当前位置： SCI文献检索 > JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY期刊下所有文献 > Immunological characterization of mononuclear cells and morphological findings in patients with mammary carcinoma.

Immunological characterization of mononuclear cells and morphological findings in patients with mammary carcinoma.

Abstract：

:Mononuclear cells from peripheral blood and draining lymph nodes of 40 patients with invasive mammary carcinoma were examined for various immunological cell surface markers including surface membrane immunoglobulins and rosetting properties (E, EA, EAC). No significant relationship could be established to anyone of the following criteria for which the literature reports varying prognostic values: Clinical staging of the disease , histological tumor type, grading, nuclear differentiation, round cell infiltration, perivenous infiltration, sinus histiocytosis, and lymph node reaction patterns (lymphocyte predominance, germinal center predominance, lymphocyte depletion, unstimulated nodes). From the reported results it is concluded that the analysis of lymphocyte cell surface markers in mammary carcinoma is not a suitable parameter for supporting the existence of specific or unspecific anti-tumor immune reactions which may be suspected from certain histological reaction patterns.

journal_name

J Cancer Res Clin Oncol

journal_title

Journal of cancer research and clinical oncology

authors

Heidenreich W,Jagla K,Schüssler J,Börner P,Dehnhard F,Deinhardt J,Kalden J,Peter HH,Deicher H

doi

10.1007/BF00411111

subject

Has Abstract

pub_date

1979-09-01 00:00:00

pages

65-74

issue

1

eissn

0171-5216

issn

1432-1335

journal_volume

95

pub_type

杂志文章

相关文献

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY文献大全
  • MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression.

    abstract：AIMS:This study aimed at evaluating the potential anti-proliferative effects of the microRNA let-7 family in nasopharyngeal carcinoma (NPC) cells. In addition, the association between let-7 suppression and DNA hypermethylation is examined. MATERIALS AND METHODS:Levels of mature let-7 family members (-a, -b, -d, -e, -g...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-010-0898-4

    authors： Wong TS,Man OY,Tsang CM,Tsao SW,Tsang RK,Chan JY,Ho WK,Wei WI,To VS

    更新日期：2011-03-01 00:00:00

  • Inhibitory effect of the angiogenesis inhibitor TNP-470 on tumor growth and metastasis in nude mice bearing human hepatocellular carcinoma.

    abstract：:The antitumor and anti-metastatic effects of a potent angiogenesis inhibitor, O-(chloroacetyl-carbamoyl)fumagillol (TNP-470), was investigated in a highly metastatic model of human hepatocellular carcinoma-LCI-D20. Small pieces of LCI-D20 tumor tissue were implanted subcutaneously into the right axillary region of 24 ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01240121

    authors： Xia JL,Yang BH,Tang ZY,Sun FX,Xue Q,Gao DM

    更新日期：1997-01-01 00:00:00

  • Proteomic analysis of pancreatic juice for the identification of biomarkers of pancreatic cancer.

    abstract：INTRODUCTION:Protein profiles of endoscopically collected pancreatic juice from normal, chronic pancreatitis patients and pancreatic cancer patients were compared to identify diagnostic biomarkers of pancreatic cancer. METHODS:Secretin was injected intravenously and pancreatic juice was collected via selective cannula...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-011-0992-2

    authors： Park JY,Kim SA,Chung JW,Bang S,Park SW,Paik YK,Song SY

    更新日期：2011-08-01 00:00:00

  • Ambulatory high-dose 5-day continuous-infusion ifosfamide combination chemotherapy in advanced solid tumors: a feasibility study.

    abstract：:The oxazaphosphorine analog ifosfamide (IFO) has demonstrated an increased therapeutic index in a variety of solid tumors and hematologic malignancies compared with its parent compound cyclophosphamide. A fractionated dose schedule over 5 days as continuous infusion in combination with the uroprotective agent sodium-2...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01613216

    authors： Loeffler TM,Weber FW,Hausamen TU

    更新日期：1991-01-01 00:00:00

  • Induced pluripotent cancer cells: progress and application.

    abstract：:Induced pluripotent stem (iPS) cells are a group of pluripotent stem cells artificially derived from non-pluripotent cells typically by a forced expression of specific transcription factors. Generation of cancer-specific iPS cells, also called induced pluripotent cancer (iPC) cells, provides valuable experimental plat...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s00432-010-0955-z

    authors： Sun C,Liu YK

    更新日期：2011-01-01 00:00:00

  • Chemosensitivity of glioma cells in vitro: a meta analysis.

    abstract：PURPOSE:The disappointing results of chemotherapy in glioblastoma might be caused by the choices of agents, which mostly include nitrosurea. We compared the in vitro efficacy of chemotherapeutic agents, developing a method to summarize published data. METHOD:Between 1966 and 1995 chemotherapy in glioma cells was repor...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s004320050305

    authors： Wolff JE,Trilling T,Mölenkamp G,Egeler RM,Jürgens H

    更新日期：1999-08-01 00:00:00

  • Morphological grades of regression in osteosarcoma after polychemotherapy - study COSS 80.

