Abstract:
:The purpose of this prospective study was to characterize the changes in serum levels of two proteins produced during the synthesis and degradation of type I collagen, i.e., the carboxyterminal propeptide of type I procollagen (PICP) and the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), respectively, after oophorectomy, and to assess the degree of correlation between changes in the serum values of these proteins and changes in bone mineral density (BMD) of the lumbar spine. Serum levels of PICP, ICTP and bone gla protein (BGP) were determined in 18 women before oophorectomy (baseline) and at 7 days, and 1, 2, 3, 6, 9 and 12 months post-oophorectomy (PO). The BMD of the lumbar spine was measured at baseline, and at 6 months and 12 months PO. ICTP had increased significantly at 7 days PO and peaked between 1 and 3 months PO. PICP and BGP had increased significantly at 2 months PO and remained at high levels thereafter. The percent changes in lumbar BMD from baseline values (% CFB) at 6 months and at 12 months PO were significantly correlated with % CFB in ICTP, but not with % CFB in PICP or BGP. Accordingly, bone resorption is a main determinant of bone mineral loss after oophorectomy and the change in recently-developed bone resorption markers, such as ICTP, is of clinical utility in predicting a degree of subsequent bone loss after surgical menopause.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Yasumizu T,Fukada Y,Hoshi Kdoi
10.1507/endocrj.46.337subject
Has Abstractpub_date
1999-04-01 00:00:00pages
337-43issue
2eissn
0918-8959issn
1348-4540journal_volume
46pub_type
杂志文章abstract::Breast cancer in young women younger than 35 years old is rare, aggressive and associated with a poor prognosis. Endocrine therapy is a preferred treatment modality in hormone receptor-positive early stage and advanced breast cancer, combined therapy of goserelin and letrozole presents an option for premenopausal wome...
journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
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更新日期:2013-01-01 00:00:00
abstract::Pregnancy in acromegalic patients is a rare event, but is usually uneventful, with stable GH and IGF-I levels and no tumor enlargement. Medical treatment can usually be withdrawn without problems and although no major adverse event has been reported, the suspension of drug treatments is generally recommended. No cas...
journal_title:Endocrine journal
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pub_type: 临床试验,杂志文章
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更新日期:2012-01-01 00:00:00
abstract::It seems reasonable to expect that biochemical changes occurring in the pregnant woman with diabetes should be reflected in the placenta structure. However, it has not been possible to correlate placental morphology with glycemic control in a comparison between those with long life diabetes and poorly controlled gesta...
journal_title:Endocrine journal
pub_type: 杂志文章
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abstract::A 77-year-old man was diagnosed as having hypothyroidism. An electrocardiogram obtained at the time of the first examination revealed Brugada electrocardiographic waveforms in leads V1 to V3. When pilsicainide hydrochloride loading changed the waveforms of the electrocardiographic ST segment, this result suggested an ...
journal_title:Endocrine journal
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journal_title:Endocrine journal
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2008-08-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1993-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2005-04-01 00:00:00
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更新日期:2016-10-29 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1999-08-01 00:00:00
abstract::Guanylin (Gn), a bioactive peptide, and its receptor, guanylyl cyclase-C (GC-C), are primarily present in the intestine and maintain homeostasis in body fluids. Recently, rats whose macrophages overexpress Gn and GC-C were found to be resistant to diet-induced obesity. Considering that obesity is strongly related to a...
journal_title:Endocrine journal
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更新日期:2015-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2004-02-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2016-06-30 00:00:00
abstract::A series of chimeric TSH-LH/CG receptors were constructed by substituting homologous segments of the extracellular domain of the rat TSH receptor with corresponding segments of rat LH/CG receptor: C1 (amino acids 37-123 substituted), C2 (91-112), C3 (173-234), C4 (233-266), C5 (268-304), C6 (112-305) and C7 (36-404). ...
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pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
abstract::Betacellulin (BTC) purified from mouse beta cell tumor (betaTC-3) is a new member of the epidermal growth factor (EGF) family which can bind receptor tyrosine kinase, EGF receptor (erbB1) and erbB4. It has been demonstrated that proBTC mRNA was abundantly expressed in human pancreas tissue, and that BTC converted amyl...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.755
更新日期:1999-12-01 00:00:00
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更新日期:1997-04-01 00:00:00
abstract::A 19-year-old girl presented at our emergency room with hypokalemic periodic paralysis. She had a thyrotoxic goiter and had experienced three paralytic attacks during the previous 2 years on occasions when she stopped taking antithyroid drugs. In addition to thyrotoxic periodic paralysis (TPP), she had metabolic acido...
journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2011-01-01 00:00:00
abstract::A 67-year-old female with hypertension and impaired glucose tolerance was admitted to our hospital because of a typical acromegalic appearance, including large, thickened bulky hands and feet, and a large prominent forehead and tongue. She did not have a Cushingoid appearance, such as a moon-face, buffalo hump, purple...
journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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更新日期:2018-10-29 00:00:00