Dept. of Microbiology, School of Medicine, East Carolina University, Greenville, NC.

abstract：PURPOSE:To study the interplay of drugs and energy metabolism of tumor cells, metabolic changes induced by chloroacetaldehyde and cytochalasin B were analyzed in colon carcinoma cells LS174T. METHODS:O(2)-consumption and extracellular acidification were recorded using a bioelectronic sensor-chip system, which monitors...

journal_title：Journal of cancer research and clinical oncology

authors： Motrescu ER,Otto AM,Brischwein M,Zahler S,Wolf B

更新日期：2005-10-01 00:00:00

abstract：:Sarcoma 180 tumor tissue from C57 mice was processed in a soft agar clonogenic assay immediately after removal from the animal and after various methods of storage. The sensitivity to the antineoplastic drug cis-platinum was not affected by different storage methods. The highest yield of colony forming cells per 100 m...

journal_title：Journal of cancer research and clinical oncology

authors： Krischke W,Hartmann R,Schneider M,Schönenberger H

更新日期：1988-01-01 00:00:00

abstract：:Multicellular tumor spheroids (MCTS) grown from the bladder cancer cell line RT112 and from the prostate cancer cell line PCA were exposed to 200 or 800 electromagnetically generated focused ultrasound shock waves. RT112 cells showed a distinct but transient decrease in proliferation whereas the effect of PCA cells wa...

journal_title：Journal of cancer research and clinical oncology

authors： Nicolai H,Steinbach P,Knuechel-Clarke R,Grimm D,Roessler W,Wieland WF,Hofstaedter F

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:In the phase 3 BFORE trial (NCT02130557), treatment with bosutinib resulted in a significantly higher major molecular response rate at 12 months versus imatinib in the modified intent-to-treat (mITT) population of patients with newly diagnosed chronic phase chronic myeloid leukemia (CP CML). Assessment of pa...

journal_title：Journal of cancer research and clinical oncology

authors： Cortes JE,Gambacorti-Passerini C,Deininger MW,Mauro MJ,Chuah C,Kim DW,Milojkovic D,le Coutre P,Garcia-Gutierrez V,Crescenzo R,Mamolo C,Reisman A,Hochhaus A,Brümmendorf TH,BFORE Study Investigators.

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:A number of studies have investigated the role of serum lactate dehydrogenase (LDH) level in patients with osteosarcoma but have yielded inconsistent and inconclusive results. Thus, we conducted a meta-analysis to assess its prognostic value more precisely. METHODS:Systematic computerized searches of PubMed...

journal_title：Journal of cancer research and clinical oncology

authors： Chen J,Sun MX,Hua YQ,Cai ZD

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:To investigate the genomic alterations in larynx carcinomas (LaCa) tissues and its prognostics values in predicting survival. METHODS:To analyse the aberrations in the genome of LaCa patients, we used array comparative genomic hybridization in 19 human laryngeal tumour samples. DNA samples were also subjected ...

journal_title：Journal of cancer research and clinical oncology

authors： Peralta R,Baudis M,Vazquez G,Juárez S,Ortiz R,Decanini H,Hernandez D,Gallegos F,Valdivia A,Piña P,Salcedo M

更新日期：2010-06-01 00:00:00

abstract：:After cure of rat leukemia L 5222 in 79 BD IX rats by single doses of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (Hydroxyethyl-CNU) a total of 9 rats (11%) developed secondary malignomas. ...

journal_title：Journal of cancer research and clinical oncology

authors： Zeller WJ,Schmähl D

更新日期：1979-09-01 00:00:00

abstract：:The clinical course--and hence the prognosis--of patients suffering from malignant tumors are essentially determined by the capability of tumor cells to metastasize. During the past decade knowledge about genetic aberrations, as well as molecular and cell biological mechanisms which are involved in the regulation of t...

journal_title：Journal of cancer research and clinical oncology

authors： Engers R,Gabbert HE

更新日期：2000-12-01 00:00:00

abstract：:Methods have been developed in an in vitro system (1) of assessing the number of disseminated tumor cells in peripheral blood and (2) of enriching tumor cells from peripheral blood samples for further characterization. Cells from three human carcinoma lines (E 14, ChaGo, and LEDWiDr) were mixed with leukocytes from no...

journal_title：Journal of cancer research and clinical oncology

authors： Schwartz R,Walk A,Toomes H,Schirrmacher V

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

journal_title：Journal of cancer research and clinical oncology

authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

更新日期：1999-08-01 00:00:00

abstract：INTRODUCTION:Kaposi's Sarcoma (KS) is a malignant neoplasm arising from endothelial cells. HHV8-infection represents a key pathogenic determinant for the development of KS. There are no standard criteria to treat KS in immunosuppressed-individuals. Six cases (2.1%) of KS occurred in our Center among 285-recipients who ...

