Vitamin D in Hashimoto's thyroiditis and its relationship with thyroid function and inflammatory status.

Abstract:

:Several studies have shown the correlation between vitamin D [25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether the low 25(OH)D levels are the result of HT disease or a part of its cause. We studied 88 patients with HT regarding vitamin D status and thyroid autoimmunity markers as well as the relationship with cytokines produced by Th1, Th2, and Th17 cells compared with a control group of 71 euthyroid healthy subjects. The present study demonstrated that vitamin D concentrations were similar in patients HT and the control group. The reduction of free T4 levels was a predictor of vitamin D insufficiency for Hashimoto's thyroiditis, but not for the control group. Lower concentrations of TNF-α was a predictor of lower levels of vitamin D. Differences in the association between HT and vitamin D insufficiency remain unresolved in the literature. The thyroid hormone status would play a role in the maintenance of vitamin D sufficiency, and its immunomodulatory role would influence the presence of autoimmune thyroid disease. The positive correlation between free T4 and vitamin D concentrations suggests that adequate levothyroxine replacement in HT would be an essential factor in maintaining vitamin D at sufficient levels.

journal_name

Endocr J

journal_title

Endocrine journal

authors

Botelho IMB,Moura Neto A,Silva CA,Tambascia MA,Alegre SM,Zantut-Wittmann DE

doi

10.1507/endocrj.EJ18-0166

subject

Has Abstract

pub_date

2018-10-29 00:00:00

pages

1029-1037

issue

10

eissn

0918-8959

issn

1348-4540

journal_volume

65

pub_type

杂志文章
  • Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells.

    abstract::Studies on resveratrol in a wide range of concentrations on obese mice and adipose cells are necessary to comprehend its range of diverse and contradictory effects. In this study, we examined the anti-obesity effects of resveratrol on high-fat diet (HFD)-induced obese mice at dosages ranging from 1 to 30 mg/kg treatme...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ15-0545

    authors: Chang CC,Lin KY,Peng KY,Day YJ,Hung LM

    更新日期:2016-01-01 00:00:00

  • Relationship between thyroid functions and urinary growth hormone secretion in patients with hyper- and hypothyroidism.

    abstract::Thyroid hormone plays an important role in growth hormone (GH) synthesis and secretion. To study the relationship between thyroid function and urinary GH secretion in the hyperthyroid and hypothyroid states, we measured thyroid hormones, simultaneously with serum and urinary GH levels, in 54 patients with thyroid dise...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.41.517

    authors: Murao K,Takahara J,Sato M,Tamaki M,Niimi M,Ishida T

    更新日期:1994-10-01 00:00:00

  • Intact sex determining region Y (SRY) in a patient with XY pure gonadal dysgenesis and a twin brother.

    abstract::A patient with an apparently normal 46, XY karyotype, suffering from pure gonadal dysgenesis and of short stature was investigated. The patient, who was growth retarded, was a 30-year-old married Japanese woman with a history of primary amenorrhea and infertility with a weight of 42 kg and a height of 146 cm. She has ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.41.281

    authors: Tsutsumi O,Iida T,Taketani Y,Sugase M,Nakahori Y,Nakagome Y

    更新日期:1994-06-01 00:00:00

  • Expression of Fas/Fas-ligand, Bcl-2 protein and apoptosis in extravillous trophoblast along invasion to the decidua in human term placenta.

    abstract::There are two local subtypes of extravillous trophoblast (EVT): one is the proliferative phenotype of EVT, which primarily consists of proximal cells and the other is the invasive phenotype of EVT, which is composed mainly of distal cells of cell columns. The mechanism of invasion of EVT to the decidua remains obscure...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.50.199

    authors: Murakoshi H,Matsuo H,Laoag-Fernandez JB,Samoto T,Maruo T

    更新日期:2003-04-01 00:00:00

  • Effect of calcimimetic agent, KRN568, on gastrin secretion in healthy subjects.

