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Tamm-Horsfall protein excretion to predict the onset of renal insufficiency.

Abstract：

OBJECTIVE:Immunosuppressive therapy after liver transplantation may be a risk for kidney dysfunction. This work was designed to determine whether Tamm-Horsfall Protein (THP) could be considered as a marker for nephrotoxicity. DESIGN AND METHODS:THP was determined by an ELISA method in serial 24-h urine from liver transplant patients. Fourteen patients suffered renal insufficiency (LTr(1)) and 20 showed no acute renal damage (LTr(2)) after liver transplantation. RESULTS:No clear association could be seen between daily THP excretion and plasma creatinine levels by comparing serial samples collected at the same time. Nevertheless, significant differences were observed in pretransplant THP excretion between both groups of patients. The results (Median/Interquartile Range) were: CONTROLS:113.2/84.9 to 146.8 mg/24 h (n = 30); LTr(1): 36.9/18.3 to 54.5 mg/24 h (p<0.001 with respect to C and LTr(2)); LTr(2): 90.8/61.5 to 139.7 mg/24 h. CONCLUSIONS:The higher pretransplant synthesis and/or secretion of THP seem to have a protective role on the kidney during and after liver transplantation.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Romero MC,Zanaro N,González L,Trigo P,Imventarza O,Nesse A

doi

10.1016/s0009-9120(02)00274-6

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

65-8

issue

1

eissn

0009-9120

issn

1873-2933

pii

S0009912002002746

journal_volume

35

pub_type

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