Abstract:
:We measured serum levels of the carboxy-terminal propeptide of type 1 procollagen (P1CP) as a marker of bone formation and the carboxy-terminal telopeptide of type 1 collagen (1CTP) as a marker of bone resorption by RIA in sera from 40 Graves' disease patients and 14 Hashimoto's disease patients before and during treatment. The serum P1CP levels of the untreated Graves' disease were significantly higher than in the controls (176.8 +/- 93.5 vs. 107 +/- 35 ng/ml, P < 0.01), and these levels decreased significantly during treatment with antithyroid drugs. There was a significant statistical correlation between serum P1CP levels and serum total alkaline-phosphatase activity (r = 0.61, P < 0.01) in the patients with Graves' disease and Hashimoto's disease as a whole. 1CTP levels were also significantly increased in untreated Graves' patients (6.5 +/- 2.8 compared with 2.7 +/- 1.1 ng/ml in normal subjects, P < 0.01). The P1CP/1CTP ratio, which reflects the relative ratio of bone formation to bone resorption, was lower than normal in untreated Graves' disease, but increased following the normalization of thyroid function. The results of this study suggest that the measurement of serum P1CP and 1CTP levels may be useful in evaluating bone metabolism in thyroid disease.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Miyakawa M,Tsushima T,Demura Hdoi
10.1507/endocrj.43.701subject
Has Abstractpub_date
1996-12-01 00:00:00pages
701-8issue
6eissn
0918-8959issn
1348-4540journal_volume
43pub_type
杂志文章abstract::Aim of this study was to examine the association between the severity of obstructive sleep apnea (OSA) and dysglycemia in Japanese individuals with and without type 2 diabetes (T2DM). We enrolled 115 individuals diagnosed with OSA with an apnea hypopnea-index (AHI) ≥ 20 in whom continuous positive airway pressure (CPA...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ17-0356
更新日期:2018-01-30 00:00:00
abstract:OBJECTIVES:To evaluate the effect of atorvastatin on bone mass and markers of bone remodeling in patients with acute coronary syndrome according to the Lys656Asn leptin receptor gene polymorphism. METHODS:Sixty-two patients with acute coronary syndrome were included. Patients were allocated to low and high doses of at...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k08e-269
更新日期:2009-01-01 00:00:00
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journal_title:Endocrine journal
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doi:10.1507/endocrj.49.473
更新日期:2002-08-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,meta分析
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更新日期:2014-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 历史文章,杂志文章
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更新日期:1995-12-01 00:00:00
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journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
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更新日期:1993-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ19-0191
更新日期:2019-12-25 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0548
更新日期:2016-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.43.417
更新日期:1996-08-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.459
更新日期:1999-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1507/endocrj.EJ16-0064
更新日期:2016-07-30 00:00:00
abstract::To assess the daily iodine intake in a population study, we have compared the validity and degree of reliability of the urine iodide/creatinine ratios and iodide concentrations of casual samples as a representative index of daily urine iodide excretion. The morning urine samples were obtained from apparently healthy 2...
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pub_type: 临床试验,杂志文章
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更新日期:1993-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.831
更新日期:1999-12-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.49.285
更新日期:2002-06-01 00:00:00
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journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1507/endocrj.EJ19-0380
更新日期:2020-04-28 00:00:00
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doi:10.1507/endocrj.EJ16-0494
更新日期:2017-06-29 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-12-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
abstract::Pseudohypoparathyroidism (PHP) is associated with compromised signal transductions via PTH receptor (PTH-R) and other G-protein-coupled receptors including GHRH-R. To date, while GH deficiency (GHD) has been reported in multiple patients with PHP-Ia caused by mutations on the maternally expressed GNAS coding regions a...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0033
更新日期:2015-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0079
更新日期:2020-09-28 00:00:00
abstract::The effect of a synthetic steroidal anti-androgen, TZP-4238, on steroid-induced rat prostatic hyperplasia was investigated. Male Wistar rats were divided into four experimental groups. Group 1 consisted of intact controls. The other animals were castrated. The castrated animals were treated for 7 weeks with 1) testost...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.40.479
更新日期:1993-08-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
abstract::The present study used intermittently scanned continuous glucose monitoring (isCGM) in 10 patients with type 1 diabetes mellitus (T1DM) to evaluate the efficacy and safety of 7-day outpatient treatment with the combination of intensive insulin therapy and sodium-glucose transporter 2 inhibitor (SGLT2-I). All participa...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0577
更新日期:2020-11-18 00:00:00
abstract::The proteins found in cow milk have been reported to cause systemic inflammation. Endoplasmic reticulum (ER) stress is known to be involved in the development of several metabolic disorders including insulin resistance and non-alcoholic fatty liver disease. However, the effect of thiazolidinediones (TZDs) on ER stress...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej13-0167
更新日期:2013-01-01 00:00:00