当前位置： SCI文献检索 > CLINICAL BIOCHEMISTRY期刊下所有文献 > Association of the MS4A2 gene promoter C-109T or the 7th exon E237G polymorphisms with asthma risk: a meta-analysis.

Association of the MS4A2 gene promoter C-109T or the 7th exon E237G polymorphisms with asthma risk: a meta-analysis.

Abstract：

BACKGROUND AND OBJECTIVE:A large number of studies have examined the association between the Membrane-spanning 4 domains, superfamily A, number 2 (MS4A2) gene C-109T (rs1441586) or E237G (rs569108) variants and asthma risk. However, the results are inconsistent and inconclusive. To derive a more precise estimation, a meta-analysis was performed. METHODS:Meta-analyses were conducted with the data from case-control association studies (24 studies with 4496 asthmatics and 4571 controls for E237G variant and 9 studies including 2005 cases and 1868 control for C-109T polymorphisms, respectively). Random-effects model was used to calculate summary odds ratios (ORs). RESULTS:For the MS4A2 gene E237G variant, no significant associations with asthma were found in overall population; we observed an elevated risk of atopic asthma among subjects with the 237G allele (OR=1.341, 95% CI: 1.039-1.732 for G versus E and OR=1.374, 95% CI: 1.032-1.828 for EG+GG versus EE) in the stratified meta-analysis. As for the MS4A2 gene C-109T polymorphism, no significant associations with asthma risk were observed in the total population; in subgroup analysis by ethnicity of subjects we found increased asthma risk among Asians carrying T allele (OR=1.140, 95% CI: 1.019-1.276 for T versus C and OR=1.359, 95% CI: 1.029-1.794 for TT versus CC). CONCLUSIONS:Data indicated that the MS4A2 gene E237G variant may be a risk factor for developing atopic asthma and the promoter -109T allele is a potential risk factor of asthma in Asians.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Yang HJ,Zheng L,Zhang XF,Yang M,Huang X

doi

10.1016/j.clinbiochem.2014.01.022

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

605-11

issue

7-8

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(14)00050-2

journal_volume

47

pub_type

杂志文章,meta分析

相关文献

CLINICAL BIOCHEMISTRY文献大全
  • Magnesium status and excretion in age-matched subjects with normal and elevated blood pressures.

    abstract：:Plasma, erythrocyte, and leucocyte magnesium (Mg) concentration, as well as urinary Mg, calcium (Ca), and phosphorus (P) excretion were determined in male subjects with elevated diastolic blood pressure (DBP) > 90 mmHg. These parameters were compared to those in normotensive age-matched (DBP < 85 mmHg) and drug-treate...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/0009-9120(93)90027-4

    authors： Fischer PW,Belonje B,Giroux A

    更新日期：1993-06-01 00:00:00

  • Screening for Down syndrome during the first and second trimesters: impact of risk estimation parameters.

    abstract：OBJECTIVES:To evaluate impact of risk estimation parameters for screening for Down Syndrome during the first and second trimesters. METHODS:We prospectively examined for their performance in the prenatal prediction of trisomy 21, alphafetoprotein (AFP), unconjugated estriol (uE3), total human chorionic gonadotropin (h...

    journal_title：Clinical biochemistry

    pub_type： 临床试验,杂志文章

    doi：10.1016/0009-9120(95)00021-z

    authors： Forest JC,Massé J,Rousseau F,Moutquin JM,Brideau NA,Bélanger M

    更新日期：1995-08-01 00:00:00

  • Biobanking 3.0: evidence based and customer focused biobanking.

    abstract：:Biobanking is a new and very dynamic field. To achieve long term financial sustainability of biobank infrastructures we propose that a new focus is needed on activities, products and services provided by the biobank that relate to the external stakeholder: biobanking 3.0. Earlier stages of biobanking are biobanking 1....

