Abstract:
:The effects of an aqueous extract of Ferula hormonis on social aggression, fertility and some physiological and biochemical parameters were investigated in male mice. The ingestion of 3 mg/kg of aqueous extract of F. hormonis for six weeks clearly inhibited social aggression. Body wet weight and other sex accessory organ weights were significantly reduced by this treatment. The ingestion of this extract by male mice resulted in a significant reduction of their fertility. This treatment caused a significant decrease in the number of pregnant females, number of implantations and viable fetuses in females impregnated by males that ingested this extract. Additionally, the numbers of epididymal sperm and their motility were dramatically reduced in F. hormonis-treated mice. Concomitant increases in sperm abnormalities were also observed when compared with control. These data indicate that F. hormonis exposure during this period puts the exposed animals at significant risk for reduced reproductive capacity in adulthood.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Khleifat K,Homady MH,Tarawneh KA,Shakhanbeh Jdoi
10.1507/endocrj.48.473subject
Has Abstractpub_date
2001-08-01 00:00:00pages
473-82issue
4eissn
0918-8959issn
1348-4540journal_volume
48pub_type
杂志文章abstract::We describe a case of diabetes insipidus (DI) due to a pituitary tumor in a 33-year-old pregnant woman who developed a sudden onset of polyuria (over 8 l/day) and polydipsia at 30 weeks of gestation. Her plasma concentration of vasopressin (AVP) was low compared with high serum osmolality (298 mOsm/kg), and her urine ...
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