当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing.

Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing.

Abstract：

:Osteosarcoma cells derived from patients have been isolated and subsequently cultured for the past 35 years. To date though, there have been no major breakthroughs in the development of a model for osteosarcoma that uses orthotopic implantation of human osteosarcoma cells and that closely emulates the clinical progression of this debilitating and fatal disease. Such a model is long overdue given the devastating demographics (second highest cause of cancer-related death in the paediatric age group) of the ailment and the lack of solid options for control, if not cure, for the disease, as it also is the most common primary tumour of bone. Only then can more robust R & D be undertaken in the search for efficacious anti-osteosarcoma agents. This review tackles this conundrum and lists the variety of models (that use human osteosarcoma cells) available and the types of studies performed with these.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Dass CR,Ek ET,Choong PF

doi

10.1007/s00432-006-0157-x

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

193-8

issue

3

eissn

0171-5216

issn

1432-1335

journal_volume

133

pub_type

杂志文章,评审

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