Serum thyrotropin concentration as a biochemical predictor of thyroid malignancy in patients presenting with thyroid nodules.

abstract：BACKGROUND:Gastric cancer (GC) is the second most common leading cause of cancer-related death. Cancer stem cell (CSC) with the mark of CD44 played an important role in GC. rMETase was wildly exploited as chemotherapeutic option for GC. Polymers synthetic nanoparticle drug delivery systems have been commonly used for c...

journal_title：Journal of cancer research and clinical oncology

authors： Li YF,Zhang HT,Xin L

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Despite of the introduction of novel treatment modalities for multiple myeloma, high-dose chemotherapy with hematopoietic stem-cell rescue is still considered the standard of care for eligible patients <65 years of age. As we have previously reported, stem-cell grafts regularly contain quantities of plasma c...

journal_title：Journal of cancer research and clinical oncology

authors： Kopp HG,Yildirim S,Weisel KC,Kanz L,Vogel W

更新日期：2009-04-01 00:00:00

abstract：:In this summary, J. Konietzko (Mainz) stressed the exceptional position of occupational cancer, which is due to the long latent period between exposure to specific carcinogens and cancer manifestation. Obviously, this long latent period of years to decades poses problems in the search for the etiology of occupational ...

journal_title：Journal of cancer research and clinical oncology

authors： Berger MR

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:We examined the influence of OGG1 c.977C>G (rs1052133), APEX1 c.444T>G (rs1130409), XRCC1 c.-77T>C (rs3213245), c.580C>T (rs1799782), c.839G>A (rs25489) and c.1196G>A (rs25487) single-nucleotide polymorphisms (SNPs), involved in base-excision repair (BER) pathway, on oropharyngeal squamous cell carcinoma (OPSCC...

journal_title：Journal of cancer research and clinical oncology

authors： Costa EF,Santos ES,Liutti VT,Leal F,Santos VC,Rinck-Junior JA,Mariano FV,Coutinho-Camillo CM,Altemani A,Lima CS,Lourenço GJ

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:This meta-analysis was conducted to quantitatively assess the prognostic significance of p53 expression in gastric cancer patients. METHODS:A systematic literature search was conducted to identify eligible studies in PubMed and Embase. The pooled hazard ratios (HRs) or odds ratios (ORs) with their correspond...

journal_title：Journal of cancer research and clinical oncology

authors： Wei K,Jiang L,Wei Y,Wang Y,Qian X,Dai Q,Guan Q

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:The growth pattern of peripheral squamous cell carcinoma (SCC) of the lung is divided into two types: alveolar space-filling (ASF) growth and alveolar space-destructive (ASD) growth. The aim of this study was to investigate the clinicopathological differences between cancer cells displaying ASF and ASD growth. ...

journal_title：Journal of cancer research and clinical oncology

authors： Omori T,Aokage K,Nakamura H,Katsumata S,Miyoshi T,Sugano M,Kojima M,Fujii S,Kuwata T,Ochiai A,Ikeda N,Tsuboi M,Ishii G

更新日期：2019-07-01 00:00:00

abstract：:Bone metastatic prostate cancer is one of the most common malignancies in developed countries and the second leading cause of cancer-related death in men. There remains no effective treatment for metastatic prostate cancer. We investigate here the anticancer effects of botanical component p-hydroxycinnamic acid (HCA) ...

journal_title：Journal of cancer research and clinical oncology

authors： Yamaguchi M,Murata T,Ramos JW

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:Dysregulation of microRNA (miRNA) metabolism has been observed in a variety of human cancers, but the expression patterns of the enzymes responsible for generating miRNAs remain largely unexplored. In this study, we investigated the expression profiles of the two most important enzymes of the miRNA machinery, D...

journal_title：Journal of cancer research and clinical oncology

authors： Guo X,Liao Q,Chen P,Li X,Xiong W,Ma J,Li X,Luo Z,Tang H,Deng M,Zheng Y,Wang R,Zhang W,Li G

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:We aimed to clarify the prognostic impact of the anatomic extent of hepatic resection (Hr) related to the tumor hepatic involvement (H) on patients' survival in the treatment of hepatocellular carcinoma (HCC). METHOD:The 305 patients with HCC who had undergone hepatectomy were analyzed retrospectively. The pat...

journal_title：Journal of cancer research and clinical oncology

authors： Ochiai T,Sonoyama T,Kikuchi S,Okayama T,Konishi H,Kitagawa M,Tagi T,Ueda Y,Otsuji E

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Mucosal inflammation in the small intestine is a potentially hazardous side effect of abdominal irradiation. In an effort to develop a quantitative method of evaluating mucosal damage, the luminal release of brush border enzymes in response to ionizing radiation was examined using two investigational strategies...

