Genetic polymorphisms of phase I and phase II metabolic enzymes as modulators of lung cancer susceptibility.

abstract：PURPOSE:In this study we investigated the effect of Taxol, radiation, or Taxol plus radiation on highly proliferative normal tissue--the intestinal crypt cells of Swiss albino mice. MATERIALS AND METHODS:Swiss-albino mice, 3-4 months old, were used in this study. Taxol was administered by bolus intravenously through t...

journal_title：Journal of cancer research and clinical oncology

authors： Ozkan L,Ozuysal S,Egeli U,Adim SB,Tunca B,Aydemir N,Ceçener G,Ergül E,Akpinar G,Cimen C,Engin K,Ahmed MM

更新日期：2001-07-01 00:00:00

abstract：:The two hormone analogues octreotide and goserelin have been shown to decelerate growth of human pancreatic cancer in vitro and in vivo. The objective of this pilot study was to investigate the efficacy and toxicity of the combination of these two agents in patients with advanced pancreatic cancer. Octreotide was inje...

journal_title：Journal of cancer research and clinical oncology

authors： Fazeny B,Baur M,Prohaska M,Hudec M,Kremnitzer M,Meryn S,Huber H,Grunt T,Tuchmann A,Dittrich C

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. METHODS:We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of th...

journal_title：Journal of cancer research and clinical oncology

authors： Rottmann M,Burges A,Mahner S,Anthuber C,Beck T,Grab D,Schnelzer A,Kiechle M,Mayr D,Pölcher M,Schubert-Fritschle G,Engel J

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:To determine the incidence of hepatocellular carcinoma in cirrhosis and to examine the influence of age and sex, and the contribution of etiological factors. METHODS:967 patients with liver cirrhosis and free of hepatocellular carcinoma were enrolled in this longitudinal, retrospective and observational study....

journal_title：Journal of cancer research and clinical oncology

authors： del Olmo JA,Serra MA,Rodríguez F,Escudero A,Gilabert S,Rodrigo JM

更新日期：1998-01-01 00:00:00

abstract：:Intravenous tumor cell injection and spontaneously metastasising transplantable tumors have been used as models for haematogenous tumor spread. To evaluate the validity of these two experimental approaches for the study of blood coagulability and metastases, the effect of anticoagulants on "secondary" tumor growth was...

journal_title：Journal of cancer research and clinical oncology

authors： Maat B,Hilgard P

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Serum thyrotropin (TSH) is a well-established growth factor for thyroid nodules and suppression of TSH concentrations by administering exogenous thyroxine may interfere with the growth of established nodules as well as the formation of new thyroid nodules. The aim of this study was to investigate whether serum ...

journal_title：Journal of cancer research and clinical oncology

authors： Polyzos SA,Kita M,Efstathiadou Z,Poulakos P,Slavakis A,Sofianou D,Flaris N,Leontsini M,Kourtis A,Avramidis A

更新日期：2008-09-01 00:00:00

abstract：:Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract...

journal_title：Journal of cancer research and clinical oncology

authors： Green U,Althoff J

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:The oncogenic roles of sphingosine kinase 1 (SphK1) in various cancers, including thyroid cancer, have been well demonstrated. However, the microRNAs (miRNAs) associated with the oncogenic roles of SphK1 remain largely unknown. METHODS:Global gene and miRNA expression in TPC1-Vector and TPC1-SphK1 cells was an...

journal_title：Journal of cancer research and clinical oncology

authors： Liang W,Xie Z,Cui W,Guo Y,Xu L,Wu J,Guan H

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:Papillary thyroid carcinoma (PTC), the most common malignant tumor of the thyroid, has been criticized as overtreated by some researchers in recent years. Active surveillance (AS) was first proposed at Kuma Hospital in 1993, and popularized in other institutes ever since. We provide a brief review of low-risk P...

journal_title：Journal of cancer research and clinical oncology

authors： Ze Y,Zhang X,Shao F,Zhu L,Shen S,Zhu D,Bi Y

更新日期：2019-11-01 00:00:00

abstract：:The effects of four barbiturates with or without liver-tumor-promoting activity were examined on survival and deoxyribonucleic acid (DNA) synthesis of suckling and adult rat hepatocytes in serum-free primary culture: Of the four barbiturates, two promoters, phenobarbital and barbital, enhanced DNA synthesis of sucklin...

journal_title：Journal of cancer research and clinical oncology

authors： Miyazaki M,Bai L,Tsuboi S,Namba M

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Death-associated protein kinase (DAPK) and adenomatous polyposis coli gene (APC) have been recently shown to be associated with outcome in patients with esophageal carcinoma, especially adenocarcinoma. We wanted to validate the correlation of these two markers with outcome by detecting methylated DNA sequenc...

