6 months after the completion of primary therapy. Recent experience with several patients with these ...

journal_title：Journal of cancer research and clinical oncology

authors： Markman M,Kennedy A,Webster K,Kulp B,Peterson G,Belinson J

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:Acute intestinal damage induced by chemotherapeutic agent is often a dose-limiting factor in clinical cancer therapy. The aim of this study was to investigate the effect of chemokine CXCL9 on the intestinal damage after chemotherapy and explore the therapeutic potential of anti-CXCL9 agents. METHODS:In vitro c...

journal_title：Journal of cancer research and clinical oncology

authors： Lu H,Liu H,Wang J,Shen J,Weng S,Han L,Sun T,Qian L,Wu M,Zhu S,Yu Y,Han W,Zhu J,Moldenhauer A

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:E- and P-selectins, expressed on vascular endothelium, and their sialyl-Lewis(x )(sLe(x))- and/or sialyl-Lewis(a) (sLe(a))-containing ligands have a crucial role in extravasation and metastasis of circulating cells. We wanted to analyse the role of selectins and their ligands in head and neck tumours. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Renkonen J,Mäkitie A,Paavonen T,Renkonen R

更新日期：1999-10-01 00:00:00

abstract：:Phenotypically altered, preneoplastic cell populations were detected by micromorphological and cytochemical methods in a number of tissues treated with various chemical carcinogens. Further cellular analysis of carcinogenesis has shown that different cellular phenotypes follow each other during tumor development. Thus...

journal_title：Journal of cancer research and clinical oncology

authors： Bannasch P

更新日期：1984-01-01 00:00:00

abstract：:Chinese hamster ovary cells were heated for 20 min at 45.5 degrees C in different conditions, and quantitative determinations of cellular membrane blebbing were performed for cells maintained at 25 degrees C and 37 degrees C after hyperthermia. The percentage of cells with blebs following heating was dependent upon th...

journal_title：Journal of cancer research and clinical oncology

authors： Kapiszewska M,Hopwood LE

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To elucidate the effect of tumor oxygenation status on recovery from damage following gamma-ray or accelerated carbon ion irradiation in vivo, including in quiescent (Q) cells. METHODS:SCC VII tumor-bearing mice were continuously given 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. They r...

journal_title：Journal of cancer research and clinical oncology

authors： Masunaga S,Hirayama R,Uzawa A,Kashino G,Suzuki M,Kinashi Y,Liu Y,Koike S,Ando K,Ono K

更新日期：2009-08-01 00:00:00

abstract：:The effects of alpha-difluoromethylornithine (DFMO), radiation and the therapy of their combination were investigated in rats bearing G-XII glioma. DFMO treatment as well as radiation therapy prolonged the survival period when compared to the results in non-treated control rats. The combination therapy showed a greate...

journal_title：Journal of cancer research and clinical oncology

authors： Tsukahara T,Tamura M,Yamazaki H,Kurihara H,Matsuzaki S

更新日期：1992-01-01 00:00:00

abstract：:Metastatic interstitial cell tumor of the testis is one of the rarest human neoplasms. This is the nineteenth case to be reported. While most of these tumors are combined with hormonal dysfunction, the present tumor, apart from its uncommon hormonal profile, is remarkable because of its capacity of producing and secre...

journal_title：Journal of cancer research and clinical oncology

authors： Higi M,Niederle N,Scheulen ME,Richter HJ

更新日期：1979-07-27 00:00:00

abstract：:Bis-beta-diketonato complexes of titanium, zirconium, and hafnium were tested against autochthonous colorectal tumors in rats. The model was found to reflect the clinical situation most closely. Of the compounds tested, budotitane was the most effective in terms of decrease in tumor weight and number and in increasing...

journal_title：Journal of cancer research and clinical oncology

authors： Bischoff H,Berger MR,Keppler BK,Schmähl D

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The development of brain metastases (BMs) was associated with poor prognosis in melanoma patients. Patients with BMs have a median survival of <6 months. Melanoma is the third most common tumor to metastasize to the brain with a reported incidence of 10-40 %. Our aim was to identify factors predicting develo...

