Comparison of ACTH secretion in Cushing's adenoma and clinically silent corticotroph adenoma by cell immunoblot assay.

abstract：:We assessed the significance of recommendations from the international consensus on continuous glucose monitoring (CGM)-derived metrics in Japanese children and adolescents with type 1 diabetes. Eighty-five patients (age, 13.5 ± 4.7 years) who wore the FreeStyle® Libre for a 28-day period were enrolled in this study. ...

journal_title：Endocrine journal

authors： Urakami T,Yoshida K,Kuwabara R,Mine Y,Aoki M,Suzuki J,Morioka I

更新日期：2020-10-28 00:00:00

abstract：:Ovarian 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), which converts progesterone to a derivative devoid of biological activity, plays a crucial role in achieving the short estrous cycle in rats. Although 20alpha-HSD activity has also been demonstrated in the thymus, its molecular nature, function, and regulatio...

journal_title：Endocrine journal

authors： Hirabayashi K,Suzuki M,Takahashi M,Nishihara M

更新日期：2001-10-01 00:00:00

abstract：:Glucocorticoids play a critical role in the regulation of homeostasis, including metabolism. In patients with Cushing's syndrome, chronic glucocorticoid excess disrupts physiological internal milieu, resulting in central obesity, muscle atrophy, fatty liver, and insulin resistance. However, the relationship among vari...

journal_title：Endocrine journal

authors： Uehara M,Yamazaki H,Yoshikawa N,Kuribara-Souta A,Tanaka H

更新日期：2020-01-28 00:00:00

abstract：:Progression to overt hypothyroidism and the associated adverse effects on lipid metabolism and the cardiovascular system are major concerns for patients diagnosed with subclinical hypothyroidism (SCH). No consensus regarding the clinical parameters associated with prognosis for this mild thyroid dysfunction has yet be...

journal_title：Endocrine journal

authors： Shin DY,Kim EK,Lee EJ

更新日期：2010-01-01 00:00:00

abstract：:In vitro studies in isolated pancreas and islets have shown that glucagon-like peptide-1 (GLP-1) promotes insulin release in a typical concentration-dependent manner. In contrast, the relationship between plasma GLP-1 and insulin concentrations in vivo is complicated, because GLP-1-promoted insulin release lowers bloo...

journal_title：Endocrine journal

authors： Eiki J,Yada T

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess the rate of malignancy in thyroid nodules incidentally detected at sonography and to determine the diagnostic value of ultrasonography-guided fine needle aspiration cytology (USgFNAC) in thyroid nodules. METHODS:Five hundred patients (84 men and 416 women) who had thyr...

journal_title：Endocrine journal

authors： Kim DL,Song KH,Kim SK

更新日期：2008-03-01 00:00:00

abstract：:Sirtuin1 (SIRT1) is activated during calorie restriction and appears to be related to energy balance through glucose or lipid metabolism and insulin signaling. These findings suggest that SIRT1 may play a role in the pathophysiology of visceral obesity. Therefore, we investigated the relationship between SIRT1 gene ex...

journal_title：Endocrine journal

authors： Lee H,Chu SH,Park JY,Park HK,Im JA,Lee JW

更新日期：2013-01-01 00:00:00

abstract：:Since accumulation and interaction of immune cells including T cells and monocytes/macrophages are involved in the processes of atherosclerosis, atherosclerosis is currently understood as an inflammatory disorder. Entrapment of extracellular matrices components such as hyaluronan by monocytes and macrophages, as well ...

journal_title：Endocrine journal

authors： Tabata T,Mine S,Okada Y,Tanaka Y

更新日期：2007-12-01 00:00:00

abstract：:Thyroid disease is known to be associated with pulmonary arterial hypertension (PAH). We investigated the prevalence of thyroid disease in patients with idiopathic PAH (IPAH) or heritable PAH (HPAH), and the factors affecting the pathogenesis of thyroid disease. We retrospectively evaluated 59 patients with IPAH or HP...

journal_title：Endocrine journal

authors： Satoh M,Aso K,Nakayama T,Saji T

更新日期：2017-12-28 00:00:00

abstract：:The present study was aimed to examine the possible functional relationship between melatonin and hypothalamic transmitters, endogenous opioids and excitatory amino acids in controlling gonadotropin secretion in ovariectomized estrogen-primed rats. An intravenous injection of naloxone (mu opioid receptor antagonist), ...

