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Aminoacids--precursors of melanin synthesis in hamster melanoma.

Abstract：

:The role of L-tyrosine, L-phenylalanine, L-dihydroxyphenylalanine (dopa) and L-tryptophan in melanin biosynthesis in melanotic hamster melanoma IC-Sofia was investigated with the aid of 14C-aminoacids. Tyrosine and phenylalanine were found to be the main melanin precursors: about 64.5% of total melanin labeling was due to tyrosine incorporation and 27.4% to phenylalanine incorporation. Negligible proportions of melanin radioactivity (5.7% and 2.4%, respectively) resulted from dopa and tryptophan utilization in melanin synthesis. The involvement of each of the aminoacids under investigation in melanin synthesis in vivo is discussed.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Blagoeva PM

doi

10.1007/BF00390476

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

366-8

issue

3

eissn

0171-5216

issn

1432-1335

journal_volume

108

pub_type

杂志文章

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