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2013.12.018

    authors： Simeon-Dubach D,Watson P

    更新日期：2014-03-01 00:00:00

  • Triglyceride assay using the ABA-50 and Boehringer Mannheim Triglyceride reagent kit.

    abstract：:1. A procedure for the assay of triglycerides on the ABA-50 is described. 2. The Boehringer Mannheim Triglyceride (Fully Enzymatic method) reagent kit has been evaluated with this method and was found to be satisfactory. ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(77)93190-3

    authors： Owen VM,Tai OH

    更新日期：1977-12-01 00:00:00

  • Non-radioactive determination of inosine 5'-monophosphate dehydro-genase (IMPDH) in peripheral mononuclear cells.

    abstract：BACKGROUND:The immunosuppressive activity of mycophenolate mofetil (MMF) is based on the reversible inhibition of inosine 5'-monophosphate dehydrogenase (IMPDH) by mycophenolic acid (MPA). It was the aim of this study to develop a nonradioactive method for specific measurement of IMPDH activity in isolated peripheral m...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(01)00267-3

    authors： Glander P,Braun KP,Hambach P,Bauer S,Mai I,Roots I,Waiser J,Fritsche L,Neumayer HH,Budde K

    更新日期：2001-10-01 00:00:00

  • Circulating miRNA as fine regulators of the physiological responses to physical activity: Pre-analytical warnings for a novel class of biomarkers.

    abstract：:MicroRNAs are endogenous non-coding RNAs that post-transcriptionally regulate gene expression by specifically binding the target mRNA and by consequently inducing its degradation. miRNAs can be released into the circulation where they remain stable and they can be measured. Their changes reflect individual biologic ad...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinbiochem.2016.09.017

    authors： Lombardi G,Perego S,Sansoni V,Banfi G

    更新日期：2016-12-01 00:00:00

  • Quality assurance practices for point of care testing programs: Recommendations by the Canadian society of clinical chemists point of care testing interest group.

    abstract：:Point of Care Testing (POCT) refers to clinical laboratory testing performed outside the central laboratory, nearer to the patient and sometimes at the patient bedside. The testing is usually performed by clinical staff, such as physicians or nurses, who are not laboratory trained. This document was developed by the P...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinbiochem.2020.11.008

    authors： Venner AA,Beach LA,Shea JL,Knauer MJ,Huang Y,Fung AWS,Dalton J,Provencal M,Shaw JLV

    更新日期：2021-02-01 00:00:00

  • Molecular and hematological characteristics of a novel form of α-globin gene triplication: the hemoglobin St.Luke's-Thailand [α95(G2)Pro→Arg] or Hb St. Luke's [A2] HBA2.

    abstract：OBJECTIVES:This study aims to report a hitherto un-described α-globin gene triplicated allele with a novel hemoglobin (Hb) variant on α2-globin gene, Hb St.Luke's-Thailand [α95(G2)Pro-Arg]. DESIGNS AND METHODS:A study was done on a 1.5-year-old Thai boy who showed pallor and jaundice after birth. Hb analysis was perfo...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2013.01.022

    authors： Singha K,Fucharoen G,Jetsrisuparb A,Fucharoen S

    更新日期：2013-05-01 00:00:00

  • Beta-hexosaminidase isoenzyme profiles in serum, plasma, platelets and mononuclear, polymorphonuclear and unfractionated total leukocytes.

    abstract：OBJECTIVES:The relative proportion in percentage of the isoenzyme A of beta-hexosaminidase (Hex) is the single discriminatory function most frequently used for the biochemical screening of heterozygote Tay-Sachs disease carriers. It has been suggested that the assay of the Hex isoenzymes in homogeneous cell preparation...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2005.05.016

    authors： Casal JA,Cano E,Tutor JC

    更新日期：2005-10-01 00:00:00

  • Modifications to commercial oxalate oxidase based determination of urinary oxalate: a method suitable for routine clinical analysis.

    abstract：:A commercially available assay (Sigma) for urinary oxalates based on the oxalate oxidase/peroxidase catalyzed reaction produced, in our hands, recoveries of added oxalate that varied from patient to patient. A modification of the assay is reported that involves the chromatographic separation of interfering substances,...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/0009-9120(90)80032-e

    authors： Mazzuchin A,Michelutti L,Falter H

    更新日期：1990-04-01 00:00:00

  • Simvastatin treatment reduces heat shock protein 60, 65, and 70 antibody titers in dyslipidemic patients: A randomized, double-blind, placebo-controlled, cross-over trial.