    abstract：:The histologic grade of regression of 50 osteosarcomas after polychemotherapy - according to the protocol study, COSS 80 - was classified on a six-stage regression scale; 56% of all patients responded well to chemotherapy regression grades I, II, and III and no significant difference between BCD- and CPL-treated patie...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00625047

    authors： Salzer-Kuntschik M,Delling G,Beron G,Sigmund R

    更新日期：1983-01-01 00:00:00

  • Factors predicting long-term survival in colorectal cancer patients with a normal preoperative serum level of carcinoembryonic antigen.

    abstract：PURPOSE:The aim of this study was to determine which clinicopathological factors influenced the long-term survival after potentially curative resection of colorectal cancer patients with a normal preoperative serum level of carcinoembryonic antigen (CEA). METHODS:A total of 1,732 patients who underwent curative surger...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-013-1459-4

    authors： Huh JW,Kim CH,Lim SW,Kim HR,Kim YJ

    更新日期：2013-09-01 00:00:00

  • Current clinical regulation of PI3K/PTEN/Akt/mTOR signalling in treatment of human cancer.

    abstract：PURPOSE:PTEN is an essential tumour suppressor gene which encodes a phosphatase protein that antagonises the PI3K/Akt/mTOR antiapoptotic pathway. Impairment of this tumour suppressor pathway potentially becomes a causal factor for development of malignancies. This review aims to assess current understanding of mechanis...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章,评审

    doi：10.1007/s00432-014-1803-3

    authors： Lim HJ,Crowe P,Yang JL

    更新日期：2015-04-01 00:00:00

  • Characterization of intracellular superoxide dismutase alterations in premalignant and malignant lesions of the oral cavity: correlation with lymph node metastasis.

    abstract：PURPOSE:The purpose of this study was to characterize changes in the expression of copper-zinc superoxide dismutase (Cu/Zn-SOD) and manganese SOD (Mn-SOD) in oral squamous-cell carcinoma (OSCC). METHODS:Real-time quantitative reverse transcriptase-polymerase chain reaction analysis of Cu/Zn-SOD and Mn-SOD mRNA express...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-009-0610-8

    authors： Yokoe H,Nomura H,Yamano Y,Fushimi K,Sakamoto Y,Ogawara K,Shiiba M,Bukawa H,Uzawa K,Takiguchi Y,Tanzawa H

    更新日期：2009-11-01 00:00:00

  • Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers.

    abstract：:Female carriers of mutations in the BRCA1 gene on chromosome 17q have a very high risk of developing breast and/or ovarian cancer during their lifetime. There is, however, little knowledge of to what extent non-genetic risk factors, such as age at menarche, age at first birth, and body mass index, alter the age at ons...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01208638

    authors： Chang-Claude J,Becher H,Eby N,Bastert G,Wahrendorf J,Hamann U

    更新日期：1997-01-01 00:00:00

  • Spontaneous high-titered IgG antibody responses against BCL-2 in patients with aggressive lymphomas.

    abstract：PURPOSE:Molecules which are exclusively or preferentially expressed by malignant cells are potential targets for immunotherapeutic approaches to the treatment of cancer. METHODS:We therefore tested serum samples of 95 patients with aggressive B-cell lymphomas for antibodies against lymphoma-associated molecules using ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-009-0561-0

    authors： Zwick C,Held G,Hammermeister V,Alahmad A,Kubuschok B,Bittenbring J,Ahlgrimm M,Neumann F,Preuss KD,Pfreundschuh M

    更新日期：2009-09-01 00:00:00

  • Intra-hepatic cholangiocarcinoma--frequency and demographic patterns: thirty-year data from the M.D. Anderson Cancer Center.

    abstract：PURPOSE:Recent reports have shown an increase in frequency of intra-hepatic cholangiocarcinoma (IHC) with a stable or decreased frequency of extra-hepatic cholangiocarcinoma (EHC). However, data on the demographic patterns associated with this change are limited. We analyzed cases of cholangiocarcinoma (CC) with aim to...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-010-0971-z

    authors： Singal AK,Vauthey JN,Grady JJ,Stroehlein JR

    更新日期：2011-07-01 00:00:00

  • Subareolar blue dye only injection sentinel lymph node biopsy could reduce the numbers of standard axillary lymph node dissection in environments without access to nuclear medicine.