journal_title：Endocrine journal

authors： Akema T,Ikeda T,Chiba A,Sugiyama H,Sato I,Kimura F,Toyoda J

更新日期：1999-12-01 00:00:00

abstract：:Unusual presentations with bone, lung or soft tissue metastases in initial diagnosis of follicular thyroid carcinoma have been reported occasionally. This implies how difficult it is to diagnosis this type of cancer at the pre-operative or intra-operative stage of treatment. Fine needle aspiration cytology has been sh...

journal_title：Endocrine journal

authors： Lin JD,Chao TC

更新日期：2006-08-01 00:00:00

abstract：:Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation....

journal_title：Endocrine journal

authors： Yamamuro T,Inoue K,Nagai Y,Azuma D,Yamamoto A,Hara K,Kohara M,Iwata T,Nakatsuka S,Morii E,Yamamoto T

更新日期：2018-12-28 00:00:00

abstract：:Pregnancy in acromegalic patients is a rare event, but is usually uneventful, with stable GH and IGF-I levels and no tumor enlargement. Medical treatment can usually be withdrawn without problems and although no major adverse event has been reported, the suspension of drug treatments is generally recommended. No cas...

journal_title：Endocrine journal

authors： Kasuki L,Neto LV,Takiya CM,Gadelha MR

更新日期：2012-01-01 00:00:00

abstract：:The octanoylation of Ser3 is essential for the biological function of ghrelin. We examined the concentrations of the n-octanoylated active-form ghrelin in cord and neonatal blood using an RIA system that specifically recognized n-octanoylated ghrelin, as well as a system that measured the total ghrelin concentration. ...

journal_title：Endocrine journal

authors： Yokota I,Kitamura S,Hosoda H,Kotani Y,Kangawa K

更新日期：2005-04-01 00:00:00

abstract：:Although several authors have reported single cases illustrative of some ultrasonographic characteristic of parathyroid carcinoma, the value of ultrasonography for diagnosing this entity remains to be determined. The purpose of our study was to investigate the ultrasonographic features of parathyroid carcinoma in a la...

journal_title：Endocrine journal

authors： Hara H,Igarashi A,Yano Y,Yashiro T,Ueno E,Aiyoshi Y,Ito K,Obara T

更新日期：2001-04-01 00:00:00

abstract：:Differentiated thyroid carcinoma (DTC) is generally indolent in nature and, even though it metastasizes to distant organs, the prognosis is normally excellent. In contrast, the overall survival (OS) of patients with radioactive iodine (RAI)-refractory and progressive metastases is dire, because no effective therapies ...

journal_title：Endocrine journal

authors： Ito Y,Suzuki S,Ito K,Imai T,Okamoto T,Kitano H,Sugitani I,Sugino K,Tsutsui H,Hara H,Yoshida A,Shimizu K

更新日期：2016-07-30 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) is a skeletal disorder with progressive heterotopic ossification in skeletal muscle. A mutation causing constitutive activation in a bone morphogenetic protein (BMP) type 1 receptor [ALK2(R206H)] is found in most patients with FOP. However, the details in the heterotopic oss...

journal_title：Endocrine journal

authors： Mao L,Yano M,Kawao N,Tamura Y,Okada K,Kaji H

更新日期：2013-01-01 00:00:00

abstract：:Diarrhea is a non-specific symptom which may be associated with Addison's disease and several causes had been demonstrated in the aetiology. We describe a patient with Addison's disease who was suffering from chronic diarrhea for three months. She was diagnosed as having collagenous colitis and successfully treated wi...

journal_title：Endocrine journal

authors： Unlühizarci K,Bayram F,Ozbakir O,Kirgin A,Patiroglu T,Yücesoy M,Keleştimur F

更新日期：1998-08-01 00:00:00

abstract：:Anaplastic carcinoma arises from differentiated carcinoma and generally shows a dire prognosis. Anaplastic transformation may occur not only in primary tumors but also in metastatic lymph nodes. We encountered 5 cases of papillary carcinoma showing anaplastic transformation in lymph nodes that were curatively resected...

journal_title：Endocrine journal

authors： Ito Y,Higashiyama T,Hirokawa M,Fukushima M,Inoue H,Yabuta T,Tomoda C,Uruno T,Kihara M,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Miyauchi A

更新日期：2008-12-01 00:00:00

abstract：:This is a case report of an 18-year-old man with central diabetes incipidus (DI). An MRI done three months after the onset of the DI did not disclose a responsible lesion. Four months later, a second MRI showed the location of the tumor origin at the upper pituitary stalk and median eminence. Eight months later, the t...

