Evidence that a "treatment-free interval of less than 6 months" does not equate with clinically defined platinum resistance in ovarian cancer or primary peritoneal carcinoma.

abstract：PURPOSE:Based on the poor prognosis of drug resistance in pediatric acute lymphoblastic leukemia (ALL) and adverse effects of chemotherapy, this study was aimed to evaluate the effect of several herbal extracts on leukemic cells. METHODS:Two subtypes of T- and B-ALL cell lines, followed by ALL primary cells were treat...

journal_title：Journal of cancer research and clinical oncology

authors： Rahimi Babasheikhali S,Rahgozar S,Mohammadi M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:Only few immunohistochemical markers besides c-kit exist for gastrointestinal stromal tumors (GISTs). Thy-1, a cell-surface glycoprotein, is a marker for several types of stem cells and particularly for neuronal precursor cells. The aim of this study was to determine Thy-1 expression in GISTs. MATERIALS AND ME...

journal_title：Journal of cancer research and clinical oncology

authors： Oikonomou D,Hassan K,Kaifi JT,Fiegel HC,Schurr PG,Reichelt U,Aridome K,Yekebas EF,Mann O,Kluth D,Strate T,Izbicki JR

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:The TNM classification is used to assess cancers of the oral cavity, and advancements in imaging techniques have revealed clear variations in tumor volume at presentation. This study therefore aimed to clarify whether preoperative imaging, with exact measurements of the tumor, could affect post-surgery survival...

journal_title：Journal of cancer research and clinical oncology

authors： Mücke T,Mitchell DA,Ritschl LM,Tannapfel A,Wolff KD,Kesting MR,Loeffelbein DJ,Kanatas A

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Cluster of differentiation (CD) 44 is a cell surface receptor that correlates with the development of drug resistance in epithelial ovarian cancer (EOC). Here, we prospectively investigated the clinical impact of CD44 expression on the development of chemoresistance, and on disease-free and overall survival in ...

journal_title：Journal of cancer research and clinical oncology

authors： Elzarkaa AA,Sabaa BE,Abdelkhalik D,Mansour H,Melis M,Shaalan W,Farouk M,Malik E,Soliman AA

更新日期：2016-05-01 00:00:00

abstract：:In order to evaluate a possible significance of the expression of proliferating cell nuclear antigen (PCNA) as clinically useful prognostic parameter, we retrospectively investigated a series of 40 glioblastomas by means of immunohistochemistry and compared the results to patient survival. All glioblastomas included i...

journal_title：Journal of cancer research and clinical oncology

authors： Figge C,Reifenberger G,Vogeley KT,Messing M,Roosen N,Wechsler W

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Long interspersed nuclear element 1 (LINE-1 or L1) is a dominant non-long terminal repeat (non-LTR) retrotransposon in the human genome that has been implicated in the overexpression of MET. Both the canonical MET and L1-MET transcripts are considered to play a role in hepatocellular carcinoma (HCC) development...

journal_title：Journal of cancer research and clinical oncology

authors： Rashed WM,Kandeil MA,Mahmoud MO,Maher D,Ezzat S,Abdel-Rahman MH

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the effectiveness and safety of ultrasound guided percutaneous radiofrequency ablation (RFA) of cervical metastatic lymph nodes (LNs) from papillary thyroid carcinoma. METHODS:54 metastatic LNs confirmed by percutaneous biopsy in 33 patients with previous total thyroidectomy...

journal_title：Journal of cancer research and clinical oncology

authors： Guang Y,Luo Y,Zhang Y,Zhang M,Li N,Zhang Y,Tang J

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The development of brain metastases (BMs) was associated with poor prognosis in melanoma patients. Patients with BMs have a median survival of <6 months. Melanoma is the third most common tumor to metastasize to the brain with a reported incidence of 10-40 %. Our aim was to identify factors predicting develo...

journal_title：Journal of cancer research and clinical oncology

authors： Gumusay O,Coskun U,Akman T,Ekinci AS,Kocar M,Erceleb OB,Yazıcı O,Kaplan MA,Berk V,Cetin B,Taskoylu BY,Yildiz A,Goksel G,Alacacioglu A,Demirci U,Algin E,Uysal M,Oztop I,Oksuzoglu B,Dane F,Gumus M,Buyukberber S

更新日期：2014-01-01 00:00:00

abstract：:Telomerase, a ribonucleoprotein enzyme, is expected to be a new marker for cancer diagnosis. TRAP (the telomeric-repeat amplification protocol) developed by Kim et al. is a sensitive method to detect telomerase activity. Telomerase activity is detected by TRAP in most malignant cells in vivo and in vitro, but it is no...

journal_title：Journal of cancer research and clinical oncology

authors： Hirose M,Abe-Hashimoto J,Ogura K,Tahara H,Ide T,Yoshimura T

更新日期：1997-01-01 00:00:00

abstract：:Bromelain, a pineapple-derived plant product, added to C57Bl/6 mice laboratory chow decreased lung metastasis of Lewis lung cancer cells implanted s.c. This antimetastatic potential was demonstrated by both the active and inactive bromelain with or without proteolytic, anticoagulant properties. ...