    abstract：OBJECTIVE:This study aimed to evaluate the effects of statin therapy on serum levels of antibodies to several specific heat shock proteins (HSPs) in dyslipidemic patients. DESIGN AND METHODS:Participants (n=102) were treated with simvastatin (40mg/day), or placebo in a randomized, double-blind, placebo-controlled, cro...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.clinbiochem.2010.09.016

    authors： Moohebati M,Bidmeshgi S,Azarpazhooh MR,Daloee MH,Ghayour-Mobarhan M,Tavallaie S,Amini M,Momenzadeh A,Sahebkar A,Paydar R,Rahsepar AA,Parizadeh SM,Akhlaghi S,Ferns GA

    更新日期：2011-02-01 00:00:00

  • False positives in plasma ammonia measurement and their clinical impact in a pediatric population.

    abstract：OBJECTIVE:Plasma ammonia measurement is greatly influenced by pre-analytical conditions, which may lead to false positives. We wanted to evaluate the prevalence and clinical impact of plasma ammonia false positives in a pediatric population. DESIGN AND METHODS:Over a 28-month period, charts of patients with elevated a...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2007.01.024

    authors： Maranda B,Cousineau J,Allard P,Lambert M

    更新日期：2007-05-01 00:00:00

  • Comparison of RIA and IRMA methods for measurement of carcinoembryonic antigen (CEA).

    abstract：:We present data comparing the Roche CEA radioimmunoassay (RIA) utilizing ultrafiltration and the Abbott CEA immunoradiometric assay (IRMA) methods for standard curve sensitivity, analytical reproducibility, recovery (pre and post extraction), dilution linearity, and patient correlation. The Roche intra- and inter-assa...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(82)97007-2

    authors： Valdes R Jr,Stein KE

    更新日期：1982-10-01 00:00:00

  • Urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as indicators of tubular damage in normoalbuminuric patients with type 2 diabetes.

    abstract：OBJECTIVES:Renal dysfunction has been reported in normoalbuminuric patients, demonstrating the necessity to improve the diagnostic and prognostic tools for diabetic kidney disease (DKD) investigation. Therefore, the aim of this study was to investigate whether the urinary levels of neutrophil gelatinase-associated lipo...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2015.10.016

    authors： de Carvalho JA,Tatsch E,Hausen BS,Bollick YS,Moretto MB,Duarte T,Duarte MM,Londero SW,Premaor MO,Comim FV,Delanghe JR,Moresco RN

    更新日期：2016-02-01 00:00:00

  • Interaction of common sequence variants and selected risk factors in determination of HDL cholesterol levels.

    abstract：OBJECTIVES:The aim of our study was to assess the association of common sequence variants, and selected interactions, with HDL-c plasma levels. DESIGN AND METHODS:We analysed 743 individuals (340 men and 403 women) with high mean triglyceride and LDL-c levels. The association of five polymorphic sites (ABCA1 g.1051G>A...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2010.04.001

    authors： Katerina H,Michaela S,Michal V,Helena S,Jana Z,Jaroslav H,Richard C

    更新日期：2010-06-01 00:00:00

  • A rapid and specific method for the determination of oxytocinase (cystine aminopeptidase) activity using continuous flow analysis and S-benzyl-L-cysteine-p-nitroanilide as substrate.

    abstract：:1. An automated method is described for the assay of pregnancy serum cystine aminopeptidase (Oxytocinase, E.C. 3.4.1.10) using continuous flow analysis. S-Genzyl-L-cysteine-p-nitroanilide, the most highly specific substrate so far available for oxytocinase is employed in this assay. Comparison with the manual method f...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(75)91273-4

    authors： Small CW,Watkins WB

    更新日期：1975-04-01 00:00:00

  • Head-to-head comparison of an automated immunometric and an automated HPLC method for the quantification of HbA1c.

