Thyroxine prophylaxis after bilateral subtotal thyroidectomy for multinodular goiter.

abstract：:In hope of understanding possible roles of estrogen during early embryogenesis, we examined the expression of both estrogen receptor alpha (ER alpha) and ER beta, a recently cloned novel subtype, in mouse oocytes and preimplantation embryos by means of reverse transcription polymerase chain reaction (RT-PCR). To inves...

journal_title：Endocrine journal

authors： Hiroi H,Momoeda M,Inoue S,Tsuchiya F,Matsumi H,Tsutsumi O,Muramatsu M,Taketani Y

更新日期：1999-02-01 00:00:00

abstract：:Antipituitary antibody (APA) has been reported to be detected in patients with autoimmune thyroid disease. Type 2 iodothyronine deiodinase (D2) is expressed in both pituitary gland and thyroid gland. We studied the association of APA and D2 peptide antibody in patients with autoimmune thyroid disease. Rat pituitary gl...

journal_title：Endocrine journal

authors： Nakahara R,Tsunekawa K,Yabe S,Nara M,Seki K,Kasahara T,Ogiwara T,Nishino M,Kobayashi I,Murakami M

更新日期：2005-12-01 00:00:00

abstract：:Circulating anti-islet autoantibodies in sera are used as a predictive marker for type 1 diabetes (T1D). We here report two Japanese patients with autoimmune thyroid disease complicated with T1D in whom the time course of anti-islet autoantibodies were observed before the clinical onset of diabetes. Case 1: A woman wh...

journal_title：Endocrine journal

authors： Horie I,Kawasaki E,Shimomura A,Satoh T,Ueki I,Kuwahara H,Ando T,Abiru N,Usa T,Eguchi K

更新日期：2010-01-01 00:00:00

abstract：:Therapeutic blocking antibodies against programmed death 1 (PD1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) are applied for advanced cancer therapy, but induce a wide range of immune-related adverse events. In our recent case of a 52-year-old female doctor suffering from breast cancer having metastasized to the lung...

journal_title：Endocrine journal

authors： Okahata S,Sakamoto K,Mitsumatsu T,Kondo Y,Noso S,Ikegami H,Shiba T

更新日期：2019-04-25 00:00:00

abstract：:We present a rare case of a 66-year-old woman with the syndrome of inappropriate antidiuresis (SIAD) accompanied by an empty sella whose symptoms were seen twice in the eight years after the administration of non-steroidal anti-inflammatory drugs (NSAID) or prochlorperazine. No diuresis or suppression of the plasma le...

journal_title：Endocrine journal

authors： Shimada T,Higashi K,Kimura K,Shido T,Tomita K

更新日期：1995-04-01 00:00:00

abstract：:Immunoreactive activin A (ir-activin A) release from cultured rat anterior pituitary cells was examined by measuring ir-activin A in culture medium by a specific radioimmunoassay. Ir-activin A release into the medium increased over 1-18 days, and reached a maximal level at 12-15 days. The basal levels of ir-activin A ...

journal_title：Endocrine journal

authors： Liu ZH,Shintani Y,Wakatsuki M,Sakamoto Y,Harada K,Zhang CY,Saito S

更新日期：1996-02-01 00:00:00

abstract：:The present study investigated the diurnal variation in GH receptor (GHR) mRNA in liver and skeletal muscle of 3-month-old GH-deficient and -sufficient mice using quantitative real-time RT-PCR. lit/lit (GH deficient) or lit/+ (GH sufficient) mice were fed ad libitum and lights were on between 0600 and 2000. Tissues we...

journal_title：Endocrine journal

authors： Itoh E,Iida K,del Rincon JP,Kim DS,Thorner MO

更新日期：2004-12-01 00:00:00

abstract：:Gitelman syndrome (GS) is a salt-wasting tubulointerstitial disease of autosomal recessive inheritance (OMIM613395) caused by genic mutation of SLC12A3, which codes thiazide-sensitive Na-Cl cotransporter (NCCT) gene. The gene mutation of the majority of GS patients is compound heterozygous. This study analyzes two cas...

journal_title：Endocrine journal

authors： Luo J,Yang X,Liang J,Li W

更新日期：2015-01-01 00:00:00

abstract：:Clinical studies have shown that hyperhomocysteinemia is associated with bone fragility. Homocysteine (Hcy) induces apoptosis of osteoblastic cell lineage by increasing oxidative stress, which may contribute to Hcy-induced bone fragility. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, ameliorate ...

journal_title：Endocrine journal

authors： Takeno A,Kanazawa I,Tanaka K,Notsu M,Yokomoto-Umakoshi M,Sugimoto T

更新日期：2016-04-25 00:00:00

abstract：:There are two local subtypes of extravillous trophoblast (EVT): one is the proliferative phenotype of EVT, which primarily consists of proximal cells and the other is the invasive phenotype of EVT, which is composed mainly of distal cells of cell columns. The mechanism of invasion of EVT to the decidua remains obscure...

