[Concentrations of cytostatic drugs in organs and tumors: comparison after intravenous and intratumoral injection (author's transl)].

abstract：:A dose-response study was carried out in male F344 rats with a specific urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), which was administered as a solution in drinking water for up to 112 weeks. BBN was given in four different concentrations, 50, 10, 5, and 1 ppm, to groups of 30 rats. The hi...

journal_title：Journal of cancer research and clinical oncology

authors： Ito N,Shirai T,Fukushima S,Hirose M

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Solute carrier organic anion transporter family member 4A1 (SLCO4A1) is involved in the transport of various compounds, including sugars, bile salts, organic acids, metal ions, amine compounds, and estrogen. SLCO4A1 is highly expressed in several cancers and a gender bias has been observed in colorectal cancer ...

journal_title：Journal of cancer research and clinical oncology

authors： Ban MJ,Ji SH,Lee CK,Bae SB,Kim HJ,Ahn TS,Lee MS,Baek MJ,Jeong D

更新日期：2017-08-01 00:00:00

abstract：:Metastatic interstitial cell tumor of the testis is one of the rarest human neoplasms. This is the nineteenth case to be reported. While most of these tumors are combined with hormonal dysfunction, the present tumor, apart from its uncommon hormonal profile, is remarkable because of its capacity of producing and secre...

journal_title：Journal of cancer research and clinical oncology

authors： Higi M,Niederle N,Scheulen ME,Richter HJ

更新日期：1979-07-27 00:00:00

abstract：:1,1,2-Triphenylbut-1-enes substituted with 3- or 4-acetoxy (OAc) groups on one, two, or three phenyl rings were tested for their estrogen receptor affinities, their estrogenic and antiestrogenic properties in the immature mouse, and their effect on the growth of the hormone-dependent MXT mammary tumor of the mouse. Th...

journal_title：Journal of cancer research and clinical oncology

authors： Schneider MR

更新日期：1986-01-01 00:00:00

abstract：:The increase of plasma cortisol in patients with tumors of five different sites compared with a control group of patients with benign surgical diseases amounted to: +39% (breast), +34% (stomach), +86% (intestine), +60% (skin) and +194% (gall bladder). The first detectable increase of cortisol occurred in patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Schaur RJ,Semmelrock HJ,Schauenstein E,Kronberger L

更新日期：1979-04-12 00:00:00

abstract：INTRODUCTION:Evidence shows that exon 19 deletions (19del) and exon 21 Leu858Arg point mutation (L858R) of EGFR are different in response to EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in advanced lung cancers. However, the impact of the two mutational types in the early stage lung adenocarcinoma is unknown. MET...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang Y,Ma Y,Li Y,Shen X,Yu Y,Pan Y,Zhang Y,Yu S,Zheng D,Zhao Y,Hu H,Sun Y,Zhang Y,Xiang J,Chen H

更新日期：2018-01-01 00:00:00

abstract：:To examine the relationship between altered spontaneous mutation rates and malignant characteristics of cells, two hydroxyurea-resistant Chinese hamster ovary cell lines, with alterations in ribonucleotide reductase, were examined for their rates of spontaneous mutation to 6-thioguanine and ouabain resistance, tumor g...

journal_title：Journal of cancer research and clinical oncology

authors： Tagger AY,Damen JE,Greenberg AH,Wright JA

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Previous studies showed poorer survival in T4 disease with residual lesion. To evaluate the efficacy and toxicity of a boost dose for T4 nasopharyngeal carcinoma (NPC), patients with a residual primary lesion after intensity-modulated radiotherapy (IMRT). METHODS:398 T4 NPC patients with residual primary le...

journal_title：Journal of cancer research and clinical oncology

authors： Fei Z,Xu T,Qiu X,Li M,Chen T,Li L,Huang C,Chen C

更新日期：2021-01-03 00:00:00

abstract：:As currently recognized, the essential aspects of ovarian carcinoma surgery are: (1) the search for occult metastases in tumors located in the lower pelvis, (2) the maximum tumor removal ("tumor-reductive surgery") in advanced ovarian carcinoma and (3) the exploratory laparotomy to confirm a complete clinical remissio...

journal_title：Journal of cancer research and clinical oncology

authors： Almendral AC

更新日期：1984-01-01 00:00:00

abstract：:Correlations between exposure to vinyl chloride and the development of malignant tumors in the liver have been know since 1974 and have been confirmed by many an experimental investigation. Based on the evaluation of mortality statistics from nine different countries an increased incidence of malignant tumors of the l...

journal_title：Journal of cancer research and clinical oncology

authors： Emmerich KH,Norpoth K

更新日期：1981-01-01 00:00:00

abstract：:The primary objective of this study was to determine the response rate of patients with metastatic colorectal cancer to combined therapy with 5-fluorouracil (5-FU), leucovorin, and intravenous azidothymidine (AZT), a thymidine nucleoside analog. By itself, AZT has limited antineoplastic efficacy. However, experimental...