journal_title：Journal of cancer research and clinical oncology

authors： Fittkau M,Grothey A,Gerlach R,Schmoll HJ

更新日期：2001-02-01 00:00:00

abstract：:Formaldehyde is a reactive chemical which undergoes spontaneous reactions with various cellular constituents. Mutagenicity data may be interpreted on the background of this behavior. Mice are better able to reduce the irritating effect of formaldehyde than rats and to reduce their ventilation rate when formaldehyde ac...

journal_title：Journal of cancer research and clinical oncology

authors： Bolt HM

更新日期：1987-01-01 00:00:00

abstract：:Using batroxobin, a thrombin-like enzyme found in snake venom, the effects of defibrinogenation on artificial lung metastasis in mice were studied. The role of natural killer (NK) cells in the inhibitory effects of defibrinogenation on metastasis was also investigated. Artificial lung metastasis experiments were perfo...

journal_title：Journal of cancer research and clinical oncology

authors： Shibuya M,Niitani H,Aoyama A,Kawachi S,Nukariya N,Baba M,Iizuka K,Sakai S,Ohtsuka M

更新日期：1990-01-01 00:00:00

abstract：:To examine the relationship between altered spontaneous mutation rates and malignant characteristics of cells, two hydroxyurea-resistant Chinese hamster ovary cell lines, with alterations in ribonucleotide reductase, were examined for their rates of spontaneous mutation to 6-thioguanine and ouabain resistance, tumor g...

journal_title：Journal of cancer research and clinical oncology

authors： Tagger AY,Damen JE,Greenberg AH,Wright JA

更新日期：1989-01-01 00:00:00

abstract：:Nitrosodiphenylamine was tested for induction of DNA single strand breaks in rat hepatocytes and Chinese hamster V 79 cells with the alkaline filter elution assay. While in rat hepatocytes DNA damage was observed, negative results were obtained in V 79 cells. In view of the metabolic capacity of hepatocytes and the ch...

journal_title：Journal of cancer research and clinical oncology

authors： Appel KE,Görsdorf S,Scheper T,Ruf HH,Rühl CS,Hildebrandt AG

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Circulating tumor cells (CTCs) have long been considered a reflection of tumor aggressiveness. Hematogenous spreading of CTCs from a primary tumor is a crucial step in the metastasis cascade, which leads ultimately to the formation of overt metastases. However, owing to the rarity of CTCs in peripheral blood...

journal_title：Journal of cancer research and clinical oncology

authors： Sun YF,Yang XR,Zhou J,Qiu SJ,Fan J,Xu Y

更新日期：2011-08-01 00:00:00

abstract：:The antigen complex A60 of Mycobacterium bovis bacillus Calmette-Guérin protected mice against experimental tuberculous infection, and prevented cancer development after challenge with EMT 6 cells. Although humoral and cellular immune reactions elicited by A60 in vivo remained unaffected in cases of tumor rejection, t...

journal_title：Journal of cancer research and clinical oncology

authors： Maes H,Cocito C

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:The PI3K pathway controls diverse cellular processes including growth, survival, metabolism, and apoptosis. Nuclear FOXO factors were observed in cancers that harbor constitutively active PI3K pathway output and stem signatures. FOXO1 and FOXO3 were previously published to induce stem genes such as OCT4 in e...

journal_title：Journal of cancer research and clinical oncology

authors： Martinez E,Vazquez N,Lopez A,Fanniel V,Sanchez L,Marks R,Hinojosa L,Cuello V,Cuevas M,Rodriguez A,Tomson C,Salinas A,Abad M,Holguin M,Garza N,Arenas A,Abraham K,Maldonado L,Rojas V,Basdeo A,Schuenzel E,Persans M

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:Long interspersed nuclear element 1 (LINE-1 or L1) is a dominant non-long terminal repeat (non-LTR) retrotransposon in the human genome that has been implicated in the overexpression of MET. Both the canonical MET and L1-MET transcripts are considered to play a role in hepatocellular carcinoma (HCC) development...

journal_title：Journal of cancer research and clinical oncology

authors： Rashed WM,Kandeil MA,Mahmoud MO,Maher D,Ezzat S,Abdel-Rahman MH

更新日期：2021-01-01 00:00:00

abstract：:According to a "two-hit" model, dominantly inherited predisposition to cancer entails a germline mutation, while tumorigenesis requires a second, somatic, mutation. Non-hereditary cancer of the same type requires the same two hits, but both are somatic. The original tumor used in this model, retinoblastoma, involves m...

