Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer.

abstract：:Three thousand Yoshida sarcoma cells were inoculated into the wall of the descending colon of each of 120 male Sprague-Dawley rats. On day 8 after the tumor implantation, the animals were at random divided into four groups of 30 rats each. The effect of cyclophosphamide (70 mg/kg), BCNU (25 mg/kg), and methyl-CCNU (45...

journal_title：Journal of cancer research and clinical oncology

authors： Bhide S,Habs M,Reinbold H,Schmähl D

更新日期：1979-05-14 00:00:00

abstract：PURPOSE:This retrospective study evaluated the diagnostic value of integrated whole-body (18)F-fluorodeoxyglucose positron-emission tomography and computed tomography ((18)F-FDG-PET/CT) in early detection of second primary malignancies in cancer patients. MATERIALS AND METHODS:From June 2007 to October 2008, 677 cance...

journal_title：Journal of cancer research and clinical oncology

authors： Xu H,Zhang M,Zhai G,Li B

更新日期：2010-08-01 00:00:00

abstract：:Mice with s.c. grafts of gastric carcinoma MKN45 or osteosarcoma 788T were injected i.v. with recombinant tumour necrosis factor alpha (rTNF alpha) and tumour blood flow rates were determined 4 h later as a fraction of the cardiac output g tissue-1. With MKN45, the tumour blood flow rate was significantly reduced from...

journal_title：Journal of cancer research and clinical oncology

authors： Pimm MV,Gribben SJ,Morris TM

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:In the phase 3 BFORE trial (NCT02130557), treatment with bosutinib resulted in a significantly higher major molecular response rate at 12 months versus imatinib in the modified intent-to-treat (mITT) population of patients with newly diagnosed chronic phase chronic myeloid leukemia (CP CML). Assessment of pa...

journal_title：Journal of cancer research and clinical oncology

authors： Cortes JE,Gambacorti-Passerini C,Deininger MW,Mauro MJ,Chuah C,Kim DW,Milojkovic D,le Coutre P,Garcia-Gutierrez V,Crescenzo R,Mamolo C,Reisman A,Hochhaus A,Brümmendorf TH,BFORE Study Investigators.

更新日期：2019-06-01 00:00:00

abstract：:Laboratory and clinical data suggest some interactions between cytotoxic agents and tamoxifen. The mechanisms of these interactions differ in estrogen-receptor-negative cell lines. The ability of tamoxifen to modify the effects of epirubicin on the cell-cycle phases of estrogen-receptor-negative Ehrlich's carcinoma as...

journal_title：Journal of cancer research and clinical oncology

authors： Aydiner A,Ridvanogullari M,Anil D,Topuz E,Nurten R,Disci R

更新日期：1997-01-01 00:00:00

abstract：:The aim of our work was to investigate whether DNA topoisomerase II participates in the repair-specific incision of UV-irradiated genomic DNA. Therefore, the influence upon DNA incision of the topoisomerase II inhibitors (nalidixic and oxolinic acid, novobiocin and coumermycin A1) as well as the intercalating agent qu...

journal_title：Journal of cancer research and clinical oncology

authors： Thielmann HW,Popanda O,Edler L

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Cancer-associated fibroblasts (CAFs) contribute to tumor progression through multiple pathways. However, the effect of CAFs on gene expression in lung cancer has been largely unknown. Here we systematically compared the gene expression changes in lung cancer cells induced by normal fibroblasts and CAFs. METHOD...

journal_title：Journal of cancer research and clinical oncology

authors： An J,Enomoto A,Weng L,Kato T,Iwakoshi A,Ushida K,Maeda K,Ishida-Takagishi M,Ishii G,Ming S,Sun T,Takahashi M

更新日期：2013-03-01 00:00:00

abstract：:A total of 30 inbred Wistar rats were orally administered 70 microgram/ml solution of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 35 weeks and then tap water for the following 20 to 30 weeks. Four of the 20 females and two of ten males developed carcinoids in the glandular stomach, but no metastasis could be found...

journal_title：Journal of cancer research and clinical oncology

authors： Tahara E,Ito H,Nakagami K,Shimamoto F

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Uterine neoplasms comprise a broad spectrum of lesions, some of which may pose a diagnostic challenge even to experienced pathologists. Recently, genome-wide DNA methylation-based classification of central nervous system tumors has been shown to increase diagnostic precision in clinical practice when combined w...

journal_title：Journal of cancer research and clinical oncology

authors： Kommoss FKF,Stichel D,Schrimpf D,Kriegsmann M,Tessier-Cloutier B,Talhouk A,McAlpine JN,Chang KTE,Sturm D,Pfister SM,Romero-Pérez L,Kirchner T,Grünewald TGP,Buslei R,Sinn HP,Mechtersheimer G,Schirmacher P,Schmidt D,Leh