    abstract：OBJECTIVES:To compare a fully automated immunoassay and a fully automated HPLC method for the quantification of HbA1c. DESIGN AND METHODS:For an inter-method comparison, 200 consecutive clinical samples were analyzed. Imprecision was studied with pooled whole blood. RESULTS:Very close agreement of results (identical ...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2008.08.084

    authors： Vogeser M,Parhofer KG

    更新日期：2008-11-01 00:00:00

  • A convenient method for the determination of non-specific binding in commercially available solid phase iodine labeled radioimmunoassay kits.

    abstract：:57Co-cyanocobalamin is substituted for iodine labeled antigen in three commercially available solid phase radioimmunoassay kits to evaluate the extent of non-specific binding by determination of the supernatant and residual fraction of unbound ligand and thus obtain a value for corrected binding throughout the range o...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(78)90070-x

    authors： Carter P

    更新日期：1978-06-01 00:00:00

  • Evaluation and risk stratification of acute coronary syndromes using a low cut-off level of cardiac troponin T, combined with CK-MB mass determination.

    abstract：OBJECTIVES:To study the usefulness of combined cardiac Troponin T (cTnT) and CK-MB mass determinations in risk stratification of acute coronary syndromes. DESIGN AND METHODS:Blood samples for cTnT and CK-MB mass were collected at arrival and 4, 8, and 12-24 later in 301 consecutive patients with recent acute chest pai...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2003.12.003

    authors： Solymoss BC,Bourassa MG,Fortier A,Théroux P

    更新日期：2004-04-01 00:00:00

  • Effect of whole soy and purified isoflavone daidzein on renal function--a 6-month randomized controlled trial in equol-producing postmenopausal women with prehypertension.

    abstract：OBJECTIVES:The aim of the study was to examine the long-term effect of commonly used whole soy foods (soy flour) and purified daidzein (one major isoflavone and the precursor of equol) on renal function among prehypertensive postmenopausal women who are also equol producers, a population most likely to benefit from soy...

    journal_title：Clinical biochemistry

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.clinbiochem.2014.05.054

    authors： Liu ZM,Ho SC,Chen YM,Tang N,Woo J

    更新日期：2014-09-01 00:00:00

  • Development of a direct DNA sequencing method for detecting heterozygous mutations of the human lipoprotein lipase gene.

    abstract：OBJECTIVE:The purpose of this study was to develop an improved method of direct DNA sequencing, which makes it possible to identify heterozygous mutations of the lipoprotein lipase (LPL) gene in order to understand the underlying genetic disorder of type IV hyperlipoproteinemia. METHODS AND RESULTS:The direct sequenci...

    journal_title：Clinical biochemistry

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0009-9120(97)00005-2

    authors： Mori A,Takagi A,Ikeda Y,Yamamoto A

    更新日期：1997-06-01 00:00:00

  • Differences in urinary albumin detected by four immunoassays and high-performance liquid chromatography.

    abstract：OBJECTIVES:To compare the analysis of urinary albumin from diabetic patients by four conventional immunoassays including radioimmunoassay (RIA), immunonephelometry (IN), and two different methods of immunoturbidimetry (IT), as well as by high-performance liquid chromatography (HPLC). DESIGN AND METHODS:Urines were col...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2003.10.008

    authors： Comper WD,Jerums G,Osicka TM

    更新日期：2004-02-01 00:00:00

  • Comparison of umbilical cord tissue and meconium for the confirmation of in utero drug exposure.

    abstract：OBJECTIVES:Drug screening in neonates is traditionally performed using meconium, but cord tissue has been proposed as an alternative specimen. This study compares the detection of drugs in a large number of paired meconium and umbilical cord tissue samples from subjects at risk of in utero drug exposure. DESIGN AND ME...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2017.03.006

    authors： Colby JM

    更新日期：2017-09-01 00:00:00

  • Changes in advanced oxidation protein products, advanced glycation end products, and s-nitrosylated proteins, in patients affected by polycythemia vera and essential thrombocythemia.