journal_title：Journal of cancer research and clinical oncology

authors： Hoffmann AC,Vallböhmer D,Prenzel K,Metzger R,Heitmann M,Neiss S,Ling F,Hölscher AH,Schneider PM,Brabender J

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Despite great progress in the diagnosis and treatment of localized prostate cancer (PCa), there remains a need for new diagnostic markers that can accurately distinguish indolent and aggressive variants. One promising approach is the antibody-based targeting of prostate stem cell antigen (PSCA), which is freque...

journal_title：Journal of cancer research and clinical oncology

authors： Kessler C,Pardo A,Tur MK,Gattenlöhner S,Fischer R,Kolberg K,Barth S

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Sec8, a component of the exocyst complex, has been implicated in tethering of secretory vesicles to specific regions on the plasma membrane. To investigate the involvement of Sec8 in oral squamous-cell carcinoma (OSCC), we evaluated the expression status and effect of Sec8 in OSCC cell lines. METHODS:Sec8 mRNA...

journal_title：Journal of cancer research and clinical oncology

authors： Yamamoto A,Kasamatsu A,Ishige S,Koike K,Saito K,Kouzu Y,Koike H,Sakamoto Y,Ogawara K,Shiiba M,Tanzawa H,Uzawa K

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:Angiosarcoma of the scalp and face is a rare malignant endothelial tumor arising mainly in elderly people. The prognosis is poor. Effective and safe treatments are warranted. METHODS:A 79-year-old woman with an angiosarcoma of the scalp larger than 5 cm in diameter was treated with intravenous liposomal doxoru...

journal_title：Journal of cancer research and clinical oncology

authors： Wollina U,Füller J,Graefe T,Kaatz M,Lopatta E

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Molecular mechanisms of response to hypomethylating agents in patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) still remain largely unknown. Therefore, the effects of 5-Azacytidine (Aza) on clonal architecture and DNA methylation were investigated in this study. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Gawlitza AL,Speith J,Rinke J,Sajzew R,Müller EK,Schäfer V,Hochhaus A,Ernst T

更新日期：2019-11-01 00:00:00

abstract：:A dose-response study was carried out in male F344 rats with a specific urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), which was administered as a solution in drinking water for up to 112 weeks. BBN was given in four different concentrations, 50, 10, 5, and 1 ppm, to groups of 30 rats. The hi...

journal_title：Journal of cancer research and clinical oncology

authors： Ito N,Shirai T,Fukushima S,Hirose M

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Melanoma antigen gene A3 (MAGE-A3) is aberrantly expressed in a number of cancer types. Because of its high specificity, MAGE-A3 has shown to be a promising candidate for cancer immunotherapy. Dendritic cells (DCs) have emerged as the natural agents for antigen delivery. DCs transduced with antigen may increase...

journal_title：Journal of cancer research and clinical oncology

authors： Lin L,Wei J,Chen Y,Huang A,Li KK,Zhang W

更新日期：2014-02-01 00:00:00

abstract：:Nitrosodiphenylamine was tested for induction of DNA single strand breaks in rat hepatocytes and Chinese hamster V 79 cells with the alkaline filter elution assay. While in rat hepatocytes DNA damage was observed, negative results were obtained in V 79 cells. In view of the metabolic capacity of hepatocytes and the ch...

journal_title：Journal of cancer research and clinical oncology

authors： Appel KE,Görsdorf S,Scheper T,Ruf HH,Rühl CS,Hildebrandt AG

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:The polymorphisms in microRNA (miRNA) machinery genes and miRNA-containing genomic regions may play an important role in cancer development and prognosis. Accordingly, the present study analyzed the single nucleotide polymorphisms (SNPs) of miRNA-related genes and their impact on the prognosis for patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Lee HC,Kim JG,Chae YS,Sohn SK,Kang BW,Moon JH,Jeon SW,Lee MH,Lim KH,Park JY,Choi GS,Jun SH

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Hand-foot syndrome (HFS) is a common adverse event that can be induced by capecitabine. It is hypothesized that capecitabine (Hoffmann-La Roche Inc.) based chemotherapy can cause overexpression of COX-2 in tumor and healthy tissue, which finally induced HFS in hands and feet. Based on this, we believed that a s...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang RX,Wu XJ,Lu SX,Pan ZZ,Wan DS,Chen G