更新日期：2020-01-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy. About 75% are sporadic (sMTC) while the remaining 25% are hereditary (hMTC). The treatment of choice for both sMTC and hMTC is surgery. An adequate initial operation provides the best chance of cure. Hence, the diagnosis of MTC should be made preoperative...

journal_title：Journal of cancer research and clinical oncology

authors： Gimm O,Sutter T,Dralle H

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:The blockade of the renin-angiotensin-aldosterone system (RAAS) by angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is one of the most common treatments for hypertension, heart failure and renal diseases. However, concerns have been raised about a possible link between RA...

journal_title：Journal of cancer research and clinical oncology

authors： Rachow T,Schiffl H,Lang SM

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Kinase insert domain-containing receptor (KDR) is one of the molecular targets used in cancer therapy. We studied the KDR expression characteristics and the relationship with the clinical parameters of the patients with lung cancer, to give the basic evidence and clue for tailoring therapy. METHODS:Reverse tra...

journal_title：Journal of cancer research and clinical oncology

authors： An SJ,Nie Q,Chen ZH,Lin QX,Wang Z,Xie Z,Chen SL,Huang Y,Zhang AY,Yan JF,Wu HS,Lin JY,Li R,Zhang XC,Guo AL,Mok TS,Wu YL

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:Dysregulation of microRNA (miRNA) metabolism has been observed in a variety of human cancers, but the expression patterns of the enzymes responsible for generating miRNAs remain largely unexplored. In this study, we investigated the expression profiles of the two most important enzymes of the miRNA machinery, D...

journal_title：Journal of cancer research and clinical oncology

authors： Guo X,Liao Q,Chen P,Li X,Xiong W,Ma J,Li X,Luo Z,Tang H,Deng M,Zheng Y,Wang R,Zhang W,Li G

更新日期：2012-01-01 00:00:00

abstract：:Although the biological action of phthalates has been widely discussed there is little information on early cellular changes indicative for toxic or carcinogenic effects. To study subtle alterations in the cell morphology, we have by means of image processing evaluated the nuclei of hamster hepatocytes after treatment...

journal_title：Journal of cancer research and clinical oncology

authors： Komitowski D,Schmezer P,Schmitt B,Ehemann V,Muto S

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:E- and P-selectins, expressed on vascular endothelium, and their sialyl-Lewis(x )(sLe(x))- and/or sialyl-Lewis(a) (sLe(a))-containing ligands have a crucial role in extravasation and metastasis of circulating cells. We wanted to analyse the role of selectins and their ligands in head and neck tumours. METHODS:...

journal_title：Journal of cancer research and clinical oncology

authors： Renkonen J,Mäkitie A,Paavonen T,Renkonen R

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:Melanoma antigen gene A3 (MAGE-A3) is aberrantly expressed in a number of cancer types. Because of its high specificity, MAGE-A3 has shown to be a promising candidate for cancer immunotherapy. Dendritic cells (DCs) have emerged as the natural agents for antigen delivery. DCs transduced with antigen may increase...

journal_title：Journal of cancer research and clinical oncology

authors： Lin L,Wei J,Chen Y,Huang A,Li KK,Zhang W

更新日期：2014-02-01 00:00:00

abstract：:Aclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study was performed in a total of 25 patients, 23 of whom are evaluable for response. All suffered from recurrent and advanced tumors. Pretreatment consisted of at least four different chemotherapeutic ...

journal_title：Journal of cancer research and clinical oncology

authors： Schütte J,Niederle N,Seeber S

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Hypersensitivity reactions (HSRs) to chemotherapy is an ongoing issue in cancer treatments. Strategies to induce tolerance and maximize chemotherapy efficacy include desensitization protocols. The precise impact of these protocols, however, in the long-term treatments remains unclear. We aim to compare overall ...

journal_title：Journal of cancer research and clinical oncology

authors： Altwerger G,Florsheim EB,Menderes G,Black J,Schwab C,Gressel GM,Nelson WK,Carusillo N,Passante T,Huang G,Litkouhi B,Azodi M,Silasi DA,Santin A,Schwartz PE,Ratner ES

更新日期：2018-12-01 00:00:00

abstract：:After cure of rat leukemia L 5222 in 79 BD IX rats by single doses of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (Hydroxyethyl-CNU) a total of 9 rats (11%) developed secondary malignomas. ...

journal_title：Journal of cancer research and clinical oncology

authors： Zeller WJ,Schmähl D

更新日期：1979-09-01 00:00:00

abstract：PURPOSE:The benefit of adding docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy to chemoradiotherapy (CRT) in head and neck squamous cell carcinoma (HNSCC) remains uncertain. We aimed to investigate whether ICT is well tolerated when given with prophylactic treatment against predicted adverse effects...

journal_title：Journal of cancer research and clinical oncology

authors： Lowe NM,Bernstein JM,Mais K,Garcez K,Lee LW,Sykes A,Thomson DJ,Homer JJ,West CM,Slevin NJ

