Abstract:
PURPOSE:Kaposi's sarcoma (KS) is a proliferative process of suspected viral aetiology associated with immune deficiency. In transplanted patients, lesions regress on discontinuation of immunosuppressive therapy. The purpose of this work was to analyse the expression of the p53 oncosuppressor gene product, a proliferation regulator overexpressed in both malignant and non-malignant conditions, with the aim of better qualifying KS proliferation characteristics. METHODS:We analysed p53 expression in a group of transplanted, cyclosporin A-treated, KS patients by immunohistochemistry, utilizing the DO-7 (with and without the antigen retrieval pretreatment), and the PAb 240 monoclonal anti-p53 antibodies, the latter of which is able to detect a mutated epitope, and evaluating staining intensity and localization, whether cytoplasmic or nuclear. RESULTS:Seventy five percent of KS lesions from transplanted patients presented both nuclear and cytoplasmic positive p53 immunostaining with DO-7 antibody, thus demonstrating a presumably functional inactivation; one case also presented immunoreactivity with the PAb 240 antibody. CONCLUSIONS:On the basis of the results obtained and in the presence of lesion regression upon immunosuppression withdrawal, it may be concluded that KS in transplanted patients can be considered a non-malignant proliferative process, and that the cytoplasmic expression of p53 may stand for a functional inactivation pattern.
journal_name
J Cancer Res Clin Oncoljournal_title
Journal of cancer research and clinical oncologyauthors
Flamini G,Magalini S,Curigliano G,Nanni G,Boninsegna A,Agnes S,Faticato D,Castagneto M,Cittadini Adoi
10.1007/BF01240324subject
Has Abstractpub_date
1997-01-01 00:00:00pages
240-2issue
4eissn
0171-5216issn
1432-1335journal_volume
123pub_type
杂志文章abstract:INTRODUCTION:The clinical assessment of the myocardial damage caused by anthracyclin (ANT)-therapy is difficult. Therefore a study was performed to evaluate non-invasive markers of anthracyclin-induced cardiac effects, with emphasis on course-to-course variation. METHODS:Eligible for study participation were patients,...
journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00
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journal_title:Journal of cancer research and clinical oncology
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journal_title:Journal of cancer research and clinical oncology
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journal_title:Journal of cancer research and clinical oncology
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章,评审
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journal_title:Journal of cancer research and clinical oncology
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章,已发布勘误
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更新日期:2019-09-01 00:00:00
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,多中心研究
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章
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journal_title:Journal of cancer research and clinical oncology
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章
doi:10.1007/BF00402603
更新日期:1983-01-01 00:00:00
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journal_title:Journal of cancer research and clinical oncology
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doi:10.1007/s00432-020-03458-6
更新日期:2020-11-18 00:00:00
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-03-01 00:00:00
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章
doi:10.1007/s00432-011-0991-3
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章,随机对照试验
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更新日期:2014-02-01 00:00:00
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章
doi:10.1007/s00432-020-03433-1
更新日期:2020-11-01 00:00:00
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journal_title:Journal of cancer research and clinical oncology
pub_type: 杂志文章
doi:10.1007/BF01209655
更新日期:1996-01-01 00:00:00
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journal_title:Journal of cancer research and clinical oncology
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更新日期:1998-01-01 00:00:00