当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Antimetastatic effect of defibrinogenation with batroxobin depends on the natural killer activity of host in mice.

Antimetastatic effect of defibrinogenation with batroxobin depends on the natural killer activity of host in mice.

Abstract：

:Using batroxobin, a thrombin-like enzyme found in snake venom, the effects of defibrinogenation on artificial lung metastasis in mice were studied. The role of natural killer (NK) cells in the inhibitory effects of defibrinogenation on metastasis was also investigated. Artificial lung metastasis experiments were performed by inoculating either B16-F10 cells or B16-BL/6 cells, highly metastatic strains of B16 melanoma cells, into C57BL/6 mice via the tail vein. The administration of batroxobin significantly inhibited lung metastasis, as did NK activity augmented by poly (I).poly (C) were administered, lung metastasis was more markedly inhibited. When NK activity was suppressed by administration of anti-(asialo GM1) antibody, lung metastasis was markedly increased. When batroxobin was administered with anti-(asialo GM1) antibody, no inhibitory effects on lung metastasis, such as those seen with batroxobin alone, were observed. The administration of batroxobin had no effect at all on spleen lymphocyte NK activity. These results indicated that defibrinogenation due to batroxobin inhibits lung metastasis, and these effects depend on NK activity of the host.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Shibuya M,Niitani H,Aoyama A,Kawachi S,Nukariya N,Baba M,Iizuka K,Sakai S,Ohtsuka M

doi

10.1007/BF01612672

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

168-72

issue

2

eissn

0171-5216

issn

1432-1335

journal_volume

116

pub_type

杂志文章

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