journal_title：Journal of cancer research and clinical oncology

authors： Gumusay O,Coskun U,Akman T,Ekinci AS,Kocar M,Erceleb OB,Yazıcı O,Kaplan MA,Berk V,Cetin B,Taskoylu BY,Yildiz A,Goksel G,Alacacioglu A,Demirci U,Algin E,Uysal M,Oztop I,Oksuzoglu B,Dane F,Gumus M,Buyukberber S

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To investigate the effect of a monoclonal antibody (CH12), targeted against epidermal growth factor receptor type III variant (EGFRvIII), on human ovarian cancer cells when administered in combination with cisplatin chemotherapy. METHODS:Western blot and reverse transcription polymerase chain reaction (RT-PCR)...

journal_title：Journal of cancer research and clinical oncology

authors： Li N,Chu Y,Yao L,Ying X,Jiang H,Zhou M,Xu C

更新日期：2011-10-01 00:00:00

abstract：:Soft-agar clonogenicity of L1210 mouse leukemia cells and of xenografts of a human melanoma and a carcinoma of the cervix was studied sectionally by the sizes of the colonies grown under hypoxic gradients and aerobic condition. Soft-agar plating efficiency was increased in cultured L1210 cells with decreasing oxygen c...

journal_title：Journal of cancer research and clinical oncology

authors： Fan D,Fan S,Morgan LR

更新日期：1984-01-01 00:00:00

abstract：:Targeted therapy refers to anticancer treatment which specifically targets key molecules of cancer cells and/or neovascular cells, aiming to thus interfere with processes of tumorigenesis, cancer progression and metastasis. The epidermal growth factor receptor (EGFR) was the first receptor to be proposed for targeted ...

journal_title：Journal of cancer research and clinical oncology

authors： Zahorowska B,Crowe PJ,Yang JL

更新日期：2009-09-01 00:00:00

abstract：:Establishment of new tumor cell lines is an important first step for biological studies of tumor cells. High success rates in establishing retinoblastoma cell lines have been reported when feeder-layer culture but not liquid-culture techniques were used. Liquid culture is, however, essential for studies in which feede...

journal_title：Journal of cancer research and clinical oncology

authors： Inomata M,Kaneko A,Saijo N,Tokura S

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:This study aimed to determine the dose effect of smoking on the mutational frequency and spectrum of epidermal growth factor receptor (EGFR) gene in Korean non-small cell lung cancer (NSCLC). METHODS:Detailed smoking histories were obtained from 324 consecutively enrolled Korean NSCLC patients. Mutational stat...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YJ,Shim HS,Kang YA,Hong SJ,Kim HK,Kim H,Kim SK,Choi SH,Kim JH,Cho BC

更新日期：2010-12-01 00:00:00

abstract：:Treatment of cultured mammalian cells with hydrogen peroxide results in the production of extensive DNA damage. Strand breakage was produced at the level of either nascent or mature DNA and the former target appeared slightly more resistant than the latter. Although inhibitors of the enzyme poly(ADP-ribose) polymerase...

journal_title：Journal of cancer research and clinical oncology

authors： Cantoni O,Fiorani M,Mugnaini M,Cattabeni F

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:How could we transfer knowledge about healing plants from other cultures? We analyzed the results of literature search in two exemplary fields-oral mucositis and polyneuropathy. MATERIALS AND METHODS:In both systematic searches of existing literature, we found 57 studies investigating 68 plants from differen...

journal_title：Journal of cancer research and clinical oncology

authors： Büntzel J,Micke O,Büntzel J

更新日期：2021-02-01 00:00:00

abstract：AIM:To examine the expressions of focal adhesion kinase (FAK) and its clinical significance in hepatocellular carcinoma (HCC). METHODS:We determined the expression levels of FAK on both steady-state mRNA and protein levels in 50 HCC samples by quantitative real-time PCR and immunohistochemistry, respectively. The corr...

journal_title：Journal of cancer research and clinical oncology

authors： Yuan Z,Zheng Q,Fan J,Ai KX,Chen J,Huang XY

更新日期：2010-10-01 00:00:00