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Genetic recombination as a major cause of mutagenesis in the human globin gene clusters.

Abstract：

OBJECTIVES:Homologous recombination is a frequent phenomenon in multigene families and as such it occurs several times in both the alpha- and beta-like globin gene families. In numerous occasions, genetic recombination has been previously implicated as a major mechanism that drives mutagenesis in the human globin gene clusters, either in the form of unequal crossover or gene conversion. Unequal crossover results in the increase or decrease of the human globin gene copies, accompanied in the majority of cases with minor phenotypic consequences, while gene conversion contributes either to maintaining sequence homogeneity or generating sequence diversity. The role of genetic recombination, particularly gene conversion in the evolution of the human globin gene families has been discussed elsewhere. CONCLUSION:Here, we summarize our current knowledge and review existing experimental evidence outlining the role of genetic recombination in the mutagenic process in the human globin gene families.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Borg J,Georgitsi M,Aleporou-Marinou V,Kollia P,Patrinos GP

doi

10.1016/j.clinbiochem.2009.07.014

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1839-50

issue

18

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(09)00300-2

journal_volume

42

pub_type

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