Effects of irradiation and cisplatin on human glioma spheroids: inhibition of cell proliferation and cell migration.

abstract：:The Harvey ras locus was examined for restriction fragment polymorphism and loss of allelic heterozygosity in 62 oral cancer patients. Southern blot analysis on BamHI digests of the tumour tissue DNA, revealed 23 patients with H-ras-1 heterozygosity. The probes used to study the polymorphism were the BamHI 6.6-kb frag...

journal_title：Journal of cancer research and clinical oncology

authors： Saranath D,Bhoite LT,Mehta AR,Sanghavi V,Deo MG

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To identify and characterize novel genetic alterations in hepatocellular carcinoma (HCC). METHODS:DNA was extracted from 29 HCC and corresponding normal tissues and amplified with 59 different 10-base arbitrary primers. A 550 bp DNA fragment amplified using primer Q-9 and which was present in 19 of 29 cases (6...

journal_title：Journal of cancer research and clinical oncology

authors： Saelee P,Wongkham S,Bhudhisawasdi V,Sripa B,Chariyalertsak S,Petmitr S

更新日期：2008-10-01 00:00:00

abstract：:Passively administered and actively induced antibodies have been associated with the eradication of circulating tumor cells and micrometastases in mice and humans. We have identified a series of cell surface carbohydrate and peptide antigens on melanomas, sarcomas, and cancer of the breast, prostate. ovary, and lung t...

journal_title：Journal of cancer research and clinical oncology

authors： Musselli C,Livingston PO,Ragupathi G

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Apatinib, a third-line or later treatment for advanced gastric cancer (aGC), was shown to improve overall survival and progression-free survival (PFS) compared with placebo in the phase III trial. Given the modest benefit with high costs, we further evaluated the cost-effectiveness of apatinib for patients w...

journal_title：Journal of cancer research and clinical oncology

authors： Chen HD,Zhou J,Wen F,Zhang PF,Zhou KX,Zheng HR,Yang Y,Li Q

更新日期：2017-02-01 00:00:00

abstract：PURPOSES:Genetic variations among prostate cancer patients who underwent radical prostatectomies were evaluated to predict biochemical recurrence, and used to develop a clinical-genetic model that combines data on clinicopathological factors of prostate cancer and individual genetic variations. MATERIALS AND METHODS:W...

journal_title：Journal of cancer research and clinical oncology

authors： Oh JJ,Park S,Lee SE,Hong SK,Lee S,Lee HM,Lee JK,Ho JN,Yoon S,Byun SS

更新日期：2015-08-01 00:00:00

abstract：:Increased expression of P glycoprotein is associated with multidrug resistance in many cell lines. P glycoprotein has been detected in different human tumors. To assess the implication of multidrug resistance in the prognosis of Ewing's sarcoma the expression of P glycoprotein was studied immunohistochemically in pre-...

journal_title：Journal of cancer research and clinical oncology

authors： Roessner A,Ueda Y,Bockhorn-Dworniczak B,Blasius S,Peters A,Wuisman P,Ritter J,Paulussen M,Jürgens H,Böcker W

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:The blockade of the renin-angiotensin-aldosterone system (RAAS) by angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) is one of the most common treatments for hypertension, heart failure and renal diseases. However, concerns have been raised about a possible link between RA...

journal_title：Journal of cancer research and clinical oncology

authors： Rachow T,Schiffl H,Lang SM

更新日期：2021-01-01 00:00:00

abstract：:Gastric and intestinal phenotypic cell markers are widely expressed in gastric carcinomas, irrespective of their histological type. In the present study, the relations between the phenotypic marker expression of the tumour, histological findings, expression of cell adhesion molecules, and the chromosomal changes in ga...

journal_title：Journal of cancer research and clinical oncology

authors： Morohara K,Tajima Y,Nakao K,Nishino N,Aoki S,Kato M,Sakamoto M,Yamazaki K,Kaetsu T,Suzuki S,Tsunoda A,Tachikawa T,Kusano M

更新日期：2006-06-01 00:00:00

abstract：:In a wider sense iatrogenic carcinogenesis means the induction of cancer by medical treatment. Some drugs have been now identified to be carcinogenic not only in experimental animals but also in man. For example, chlornaphazine used in the treatment of polycythemia has been proved to induce bladder cancer in 30% of th...

journal_title：Journal of cancer research and clinical oncology

authors： Schmähl D

更新日期：1981-01-01 00:00:00

abstract：:Nitrosodiphenylamine was tested for induction of DNA single strand breaks in rat hepatocytes and Chinese hamster V 79 cells with the alkaline filter elution assay. While in rat hepatocytes DNA damage was observed, negative results were obtained in V 79 cells. In view of the metabolic capacity of hepatocytes and the ch...