    abstract::KRN568 is a calcimimetic compound which acts on the calcium sensing receptors (CaR) on the parathyroid gland to suppress secretion of PTH. A recent report has demonstrated that CaRs are expressed on cultured human antral gastrin cells and that gastrin secretion is stimulated by an increase in extracellular calcium lev...

    journal_title:Endocrine journal

    pub_type: 临床试验,杂志文章

    doi:10.1507/endocrj.47.517

    authors: Igarashi T,Ogata E,Maruyama K,Fukuda T

    更新日期:2000-10-01 00:00:00

  • Pancreas volume reduction and metabolic effects in Japanese patients with severe obesity following laparoscopic sleeve gastrectomy.

    abstract::This study aimed to assess the relationship between the metabolic effect after laparoscopic sleeve gastrectomy (LSG) in morbidly obese Japanese patients, with or without type 2 diabetes mellitus (T2DM), and improved pancreatic steatosis (PS). The study enrolled 27 morbidly obese Japanese patients who were undergoing L...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ16-0321

    authors: Umemura A,Sasaki A,Nitta H,Baba S,Ando T,Kajiwara T,Ishigaki Y

    更新日期:2017-05-30 00:00:00

  • Diurnal variation in growth hormone receptor messenger ribonucleic acid in liver and skeletal muscle of lit/+ and lit/lit mice.

    abstract::The present study investigated the diurnal variation in GH receptor (GHR) mRNA in liver and skeletal muscle of 3-month-old GH-deficient and -sufficient mice using quantitative real-time RT-PCR. lit/lit (GH deficient) or lit/+ (GH sufficient) mice were fed ad libitum and lights were on between 0600 and 2000. Tissues we...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.51.529

    authors: Itoh E,Iida K,del Rincon JP,Kim DS,Thorner MO

    更新日期:2004-12-01 00:00:00

  • A pedigree analysis of two homozygous mutant Gitelman syndrome cases.

    abstract::Gitelman syndrome (GS) is a salt-wasting tubulointerstitial disease of autosomal recessive inheritance (OMIM613395) caused by genic mutation of SLC12A3, which codes thiazide-sensitive Na-Cl cotransporter (NCCT) gene. The gene mutation of the majority of GS patients is compound heterozygous. This study analyzes two cas...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ14-0289

    authors: Luo J,Yang X,Liang J,Li W

    更新日期:2015-01-01 00:00:00

  • Simvastatin rescues homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by decreasing the expressions of NADPH oxidase 1 and 2.

    abstract::Clinical studies have shown that hyperhomocysteinemia is associated with bone fragility. Homocysteine (Hcy) induces apoptosis of osteoblastic cell lineage by increasing oxidative stress, which may contribute to Hcy-induced bone fragility. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, ameliorate ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ15-0480

    authors: Takeno A,Kanazawa I,Tanaka K,Notsu M,Yokomoto-Umakoshi M,Sugimoto T

    更新日期:2016-04-25 00:00:00

  • Cloning and characterization of the 4.2 kb region of the rat thyrotropin receptor promoter.

    abstract::We previously identified an approximately 200 bp "minimal promoter" of the rat TSH receptor (TSHR) gene which is essential for the promoter activity. In the present study, we have cloned and characterized an upstream region of the TSHR promoter to disclose additional functional element(s). We screened a rat genomic li...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.44.247

    authors: Ikuyama S,Ohe K,Takayanagi R,Kohn LD,Nawata H

    更新日期:1997-04-01 00:00:00

  • Prolactin expresses differential effects on apoptotic cell death of luteal cells in vivo and in vitro.

    abstract::PRL surges in female rats have dual effects of luteal function: either inducing luteolysis during the estrous cycle or rescuing and maintaining luteal function during pseudopregnancy. We analyzed these apparent contradictory effects in relation to apoptosis. The detection of fragmented DNA and in situ 3'-end labeling ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.44.11

    authors: Kanuka H,Matsuyama S,Ohnishi M,Matsumoto Y,Nishihara M,Takahashi M

    更新日期:1997-02-01 00:00:00

  • Pathogenesis and diagnostic criteria for rickets and osteomalacia - proposal by an expert panel supported by Ministry of Health, Labour and Welfare, Japan, The Japanese Society for Bone and Mineral Research and The Japan Endocrine Society.

