Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion.

Abstract:

:Central diabetes insipidus (CDI) is characterized by polyuria and polydipsia caused by impairment of arginine vasopressin (AVP) secretion. In this study, we evaluated plasma AVP concentrations during a hypertonic saline infusion test using a new AVP radioimmunoassay (RIA) which is now available in Japan. Thirteen control subjects, mostly with hypothalamo-pituitary disease but without CDI, and 13 patients with CDI were enrolled in the study. Whether or not subjects had CDI was determined based on the totality of clinical data, which included urine volumes and osmolality. Regression analysis of plasma AVP and serum Na concentrations revealed that the gradient was significantly lower in the CDI group than in the control group. The area under the receiver-operating-characteristic (ROC) curve was 0.99, and the <0.1 gradient cut-off values for the simple regression line to distinguish CDI from control had a 100% sensitivity and a 77% specificity. The ROC analysis with estimated plasma AVP concentrations at a serum Na concentration of 149 mEq/L showed that the area under the ROC curve was 1.0 and the <1.0 pg/mL cut-off values of plasma AVP had a 99% sensitivity and a 95% specificity. We conclude that measurement of AVP by RIA during a hypertonic saline infusion test can differentiate patients with CDI from those without CDI with a high degree of accuracy. Further investigation is required to confirm whether the cut-off values shown in this study are also applicable to a diagnosis of partial CDI or a differential diagnosis between CDI and primary polydipsia.

journal_name

Endocr J

journal_title

Endocrine journal

authors

Takagi H,Hagiwara D,Handa T,Sugiyama M,Onoue T,Tsunekawa T,Ito Y,Iwama S,Goto M,Suga H,Banno R,Takahashi K,Matsui S,Arima H

doi

10.1507/endocrj.EJ19-0224

subject

Has Abstract

pub_date

2020-03-28 00:00:00

pages

267-274

issue

3

eissn

0918-8959

issn

1348-4540

journal_volume

67

pub_type

杂志文章
  • Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests.

    abstract::Since there is increasing evidence that postprandial hyperglycemia is a risk factor for the development of macrovascular complications, it is important to predict postprandial hyperglycemia in the early stages of glucose intolerance, and routine medical checkups provide a good opportunity to do so. The aim of this stu...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k10e-224

    authors: Goto M,Yamamoto-Honda R,Shimbo T,Goto A,Terauchi Y,Kanazawa Y,Noda M

    更新日期:2011-01-01 00:00:00

  • Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.

    abstract::Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-rel...

    journal_title:Endocrine journal

    pub_type: 临床试验,杂志文章

    doi:10.1507/endocrj.EJ19-0313

    authors: Irie J,Inagaki E,Fujita M,Nakaya H,Mitsuishi M,Yamaguchi S,Yamashita K,Shigaki S,Ono T,Yukioka H,Okano H,Nabeshima YI,Imai SI,Yasui M,Tsubota K,Itoh H

    更新日期:2020-02-28 00:00:00

  • Absence of mutations at codon 768 of the RET proto-oncogene in sporadic and hereditary pheochromocytomas.

    abstract::Sixteen sporadic pheochromocytomas, 3 pheochromocytomas in neurofibromatosis 1, and 4 pheochromocytomas in multiple endocrine neoplasia (MEN) 2A or 2B were screened for mutations at codon 768 of the RET proto-oncogene by AluI digestion of polymerase chain reaction PCR products and mutations in exon 13 by PCR-single st...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.43.109

    authors: Yoshimoto K,Kimura T,Tanaka C,Moritani M,Iwahana H,Itakura M

    更新日期:1996-02-01 00:00:00

  • Prolactin expresses differential effects on apoptotic cell death of luteal cells in vivo and in vitro.

    abstract::PRL surges in female rats have dual effects of luteal function: either inducing luteolysis during the estrous cycle or rescuing and maintaining luteal function during pseudopregnancy. We analyzed these apparent contradictory effects in relation to apoptosis. The detection of fragmented DNA and in situ 3'-end labeling ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.44.11

    authors: Kanuka H,Matsuyama S,Ohnishi M,Matsumoto Y,Nishihara M,Takahashi M

    更新日期:1997-02-01 00:00:00

  • Statural growth in 31 Japanese patients with SHOX haploinsufficiency: support for a disadvantageous effect of gonadal estrogens.

    abstract::Although gonadal estrogens are known to facilitate the development of skeletal lesion in SHOX haploinsufficiency, controversy exists as to whether gonadal estrogens are disadvantageous to pubertal growth. To clarify this matter, we analyzed growth pattern in 31 Japanese patients with a normal karyotype and molecularly...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.51.197

    authors: Fukami M,Nishi Y,Hasegawa Y,Miyoshi Y,Okabe T,Haga N,Nagai T,Tanaka T,Ogata T

    更新日期:2004-04-01 00:00:00

  • Lower body weight and BMI at birth were associated with early adiposity rebound in 21-hydroxylase deficiency patients.

    abstract::21-hydroxylase deficiency (21-OHD) is the most common type of congenital adrenal hyperplasia. In addition to the clinical problems caused by adrenal insufficiency and androgen excess, a risk for obesity and metabolic syndrome during young adulthood is a major ramification of the disease. Although glucocorticoid therap...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ16-0194

    authors: Takishima S,Nakajima K,Nomura R,Tsuji-Hosokawa A,Matsuda N,Matsubara Y,Ono M,Miyai K,Takasawa K,Morio T,Hasegawa Y,Kashimada K