journal_title：Endocrine journal

authors： Murakoshi H,Matsuo H,Laoag-Fernandez JB,Samoto T,Maruo T

更新日期：2003-04-01 00:00:00

abstract：:A case of isolated ACTH deficiency who developed autoimmune-mediated hypothyroidism and still showed impaired water diuresis during glucocorticoid replacement therapy is reported. A 45-year-old woman was initially admitted for nausea, vomiting, and general malaise. Her serum sodium and plasma osmolality, ACTH and cort...

journal_title：Endocrine journal

authors： Kageyama Y

更新日期：2000-12-01 00:00:00

abstract：:A 19-year-old girl presented at our emergency room with hypokalemic periodic paralysis. She had a thyrotoxic goiter and had experienced three paralytic attacks during the previous 2 years on occasions when she stopped taking antithyroid drugs. In addition to thyrotoxic periodic paralysis (TPP), she had metabolic acido...

journal_title：Endocrine journal

authors： Im EJ,Lee JM,Kim JH,Chang SA,Moon SD,Ahn YB,Son HS,Cha BY,Lee KW,Son HY

更新日期：2010-01-01 00:00:00

abstract：:Ketoconazole is an imidazole derivative used to treat systemic and superficial mycoses by inhibiting sterol synthesis in fungi. The drug impairs steroid hormone synthesis by blocking mitochondrial P450-dependent enzyme systems. Because of its potent inhibitory effects on adrenal steroidogenesis, ketoconazole is valuab...

journal_title：Endocrine journal

authors： Chou SC,Lin JD

更新日期：2000-08-01 00:00:00

abstract：:Pituitary adrenocorticotropic hormone (ACTH)-secreting tumor presents with a variety of clinical features. We outlined the features of ACTH release and characteristics of corticotroph adenoma cells. We especially focused on the corticotroph adenomas in patients with no clinical features of Cushing's disease. Subclinic...

journal_title：Endocrine journal

authors： Kageyama K,Oki Y,Nigawara T,Suda T,Daimon M

更新日期：2014-01-01 00:00:00

abstract：:Previously, we reported that short-term continuous glucose monitoring (CGM) with the professional iPro2© CGM device is a good clinical indicator of glycated hemoglobin (HbA1c) levels. However, there was no significant correlation between CGM and HbA1c levels when HbA1c levels were >8.0%. To further investigate this is...

journal_title：Endocrine journal

authors： Yamada M,Okada S,Oda H,Nakajima Y,C Bastie C,Kasai Y,Osaki A,Shimoda Y,Shibusawa R,Uehara R,Saito T,Ozawa A,Yamada E

更新日期：2020-05-28 00:00:00

abstract：:We previously reported that IA-2 autoantibodies (Ab) facilitated the diagnosis of Japanese insulin-dependent diabetes mellitus (IDDM), but the number tested was not large enough to investigate whether IA-2Ab can improve the diagnostic accuracy. In this report, sera from 78 patients with less than 2 year-disease durati...

journal_title：Endocrine journal

authors： Kasuga A,Ozawa Y,Maruyama T,Ishihara T,Amemiya S,Saruta T

更新日期：1997-08-01 00:00:00

abstract：:KRN568 is a calcimimetic compound which acts on the calcium sensing receptors (CaR) on the parathyroid gland to suppress secretion of PTH. A recent report has demonstrated that CaRs are expressed on cultured human antral gastrin cells and that gastrin secretion is stimulated by an increase in extracellular calcium lev...

journal_title：Endocrine journal

authors： Igarashi T,Ogata E,Maruyama K,Fukuda T

更新日期：2000-10-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) in placenta is believed to be involved in pathogenesis of intrauterine growth restriction. In contrast, insulin-like growth factors (IGFs) are believed to be important for stimulation of fetal and placental growth. IGF-I stimulates metabolic and growth-promoting actions directly...

journal_title：Endocrine journal

authors： Hashimoto R,Sakai K,Matsumoto H,Iwashita M

更新日期：2010-01-01 00:00:00

abstract：:We saw a 57-yr-old female non-insulin dependent diabetes mellitus (NIDDM) patient with antiinsulin antibody, in whom insulin-like growth factor-I (IGF-I) was shown to be effective as a blood glucose-lowering agent. Due to the presence of the antibody, the patient suffered from postprandial hyperglycemia and frequent h...

journal_title：Endocrine journal

authors： Kajimoto Y,Kawamori R,Fujitani Y,Kishimoto M,Kubota M,Yamasaki Y,Morishima T,Kamada T

更新日期：1995-02-01 00:00:00

abstract：:Patients with adrenal insufficiency require appropriate glucocorticoid replacement therapy; however, reliable biological parameters for optimizing glucocorticoid supplementation are limited. The physician has to rely primarily on clinical judgment, carefully taking into account signs and symptoms potentially suggestiv...

journal_title：Endocrine journal

authors： Watanabe T,Ozawa A,Ishii S,Tomaru T,Shibusawa N,Saito T,Yamada E,Horiguchi K,Nakajima Y,Matsumoto S,Yoshino S,Katano-Toki A,Hashimoto K,Mori M,Okada S,Satoh T,Yamada M

