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Clinical evaluation of in vitro chemosensitivity testing: the example of uveal melanoma.

Abstract：

PURPOSE:Results from in vitro chemosensitivity testing recommend treosulfan/gemcitabine chemotherapy for the treatment of stage IV uveal melanoma. METHODS:Twenty patients received treosulfan 3,500 mg/m2 followed by gemcitabine 1,000 mg/m2 on day 1 and day 8 repeated on day 29. In cases of prior chemotherapy only 75% of these dosages were used. RESULTS:Without any patient achieving an objective response, 25% of patients (95% confidence interval, 8.6-49.1%) had stabilisation of disease. This stabilisation was associated with a prolonged median overall survival of 17 months compared with 7 months for the patients with progressive disease. First-line treatment was not associated with better response or survival although prognostic parameters did not significantly differ from that of other patients. CONCLUSIONS:The results are disappointing and question the value of individualized chemotherapy based on in vitro assays.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Terheyden P,Bröcker EB,Becker JC

doi

10.1007/s00432-004-0569-4

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

395-9

issue

7

eissn

0171-5216

issn

1432-1335

journal_volume

130

pub_type

临床试验,杂志文章

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