Polyploidization of G2M phase cells separated from aerobically and anaerobically grown Ehrlich ascites tumor cells.

Abstract:

:G2-enriched fractions of Ehrlich ascites tumor cells (up to 80%-85% G2 cells) separated from anaerobically and aerobically cultured asynchronous populations by centrifugal elutriation revealed the same growth characteristics after recultivation under standard conditions: a significant proportion of cells with increased DNA (DNA content greater than 4C) emerged. Interruption of DNA synthesis by deprivation of oxygen may account for polyploidization (over-replication) of DNA but other mechanisms must be taken into consideration.

authors

Kroll C,Schneider F

doi

10.1007/BF00396389

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

298-300

issue

3

eissn

0171-5216

issn

1432-1335

journal_volume

113

pub_type

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