journal_title：Journal of cancer research and clinical oncology

authors： Appel KE,Görsdorf S,Scheper T,Ruf HH,Rühl CS,Hildebrandt AG

更新日期：1987-01-01 00:00:00

abstract：:The concentration of estrogen receptor protein (ER) in 113 primary or metastatic breast cancers was studied. ER was found to be correlated with the age of the patient. The ER values were generally lower in premenopausal patients (5.6 fmol/mg cytosol protein) than in postmenopausal patients (32.8 fmol/mg cytosol protei...

journal_title：Journal of cancer research and clinical oncology

authors： Johansson R,Vanharanta R,Söderholm J

更新日期：1984-01-01 00:00:00

abstract：:Carboplatin and interferon beta (IFN beta) were tested alone and in combination for their antiproliferative activity on the human melanoma cell line SK-MEL 28 in vitro. Cells were incubated for 4 days in the presence of carboplatin (0.1 mM and 0.1 microM) and interferon beta (5 pM and 5 nM) and cell growth inhibition ...

journal_title：Journal of cancer research and clinical oncology

authors： Hübner B,Eckert K,Garbe C,Maurer HR

更新日期：1995-01-01 00:00:00

abstract：:A new experimental method to test the effect of drugs on tumor-induced osteolysis using a bladder tumor in mice has been designed. The method consisted of inoculating MBT-2 tumor cells s.c. over the calvaria in mice, resulting in a local tumor causing fragmentation of the bone. This was accompanied by adjacent osteopl...

journal_title：Journal of cancer research and clinical oncology

authors： Nemoto R,Uchida K,Tsutsumi M,Koiso K,Satou S,Satou T

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:The benefit of adding docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy to chemoradiotherapy (CRT) in head and neck squamous cell carcinoma (HNSCC) remains uncertain. We aimed to investigate whether ICT is well tolerated when given with prophylactic treatment against predicted adverse effects...

journal_title：Journal of cancer research and clinical oncology

authors： Lowe NM,Bernstein JM,Mais K,Garcez K,Lee LW,Sykes A,Thomson DJ,Homer JJ,West CM,Slevin NJ

更新日期：2018-02-01 00:00:00

abstract：:The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep r...

journal_title：Journal of cancer research and clinical oncology

authors： Gautam SC,Gautam S,Deodhar SD

更新日期：1981-01-01 00:00:00

abstract：:We describe a slide assay that allows the demonstration of antigens localized in the nucleus from isolated white blood cells as well as from single tumor cells derived from malignant effusions. With the antibodies Ki-67 and anti-p-145 an increased rate of nuclear and nucleolar staining resulted in cells from highly ma...

journal_title：Journal of cancer research and clinical oncology

authors： Hirsch FW,Deibert P,Busch H,Löhr GW,Bross KJ

更新日期：1991-01-01 00:00:00

abstract：:This study was undertaken in order to compare the usefulness of three indices of tumour proliferation in detecting primary hepatocellular carcinoma (HCC) and in differentiating this neoplasm from liver cirrhosis. In 10 patients with HCC and in 63 with liver cirrhosis serum alpha-fetoprotein (AFP), tissue polypeptide a...

journal_title：Journal of cancer research and clinical oncology

authors： Leandro G,Basso D,Fabris C,Zizzari S,Elba S,Del Favero G,Di Mario F,Meggiato T,Angonese C,Naccarato R

更新日期：1989-01-01 00:00:00

abstract：:After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50). This change of the organ-specific carcinogenic effect is not observed in exper...

journal_title：Journal of cancer research and clinical oncology

authors： Schweinsberg F,Kouros M,Manncke K

更新日期：1979-10-01 00:00:00

abstract：PURPOSE:Genomic stability is maintained by error-free DNA replication, repair, and recombination. To determine if repair genes contribute to genomic instability, we used a newly established cell line RCC-AJR (from clear-cell renal cell carcinoma) to examine hMSH2 (a mismatch-repair gene) and the gene encoding DNA beta ...

journal_title：Journal of cancer research and clinical oncology

authors： Chen HC,Bhattacharyya N,Wang L,Recupero AJ,Klein EA,Harter ML,Banerjee S

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:It is estimated that about half of cancer patients use at least one form of complementary and alternative medicines (CAM) in their life but there is a strong reticence of patients in talking about CAM with their oncologist. Primary aim of this study was to inform patients about CAM, focusing on their suppose...

journal_title：Journal of cancer research and clinical oncology

authors： Bozza C,Gerratana L,Basile D,Vitale MG,Bartoletti M,Agostinetto E,Russo S,Follador A,De Carlo E,Pella N,Sottile R,Fasola G,Puglisi F

更新日期：2018-10-01 00:00:00

abstract：:In the human gastric adenocarcinoma cell line AGS the effects of the protein-kinase-C-activating phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), the protein kinase C inhibitor staurosporine, the adenylate-cyclase activating agent forskolin, and the permeable dibutyryl-adenosine 3',5'-monophosphate (Bt2cAMP) ...

