Abstract:
:The human endometrium undergoes cyclical changes including proliferation, differentiation, tissue breakdown, and shedding (menstruation) throughout a woman's reproductive life. The postovulatory rise in ovarian progesterone induces profound remodeling and differentiation of the estradiol-primed endometrium. This change, termed decidualization, is crucial for embryo implantation and maintenance of the pregnancy. To date, activation and crosstalk of cAMP- and progesterone-mediated signaling pathways have emerged as key cellular events to drive integrated changes at both the transcriptome and the proteome levels. This results in the induction and maintenance of the decidual phenotype and function. Our recent series of studies highlights the critical role of SRC kinase activation (v-src sarcoma viral oncogene homolog) and STAT5 (signal transducer and activator of transcription 5) phosphorylation in decidualization. After separation of the functional layer of the differentiated endometrium that follows progesterone withdrawal, i.e., menstruation, the basal layer of the endometrium, under the influence of estradiol, regrows and initiates a unique form of angiogenesis and regenerates a new functional layer. The molecular and cellular mechanisms for this process remain elusive, mainly because of difficulties in reproducing menstrual tissue breakdown, shedding, and subsequent tissue regeneration in vitro. We have recently developed a "humanized" mouse model in which a functional human endometrium is reconstituted. It may be used as an in vivo experimental tool for the study of endometrial angiogenesis and regeneration. This model may also be used to identify and test new therapeutic strategies for endometriosis, endometrial cancer, implantation failure, and infertility related to endometrial dysfunction.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Maruyama T,Yoshimura Ydoi
10.1507/endocrj.k08e-067subject
Has Abstractpub_date
2008-10-01 00:00:00pages
795-810issue
5eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/K08E-067journal_volume
55pub_type
杂志文章,评审abstract::Sexual differentiation of the rodent brain is recognized to involve transcriptional activation of multiple genes induced by gonadal steroids at developmental stages. To identify the genes differing in expression level between sexes, we analyzed gene expression in male and female rat hypothalami at postnatal day 5 by m...
journal_title:Endocrine journal
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abstract::In an attempt to define the hypothalamic-pituitary-adrenal (HPA) axis in non-insulin dependent diabetic rats (WBN/Kob), we measured plasma corticotropin releasing factor (CRF), as well as arginine vasopressin (AVP), ACTH, and corticosterone (B), CRF concentrations in the median eminence (ME), the remainder of the hypo...
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journal_title:Endocrine journal
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-07-30 00:00:00
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pub_type: 杂志文章
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1998-06-01 00:00:00
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更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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更新日期:2007-04-01 00:00:00
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更新日期:2018-08-27 00:00:00
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pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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