    abstract：OBJECTIVES:Oxidative stress has a clear pro tumoral effect in myeloproliferative neoplasms (MPDs). In this study, we analyzed oxidative stress in patients with essential thrombocythemia (ET) and polycythemia vera (PV). Design and methods We analyzed serum levels of advanced oxidation protein products (AOPPs) degradatio...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2012.07.100

    authors： Musolino C,Allegra A,Saija A,Alonci A,Russo S,Spatari G,Penna G,Gerace D,Cristani M,David A,Saitta S,Gangemi S

    更新日期：2012-11-01 00:00:00

  • AD biomarker discovery in CSF and in alternative matrices.

    abstract：:Core Alzheimer's Disease (AD) biomarkers are the cerebrospinal fluid (CSF) proteins amyloid β42 and β40, and the tau proteins, total and phosphorylated. Their use is recommended by research guidelines for diagnostic purpose and for stratification of patients for clinical trials. However, novel potential biomarkers are...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/j.clinbiochem.2019.08.008

    authors： Sancesario G,Bernardini S

    更新日期：2019-10-01 00:00:00

  • Comparison of new solid-phase extraction methods for chromatographic identification of drugs in clinical toxicological analysis.

    abstract：OBJECTIVES:Newly presented solid-phase extraction methods (Solid Phase Disc Extraction, SPEC-Plus, Multi-Modal, and Solid Phase Micro Extraction, SPME have been checked with respect to their applicability to clinical toxicological analysis. In comparison with conventional liquid/liquid-extraction and a common mixed-pha...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(96)00096-3

    authors： Degel F

    更新日期：1996-12-01 00:00:00

  • Clinical varieties of carnitine and carnitine palmitoyltransferase deficiency.

    abstract：:Several clinical entities are associated with disorders of fatty acid oxidation or transfer across the inner mitochondrial membrane. Over 40 cases of the primary carnitine deficiency syndrome have been reported to date and various subtypes have been characterized. This represents a large clinical spectrum. The deficie...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章,评审

    doi：10.1016/s0009-9120(87)80090-5

    authors： Angelini C,Trevisan C,Isaya G,Pegolo G,Vergani L

    更新日期：1987-02-01 00:00:00

  • Separation of lipids by new thin-layer chromatography and overpressured thin-layer chromatography methods.

    abstract：:New methods were developed for the separation of major lipid classes varying in polarity from cholesterol esters to lysophosphatidylcholine. The methods were used for the analysis of extracts obtained from human sera. The lipids were separated by overpressured thin-layer chromatography, classical thin-layer chromatogr...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(88)80092-4

    authors： Pucsok J,Kovács L,Zalka A,Dobó R

    更新日期：1988-04-01 00:00:00

  • Comparison of high sensitivity troponin T and I assays in the diagnosis of non-ST elevation acute myocardial infarction in emergency patients with chest pain.

    abstract：OBJECTIVES:Concentrations of troponin measured with high sensitivity troponin assays are raised in a number of emergency department (ED) patients; however many are not diagnosed with acute myocardial infarction (AMI). Clinical comparisons between the early use (2h after presentation) of high sensitivity cardiac troponi...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/j.clinbiochem.2013.11.019

    authors： Cullen L,Aldous S,Than M,Greenslade JH,Tate JR,George PM,Hammett CJ,Richards AM,Ungerer JP,Troughton RW,Brown AF,Flaws DF,Lamanna A,Pemberton CJ,Florkowski C,Pretorius CJ,Chu K,Parsonage WA

    更新日期：2014-04-01 00:00:00

  • Effects of non-pharmacological sympathetic sudomotor denervation on sweating in humans with essential palmar hyperhidrosis.

    abstract：OBJECTIVE:Quantitative sweat production and -ionic composition in Essential Hyperhidrosis (EH), and the effects of T2-T3 thoracoscopic sympathicolysis (TS) hereon, are unknown. Standardised pilocarpine iontophoresis sweat tests were performed before and after TS in order to study these issues. DESIGN AND METHODS:Piloc...

    journal_title：Clinical biochemistry

    pub_type： 杂志文章

    doi：10.1016/s0009-9120(96)00165-8

    authors： Noppen M,Sevens C,Vincken WG

    更新日期：1997-03-01 00:00:00