journal_title：Endocrine journal

authors： Saeki N,Uchida D,Tatsuno I,Saito Y,Yamaura A

更新日期：1999-04-01 00:00:00

abstract：:Estrogen has been shown to stimulate lactotroph proliferation and expression of the prolactin (PRL) gene. Recently it has been established that Pit-1, a pituitary-specific transcription factor, is required for lactotroph proliferation. Furthermore, in vitro studies showed that an increase in the PRL promoter activity ...

journal_title：Endocrine journal

authors： Tsukahara S,Kambe F,Suganuma N,Tomoda Y,Seo H

更新日期：1994-10-01 00:00:00

abstract：:Betacellulin (BTC) purified from mouse beta cell tumor (betaTC-3) is a new member of the epidermal growth factor (EGF) family which can bind receptor tyrosine kinase, EGF receptor (erbB1) and erbB4. It has been demonstrated that proBTC mRNA was abundantly expressed in human pancreas tissue, and that BTC converted amyl...

journal_title：Endocrine journal

authors： Miyagawa J,Hanafusa O,Sasada R,Yamamoto K,Igarashi K,Yamamori K,Seno M,Tada H,Nammo T,Li M,Yamagata K,Nakajima H,Namba M,Kuwajima M,Matsuzawa Y

更新日期：1999-12-01 00:00:00

abstract：:The effect of luteinizing hormone releasing hormone (LHRH) on the neuronal activity of CA1 and CA3 regions of the hippocampus was studied by means of extracellular recordings in the castrated male, intact male, castrated female, and castrated female injected s.c. with 20 micrograms estradiol benzoate (EB) for 3 days. ...

journal_title：Endocrine journal

authors： Osada T,Kimura F

更新日期：1995-04-01 00:00:00

abstract：:We propose a new classification of thyroid follicular cell tumors which is correlated with patient's prognosis. It is unique as to two new categories: borderline malignancy between benign and malignant, and moderately differentiated adenocarcinoma (MDA) as a differentiation classification to stratify tumor aggressive...

journal_title：Endocrine journal

authors： Kakudo K,Bai Y,Liu Z,Li Y,Ito Y,Ozaki T

更新日期：2012-01-01 00:00:00

abstract：:Primary granulomatous hypophysitis (PGH) is a rarely occurred inflammatory disease of unknown etiology. We retrospective review a case of PGH treated by microsurgical transsphenoidal approach and review the appropriately documented cases of PGH collected from the literatures. The patient was a 56-year-old female who p...

journal_title：Endocrine journal

authors： Su SB,Zhang DJ,Yue SY,Zhang JN

更新日期：2011-01-01 00:00:00

abstract：:Estrogen-secreting adrenal cancers are extremely rare, with feminizing symptoms attributed to aromatase expression in the adrenal tumor. We describe a case of hypogonadotropic hypogonadism as a consequence of aberrant aromatase expression in a patient with adrenocortical adenocarcinoma. A 54 year-old man presented wit...

journal_title：Endocrine journal

authors： Advani A,Johnson SJ,Nicol MR,Papacleovoulou G,Evans DB,Vaikkakara S,Mason JI,Quinton R

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this study was to determine whether treatment using the active form of vitamin D (1,25(OH)2D3) could protect against high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in rats and ameliorate oxidative stress. Male Sprague-Dawley rats were divided into three groups and treated with sta...

journal_title：Endocrine journal

authors： Zhu CG,Liu YX,Wang H,Wang BP,Qu HQ,Wang BL,Zhu M

更新日期：2017-07-28 00:00:00

abstract：:Triptolide, a major active component of Tripterygium wilfordii Hook F (TWHF), is known to have multiple pharmacological activities. However, studies have also shown that triptolide is highly toxic to the reproductive system by disrupting normal androgen and estrogen signaling. In the present study, we investigated the...

journal_title：Endocrine journal

authors： Zhang J,Liu L,Mu X,Jiang Z,Zhang L

更新日期：2012-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is known to stimulate the synthesis and secretion of various proinflammatory cytokines in both the peripheral immune cells and the brain. Yet, the relative contribution of peripheral and central cytokines to the LPS-induced activation of the hypothalamo-pituitary-adrenal axis is still poorly u...

journal_title：Endocrine journal

authors： Kakizaki Y,Watanobe H,Kohsaka A,Suda T

更新日期：1999-08-01 00:00:00

abstract：:To assess the daily iodine intake in a population study, we have compared the validity and degree of reliability of the urine iodide/creatinine ratios and iodide concentrations of casual samples as a representative index of daily urine iodide excretion. The morning urine samples were obtained from apparently healthy 2...

journal_title：Endocrine journal

authors： Konno N,Yuri K,Miura K,Kumagai M,Murakami S

更新日期：1993-02-01 00:00:00