Sialyl-Lewis(x/a)-decorated selectin ligands in head and neck tumours.

abstract：BACKGROUND:Triple negative breast cancer (TNBC) harbors a heterogeneous group of carcinomas with poor prognosis and high genetic variability. As a potential aim for targeted therapy, genetic mutations leading to an activation of the phosphoinositide 3-kinase pathway in a catalytic subunit (PIK3CA) in breast cancer have...

journal_title：Journal of cancer research and clinical oncology

authors： Elfgen C,Reeve K,Moskovszky L,Güth U,Bjelic-Radisic V,Fleisch M,Tausch C,Varga Z

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Aberrant expression of RNA-binding motif protein 3 (RBM3) has been suggested as a prognostic biomarker in several malignancies. MATERIALS AND METHODS:This study was performed to analyse the prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers (NSCLCs). Therefore, we t...

journal_title：Journal of cancer research and clinical oncology

authors： Melling N,Bachmann K,Hofmann B,El Gammal AT,Reeh M,Mann O,Moebius C,Blessmann M,Izbicki JR,Grupp K

更新日期：2019-04-01 00:00:00

abstract：:The nuclear DNA content (DNA ploidy) level was determined in a series of 83 human brain metastases, for which 35 complete clinical follow-ups were available. The DNA ploidy level determination was carried out by means of DNA histogram types. The results show that certain brain metastases were diploid, while others exh...

journal_title：Journal of cancer research and clinical oncology

authors： Kiss R,Rorive S,Camby I,Pasteels JL,Brotchi J,Salmon I

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. METHODS:TNBC patients (n = 179) with complete clinical data and up to 18-year follow-up...

journal_title：Journal of cancer research and clinical oncology

authors： Vihervuori H,Autere TA,Repo H,Kurki S,Kallio L,Lintunen MM,Talvinen K,Kronqvist P

更新日期：2019-12-01 00:00:00

abstract：:In a population-based case/control study the differential lung cancer risk patterns due to tobacco smoking habits of various histological types have been investigated. The cases were 1432 deaths from lung cancer in the years 1980-1987, of which the histological type was known for 627 individuals. There was 54% squamou...

journal_title：Journal of cancer research and clinical oncology

authors： Jedrychowski W,Becher H,Wahrendorf J,Basa-Cierpialek Z,Gomola K

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:PTEN is an essential tumour suppressor gene which encodes a phosphatase protein that antagonises the PI3K/Akt/mTOR antiapoptotic pathway. Impairment of this tumour suppressor pathway potentially becomes a causal factor for development of malignancies. This review aims to assess current understanding of mechanis...

journal_title：Journal of cancer research and clinical oncology

authors： Lim HJ,Crowe P,Yang JL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:The aim of this study was to combine clinical pathologic variables that are associated with pathologic completer response (pCR) and relapse-free survival (RFS) after neoadjuvant chemotherapy into prediction nomograms. METHODS:A total of 370 stage II or III breast cancer patients who received neoadjuvant doceta...

journal_title：Journal of cancer research and clinical oncology

authors： Keam B,Im SA,Park S,Nam BH,Han SW,Oh DY,Kim JH,Lee SH,Han W,Kim DW,Kim TY,Park IA,Noh DY,Heo DS,Bang YJ

更新日期：2011-09-01 00:00:00

abstract：:Male Sprague-Dawley rats were treated for 7 weeks with 120 mg/l N-nitrosomorpholine in their drinking water. At the end of the treatment period there were large numbers of enzyme-altered foci in the liver. During the following 10 weeks, the number of foci decreased significantly. This decrease in the number of enzyme-...

journal_title：Journal of cancer research and clinical oncology

authors： Enzmann H,Bannasch P

更新日期：1988-01-01 00:00:00

abstract：:Genetic predisposition is responsible for 5% 10% of all breast cancer cases. Therefore, the inherited susceptibility to breast cancer has been intensively investigated during the last 10 years. In particular, the identification of the breast cancer susceptibility genes BRCA1 (breast cancer gene 1) and BRCA2 and the cu...

journal_title：Journal of cancer research and clinical oncology

authors： Hofmann W,Schlag PM

更新日期：2000-09-01 00:00:00

abstract：:In this summary, J. Konietzko (Mainz) stressed the exceptional position of occupational cancer, which is due to the long latent period between exposure to specific carcinogens and cancer manifestation. Obviously, this long latent period of years to decades poses problems in the search for the etiology of occupational ...

