Prevalence and clinical significance of RBM3 immunostaining in non-small cell lung cancers.

abstract：:Recently a new proto-oncogene, the murine double-minute 2 (MDM2), has been described. MDM2 becomes oncogenic due to amplification and overexpression. Among other proto-oncogenes MDM2 becomes interesting since MDM2 protein can associate with both mutant and wild type p53 tumor suppressor gene products and thus inhibit ...

journal_title：Journal of cancer research and clinical oncology

authors： Wiethege T,Voss B,Müller KM

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:A growing body of evidence has shown the possible relevance of survivin -31G>C (rs9904341) promoter polymorphism to the genetic susceptibility of cancer. Because of the lack of available conclusive data, we performed a meta-analysis of all relevant available studies to derive a more precise estimation of the re...

journal_title：Journal of cancer research and clinical oncology

authors： Qin Q,Zhang C,Zhu H,Yang X,Xu L,Liu J,Lu J,Zhan L,Cheng H,Sun X

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:Cholangiocarcinoma is defined as a chronic liver disease with altered estrogen metabolism and could result in estrogen retention. Estrogenic response was known as a promoting factor in progression of some cancer. In this study, we determined the significant increase of estrogen level in cholangiocarcinoma patie...

journal_title：Journal of cancer research and clinical oncology

authors： Hunsawong T,Singsuksawat E,In-chon N,Chawengrattanachot W,Thuwajit C,Sripa B,Paupairoj A,Chau-in S,Thuwajit P

更新日期：2012-08-01 00:00:00

abstract：:Ovarian cancer is a leading cause of death among gynecologic malignancies. This disappointing prognosis is closely related to intrinsic or acquired resistance to conventional platinum-based chemotherapy, which can affect a third of patients. As such, investigating relevant molecular targets is crucial in the fight aga...

journal_title：Journal of cancer research and clinical oncology

authors： Gasparri ML,Besharat ZM,Farooqi AA,Khalid S,Taghavi K,Besharat RA,Sabato C,Papadia A,Panici PB,Mueller MD,Ferretti E

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To explore the value of Prostate Imaging Reporting and Data System Version 2 (PI-RADS v2) for predicting prostate biopsy results in patients with prostate specific antigen (PSA) levels of 4-10 ng/ml. METHODS:We retrospectively reviewed multi-parameter magnetic resonance images from 528 patients with PSA levels...

journal_title：Journal of cancer research and clinical oncology

authors： Xu N,Wu YP,Chen DN,Ke ZB,Cai H,Wei Y,Zheng QS,Huang JB,Li XD,Xue XY

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:PIK3CA mutation appears to predict a lack of response to anti-EGFR monoclonal antibody (mAb) treatment in patients with metastatic colorectal cancer (mCRC). However, the predictive value of PIK3CA mutations for survival remains inconclusive. Here, we pooled the data from published studies to estimate the associ...

journal_title：Journal of cancer research and clinical oncology

authors： Wu S,Gan Y,Wang X,Liu J,Li M,Tang Y

更新日期：2013-05-01 00:00:00

abstract：INTRODUCTION:In advanced ovarian cancers (OCs), p53 mutations are frequently observed. The objective of this study was to explore the value of the p53 mutational status, using four different techniques, in advanced OC patients as a predictive marker for responsiveness to platinum-based chemotherapy. METHODS:One hundre...

journal_title：Journal of cancer research and clinical oncology

authors： Bauerschlag DO,Schem C,Weigel MT,Von Kaisenberg C,Strauss A,Bauknecht T,Maass N,Meinhold-Heerlein I

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:The monoterpene perillyl alcohol (POH) a Ras inhibitor with potential capacity to arrest gliomagenesis is being used in a phase I/II clinical trial in adults with recurrent malignant glioma. The present study aimed to investigate the efficacy of intranasal administration of monoterpene POH upon survival rate of...

journal_title：Journal of cancer research and clinical oncology

authors： da Fonseca CO,Simão M,Lins IR,Caetano RO,Futuro D,Quirico-Santos T

更新日期：2011-02-01 00:00:00

abstract：CONTEXT:Parathyroid carcinoma (PC) is a rare endocrine malignancy with no approved systemic therapies for unresectable locally invasive or distant metastatic disease. Understanding the molecular changes in advanced PC can provide better understanding of this disease and potentially help directing targeted therapy. OBJ...

journal_title：Journal of cancer research and clinical oncology

authors： Kutahyalioglu M,Nguyen HT,Kwatampora L,Clarke C,Silva A,Ibrahim E,Waguespack SG,Cabanillas ME,Jimenez C,Hu MI,Sherman SI,Kopetz S,Broaddus R,Dadu R,Wanland K,Williams M,Zafereo M,Perrier N,Busaidy NL