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Two large, randomized, placebo-controlled trials (IRESSA NSCLC Trial Assessing Combination Therapy; INTACT 1 and 2) in non-small-cell lung cancer (NSCLC) failed to show survival benefit for gefitinib (IRESSA) in combination with first-line platinum-based chemotherapy. Epidermal growth factor receptor (EGFR) sta...

journal_title：Journal of cancer research and clinical oncology

authors： Giaccone G,Iacona RB,Fandi A,Janas M,Ochs JS,Herbst RS,Johnson DH

更新日期：2009-03-01 00:00:00

abstract：:The occurrence of malignancies during pregnancy has increased over the last decades. They complicate approximately 1 per 1000 pregnancies. The most common malignancies associated with pregnancy include malignant melanoma, malignant lymphomas and leukemia, and cancer of the cervix, breast, ovary, colon and thyroid. Sin...

journal_title：Journal of cancer research and clinical oncology

authors： Oduncu FS,Kimmig R,Hepp H,Emmerich B

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:RhoA and RhoC are closely related, small GTPases that are clearly involved in breast cancer tumorigenesis. Nonetheless, their specific roles in the control of estrogen receptor alpha (ERα) activities have not been elucidated. METHODS:We used siRNA sequences to specifically down-regulate RhoA and RhoC expressio...

journal_title：Journal of cancer research and clinical oncology

authors： Malissein E,Meunier E,Lajoie-Mazenc I,Médale-Giamarchi C,Dalenc F,Doisneau-Sixou SF

更新日期：2013-12-01 00:00:00

abstract：:The aim of this study was to produce large liver tumors reliably, and to diagnose the tumors during development. Therefore, New Zealand white rabbits were treated with N-nitrosodiethylamine orally three times per week by gavage and were examined by clinical-chemical assay at regular intervals during the average treatm...

journal_title：Journal of cancer research and clinical oncology

authors： Reznik GK,Padberg G

更新日期：1991-01-01 00:00:00

abstract：:The XP cell strain XP29MA, its malignant counterpart XP29MAmal and a normal human fibroblast strain were tested for colony-forming ability after treatment with HECNU in the presence of m6G, m6Gua, and he7G. In XP29MAmal, inhibition of post-HECNU colony-forming ability was 35% when 0.25 mM of either m6G or m6Gua were p...

journal_title：Journal of cancer research and clinical oncology

authors： Thielmann HW,Edler L,Müller N,Eisenbrand G

更新日期：1987-01-01 00:00:00

abstract：:Several large, well-controlled clinical trials have now established that the aromatase inhibitors (AIs), including letrozole, anastrozole, and exemestane, are more effective than tamoxifen when used as adjuvant endocrine therapy in postmenopausal women with breast cancer. Yet, it is an open question as to how these dr...

journal_title：Journal of cancer research and clinical oncology

authors： Paepke S,Jacobs VR,Ohlinger R,Warm M,Kümmel S,Thomas A,Harbeck N,Kiechle-Bahat M

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:Non-adherence to anti-hormonal therapy is a major problem in gynecologic oncology. Reasons reported are side effects and lack of support. The aim of our study was an analysis of influence of experiences of patients with endocrine therapy and communication and information on this topic and their influence o...

journal_title：Journal of cancer research and clinical oncology

authors： Wuensch P,Hahne A,Haidinger R,Meißler K,Tenter B,Stoll C,Senf B,Huebner J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cancer is a serious public health problem worldwide, and difficulty in early diagnosis has been the chief obstacle to improve the prognosis of patients. Recently, microRNAs (miRNAs) were widely studied to be potential biomarkers for cancer detection. miR-16 is a prevalent but sophisticated one. In the curren...

journal_title：Journal of cancer research and clinical oncology

authors： Huang Z,Chen W,Du Y,Guo Q,Mao Y,Zhou X,Hua D

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To explore the value of Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2) for predicting prostate biopsy results in patients with prostate specific antigen (PSA) levels of 4-10 ng/ml. METHODS:We retrospectively reviewed multi-parameter magnetic resonance images from 528 patients with PSA levels...

journal_title：Journal of cancer research and clinical oncology

authors： Xu N,Wu YP,Chen DN,Ke ZB,Cai H,Wei Y,Zheng QS,Huang JB,Li XD,Xue XY

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Patients with metastatic nonseminomatous germ cell tumors (mNSGCT) and a high tumor burden or a poor performance status at initial diagnosis are at risk from potentially life-threatening early complications during or after the first chemotherapy cycle. The outcomes with dose-reduced first cycle of chemotherapy ...

journal_title：Journal of cancer research and clinical oncology

authors： Tryakin A,Fedyanin M,Bulanov A,Kashia S,Kurmukov I,Matveev V,Fainstein I,Gordeeva O,Zakharova T,Tjulandin S

更新日期：2018-09-01 00:00:00