journal_title：Journal of cancer research and clinical oncology

authors： Batkin S,Taussig SJ,Szekerezes J

更新日期：1988-01-01 00:00:00

abstract：:Repeated doses of beta-radiation in the mouse skin model have been reported to produce carcinomas and sarcomas with equal frequency. Among sarcomas, fibrosarcomas and osteosarcomas have been the predominant reported histologies. In this report we describe the beta-radiation induction of rhabdomyosarcoma (RMS), a histo...

journal_title：Journal of cancer research and clinical oncology

authors： Gupta A,Andrews KL,McDaniel KM,Nagle RB,Bowden GT

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Pheochromocytomas/paragangliomas (PHEOs/PGLs) are rare in children with only a few SDHB mutation-related cases. Previous studies on children were conducted in small cohorts. This large set of pediatric patients provides robust data in the evaluation of clinical outcomes. METHODS:Sixty-four pediatric PHEO/PGL p...

journal_title：Journal of cancer research and clinical oncology

authors： Jochmanova I,Abcede AMT,Guerrero RJS,Malong CLP,Wesley R,Huynh T,Gonzales MK,Wolf KI,Jha A,Knue M,Prodanov T,Nilubol N,Mercado-Asis LB,Stratakis CA,Pacak K

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To investigate the expression of sex steroid receptors in gastric cancer and to correlate their tumor expression profile with the clinicopathological parameters and overall survival of the patients. METHODS:Immunohistochemical methodology was employed in formalin-fixed paraffin-embedded sections from 86 patien...

journal_title：Journal of cancer research and clinical oncology

authors： Kominea A,Konstantinopoulos PA,Kapranos N,Vandoros G,Gkermpesi M,Andricopoulos P,Artelaris S,Savva S,Varakis I,Sotiropoulou-Bonikou G,Papavassiliou AG

更新日期：2004-05-01 00:00:00

abstract：:Synergy of folinic acid and FU has been shown in several experimental systems. In the present study we examined the kinetics of concurrent administration of folinic acid on the kinetics of FU in an in vivo model. Folinic acid significantly increased the amount of FU bound to the TS complex. In the sequential combinati...

journal_title：Journal of cancer research and clinical oncology

authors： Herrmann R,Reuter J,Port R,Osswald H

更新日期：1988-01-01 00:00:00

abstract：:DNA repair is an important process. It is as essential for the cell as is transcription and replication. There is evidence that deficient DNA repair processes lead to human disease including cancer, and recent progress in the field of DNA repair is likely to expand our knowledge about these relationships considerably....

journal_title：Journal of cancer research and clinical oncology

authors： Bohr VA

更新日期：1990-01-01 00:00:00

abstract：:Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract...

journal_title：Journal of cancer research and clinical oncology

authors： Green U,Althoff J

更新日期：1982-01-01 00:00:00

abstract：:The arabinofuranosylcytosine (AraC) derivative N4-octadecyl-1-beta-D-arabinofuranosylcytosine (NOAC) and its (5'-->5')-heterodinucleoside phosphate analog NOAC-AraC were compared with AraC for cytotoxicity, cell-cycle dependence, phosphorylation by deoxycytidine (dC) kinase and apoptosis induction in native, AraC- or ...

journal_title：Journal of cancer research and clinical oncology

authors： Horber DH,Cattaneo-Pangrazzi RM,von Ballmoos P,Schott H,Ludwig PS,Eriksson S,Fichtner I,Schwendener RA

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Isocitrate dehydrogenase (IDH)-wildtype glioblastomas are the most malignant glial tumours. Median survival is only 14-16 months after diagnosis, with patients aged ≥ 65 years reportedly showing worse outcome. This study aimed to further evaluate the prognostic role of age in a homogenously treated patient co...

journal_title：Journal of cancer research and clinical oncology

authors： Berger K,Turowski B,Felsberg J,Malzkorn B,Reifenberger G,Steiger HJ,Budach W,Haussmann J,Knipps J,Rapp M,Hänggi D,Sabel M,Mijderwijk HJ,Kamp MA

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine breast tumors and normal breast tissues for the expression of the glycoprotein lacritin. The mRNA and protein expression of lacritin has been reported to be restricted to the lacrimal gland. METHODS:We investigated 37 human primary invasive breast tumors, seven breast c...

journal_title：Journal of cancer research and clinical oncology

authors： Weigelt B,Bosma AJ,van 't Veer LJ

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:In this study we investigated the effect of Taxol, radiation, or Taxol plus radiation on highly proliferative normal tissue--the intestinal crypt cells of Swiss albino mice. MATERIALS AND METHODS:Swiss-albino mice, 3-4 months old, were used in this study. Taxol was administered by bolus intravenously through t...