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Ultrasound (US)-guided breast biopsy is a routine diagnostic method used to correlate imaging finding to a histological diagnosis which is still the gold standard in preoperative diagnostics. The accuracy of US-guided breast biopsies relies on a precise radiologic-histopathologic correlation, which is discus...

journal_title：Journal of cancer research and clinical oncology

authors： Jörg I,Wieler J,Elfgen C,Bolten K,Hutzli C,Talimi J,Vorburger D,Choschzick M,Moskovszky L,Dedes K,Varga Z

更新日期：2020-12-07 00:00:00

abstract：:In 1989, 65%-75% of previously untreated adults with ALL or AML may be expected to enter complete remission. Approximately 40% of these completely responding patients, whether they are treated with intensive chemotherapy, intensive chemotherapy followed by autologous bone marrow transplantation, or allogeneic bone mar...

journal_title：Journal of cancer research and clinical oncology

authors： Mayer RJ

更新日期：1990-01-01 00:00:00

abstract：:In this study, lipid peroxide and total sulfhydryl contents and activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in the plasma of patients with benign prostatic hyperplasia (BPH) and prostate cancer. No significant change was found in lipid peroxidation or an...

journal_title：Journal of cancer research and clinical oncology

authors： Doğru-Abbasoğlu S,Aykaç-Toker G,Koçak T,Unlüer E,Uysal M

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:The molecular mechanisms underlying the development of intestinal metaplasia (IM) of the human stomach have yet to be clarified in detail. Besides ectopic expression of intestinal transcription factors, Cdx1 and Cdx2, little information is available regarding other regulatory factors. Hence, we here analyzed So...

journal_title：Journal of cancer research and clinical oncology

authors： Tsukamoto T,Inada K,Tanaka H,Mizoshita T,Mihara M,Ushijima T,Yamamura Y,Nakamura S,Tatematsu M

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:The N-myc downstream regulated gene 1 (NDRG1)/Cap43 is overexpressed in multiple cancer types, including lung cancer. In this study, we investigated the expression of NDRG1/Cap43 in lung cancer tissues and in serum from 90 lung cancer patients and 60 healthy controls. MATERIALS AND METHODS:Ninety patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Wang D,Tian X,Jiang Y

更新日期：2012-11-01 00:00:00

abstract：:Three phase I/II trials were performed in patients with metastatic colorectal cancer using immunochemotherapy--a combination of recombinant interferon beta and gamma with low doses of cytostatic drugs. The third regimen, consisting of a cytostatic component containing 5-fluorouracil plus carboplatin plus mitomycin C b...

journal_title：Journal of cancer research and clinical oncology

authors： Klein HO,Golbach G,Voigt P,Coerper C,Bernhardt C

更新日期：1991-01-01 00:00:00

abstract：:Coumarin (1,2-benzopyrone) is a natural substance that has shown antitumor activity in vivo. The major human metabolite of coumarin, 7-hydroxycoumarin (7-HC), is the active form of the drug. While the exact mechanism(s) of action of coumarin is unknown, it has been shown previously that this drug possesses immunomodul...

journal_title：Journal of cancer research and clinical oncology

authors： Marshall ME,Kervin K,Benefield C,Umerani A,Albainy-Jenei S,Zhao Q,Khazaeli MB

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:Pheochromocytomas/paragangliomas (PHEOs/PGLs) are rare in children with only a few SDHB mutation-related cases. Previous studies on children were conducted in small cohorts. This large set of pediatric patients provides robust data in the evaluation of clinical outcomes. METHODS:Sixty-four pediatric PHEO/PGL p...

journal_title：Journal of cancer research and clinical oncology

authors： Jochmanova I,Abcede AMT,Guerrero RJS,Malong CLP,Wesley R,Huynh T,Gonzales MK,Wolf KI,Jha A,Knue M,Prodanov T,Nilubol N,Mercado-Asis LB,Stratakis CA,Pacak K

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To investigate the interaction between Wnt/β-catenin and estrogen signaling pathways in endometrial cancer (EC). METHODS:119 women were involved in this study, including 65 women with histologically confirmed EC and 54 healthy women as a control group. Serum protein levels of Dkk1 were measured using ELISA. Pr...

journal_title：Journal of cancer research and clinical oncology

authors： Kasoha M,Dernektsi C,Seibold A,Bohle RM,Takacs Z,Ioan-Iulian I,Solomayer EF,Juhasz-Böss I

更新日期：2020-02-01 00:00:00

abstract：:Preoperative cytologic examinations were performed on bronchial material from 92 patients with postsurgical (pathologic) stage I (American Joint Committee) adenocarcinoma of the lung. All patients were followed up for at least 5 years or until death; thus, cases of adenocarcinoma metastatic to the lungs were virtually...