journal_title：Journal of cancer research and clinical oncology

authors： Di Benedetto F,Di Sandro S,De Ruvo N,Berretta M,Masetti M,Montalti R,Ballarin R,Cocchi S,Potenza L,Luppi M,Gerunda GE

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Imatinib is a small molecule inhibiting the tyrosine kinases bcr-abl, c-kit, PDGFR-alpha and PDGFR-beta. Investigations were performed to screen ovarian cancer cell lines and tumor samples for target receptor expression. Effects of Imatinib on cell proliferation and apoptosis induction were measured with and wi...

journal_title：Journal of cancer research and clinical oncology

authors： Mundhenke C,Weigel MT,Sturner KH,Roesel F,Meinhold-Heerlein I,Bauerschlag DO,Schem C,Hilpert F,Jonat W,Maass N

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Objective of this work was to extend pharmacokinetic scaling theory of the writer for bolus dosing to include the case of constant-rate i.v. dosing over fixed interval so as to allow projection of adult dose and schedule of typically administered anticancer agents to children. METHODS:The basis for the scaling...

journal_title：Journal of cancer research and clinical oncology

authors： Dawson TH

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Targeted treatment of chronic myelogenous leukemia using imatinib has dramatically improved patient outcome. However, residual disease can be detected in the majority of patients treated with imatinib. Compensatory activation of MAP kinases (MAPK1/2) in response to BCR-ABL-inhibitors has been reported as a p...

journal_title：Journal of cancer research and clinical oncology

authors： Härtel N,Klag T,Hanfstein B,Mueller MC,Schenk T,Erben P,Hochhaus A,La Rosée P

更新日期：2012-02-01 00:00:00

abstract：:(alpha 1----3)-L-Fucosyltransferase activity was measured in serum samples from 90 gastric cancer patients, 10 patients with benign diseases and 100 healthy controls. The enzyme activity was significantly elevated in the serum samples of patients with cancer compared to those from patients with benign diseases (P less...

journal_title：Journal of cancer research and clinical oncology

authors： Yazawa S,Asao T,Nagamachi Y,Abbas SA,Matta KL

更新日期：1989-01-01 00:00:00

abstract：:The proliferative activity in 70 cases of soft-tissue tumours was estimated immunohistochemically using the monoclonal antibody PC-10, which recognizes proliferating-cell nuclear antigen (PCNA) in paraffin sections. The PCNA index (i.e. the percentage of positive neoplastic nuclei) and to a lesser degree the PCNA coun...

journal_title：Journal of cancer research and clinical oncology

authors： Korkolopoulou P,Christodoulou P,Papanikolaou A,Tsenga A,Thomas-Tsagli E

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:In the United States, cancer is the second leading cause of mortality, and millions more battle cancer worldwide. As such, primary prevention of cancer is a major interest globally. Aspirin has been studied as a primary prevention method for multiple diseases, mainly cardiovascular disease and various forms ...

journal_title：Journal of cancer research and clinical oncology

authors： Haykal T,Barbarawi M,Zayed Y,Yelangi A,Dhillon H,Goranta S,Kheiri B,Chahine A,Samji V,Kerbage J,Katato K,Bachuwa G

更新日期：2019-07-01 00:00:00

abstract：:The two hormone analogues octreotide and goserelin have been shown to decelerate growth of human pancreatic cancer in vitro and in vivo. The objective of this pilot study was to investigate the efficacy and toxicity of the combination of these two agents in patients with advanced pancreatic cancer. Octreotide was inje...

journal_title：Journal of cancer research and clinical oncology

authors： Fazeny B,Baur M,Prohaska M,Hudec M,Kremnitzer M,Meryn S,Huber H,Grunt T,Tuchmann A,Dittrich C

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Multiple gastrointestinal stromal tumors (GISTs) rarely occur in patients with neurofibromatosis type 1 (NF-1). In contrast to sporadic GISTs characterized by frequent allelic losses of 1p, 14q and 22q and mutations of KIT or PDGFRA gene with the activation of the downstream RAS-MAPK pathway, the molecular path...

journal_title：Journal of cancer research and clinical oncology

authors： Yamamoto H,Tobo T,Nakamori M,Imamura M,Kojima A,Oda Y,Nakamura N,Takahira T,Yao T,Tsuneyoshi M

更新日期：2009-06-01 00:00:00

abstract：:The occurrence of malignancies during pregnancy has increased over the last decades. They complicate approximately 1 per 1000 pregnancies. The most common malignancies associated with pregnancy include malignant melanoma, malignant lymphomas and leukemia, and cancer of the cervix, breast, ovary, colon and thyroid. Sin...

