当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells.

GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells.

Abstract：

PURPOSE:The orphan, membrane-bound estrogen receptor (GPER) is expressed at high levels in a large fraction of breast cancer patients, and its expression is favorable for patients' survival. We investigated the role of GPER as a potential tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells. METHODS:The effect of GPER agonist G-1 in cell culture was used to determine whether GPER inhibit cell growth. The methylation status of GPER promoter was investigated by methylation-specific PCR. RESULTS:GPER-specific agonist G-1 inhibited breast cancer cell proliferation in concentration-dependent manner via induction of the cell cycle arrest in M-phase, enhanced phosphorylation of histone 3 and cell apoptosis. Analysis of the methylation status of the GPER promoter in MCF-7 and SK-BR-3 cells revealed that GPER expression is regulated by epigenetic mechanisms and GPER expression is inactivated by promoter methylation. Overall, our results are consistent with our recent findings in triple-negative breast cancer cells, and the cell surface expression of GPER makes it an excellent potential therapeutic target for non-triple-negative breast cancer.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Weißenborn C,Ignatov T,Poehlmann A,Wege AK,Costa SD,Zenclussen AC,Ignatov A

doi

10.1007/s00432-014-1598-2

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

663-71

issue

4

eissn

0171-5216

issn

1432-1335

journal_volume

140

pub_type

杂志文章

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