journal_title：Journal of cancer research and clinical oncology

authors： Bjornsson J,Goellner JR,Williams DE,Scheiber MV

更新日期：1986-01-01 00:00:00

abstract：:The occurrence of malignancies during pregnancy has increased over the last decades. They complicate approximately 1 per 1000 pregnancies. The most common malignancies associated with pregnancy include malignant melanoma, malignant lymphomas and leukemia, and cancer of the cervix, breast, ovary, colon and thyroid. Sin...

journal_title：Journal of cancer research and clinical oncology

authors： Oduncu FS,Kimmig R,Hepp H,Emmerich B

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-gamma) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expre...

journal_title：Journal of cancer research and clinical oncology

authors： Coppola D,Parikh V,Boulware D,Blanck G

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the effectiveness and safety of ultrasound guided percutaneous radiofrequency ablation (RFA) of cervical metastatic lymph nodes (LNs) from papillary thyroid carcinoma. METHODS:54 metastatic LNs confirmed by percutaneous biopsy in 33 patients with previous total thyroidectomy...

journal_title：Journal of cancer research and clinical oncology

authors： Guang Y,Luo Y,Zhang Y,Zhang M,Li N,Zhang Y,Tang J

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:This study was to investigate whether the topoisomerase (Top) I inhibitor topotecan and the Top II inhibitor etoposide could modulate the hypoxia-induced HIF-1alpha expression in non-small cell lung cancer (NSCLC) cell lines. METHODS:Hypoxic conditions were maintained in a humidified airtight anaerobic incubat...

journal_title：Journal of cancer research and clinical oncology

authors： Choi YJ,Rho JK,Lee SJ,Jang WS,Lee SS,Kim CH,Lee JC

更新日期：2009-08-01 00:00:00

abstract：:This paper confirms previous results that hyperglycemia (5 g/l) lasting 250 min, when combined with local hyperthermia (43 degrees C) for the last 100 min, strongly inhibits microcirculation in Yoshida sarcomas and DS-carcinosarcomas. This inhibition occurs independently of heparinization of the animals (700 IU/200 G ...

journal_title：Journal of cancer research and clinical oncology

authors： von Ardenne M,Reitnauer PG

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Tumor grade is one of the more controversial factors with limited prognostic information in squamous cell carcinomas (SCC) of the uterine cervix. METHODS:Histologic slides of 233 surgically treated cervical SCC (FIGO IB1) were re-examined regarding the prognostic impact of the WHO-based grading system, using t...

journal_title：Journal of cancer research and clinical oncology

authors： Horn LC,Höhn AK,Hentschel B,Fischer U,Bilek K,Brambs CE

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:To evaluate the role of radioembolization and systemic chemotherapy as a combined modality therapy for unresectable colorectal liver metastases. PATIENTS AND METHODS:Prospective database of a major yttrium-90 microsphere radioembolization treatment center in Sydney, Australia, that included 140 patients with u...

journal_title：Journal of cancer research and clinical oncology

authors： Chua TC,Bester L,Saxena A,Morris DL

更新日期：2011-05-01 00:00:00

abstract：:The effect of a single blood transfusion on the formation and outgrowth of experimental lung metastases was assessed in two tumor models in rats. The transfusions were given either 1 week before (day -7) or 1 week after (day +7) tumor cell inoculation. The first approach was performed to investigate the effect of tran...

journal_title：Journal of cancer research and clinical oncology

authors： Marquet RL,de Bruin RW,Dallinga RJ,Singh SK,Jeekel J

更新日期：1986-01-01 00:00:00

abstract：:Female carriers of mutations in the BRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their lifetime. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index, alter the age at ons...

journal_title：Journal of cancer research and clinical oncology

authors： Chang-Claude J,Becher H,Eby N,Bastert G,Wahrendorf J,Hamann U

更新日期：1997-01-01 00:00:00

abstract：AIM:In men with adverse pathology after radical prostatectomy, the most appropriate timing to administer radiotherapy (RT) remains a topic of debate. We analyzed in terms of efficacy, prognostic factors and toxicity the two therapeutic strategies: immediate postoperative radiotherapy (PORT) and salvage radiotherapy (SA...

journal_title：Journal of cancer research and clinical oncology

authors： Detti B,Scoccianti S,Cassani S,Cipressi S,Villari D,Lapini A,Saieva C,Cai T,Pertici M,Giacomelli I,Livi L,Ceroti M,Nicita G,Carini M,Biti G

更新日期：2013-01-01 00:00:00

abstract：:Lambda-DNA and plasmid pBR 322-DNA, respectively, were treated in vitro with increasing amounts of 4-S-ethanolsulfido-cyclophosphamide (CPA-P1). Subsequent digestion with restriction endonuclease Pvu II or Mbo II revealed discrete alterations in the cleavage patterns as compared to the controls, indicating subtle chan...

journal_title：Journal of cancer research and clinical oncology

authors： Lindemann H

更新日期：1985-01-01 00:00:00