journal_title：Journal of cancer research and clinical oncology

authors： Berger MR

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:We have demonstrated that overexpression of osteopontin (OPN) could contribute to metastasis in hepatocellular carcinoma (HCC), and that OPN-positive cancer cells are often localized in the periphery of cancer nodules adjacent to stromal cells. This study was to identify the difference of intratumor genomic abe...

journal_title：Journal of cancer research and clinical oncology

authors： Wu JC,Sun BS,Ren N,Ye QH,Qin LX

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00

abstract：:Intravenous tumor cell injection and spontaneously metastasising transplantable tumors have been used as models for haematogenous tumor spread. To evaluate the validity of these two experimental approaches for the study of blood coagulability and metastases, the effect of anticoagulants on "secondary" tumor growth was...

journal_title：Journal of cancer research and clinical oncology

authors： Maat B,Hilgard P

更新日期：1981-01-01 00:00:00

abstract：:Using batroxobin, a thrombin-like enzyme found in snake venom, the effects of defibrinogenation on artificial lung metastasis in mice were studied. The role of natural killer (NK) cells in the inhibitory effects of defibrinogenation on metastasis was also investigated. Artificial lung metastasis experiments were perfo...

journal_title：Journal of cancer research and clinical oncology

authors： Shibuya M,Niitani H,Aoyama A,Kawachi S,Nukariya N,Baba M,Iizuka K,Sakai S,Ohtsuka M

更新日期：1990-01-01 00:00:00

abstract：:(alpha 1----3)-L-Fucosyltransferase activity was measured in serum samples from 90 gastric cancer patients, 10 patients with benign diseases and 100 healthy controls. The enzyme activity was significantly elevated in the serum samples of patients with cancer compared to those from patients with benign diseases (P less...

journal_title：Journal of cancer research and clinical oncology

authors： Yazawa S,Asao T,Nagamachi Y,Abbas SA,Matta KL

更新日期：1989-01-01 00:00:00

abstract：:Targeted therapy refers to anticancer treatment which specifically targets key molecules of cancer cells and/or neovascular cells, aiming to thus interfere with processes of tumorigenesis, cancer progression and metastasis. The epidermal growth factor receptor (EGFR) was the first receptor to be proposed for targeted ...

journal_title：Journal of cancer research and clinical oncology

authors： Zahorowska B,Crowe PJ,Yang JL

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in gastric cancer patients. METHODS:A systematic literature search was conducted to identify eligible studies in PubMed and Embase. The pooled hazard ratios (HRs) or odds ratios (ORs) with their correspond...

journal_title：Journal of cancer research and clinical oncology

authors： Wei K,Jiang L,Wei Y,Wang Y,Qian X,Dai Q,Guan Q

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:There was no standard treatment for hepatocellular carcinoma with portal vein tumour thrombosis (PVTT). This prospective, randomised, two-arm clinical trial aims to investigate the feasibility, safety and effectiveness of transarterial chemoembolisation (TACE) combined with the endovascular implantation of an i...

journal_title：Journal of cancer research and clinical oncology

authors： Yang M,Fang Z,Yan Z,Luo J,Liu L,Zhang W,Wu L,Ma J,Yang Q,Liu Q

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Death-associated protein kinase (DAPK) and adenomatous polyposis coli gene (APC) have been recently shown to be associated with outcome in patients with esophageal carcinoma, especially adenocarcinoma. We wanted to validate the correlation of these two markers with outcome by detecting methylated DNA sequenc...

journal_title：Journal of cancer research and clinical oncology

authors： Hoffmann AC,Vallböhmer D,Prenzel K,Metzger R,Heitmann M,Neiss S,Ling F,Hölscher AH,Schneider PM,Brabender J

更新日期：2009-09-01 00:00:00

abstract：:Metastatic interstitial cell tumor of the testis is one of the rarest human neoplasms. This is the nineteenth case to be reported. While most of these tumors are combined with hormonal dysfunction, the present tumor, apart from its uncommon hormonal profile, is remarkable because of its capacity of producing and secre...

journal_title：Journal of cancer research and clinical oncology

authors： Higi M,Niederle N,Scheulen ME,Richter HJ

更新日期：1979-07-27 00:00:00

abstract：PURPOSE:Prostate cancer is one of the leading causes of cancer death for male. In the present study, we applied an integrated bioinformatics approach to provide a novel perspective and identified some hub genes of prostate cancer. METHOD:Microarray data of fifty-nine prostate cancer were downloaded from Gene Expressio...