journal_title：Journal of cancer research and clinical oncology

authors： Clark J,Sikov W,Cummings F,Browne M,Akerley W,Wanebo H,Weitberg A,Kennedy T,Cole B,Bigley J,Beitz J,Darnowski J

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:It is estimated that about half of cancer patients use at least one form of complementary and alternative medicines (CAM) in their life but there is a strong reticence of patients in talking about CAM with their oncologist. Primary aim of this study was to inform patients about CAM, focusing on their suppose...

journal_title：Journal of cancer research and clinical oncology

authors： Bozza C,Gerratana L,Basile D,Vitale MG,Bartoletti M,Agostinetto E,Russo S,Follador A,De Carlo E,Pella N,Sottile R,Fasola G,Puglisi F

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:The feasibility of radioimmunotherapy (RAIT) combined with 5-fluorouracil (5-FU) was examined in colon cancer xenografts. The mode of interaction of the two treatments was also investigated. METHODS:Mice bearing human colon cancer were treated with a combination of 4.63 MBq (L-RAIT) or 9.25 MBq (H-RAIT) (131)I...

journal_title：Journal of cancer research and clinical oncology

authors： Kinuya S,Yokoyama K,Tega H,Hiramatsu T,Konishi S,Watanabe N,Shuke N,Aburano T,Takayama T,Michigishi T,Tonami N

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Human embryonic lethal abnormal visual-like protein, HuR, belongs to a member of the Hu family of RNA-binding protein and plays a critical role in urinary tumors. The purpose of this review is to summarize the current literature to demonstrate the importance of HuR in urinary tract tumors' biology and explore t...

journal_title：Journal of cancer research and clinical oncology

authors： Zhang F,Cai Z,Lv H,Li W,Liang M,Wei X,Zhou F

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether an association exists between a history of fertility treatments and future risk of female malignancies. STUDY DESIGN:A population-based study compared the incidence of long-term female malignancies in a cohort of women with and without a history of fertility treatments including in vit...

journal_title：Journal of cancer research and clinical oncology

authors： Kessous R,Davidson E,Meirovitz M,Sergienko R,Sheiner E

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:The present study was undertaken to examine the amplification and expression status of Cks1 in breast cancer and its significance. METHODS:The amplification and expression status of Cks1 gene was examined by FISH, real-time PCR and immunohistochemistry, respectively. RNA interference was used to detect the eff...

journal_title：Journal of cancer research and clinical oncology

authors： Wang XC,Tian LL,Tian J,Wu HL,Meng AM

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Death-associated protein kinase (DAPK) and adenomatous polyposis coli gene (APC) have been recently shown to be associated with outcome in patients with esophageal carcinoma, especially adenocarcinoma. We wanted to validate the correlation of these two markers with outcome by detecting methylated DNA sequenc...

journal_title：Journal of cancer research and clinical oncology

authors： Hoffmann AC,Vallböhmer D,Prenzel K,Metzger R,Heitmann M,Neiss S,Ling F,Hölscher AH,Schneider PM,Brabender J

更新日期：2009-09-01 00:00:00

abstract：:Breast cancer tissue was examined for overexpression of HER-2/neu and p53 oncogene proteins. Samples from 105 breast cancer patients were investigated by Western-blot analysis and their relationship to other established markers and clinical outcome was examined. In 21.0% of the cases HER-2/neu was overexpressed, and i...

journal_title：Journal of cancer research and clinical oncology

authors： Wiltschke C,Kindas-Muegge I,Steininger A,Reiner A,Reiner G,Preis PN

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:There was no standard treatment for hepatocellular carcinoma with portal vein tumour thrombosis (PVTT). This prospective, randomised, two-arm clinical trial aims to investigate the feasibility, safety and effectiveness of transarterial chemoembolisation (TACE) combined with the endovascular implantation of an i...

journal_title：Journal of cancer research and clinical oncology

authors： Yang M,Fang Z,Yan Z,Luo J,Liu L,Zhang W,Wu L,Ma J,Yang Q,Liu Q

更新日期：2014-02-01 00:00:00

abstract：:Preoperative cytologic examinations were performed on bronchial material from 92 patients with postsurgical (pathologic) stage I (American Joint Committee) adenocarcinoma of the lung. All patients were followed up for at least 5 years or until death; thus, cases of adenocarcinoma metastatic to the lungs were virtually...

journal_title：Journal of cancer research and clinical oncology

authors： Bjornsson J,Goellner JR,Williams DE,Scheiber MV

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:In this study, we applied laser capture microdissection and a proteomic approach to identify novel nasopharyngeal carcinoma (NPC) biomarkers. METHODS:Proteins from pooled microdissected NPC and normal nasopharyngeal epithelial tissues (NNET) were separated by two-dimensional gel electrophoresis, and differenti...

