当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Application of restriction endonucleases as a tool for studying the action of 4-S-ethanolsulfido-cyclophosphamide on DNA with known sequences.

Application of restriction endonucleases as a tool for studying the action of 4-S-ethanolsulfido-cyclophosphamide on DNA with known sequences.

Abstract：

:Lambda-DNA and plasmid pBR 322-DNA, respectively, were treated in vitro with increasing amounts of 4-S-ethanolsulfido-cyclophosphamide (CPA-P1). Subsequent digestion with restriction endonuclease Pvu II or Mbo II revealed discrete alterations in the cleavage patterns as compared to the controls, indicating subtle changes in DNA structure due to CPA-P1 interaction. In the case of pBR 322-DNA the CPA-P1 treatment of supercoiled circular DNA was more inhibitory to subsequent digestion as compared to the treatment of linearized plasmid DNA molecules.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Lindemann H

doi

10.1007/BF00402734

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

170-2

issue

2

eissn

0171-5216

issn

1432-1335

journal_volume

110

pub_type

杂志文章

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