    abstract::Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix. Recent investigations revealed that the causes for rickets and osteomalacia are quite variable. While these diseases can severely impair the quality of life of the affected patients, rickets and osteomalacia can be completel...

    journal_title:Endocrine journal

    pub_type: 杂志文章,实务指引

    doi:10.1507/endocrj.EJ15-0289

    authors: Fukumoto S,Ozono K,Michigami T,Minagawa M,Okazaki R,Sugimoto T,Takeuchi Y,Matsumoto T

    更新日期:2015-01-01 00:00:00

  • Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes.

    abstract::Aim of this study was to examine the association between the severity of obstructive sleep apnea (OSA) and dysglycemia in Japanese individuals with and without type 2 diabetes (T2DM). We enrolled 115 individuals diagnosed with OSA with an apnea hypopnea-index (AHI) ≥ 20 in whom continuous positive airway pressure (CPA...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ17-0356

    authors: Kurosawa H,Saisho Y,Fukunaga K,Haraguchi M,Yamasawa W,Kurihara I,Betsuyaku T,Itoh H

    更新日期:2018-01-30 00:00:00

  • Effects of a diet with or without physical activity on angiopoietin-like protein 8 concentrations in overweight/obese patients with newly diagnosed type 2 diabetes: a randomized controlled trial.

    abstract::Angiopoietin-like protein 8 (ANGPTL8) is a newly discovered adipokine plays an important role in energy homoeostasis, obesity and type 2 diabetes (T2D). Although lifestyle modification in obesity and T2D is known to offer metabolic benefits, there is paucity of comprehensive data on change in ANGPTL8. We investigated ...

    journal_title:Endocrine journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1507/endocrj.EJ18-0191

    authors: Hu H,Yuan G,Wang X,Sun J,Gao Z,Zhou T,Yin W,Cai R,Ye X,Wang Z

    更新日期:2019-01-28 00:00:00

  • Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion.

    abstract::Central diabetes insipidus (CDI) is characterized by polyuria and polydipsia caused by impairment of arginine vasopressin (AVP) secretion. In this study, we evaluated plasma AVP concentrations during a hypertonic saline infusion test using a new AVP radioimmunoassay (RIA) which is now available in Japan. Thirteen cont...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ19-0224

    authors: Takagi H,Hagiwara D,Handa T,Sugiyama M,Onoue T,Tsunekawa T,Ito Y,Iwama S,Goto M,Suga H,Banno R,Takahashi K,Matsui S,Arima H

    更新日期:2020-03-28 00:00:00

  • A case of nonfunctioning pituitary adenoma resembling so-called silent corticotroph adenoma.

    abstract::It has been indicated that some subsets of clinically nonfunctioning pituitary adenoma exhibit immunohistochemical and ultrastructural features of somatotroph or corticotroph cells, which are described as silent somatotroph and corticotroph adenomas, respectively. We here describe a 70-year-old woman with nonfunctioni...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.44.329

    authors: Sakaguchi H,Koshiyama H,Sano T,Inoue D,Hashimoto N,Aoki N,Nakao K

    更新日期:1997-04-01 00:00:00

  • A case of non-insulin dependent diabetes mellitus with antiinsulin antibody: effect of subcutaneous injection of human recombinant insulin-like growth factor-I.

    abstract::We saw a 57-yr-old female non-insulin dependent diabetes mellitus (NIDDM) patient with antiinsulin antibody, in whom insulin-like growth factor-I (IGF-I) was shown to be effective as a blood glucose-lowering agent. Due to the presence of the antibody, the patient suffered from postprandial hyperglycemia and frequent h...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.42.101

    authors: Kajimoto Y,Kawamori R,Fujitani Y,Kishimoto M,Kubota M,Yamasaki Y,Morishima T,Kamada T