更新日期：2018-05-28 00:00:00

abstract：:Insulin-like growth factor-I activates a calcium-permeable cation channel GRC (growth factor-regulated channel). In the present study, we investigated the immunohistochemical localization of GRC in human tissues using a polyclonal anti-GRC antibody. Immunoreactive GRC was detected in the stomach, duodenum, large intes...

journal_title：Endocrine journal

authors： Kowase T,Nakazato Y,Yoko-O H,Morikawa A,Kojima I

更新日期：2002-06-01 00:00:00

abstract：:The purpose of this prospective study was to characterize the changes in serum levels of two proteins produced during the synthesis and degradation of type I collagen, i.e., the carboxyterminal propeptide of type I procollagen (PICP) and the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICT...

journal_title：Endocrine journal

authors： Yasumizu T,Fukada Y,Hoshi K

更新日期：1999-04-01 00:00:00

abstract：:Troglitazone (T) and d-chiroinositol (DCI) have been reported to improve insulin resistance associated with obesity and NIDDM. We tested whether these compounds counteract the insulin antagonistic effects of recombinant human GH. Male Wistar rats were allocated to 4 different treatment groups, rhGH (n=8), rhGH+T (n=7)...

journal_title：Endocrine journal

authors： Sugimoto M,Takeda N,Hattori J,Yoshino K,Nakashima K,Okumura S,Ishimori M,Yasuda K

更新日期：1999-03-01 00:00:00

abstract：:Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease characterized by resistance to aldosterone, and the renal form of PHA1 is associated with heterozygous inactivating mutations in NR3C2, which encodes mineralocorticoid receptor (MR). Here we report a case of renal PHA1 due to a novel frameshift mutation i...

journal_title：Endocrine journal

authors： Kawashima Sonoyama Y,Tajima T,Fujimoto M,Hasegawa A,Miyahara N,Nishimura R,Hashida Y,Hayashi A,Hanaki K,Kanzaki S

更新日期：2017-01-30 00:00:00

abstract：:A 70-year-old man with abdominal aortic aneurysm underwent surgical repair with Hemashield vascular graft. Postoperatively, he was found to have very low plasma cortisol levels, which failed to increase after stimulation with ACTH. A tentative diagnosis of adrenal insufficiency was made despite the lack of its clinica...

journal_title：Endocrine journal

authors： Sakai H,Matsumoto K,Sugiyama M,Yoshimoto T,Doi M,Izumiyama H,Hirata Y

更新日期：2006-06-01 00:00:00

abstract：:The renin-angiotensin system (RAS) has been unequivocally implicated as a mediator of diabetic complications. The present study was designed to evaluate the RAS in non-insulin dependent diabetic patients with diabetic nephropathy. Plasma renin activity, plasma angiotensin II and serum angiotensin-converting enzyme (AC...

journal_title：Endocrine journal

authors： Nicola W,Sidhom G,El Khyat Z,Ibrahim S,Salah A,El Sayed A

更新日期：2001-02-01 00:00:00

abstract：:X-linked hypophosphatemic rickets (XLH) is one of the most common causes of rickets in infancy and childhood. Combination therapy of vitamin D and phosphate is generally used for patients with XLH. Effect of treatment of vitamin D and phosphate during childhood on final height of XLH has to be elucidated in Japanese. ...

journal_title：Endocrine journal

authors： Miyamoto J,Koto S,Hasegawa Y

更新日期：2000-04-01 00:00:00

abstract：:A 67-year-old female with hypertension and impaired glucose tolerance was admitted to our hospital because of a typical acromegalic appearance, including large, thickened bulky hands and feet, and a large prominent forehead and tongue. She did not have a Cushingoid appearance, such as a moon-face, buffalo hump, purple...

journal_title：Endocrine journal

authors： Kobayashi Y,Takei M,Ohkubo Y,Kakizawa Y,Matoba H,Kumagai M,Takeda T,Suzuki S,Komatsu M

更新日期：2014-01-01 00:00:00

abstract：:The present study used intermittently scanned continuous glucose monitoring (isCGM) in 10 patients with type 1 diabetes mellitus (T1DM) to evaluate the efficacy and safety of 7-day outpatient treatment with the combination of intensive insulin therapy and sodium-glucose transporter 2 inhibitor (SGLT2-I). All participa...

journal_title：Endocrine journal

authors： Kurozumi A,Okada Y,Tanaka Y

更新日期：2020-11-18 00:00:00

abstract：:Estrogen plays pivotal roles in body weight regulation through its effects on central estrogen receptor-α (ERα) expression. ERα is found on neurons that express the hypothalamic anorexigenic factors steroidogenic factor-1 (SF-1) and pro-opiomelanocortin (POMC) mediate these effects of estrogen. As the gonadal hormonal...

journal_title：Endocrine journal

authors： Iwasa T,Matsuzaki T,Mayila Y,Yano K,Irahara M

更新日期：2017-12-28 00:00:00