journal_title：Journal of cancer research and clinical oncology

authors： Ozkan L,Ozuysal S,Egeli U,Adim SB,Tunca B,Aydemir N,Ceçener G,Ergül E,Akpinar G,Cimen C,Engin K,Ahmed MM

更新日期：2001-07-01 00:00:00

abstract：:The precise place of local estrogen production in mammary cancer is still controversial. In this investigation localization of aromatase (the key enzyme of estrogen biosynthesis) was studied in breast cancer tissue by immunohistochemical method using polyclonal rabbit antibodies. The cytoplasmic staining was found in ...

journal_title：Journal of cancer research and clinical oncology

authors： Berstein LM,Larionov AA,Kyshtoobaeva ASh,Pozharisski KM,Semiglazov VF,Ivanova OA

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To investigate the efficacy and safety of nab-paclitaxel plus S-1 (nab-P/S) versus nab-paclitaxel plus gemcitabine (nab-P/G) as first-line chemotherapy in patients with advanced pancreatic ductal adenocarcinoma (PDAC). METHODS:Treatment-naïve patients with advanced PDAC were equally randomized to receive nab-P...

journal_title：Journal of cancer research and clinical oncology

authors： Zong Y,Yuan J,Peng Z,Lu M,Wang X,Shen L,Zhou J

更新日期：2020-11-15 00:00:00

abstract：:Carboplatin therapy has a more favorable toxicity profile than cisplatin and, given in appropriate doses, is equivalent in efficacy to cisplatin for suboptimal ovarian cancer. However myelosuppression frequently curtails therapy with carboplatin. Diethyldithiocarbamate (DDTC) is a thiol compound and heavy-metal-chelat...

journal_title：Journal of cancer research and clinical oncology

authors： Francis P,Markman M,Hakes T,Reichman B,Rubin S,Jones W,Lewis JL Jr,Curtin J,Barakat R,Phillips M

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:G-protein-coupled receptors are known to mediate cell growth via divergent signaling pathways. It has been reported that colon cancer cells express muscarinic acetylcholine receptor (mAChR) although their functional role is largely unknown. The aim of this study is to elucidate possible mechanisms responsible f...

journal_title：Journal of cancer research and clinical oncology

authors： Ukegawa JI,Takeuchi Y,Kusayanagi S,Mitamura K

更新日期：2003-05-01 00:00:00

abstract：:Point mutations occurring at codon 201 of the gene coding for the alpha subunit of the stimulatory G protein impair intrinsic GTPase activity and lead to a constitutive activation of adenylate cyclase. We have examined thyroid follicular and papillary carcinomas and follicular adenomas and found samples that bear this...

journal_title：Journal of cancer research and clinical oncology

authors： Gorelov VN,Dumon K,Barteneva NS,Palm D,Röher HD,Goretzki PE

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:The molecular mechanisms underlying the development of intestinal metaplasia (IM) of the human stomach have yet to be clarified in detail. Besides ectopic expression of intestinal transcription factors, Cdx1 and Cdx2, little information is available regarding other regulatory factors. Hence, we here analyzed So...

journal_title：Journal of cancer research and clinical oncology

authors： Tsukamoto T,Inada K,Tanaka H,Mizoshita T,Mihara M,Ushijima T,Yamamura Y,Nakamura S,Tatematsu M

更新日期：2004-03-01 00:00:00

abstract：:This study was undertaken in order to compare the usefulness of three indices of tumour proliferation in detecting primary hepatocellular carcinoma (HCC) and in differentiating this neoplasm from liver cirrhosis. In 10 patients with HCC and in 63 with liver cirrhosis serum alpha-fetoprotein (AFP), tissue polypeptide a...

journal_title：Journal of cancer research and clinical oncology

authors： Leandro G,Basso D,Fabris C,Zizzari S,Elba S,Del Favero G,Di Mario F,Meggiato T,Angonese C,Naccarato R

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:In selected patients with rectal cancer, laparoscopic surgery is as safe as open surgery, with similar resection margins and completeness of resection. In addition, recovery is faster after laparoscopic surgery. We analyzed long-term outcomes in a group of patients with locally advanced rectal cancer (LARC) ...

journal_title：Journal of cancer research and clinical oncology

authors： Calvo FA,Sole CV,Serrano J,Rodriguez M,Marcos F,Muñoz-Calero A,Zorrilla J,Lopez-Baena JA,Diaz-Zorita B,García-Sabrido JL,del Valle E

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:Although important for apoptosis, the signaling pathway involving MOAP-1(Modulator of Apoptosis 1), RASSF1A (RAS association domain family 1A), and Bax (Bcl-2 associated X protein) is likely to be dysfunctional in many types of human cancers due to mechanisms associated with gene mutation and DNA hyper-methylat...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YH,Pang SW,Revai Lechtich E,Shah K,Simon SE,Ponnusamy S,Narayanan R,Poh CL,Tan KO

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00