journal_title：Journal of cancer research and clinical oncology

authors： Huang H,Zhang Q,Ye C,Lv JM,Liu X,Chen L,Wu H,Yin L,Cui XG,Xu DF,Liu WH

更新日期：2017-12-01 00:00:00

abstract：:The inducibility of cytotoxic T lymphocytes (CTL) that react with carcinoembryonic antigen (CEA) was tested in cancer patients with elevated (more than 5 ng/ml) serum CEA levels when antigen presentation was carried out with paraformaldehyde-fixed adhesive peripheral blood mononuclear cells (PBMC) from the patient tha...

journal_title：Journal of cancer research and clinical oncology

authors： Kim CH,Todoroki T,Matsumura M,Ohno T

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Riproximin, a type II ribosome-inactivating protein (RIP), has shown significant cytotoxic effects in diverse types of cancer cells. To better understand its therapeutic potential, elaborated investigations on the mechanistic aspects of riproximin deem crucial. In this study, we focused on riproximin-mediate...

journal_title：Journal of cancer research and clinical oncology

authors： Pervaiz A,Zepp M,Adwan H,Berger MR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Several reports describe the importance of the chaperone HSP27 (HSPB1) in cancer progression, and the demand for drugs that modulate HSPB1-activity is increasing rapidly. We reported earlier that RP101 (Bromovinyldeoxyuridine, BVDU, Brivudine) improves the efficacy of chemotherapy in pancreatic cancer. METH...

journal_title：Journal of cancer research and clinical oncology

authors： Heinrich JC,Tuukkanen A,Schroeder M,Fahrig T,Fahrig R

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:Genomic stability is maintained by error-free DNA replication, repair, and recombination. To determine if repair genes contribute to genomic instability, we used a newly established cell line RCC-AJR (from clear-cell renal cell carcinoma) to examine hMSH2 (a mismatch-repair gene) and the gene encoding DNA beta ...

journal_title：Journal of cancer research and clinical oncology

authors： Chen HC,Bhattacharyya N,Wang L,Recupero AJ,Klein EA,Harter ML,Banerjee S

更新日期：2000-04-01 00:00:00

abstract：:A novel butyric acid derivative, pivaloyloxymethyl butyrate, AN-9, was previously shown to be a potent differentiating agent. AN-9 exerts a significant anticancer activity in vitro and in vivo. In all the activities examined, AN-9 was more potent than butyric acid. Here we show that AN-9 and butyric acid induce cell d...

journal_title：Journal of cancer research and clinical oncology

authors： Zimra Y,Wasserman L,Maron L,Shaklai M,Nudelman A,Rephaeli A

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Clinical trials have reported conflicting results as to whether taxane-based doublet improves outcome over single-agent taxane in patients with advanced breast cancer. METHODS:We performed a meta-analysis comparing primary and secondary end points of taxane-based doublet with single-agent taxane chemotherapy i...

journal_title：Journal of cancer research and clinical oncology

authors： Xu HB,Xu Q,Li L

更新日期：2011-06-01 00:00:00

abstract：:The isolation of deoxyguanosine-resistant 10T1/2 mouse cell lines following stepwise selection in the presence of increasing concentrations of drug led to the identification of a highly metastatic line, as measured by the ability to form secondary tumors in syngenic mice after intravenous injection. This metastatic de...

journal_title：Journal of cancer research and clinical oncology

authors： Damen JE,Spearman MA,Greenberg AH,Wright JA

更新日期：1991-01-01 00:00:00

abstract：:Mice with s.c. grafts of gastric carcinoma MKN45 or osteosarcoma 788T were injected i.v. with recombinant tumour necrosis factor alpha (rTNF alpha) and tumour blood flow rates were determined 4 h later as a fraction of the cardiac output g tissue-1. With MKN45, the tumour blood flow rate was significantly reduced from...

journal_title：Journal of cancer research and clinical oncology

authors： Pimm MV,Gribben SJ,Morris TM

更新日期：1991-01-01 00:00:00

abstract：:Osteosarcoma cells derived from patients have been isolated and subsequently cultured for the past 35 years. To date though, there have been no major breakthroughs in the development of a model for osteosarcoma that uses orthotopic implantation of human osteosarcoma cells and that closely emulates the clinical progres...

journal_title：Journal of cancer research and clinical oncology

authors： Dass CR,Ek ET,Choong PF

更新日期：2007-03-01 00:00:00