    abstract：PURPOSE:The gold standard of axillary sentinel lymph node biopsy (SLNB) in breast cancer is the combination of radioactive colloid and blue dye injection. Worldwide, numerous hospitals without access to radioactive tracers still perform a routine complete axillary lymph node dissection (ALND). We retrospectively analyz...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-007-0333-7

    authors： Kavallaris A,Camara O,Runnebaum IB

    更新日期：2008-06-01 00:00:00

  • Comparable outcome after single-antigen-mismatched versus matched unrelated donor haematopoietic cell transplantation.

    abstract：PURPOSE:Allogeneic haematopoietic stem cell transplantation (HSCT) is a proven treatment for patients with haematological malignancies. In this retrospective analysis, the impact of donor matching on outcome of unrelated HSCT was analysed in patients transplanted at the University of Leipzig. METHODS:From 2000 to 2009...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-015-2003-5

    authors： Rockstroh A,Al-Ali HK,Lange T,Pönisch W,Krahl R,Cross M,Behre G,Niederwieser D,Pfrepper C

    更新日期：2015-12-01 00:00:00

  • Is cyclophosphamide self-defeating as an antitumor agents?

    abstract：:The study shows inhibition of the antitumor effect of cyclophosphamide (CPA) on mammary carcinomas growing in mice prior-immunized by intragastric inoculations of the tumor. Immunization with tumor cells through this route produces under certain conditions factors able to modulate the antigenic determinants on tumor c...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00411282

    authors： Laursen ML

    更新日期：1980-01-01 00:00:00

  • Phase II trial of aclacinomycin A in acute leukemia and various solid tumors.

    abstract：:Aclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study was performed in a total of 25 patients, 23 of whom are evaluable for response. All suffered from recurrent and advanced tumors. Pretreatment consisted of at least four different chemotherapeutic ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00406927

    authors： Schütte J,Niederle N,Seeber S

    更新日期：1983-01-01 00:00:00

  • Riproximin modulates multiple signaling cascades leading to cytostatic and apoptotic effects in human breast cancer cells.

    abstract：BACKGROUND:Riproximin, a type II ribosome-inactivating protein (RIP), has shown significant cytotoxic effects in diverse types of cancer cells. To better understand its therapeutic potential, elaborated investigations on the mechanistic aspects of riproximin deem crucial. In this study, we focused on riproximin-mediate...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-015-2013-3

    authors： Pervaiz A,Zepp M,Adwan H,Berger MR

    更新日期：2016-01-01 00:00:00

  • Additive effect of concomitant multiple low-dose doxorubicin and thoracic irradiation on ex vivo cardiac performance of the rat heart.

    abstract：:The effects of doxorubicin alone or combined with local heart irradiation on ex vivo cardiac performance were studied in Sprague-Dawley rats. Rats were treated with doxorubicin either administered as a single bolus injection or administered weekly during a period of 10 weeks. In "combined" experiments, local heart irr...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s004320050148

    authors： Wondergem J,Franken NA,Chin A,van Ravels FJ,Leer JW

    更新日期：1998-01-01 00:00:00

  • Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.

    abstract：:The DMBA-TPA-mediated two-stage skin carcinogenesis experiment was modified in that pregnant mice were systemically treated once during pregnancy with the carcinogen. Intragastric application times were fetal days 6, 8, and 10-20. A control group of pregnant mice received repeated doses (from days 8-20) of sesame oil,...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00410789

    authors： Goerttler K,Loehrke H,Schweizer J,Hesse B

    更新日期：1980-01-01 00:00:00

  • Age-, sex-, and strain-dependent differences in the induction of enzyme-altered islands in rat liver by diethylnitrosamine.

    abstract：:The formation of foci with loss of ATPase and emergence of gamma-GTase was studied histochemically in livers of male and female Wistar and Sprague-Dawley rats of 3--4 and 6--7 weeks of age, respectively, after application of diethylnitrosamine. A single dose of 8 mg/kg body weight induced a considerable island formati...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00403362

    authors： Deml E,Oesterle D,Wolff T,Greim H

    更新日期：1981-01-01 00:00:00

  • Alpha-fetoprotein, tissue polypeptide antigen and ferritin in diagnosing primary hepatocellular carcinoma in patients with liver cirrhosis.

    abstract：:This study was undertaken in order to compare the usefulness of three indices of tumour proliferation in detecting primary hepatocellular carcinoma (HCC) and in differentiating this neoplasm from liver cirrhosis. In 10 patients with HCC and in 63 with liver cirrhosis serum alpha-fetoprotein (AFP), tissue polypeptide a...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00391702

    authors： Leandro G,Basso D,Fabris C,Zizzari S,Elba S,Del Favero G,Di Mario F,Meggiato T,Angonese C,Naccarato R

    更新日期：1989-01-01 00:00:00

  • Using etoposide + dexamethasone-based regimens to treat nasal type extranodal natural killer/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis.