    更新日期:1995-02-01 00:00:00

  • Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia.

    abstract::In vitro studies in isolated pancreas and islets have shown that glucagon-like peptide-1 (GLP-1) promotes insulin release in a typical concentration-dependent manner. In contrast, the relationship between plasma GLP-1 and insulin concentrations in vivo is complicated, because GLP-1-promoted insulin release lowers bloo...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k11e-096

    authors: Eiki J,Yada T

    更新日期:2011-01-01 00:00:00

  • Systemic distribution of somatostatin receptor subtypes in human: an immunohistochemical study.

    abstract::Somatostatin is well known to inhibit the hormone secretion of various peptides. This action has been considered to be generally mediated via six different specific somatostatin receptors (sstr), sstr1, sstr2A, sstr2B, sstr3, sstr4, and sstr5. It then becomes very important to demonstrate the localization of these sst...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.52.605

    authors: Taniyama Y,Suzuki T,Mikami Y,Moriya T,Satomi S,Sasano H

    更新日期:2005-10-01 00:00:00

  • Increase in Pit-1 mRNA is not required for the estrogen-induced expression of prolactin gene and lactotroph proliferation.

    abstract::Estrogen has been shown to stimulate lactotroph proliferation and expression of the prolactin (PRL) gene. Recently it has been established that Pit-1, a pituitary-specific transcription factor, is required for lactotroph proliferation. Furthermore, in vitro studies showed that an increase in the PRL promoter activity ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.41.579

    authors: Tsukahara S,Kambe F,Suganuma N,Tomoda Y,Seo H

    更新日期:1994-10-01 00:00:00

  • A novel heterozygous mutation of steroidogenic factor-1 (SF-1/Ad4BP) gene (NR5A1) in a 46, XY disorders of sex development (DSD) patient without adrenal failure.

    abstract::Steroidogenic factor-1 [(SF-1/Ad4BP) (MIM184757)] is a nuclear receptor that regulates multiple genes involved in adrenal and gonadal development, steroidogenesis, reproduction, and other metabolic functions. Initially, mutations of SF-1/Ad4BP gene (NR5A1) in humans were identified in two 46, XY female patients with a...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k08e-380

    authors: Tajima T,Fujiwara F,Fujieda K

    更新日期:2009-01-01 00:00:00

  • Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.

    abstract::Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-rel...

    journal_title:Endocrine journal

    pub_type: 临床试验,杂志文章

    doi:10.1507/endocrj.EJ19-0313

    authors: Irie J,Inagaki E,Fujita M,Nakaya H,Mitsuishi M,Yamaguchi S,Yamashita K,Shigaki S,Ono T,Yukioka H,Okano H,Nabeshima YI,Imai SI,Yasui M,Tsubota K,Itoh H

    更新日期:2020-02-28 00:00:00

  • Influence of thyroid dysfunction on brain natriuretic peptide level in health examination participants.

    abstract::The tissue-specific circulating markers of thyroid hormone action on cardiac function have not been established. Although the relationship between thyroid function and plasma brain natriuretic peptide (BNP) levels has been evaluated in patients with thyroid disorders, the relationship between these parameters in the g...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ19-0380

    authors: Ohba K,Okada E,Goto Y,Suzuki S,Machii M,Nonaka D,Matsushita A,Sasaki S,Suda T,Oki Y,Takase H

    更新日期:2020-04-28 00:00:00

  • Serum levels of 20 kilodalton human growth hormone (20K-hGH) in patients with acromegaly before and after treatment with octreotide and transsphenoidal surgery.

    abstract::Circulating human GH (hGH) consists of several molecular isoforms. It was previously reported that the proportion of 20 kilodalton hGH (20K-hGH) was elevated in the serum of patients with active acromegaly. In this study, we investigated the effects of octreotide and transsphenoidal adenomectomy on the proportion of 2...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.51.343

    authors: Murakami Y,Shimizu T,Yamamoto M,Kato Y

    更新日期:2004-06-01 00:00:00

  • Organ-specific autoantibodies in Chinese patients newly diagnosed with type 1 diabetes mellitus.