journal_title：Journal of cancer research and clinical oncology

authors： Knudson AG

更新日期：1996-01-01 00:00:00

abstract：:The distribution, size, and configuration of intercellular junctions in the sebaceous tumor of mice were examined using the freeze-fracture technique. Three types of junctions were observed: desmosomes, gap, and tight junctions. Tight junctions in general consisted of short linear unbranched fibrils, and macular or co...

journal_title：Journal of cancer research and clinical oncology

authors： Robenek H,Schöpper C,Fasske E,Fetting R,Themann H

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Elevated expression of the beta-thymosin isotypes T beta(4), T beta(10), and T(15) appears to be involved in the manifestation of a malignant phenotype of human tumor cells, including those of mammary carcinomas. This has evoked an interest in these peptides as diagnostic/prognostic tumor markers. If increased ...

journal_title：Journal of cancer research and clinical oncology

authors： Otto AM,Müller CS,Huff T,Hannappel E

更新日期：2002-05-01 00:00:00

abstract：:In order to evaluate the preventive efficacy, safety and usefulness of mesna (Sodium 2-mercaptoethane sulfonate) against ifosfamide-induced urinary disorders, a placebo-controlled double-blind comparative study was performed. Ifosfamide was administered by intravenous drip infusion at a daily dose of 2 g/m2 for 5 cons...

journal_title：Journal of cancer research and clinical oncology

authors： Fukuoka M,Negoro S,Masuda N,Furuse K,Kawahara M,Kodama N,Ikegami H,Nakamura S,Nishio H,Ohnoshi T

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:Cancer incidence in the elderly population has been continuously rising, and their treatment is an increasing concern among oncologists. This study aimed to evaluate the incidence and risk factors for morbidity and mortality after major oncological surgery in elderly patients with head and neck squamous cell ca...

journal_title：Journal of cancer research and clinical oncology

authors： Yoo SH,Roh JL,Choi SH,Nam SY,Kim SY

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:TNF-related apoptosis-inducing ligand (TRAIL) is a potential cancer therapeutic agent that preferentially induces apoptosis in cancer cells. However, breast cancer cells are generally resistant to TRAIL. Bufalin is a major active ingredient of the traditional Chinese medicine ChanSu. The present study aimed to ...

journal_title：Journal of cancer research and clinical oncology

authors： Yan S,Qu X,Xu C,Zhu Z,Zhang L,Xu L,Song N,Teng Y,Liu Y

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:Metastatic renal cell carcinoma (mRCC) sometimes presents with an indolent course without any significant symptoms. Here, the potential impact of active surveillance (AS) on clinical outcomes in asymptomatic or minimally symptomatic mRCC patients was retrospectively evaluated. METHODS:mRCC patients who were fo...

journal_title：Journal of cancer research and clinical oncology

authors： Park I,Lee JL,Ahn JH,Lee DH,Lee KH,Jeong IG,Song C,Hong B,Hong JH,Ahn H

更新日期：2014-08-01 00:00:00

abstract：:The role of different cytogenetic changes has been extensively evaluated in patients with acute myeloid leukemia (AML), and cytogenetic analysis of AML blasts is essential to form prognostic subgroups in order to stratify for the extent of therapy. Nevertheless, 40-45% of AML patients lack such cytogenetic markers, i....

journal_title：Journal of cancer research and clinical oncology

authors： Scholl S,Fricke HJ,Sayer HG,Höffken K

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:To evaluate the role of radioembolization and systemic chemotherapy as a combined modality therapy for unresectable colorectal liver metastases. PATIENTS AND METHODS:Prospective database of a major yttrium-90 microsphere radioembolization treatment center in Sydney, Australia, that included 140 patients with u...

journal_title：Journal of cancer research and clinical oncology

authors： Chua TC,Bester L,Saxena A,Morris DL

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:Kinase insert domain-containing receptor (KDR) is one of the molecular targets used in cancer therapy. We studied the KDR expression characteristics and the relationship with the clinical parameters of the patients with lung cancer, to give the basic evidence and clue for tailoring therapy. METHODS:Reverse tra...

journal_title：Journal of cancer research and clinical oncology

authors： An SJ,Nie Q,Chen ZH,Lin QX,Wang Z,Xie Z,Chen SL,Huang Y,Zhang AY,Yan JF,Wu HS,Lin JY,Li R,Zhang XC,Guo AL,Mok TS,Wu YL

更新日期：2007-09-01 00:00:00

abstract：:The hospital records of 60 female and 56 male pancreatic cancer patients and 232 age-, race-, sex-, and hospital-matched controls were reviewed for evidence of prior thyroid disease, cholecystectomy, appendectomy, alcohol consumption and among females, for diseases for the endometrium and ovary. No statistically signi...

journal_title：Journal of cancer research and clinical oncology

authors： Haines AP,Moss AR,Whittemore A,Quivey J

更新日期：1982-01-01 00:00:00