    abstract：PURPOSE:Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) can be associated with hemophagocytic lymphohistiocytosis (NK/T-LAHLH), which is a rare and fatal disease with no effective therapy. We evaluated whether etoposide + dexamethasone-based chemotherapy regimens might be useful for treating NK/T-LAHLH. M...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-020-03376-7

    authors： Wei L,Yang L,Cong J,Ye J,Li X,Yao N,Yang J,Ding J,Wang J

    更新日期：2020-10-06 00:00:00

  • Determination of growth kinetics in a renal sarcoma of the rat by double labeling with 14C- and 3H-thymidine.

    abstract：:An in vitro double-labeling technique for determination of kinetic growth parameters was tested; 13 renal sarcomas of rats were incubated after excision under standardized conditions with 14C- and 3H-thymidine successively. Another ten tumors were evaluated after in vivo double injection of 14C and 3H-thymidine into s...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00391832

    authors： Lang W,Kienzle S,Georgii A

    更新日期：1983-01-01 00:00:00

  • CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression.

    abstract：PURPOSE:Lysine-specific demethylase 1 (LSD1) was highly expressed in several malignancies and had been implicated in pathological processes of cancer cells. However, the role of LSD1 in colorectal cancer (CRC) carcinogenesis, prognosis and treatment remains uncharacterized. METHODS:In this study, we examined LSD1 expr...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-014-1782-4

    authors： Hsu HC,Liu YS,Tseng KC,Yang TS,Yeh CY,You JF,Hung HY,Chen SJ,Chen HC

    更新日期：2015-01-01 00:00:00

  • Carcinogenicity studies of masheri: pyrolysed tobacco product, in vitamin-A-deficient Sprague Dawley rats.

    abstract：:The carcinogenicity of long-term feeding of masheri extract to animals in a vitamin-A-sufficient (SLO+) and deficient (SLO-) state was studied in Sprague Dawley rats by feeding daily dose of 3 mg extract over a period of 21 months. The phase I activating enzymes, the glutathione (GSH)/glutathione S-transferase (GST) d...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01613196

    authors： Ammigan N,Nair UJ,Lalitha VS,Bhide SV

    更新日期：1991-01-01 00:00:00

  • Pre-treatment global quality of health predicts progression free survival in metastatic kidney cancer patients treated with sorafenib or sunitinib.

    abstract：PURPOSE:Our goal was to prospectively evaluate self-reported quality-of-life (QoL) during second-line therapy in 51 consecutive patients with cytokine-refractory kidney cancer treated with sorafenib or sunitinib. METHODS:QoL was assessed by the EORTC QoL questionnaire QLQ-C30 at baseline and at weeks 4, 6, 10, 12 and ...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/s00432-008-0438-7

    authors： Herrmann E,Gerss J,Bierer S,Köpke T,Bolenz C,Hertle L,Wülfing C

    更新日期：2009-01-01 00:00:00

  • Identification of three indolic compounds in a pigmented-melanoma cell-culture supernatant by gas chromatography-mass spectrometry.

    abstract：:In the supernatant of melanoma cell culture SK mel 25 three indolic compounds - 5-hydroxy-6-methoxyindole, 5-hydroxy-6-methoxyindolyl-2-carboxylic, and 6-hydroxy-5-methoxyindolyl-2-carboxylic acids - have been identified. The supernatants were extracted with ethyl acetate, derivatized, and analyzed by gas chromatograp...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF00395758

    authors： Pavel S,Muskiet FA,de Ley L,The TH,van der Slik W

    更新日期：1983-01-01 00:00:00

  • Differentiation of the rat myelomonocytic leukemia cell line c-WRT-7 by in vitro culture with the rat bone marrow preadipocyte cell line REC A16.

    abstract：:Differentiation of the rat myelomonocytic leukemia cell line (c-WRT-7) was investigated, by co-culture with a rat embryonic bone marrow preadipose cell line (REC A16). Co-cultivation with REC A16, or with conditioned medium from REC A16 cultures (REC-CM), induced differentiation of c-WRT-7 cells to macrophages. A solu...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 杂志文章

    doi：10.1007/BF01208841

    authors： Tanaka T,Okamura S,Yasumoto S,Takeichi N,Kobayashi H,Niho Y

    更新日期：1993-01-01 00:00:00

  • Drug resistance in oncology: from concepts to applications.

    abstract：:The complex problem of drug resistance is discussed with respect to host toxicity, to tumor characteristics (kinetic resistance, heterogeneity of cell subpopulations, hypoxia, mutation and gene amplification), and to the medication itself (pharmacokinetic and pharmacodynamic resistance: cell membrane, intracellular me...

    journal_title：Journal of cancer research and clinical oncology

    pub_type： 社论,评审

    doi：10.1007/BF01209660

    authors： Cazin JL,Gosselin P,Cappelaere P,Robert J,Demaille A

    更新日期：1992-01-01 00:00:00