    abstract::This study aims to investigate the prevalence of islet autoantibodies and other organ-specific autoantibodies in type 1 diabetes mellitus (T1DM) patients and characterize their clinical features. Glutamic acid decarboxylase antibody (GADA), insulinoma antigen 2 antibody (IA-2A), zinc transporter 8 antibody (ZnT8A) and...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ20-0002

    authors: Pan S,Wu T,Shi X,Xie Z,Huang G,Zhou Z

    更新日期:2020-07-28 00:00:00

  • Fulminant type 1 diabetes associated with Isolated ACTH deficiency induced by anti-programmed cell death 1 antibody-insight into the pathogenesis of autoimmune endocrinopathy.

    abstract::Therapeutic blocking antibodies against programmed death 1 (PD1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) are applied for advanced cancer therapy, but induce a wide range of immune-related adverse events. In our recent case of a 52-year-old female doctor suffering from breast cancer having metastasized to the lung...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ18-0328

    authors: Okahata S,Sakamoto K,Mitsumatsu T,Kondo Y,Noso S,Ikegami H,Shiba T

    更新日期:2019-04-25 00:00:00

  • Effects of GnRH on protein kinase C activity, Ca2+ mobilization and steroidogenesis of human granulosa cells.

    abstract::Gonadotropin-releasing hormone (GnRH) and its agonists have been known to directly affect steroid hormone production in human granulosa cells. In this study, we examined effects of GnRH on Ca2+ mobilization, protein kinase C activity and steroidogenesis of human granulosa cells. Human granulosa cells were harvested by...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.45.175

    authors: Hori H,Uemura T,Minaguchi H

    更新日期:1998-04-01 00:00:00

  • Successful management of a patient with active Cushing‍'‍s disease complicated with coronavirus disease 2019 (COVID-19) pneumonia.

    abstract::We provide the details of the successful management of a patient with active Cushing's disease complicated with coronavirus disease 2019 (COVID-19) pneumonia. The patient was a 27-year-old Japanese female healthcare worker who was scheduled to undergo pituitary surgery for Cushing's disease. She had been in close cont...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ20-0613

    authors: Yuno A,Kenmotsu Y,Takahashi Y,Nomoto H,Kameda H,Cho KY,Nakamura A,Yamashita Y,Nakamura J,Nakakubo S,Kamada K,Suzuki M,Sugino H,Inoshita N,Konno S,Miyoshi H,Atsumi T,Sawamura Y,Shimatsu A

    更新日期:2020-12-24 00:00:00

  • Exenatide exhibits dose-dependent effects on glycemic control over 12 weeks in Japanese patients with suboptimally controlled type 2 diabetes.

    abstract::This study assessed the dose-dependent efficacy and safety of exenatide over 12 weeks in Japanese patients with type 2 diabetes suboptimally controlled despite therapeutic doses of sulfonylurea (SU), SU plus biguanide, or SU plus thiazolidinedione. Patients were randomly assigned to placebo (N = 40), 2.5 microg (N = 3...

    journal_title:Endocrine journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1507/endocrj.k08e-296

    authors: Kadowaki T,Namba M,Yamamura A,Sowa H,Wolka AM,Brodows RG

    更新日期:2009-01-01 00:00:00

  • Pituitary apoplexy after cardiac surgery in a 14-year-old girl with Carney complex: a case report.

    abstract::A 14-year-old girl was referred to our department because of headache and visual impairment following the resection of recurrent cardiac myxoma. Head magnetic resonance imaging (MRI) scan detected an intra- and supra-sellar tumor. Moreover, the patient showed the presence of spotty skin pigmentations on her cheeks and...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ19-0183

    authors: Naito Y,Mori J,Tazoe J,Tomida A,Yagyu S,Nakajima H,Iehara T,Tatsuzawa K,Mukai T,Hosoi H

    更新日期:2019-12-25 00:00:00