journal_title：Journal of cancer research and clinical oncology

authors： Oduncu FS,Kimmig R,Hepp H,Emmerich B

更新日期：2003-03-01 00:00:00

abstract：:The isolation of deoxyguanosine-resistant 10T1/2 mouse cell lines following stepwise selection in the presence of increasing concentrations of drug led to the identification of a highly metastatic line, as measured by the ability to form secondary tumors in syngenic mice after intravenous injection. This metastatic de...

journal_title：Journal of cancer research and clinical oncology

authors： Damen JE,Spearman MA,Greenberg AH,Wright JA

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Two hundred and fourteen patients with benign giant cell tumor of bone (GCTB), treated from 1980 to 2007 at the Department of Orthopedics of the University of Muenster (Germany), were analyzed in a retrospective study. PATIENTS AND METHODS:The mean age was 33.3 years with a female-to-male ratio of 1.2 : 1. ...

journal_title：Journal of cancer research and clinical oncology

authors： Balke M,Schremper L,Gebert C,Ahrens H,Streitbuerger A,Koehler G,Hardes J,Gosheger G

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:Although important for apoptosis, the signaling pathway involving MOAP-1(Modulator of Apoptosis 1), RASSF1A (RAS association domain family 1A), and Bax (Bcl-2 associated X protein) is likely to be dysfunctional in many types of human cancers due to mechanisms associated with gene mutation and DNA hyper-methylat...

journal_title：Journal of cancer research and clinical oncology

authors： Lee YH,Pang SW,Revai Lechtich E,Shah K,Simon SE,Ponnusamy S,Narayanan R,Poh CL,Tan KO

更新日期：2020-07-01 00:00:00

abstract：:A brain metastasis of bronchial squamous cell carcinoma in a patient was cultivated. The cells with epithelium-like characteristics were selected from the primary culture, and were subcultured to establish a cell line. The cultured cells were identified to be neoplastic by means of heterologous transplantation to nude...

journal_title：Journal of cancer research and clinical oncology

authors： Takaki T

更新日期：1980-01-01 00:00:00

abstract：:The formation of foci with loss of ATPase and emergence of gamma-GTase was studied histochemically in livers of male and female Wistar and Sprague-Dawley rats of 3--4 and 6--7 weeks of age, respectively, after application of diethylnitrosamine. A single dose of 8 mg/kg body weight induced a considerable island formati...

journal_title：Journal of cancer research and clinical oncology

authors： Deml E,Oesterle D,Wolff T,Greim H

更新日期：1981-01-01 00:00:00

abstract：:The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by means of the siliconoil-filtration technique. At 10 mM concentration no permeation of the metabolite into the tumor cells could be found within 5 min at 1 degrees C, while its congenors cyclop...

journal_title：Journal of cancer research and clinical oncology

authors： Lenssen U,Hohorst HJ

更新日期：1979-02-19 00:00:00

abstract：:The role of L-tyrosine, L-phenylalanine, L-dihydroxyphenylalanine (dopa) and L-tryptophan in melanin biosynthesis in melanotic hamster melanoma IC-Sofia was investigated with the aid of 14C-aminoacids. Tyrosine and phenylalanine were found to be the main melanin precursors: about 64.5% of total melanin labeling was du...

journal_title：Journal of cancer research and clinical oncology

authors： Blagoeva PM

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Multidrug resistance (MDR) has been linked to sphingolipid metabolism and preclinical data ascribe glucosylceramide synthase (GCS) a major role for MDR especially in breast cancer cells but no profound data are available on the expression of this potential therapeutic target in clinical breast cancer specimens....

journal_title：Journal of cancer research and clinical oncology

authors： Ruckhäberle E,Karn T,Hanker L,Gätje R,Metzler D,Holtrich U,Kaufmann M,Rody A

更新日期：2009-01-01 00:00:00

abstract：:After 12 oral applications of 80 mg/kg MNNG as a suspension in 30% aqueous ethanol at weekly intervals, 98 Sprague-Dawley rats died with multiple tumors of the forestomach after a medium latency period of 226 days. Histological examination showed generalized papillomatosis developing into keratinizing squamous cell ca...

journal_title：Journal of cancer research and clinical oncology

authors： Eichler G,Habs M,Schmähl D

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and survival time of acquired immunodeficiency syndrome-related malignancies among HIV-infected population. METHODS:A clinical database search, chart review and verification with health records were undertaken for all AIDS-defining cancers diagnosed in Zhongnan Hospital Wuhan Unive...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang YX,Gui XE,Zhong YH,Rong YP,Yan YJ

更新日期：2011-04-01 00:00:00