journal_title：Journal of cancer research and clinical oncology

authors： Piontek M,Hengels KJ,Porschen R,Strohmeyer G

更新日期：1993-01-01 00:00:00

abstract：:Lambda-DNA and plasmid pBR 322-DNA, respectively, were treated in vitro with increasing amounts of 4-S-ethanolsulfido-cyclophosphamide (CPA-P1). Subsequent digestion with restriction endonuclease Pvu II or Mbo II revealed discrete alterations in the cleavage patterns as compared to the controls, indicating subtle chan...

journal_title：Journal of cancer research and clinical oncology

authors： Lindemann H

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Lung cancer is the commonest cause of cancer deaths worldwide, and its mortality can be reduced significantly by performing early diagnosis and screening. Since the 1960s, driven by the pressing needs to accurately and effectively interpret the massive volume of chest images generated daily, computer-assisted d...

journal_title：Journal of cancer research and clinical oncology

authors： Liu B,Chi W,Li X,Li P,Liang W,Liu H,Wang W,He J

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:The spread of malignant lymph nodes due to malignancies of the head and neck is systematically observed. However, sentinel lymph nodes in the cervical region, such as in the axillary or supraclavicular regions, are not described. Therefore, precise preoperative lymph node screening of all neck compartments is r...

journal_title：Journal of cancer research and clinical oncology

authors： Hohlweg-Majert B,Metzger MC,Voss PJ,Hölzle F,Wolff KD,Schulze D

更新日期：2009-06-01 00:00:00

abstract：:The nuclear DNA content (DNA ploidy) level was determined in a series of 83 human brain metastases, for which 35 complete clinical follow-ups were available. The DNA ploidy level determination was carried out by means of DNA histogram types. The results show that certain brain metastases were diploid, while others exh...

journal_title：Journal of cancer research and clinical oncology

authors： Kiss R,Rorive S,Camby I,Pasteels JL,Brotchi J,Salmon I

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Acute intestinal damage induced by chemotherapeutic agent is often a dose-limiting factor in clinical cancer therapy. The aim of this study was to investigate the effect of chemokine CXCL9 on the intestinal damage after chemotherapy and explore the therapeutic potential of anti-CXCL9 agents. METHODS:In vitro c...

journal_title：Journal of cancer research and clinical oncology

authors： Lu H,Liu H,Wang J,Shen J,Weng S,Han L,Sun T,Qian L,Wu M,Zhu S,Yu Y,Han W,Zhu J,Moldenhauer A

更新日期：2015-06-01 00:00:00

abstract：:Female wistar rats were fed on an Mg-deficient diet. After 8 to 10 weeks, the thymus glands were strongly degenerated and the number of lymphocytes was reduced, especially in the cortex. Thymus degeneration was associated with a decreased rate of DNA, RNA, and protein biosynthesis and necrosis and phagocytosis of lymp...

journal_title：Journal of cancer research and clinical oncology

authors： Averdunk R,Bippus PH,Günther T,Merker HJ

更新日期：1982-01-01 00:00:00

abstract：:The aim of the present studies was to elucidate the effects and optimal modulatory conditions of 5-ethyl-2'-deoxyuridine (EtdUrd) on the antitumour efficacy, pharmacokinetics and catabolism of 5-fluorouracil (5-FU) on Colon-26 and Colon-38 murine tumours. HPLC and GC-MS techniques were used to measure the concentratio...

journal_title：Journal of cancer research and clinical oncology

authors： Kralovánszky J,Katona C,Jeney A,Pandi E,Noordhuis P,Erdélyi-Tóth V,Otvös L,Kovács P,Van der Wilt CL,Peters GJ

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:Serum thyrotropin (TSH) is a well-established growth factor for thyroid nodules and suppression of TSH concentrations by administering exogenous thyroxine may interfere with the growth of established nodules as well as the formation of new thyroid nodules. The aim of this study was to investigate whether serum ...

journal_title：Journal of cancer research and clinical oncology

authors： Polyzos SA,Kita M,Efstathiadou Z,Poulakos P,Slavakis A,Sofianou D,Flaris N,Leontsini M,Kourtis A,Avramidis A

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:Solitary plasmacytoma (SP) is characterized by a single mass of clonal plasma cells. Definitive RT can result in long-term local control of the SP. Due to the small number of patients and narrow range of doses, phase III randomized trials are lacking. The aim of this study is to further support the potential...

journal_title：Journal of cancer research and clinical oncology

authors： Alghisi A,Borghetti P,Maddalo M,Roccaro AM,Tucci A,Mazzola R,Magrini SM,Lo Casto A,Bonù ML,Tomasini D,Pasinetti N,Peretto G,Bertagna F,Tomasi C,Buglione M,Triggiani L

更新日期：2020-11-17 00:00:00