更新日期：2011-06-01 00:00:00

abstract：:The human histiocytic cell line U 937, which expresses a number of monocyte markers and properties, was investigated with regard to its ability to be activated for NO and tumor necrosis factor (TNF) release after treatment with alkylphosphocholines (APC) and APC liposomes. Using APC multilamellar vesicles (MLV) a clea...

journal_title：Journal of cancer research and clinical oncology

authors： Eue I,Zeisig R,Arndt D

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Bone marrow adherent cells contain conventional bone marrow stromal cells and mesenchymal stem cells and these cells constitute the hematopoietic microenvironment. Mesenchymal stem cells have the capacity to give rise to multiple mesenchymal lineage cells and even ectodermal lineage cells. In the present study,...

journal_title：Journal of cancer research and clinical oncology

authors： Li Q,Hisha H,Takaki T,Adachi Y,Li M,Song C,Feng W,Okazaki S,Mizokami T,Kato J,Inaba M,Hosaka N,Maki M,Ikehara S

更新日期：2010-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a very important in the process of tumor angiogenesis, was chosen as a target in a study to determine whether manipulation of angiogenesis with antibody against VEGF may interrupt tumor growth and metastasis. Anti-VEGF antibody was obtained from immunized rabbits, purified on...

journal_title：Journal of cancer research and clinical oncology

authors： Wang G,Dong Z,Xu G,Yang Z,Shou C,Wang N,Liu T

更新日期：1998-01-01 00:00:00

abstract：:In 1989, 65%-75% of previously untreated adults with ALL or AML may be expected to enter complete remission. Approximately 40% of these completely responding patients, whether they are treated with intensive chemotherapy, intensive chemotherapy followed by autologous bone marrow transplantation, or allogeneic bone mar...

journal_title：Journal of cancer research and clinical oncology

authors： Mayer RJ

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Acute intestinal damage induced by chemotherapeutic agent is often a dose-limiting factor in clinical cancer therapy. The aim of this study was to investigate the effect of chemokine CXCL9 on the intestinal damage after chemotherapy and explore the therapeutic potential of anti-CXCL9 agents. METHODS:In vitro c...

journal_title：Journal of cancer research and clinical oncology

authors： Lu H,Liu H,Wang J,Shen J,Weng S,Han L,Sun T,Qian L,Wu M,Zhu S,Yu Y,Han W,Zhu J,Moldenhauer A

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:The p16/cyclin D1/pRb pathway plays a critical role in tumourigenesis. We recently reported alterations in expression of tumour suppressor gene products, p16 and pRb in esophageal cancer. Knowledge of alterations in cyclin D1, a vital component of this pathway in esophageal carcinomas from the Indian subcontine...

journal_title：Journal of cancer research and clinical oncology

authors： Mathew R,Arora S,Khanna R,Shukla NK,Mathur M,Ralhan R

更新日期：2001-04-01 00:00:00

abstract：:The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by means of the siliconoil-filtration technique. At 10 mM concentration no permeation of the metabolite into the tumor cells could be found within 5 min at 1 degrees C, while its congenors cyclop...

journal_title：Journal of cancer research and clinical oncology

authors： Lenssen U,Hohorst HJ

更新日期：1979-02-19 00:00:00

abstract：PURPOSE:This retrospective study evaluated the diagnostic value of integrated whole-body (18)F-fluorodeoxyglucose positron-emission tomography and computed tomography ((18)F-FDG-PET/CT) in early detection of second primary malignancies in cancer patients. MATERIALS AND METHODS:From June 2007 to October 2008, 677 cance...

journal_title：Journal of cancer research and clinical oncology

authors： Xu H,Zhang M,Zhai G,Li B

更新日期：2010-08-01 00:00:00

abstract：:In view of the great variation in the size of epithelial cell nuclei in benign changes in the mammary gland, the cytologist is often faced with diagnostic difficulties. Clear differences in the size of the nuclei in aspiration biopsies from the mammary glands of pregnant women and those from the mammary glands of post...

journal_title：Journal of cancer research and clinical oncology

authors： Schöndorf H,Naujoks H

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Recent advances in sequencing technologies supported the development of molecularly targeted therapy in cancer patients. Thus, genomic analyses are becoming a routine part in clinical practice and accurate detection of actionable mutations is essential to assist diagnosis and therapy choice. However, this is...

journal_title：Journal of cancer research and clinical oncology

authors： Ofner R,Ritter C,Ugurel S,Cerroni L,Stiller M,Bogenrieder T,Solca F,Schrama D,Becker JC

更新日期：2017-07-01 00:00:00