journal_title：Journal of cancer research and clinical oncology

authors： Li XM,Huang WG,Yi H,Cheng AL,Xiao ZQ

更新日期：2009-12-01 00:00:00

abstract：:Treatment of cultured mammalian cells with hydrogen peroxide results in the production of extensive DNA damage. Strand breakage was produced at the level of either nascent or mature DNA and the former target appeared slightly more resistant than the latter. Although inhibitors of the enzyme poly(ADP-ribose) polymerase...

journal_title：Journal of cancer research and clinical oncology

authors： Cantoni O,Fiorani M,Mugnaini M,Cattabeni F

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the frequency of second primary non-breast cancer after breast cancer diagnosis and treatment, and its correlation with clinicopathological features. METHODS:Data from 21,527 patients with primary breast cancer were collected retrospectively in a single cancer centre; 4.1% o...

journal_title：Journal of cancer research and clinical oncology

authors： Corso G,Veronesi P,Santomauro GI,Maisonneuve P,Morigi C,Peruzzotti G,Intra M,Sacchini V,Galimberti V

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:In the United States, cancer is the second leading cause of mortality, and millions more battle cancer worldwide. As such, primary prevention of cancer is a major interest globally. Aspirin has been studied as a primary prevention method for multiple diseases, mainly cardiovascular disease and various forms ...

journal_title：Journal of cancer research and clinical oncology

authors： Haykal T,Barbarawi M,Zayed Y,Yelangi A,Dhillon H,Goranta S,Kheiri B,Chahine A,Samji V,Kerbage J,Katato K,Bachuwa G

更新日期：2019-07-01 00:00:00

abstract：:Chemically induced (autochthonous) tumors in the rodent are thought to be the best models at hand to obtain results transferable to the clinical situation. Four different autochthonous tumor models: 1,2-dimethylhydrazine, N-methylnitrosourea (MNU), N-methyl-N-nitro-nitrosoguanidine (MNNG), and N-nitroso-acetoxymethyl-...

journal_title：Journal of cancer research and clinical oncology

authors： Amberger H

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To investigate the efficacy and safety of nab-paclitaxel plus S-1 (nab-P/S) versus nab-paclitaxel plus gemcitabine (nab-P/G) as first-line chemotherapy in patients with advanced pancreatic ductal adenocarcinoma (PDAC). METHODS:Treatment-naïve patients with advanced PDAC were equally randomized to receive nab-P...

journal_title：Journal of cancer research and clinical oncology

authors： Zong Y,Yuan J,Peng Z,Lu M,Wang X,Shen L,Zhou J

更新日期：2020-11-15 00:00:00

abstract：PURPOSE:The appearance of the cervical mucosa is regulated by different factors including retinoic acid. Hormone-dependent alteration of the cervix uteri mucosa is accompanied by a decrease or increase of cytoplasmatic retinoic-acid-binding protein (CRABP). To elucidate whether this hormone-dependent alteration of CRAB...

journal_title：Journal of cancer research and clinical oncology

authors： Volz-Köster S,Volz J,Kiefer A,Biesalski HK

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:MicroRNAs are small, non-coding RNAs that are critical regulators of various diseases including cancer, and may represent a novel class of cancer biomarkers. Recent reports have highlighted the oncogenic aspects of miR-125b. However, the level and clinical relevance of circulating miR-125b transcripts in human ...

journal_title：Journal of cancer research and clinical oncology

authors： Yuxia M,Zhennan T,Wei Z

更新日期：2012-12-01 00:00:00

abstract：:A new experimental method to test the effect of drugs on tumor-induced osteolysis using a bladder tumor in mice has been designed. The method consisted of inoculating MBT-2 tumor cells s.c. over the calvaria in mice, resulting in a local tumor causing fragmentation of the bone. This was accompanied by adjacent osteopl...

journal_title：Journal of cancer research and clinical oncology

authors： Nemoto R,Uchida K,Tsutsumi M,Koiso K,Satou S,Satou T

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Liver cancers are among the deadliest malignancies due to a limited efficacy of early diagnostics, the lack of appropriate biomarkers and insufficient discrimination of different types of tumors by classic and molecular methods. In this study, we searched for novel long non-coding RNA (lncRNA) as well as valida...

journal_title：Journal of cancer research and clinical oncology

authors： Burenina OY,Lazarevich NL,Kustova IF,Shavochkina DA,Moroz EA,Kudashkin NE,Patyutko YI,Metelin AV,Kim EF,Skvortsov DA,Zatsepin TS,Rubtsova MP,Dontsova OA

更新日期：2021-01-01 00:00:00