Abstract:
:The octanoylation of Ser3 is essential for the biological function of ghrelin. We examined the concentrations of the n-octanoylated active-form ghrelin in cord and neonatal blood using an RIA system that specifically recognized n-octanoylated ghrelin, as well as a system that measured the total ghrelin concentration. Plasma levels of active ghrelin in cord blood ranged from 7.7 to 38.4 pmol/l and correlated excellently with those of total ghrelin (r = 0.81, p<0.0001). The active ghrelin/total ghrelin (A/T) ratio ranged from 0.038 to 0.12 (median 0.072). The active ghrelin concentrations negatively correlated with birth body weight (r = -0.34, p = 0.01) and IGF-1 concentrations (r = -0.40, p = 0.003), but did not correlate with growth hormone (GH) concentrations. A considerable level of active ghrelin was detected in premature newborns. Venous cord blood samples showed a significantly higher active ghrelin concentration (p = 0.03) and A/T ratio (p = 0.01) than those in the artery. In neonatal blood, active ghrelin concentrations ranged from 4.6 to 22.6 pmol/l and the A/T ratio ranged from 0.02 to 0.081. These results demonstrate the existence of active-form ghrelin in fetal and neonatal circulation and may suggest the energy supply-dependent regulation of ghrelin expression/secretion in utero.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Yokota I,Kitamura S,Hosoda H,Kotani Y,Kangawa Kdoi
10.1507/endocrj.52.271subject
Has Abstractpub_date
2005-04-01 00:00:00pages
271-6issue
2eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/52.271journal_volume
52pub_type
杂志文章abstract::Pseudohypoparathyroidism (PHP) is associated with compromised signal transductions via PTH receptor (PTH-R) and other G-protein-coupled receptors including GHRH-R. To date, while GH deficiency (GHD) has been reported in multiple patients with PHP-Ia caused by mutations on the maternally expressed GNAS coding regions a...
journal_title:Endocrine journal
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doi:10.1507/endocrj.EJ15-0033
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doi:10.1507/endocrj.EJ15-0480
更新日期:2016-04-25 00:00:00
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journal_title:Endocrine journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-02-01 00:00:00
abstract::21-hydroxylase deficiency (21-OHD) is the most common type of congenital adrenal hyperplasia. In addition to the clinical problems caused by adrenal insufficiency and androgen excess, a risk for obesity and metabolic syndrome during young adulthood is a major ramification of the disease. Although glucocorticoid therap...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0194
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journal_title:Endocrine journal
pub_type: 杂志文章
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.41.437
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journal_title:Endocrine journal
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0731
更新日期:2016-09-30 00:00:00
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journal_title:Endocrine journal
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更新日期:2014-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1507/endocrj.47.supplmarch_s125
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journal_title:Endocrine journal
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更新日期:2002-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1507/endocrj.EJ15-0500
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2000-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0342
更新日期:2016-11-30 00:00:00
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更新日期:2009-01-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2000-04-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2008-05-01 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:1995-12-01 00:00:00
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