Abstract:
:It seems reasonable to expect that biochemical changes occurring in the pregnant woman with diabetes should be reflected in the placenta structure. However, it has not been possible to correlate placental morphology with glycemic control in a comparison between those with long life diabetes and poorly controlled gestational diabetes. In the present study we have histologically studied the syncytiotrophoblast of human placentae from overt diabetic and poorly controlled gestational diabetic patients. Using specific staining techniques and direct light microscopy we qualitatively studied these placentae and compared them with the normal placentae. We found fibrin thrombi, villous oedema, hyperplasia and thickening of basement membrane in the placentae of poorly controlled gestational diabetic mothers. Direct microscopy revealed that these various changes in syncytiotrophoblast structure were marked in the poorly controlled gestational placenta compared with overt diabetics, and could have been due to the presence of histochemical compounds e.g. general carbohydrates and lipids. These studies may indicate that poor control of diabetes during the gestation as indicated by high level HbAlc may result in the accummulation of carbohydrate compounds and fat droplets in the placental basement membrane, leading to structural changes in the placental cells.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
al-Okail MS,al-Attas OSdoi
10.1507/endocrj.41.355subject
Has Abstractpub_date
1994-08-01 00:00:00pages
355-60issue
4eissn
0918-8959issn
1348-4540journal_volume
41pub_type
杂志文章abstract::The cytologic localization and cellular levels of insulin-like growth factor binding protein-4 (IGFBP-4) in follicular and stromal compartments of normal and polycystic ovary syndrome (PCOS) ovaries during follicular growth and regression were investigated by the avidin/biotin immunoperoxidase method with a polyclonal...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.43.269
更新日期:1996-06-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2009-01-01 00:00:00
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journal_title:Endocrine journal
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更新日期:2017-12-28 00:00:00
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更新日期:2020-04-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1997-10-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k07-044
更新日期:2007-12-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ17-0539
更新日期:2018-06-27 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ17-0325
更新日期:2018-01-30 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ19-0224
更新日期:2020-03-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1997-04-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0078
更新日期:2016-07-30 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-12-30 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章,meta分析
doi:10.1507/endocrj.ej14-0071
更新日期:2014-01-01 00:00:00
abstract::A fasting triglyceridemia >10 mmol/L is associated with chylomicronemia (CM) and an increased recurrent acute pancreatitis (RAP) risk. The number of pancreatitis episodes varies significantly between patients with CM. The objective of this study was to investigate gene expression profiles of RAP in patients with CM. A...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ20-0123
更新日期:2020-11-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.47.supplmarch_s77
更新日期:2000-03-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.50.61
更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Endocrine journal
pub_type: 临床试验,杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ14-0289
更新日期:2015-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej11-0306
更新日期:2012-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k07e-020
更新日期:2008-03-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k06-010
更新日期:2006-10-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k06-103
更新日期:2007-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k10e-046
更新日期:2010-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k05-120
更新日期:2007-12-01 00:00:00
abstract::This study assessed the dose-dependent efficacy and safety of exenatide over 12 weeks in Japanese patients with type 2 diabetes suboptimally controlled despite therapeutic doses of sulfonylurea (SU), SU plus biguanide, or SU plus thiazolidinedione. Patients were randomly assigned to placebo (N = 40), 2.5 microg (N = 3...
journal_title:Endocrine journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1507/endocrj.k08e-296
更新日期:2009-01-01 00:00:00