    更新日期:2016-11-30 00:00:00

  • Immunoglobulin G can cross-react with glucagon antisera and cause a spuriously high plasma immunoreactive glucagon level.

    abstract::We had a patient with asymptomatic hyper-immunoreactive glucagonemia and with no evidence of pancreatic tumor detected by radiological examinations. The glucagon level was not decreased by the administration of glucose or somatosatin analogue (SMS 201-995). Gel filtration studies revealed that most glucagon immunoreac...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.42.455

    authors: Hattori N,Saiki Y,Kajikawa M,Ishihara T,Moridera K,Hino M,Ikekubo K,Kurahachi H

    更新日期:1995-08-01 00:00:00

  • Increased Fructose 2,6-bisphosphate in peripheral blood mononuclear cells of patients with diabetes.

    abstract::Fructose 2,6-bisphosphate (F2,6BP) is a powerful allosteric activator of 6-phosphofructo-1-kinase, which is the rate-limiting enzyme for glycolysis. Mitogenic stimulation of lymphocytes is related to an enhanced rate of glucose utilization and F2,6BP mediated activation of glycolysis. To determine the effect of hyperg...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k06-205

    authors: Atsumi T,Chiba H,Yoshioka N,Bucala R,Koike T

    更新日期:2007-08-01 00:00:00

  • Tumor necrosis factor-alpha (TNF-alpha) inhibits insulin-like growth factor-I (IGF-I) activities in human trophoblast cell cultures through IGF-I/insulin hybrid receptors.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) in placenta is believed to be involved in pathogenesis of intrauterine growth restriction. In contrast, insulin-like growth factors (IGFs) are believed to be important for stimulation of fetal and placental growth. IGF-I stimulates metabolic and growth-promoting actions directly...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k09e-189

    authors: Hashimoto R,Sakai K,Matsumoto H,Iwashita M

    更新日期:2010-01-01 00:00:00

  • Efficiency of stem cell based therapy in the treatment of diabetic foot ulcer: a meta-analysis.

    abstract::Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patient. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. Howe...

    journal_title:Endocrine journal

    pub_type: 杂志文章,meta分析

    doi:10.1507/endocrj.EJ17-0424

    authors: Shu X,Shu S,Tang S,Yang L,Liu D,Li K,Dong Z,Ma Z,Zhu Z,Din J

    更新日期:2018-04-26 00:00:00

  • Thyroxine prophylaxis after bilateral subtotal thyroidectomy for multinodular goiter.

    abstract::In this study, we investigated the value of thyroxine administration to prevent recurrence after bilateral subtotal thyroidectomy for multinodular goiter. Patients that had benign multinodular goiter were operated on with the same surgical principles: ligation of both superior and inferior thyroid arteries on both sid...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.47.349

    authors: Kulaçoglu H,Dener C,Ziraman I,Kama NA

    更新日期:2000-06-01 00:00:00

  • Ratio of serum free triiodothyronine to free thyroxine in Graves' hyperthyroidism and thyrotoxicosis caused by painless thyroiditis.

    abstract::The serum T3 to T4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T3 (FT3) to free T4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made u...

    journal_title:Endocrine journal

    pub_type: 杂志文章,多中心研究

    doi:10.1507/endocrj.52.537

    authors: Yoshimura Noh J,Momotani N,Fukada S,Ito K,Miyauchi A,Amino N

    更新日期:2005-10-01 00:00:00

  • Insulin secretion and insulin sensitivity on the oral glucose tolerance test (OGTT) in middle-aged Japanese.

    abstract::The aim of this study was to assess the changes in insulin secretion and insulin sensitivity in relation to fasting and 2-hour plasma glucose (PG) levels and to assess the independent contributions of their impairments to non-diabetic hyperglycemia. A total of 2157 Japanese workers (mean age 52.6±7.3 years and mean B...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.ej11-0157

    authors: Oka R,Yagi K,Sakurai M,Nakamura K,Moriuchi T,Miyamoto S,Nohara A,Kawashiri MA,Takeda Y,Yamagishi M

    更新日期:2012-01-01 00:00:00

  • Self-examination of thyroid nodules.

    abstract::The management of occult small thyroid nodules found by ultrasonography is sometimes problematic. Self-palpation may be utilized in the follow-up of these nodules. We developed a method of thyroid self-examination (TSE). We examined the size of the nodules palpable by this method by ultrasonography. In 78 patients exa...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.47.591

    authors: Takano T,Hasegawa Y,Amino N

    更新日期:2000-10-01 00:00:00

  • Simvastatin rescues homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by decreasing the expressions of NADPH oxidase 1 and 2.

    abstract::Clinical studies have shown that hyperhomocysteinemia is associated with bone fragility. Homocysteine (Hcy) induces apoptosis of osteoblastic cell lineage by increasing oxidative stress, which may contribute to Hcy-induced bone fragility. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, ameliorate ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ15-0480

    authors: Takeno A,Kanazawa I,Tanaka K,Notsu M,Yokomoto-Umakoshi M,Sugimoto T

    更新日期:2016-04-25 00:00:00

  • Individualization of recommendations from the international consensus on continuous glucose monitoring-derived metrics in Japanese children and adolescents with type 1 diabetes.

    abstract::We assessed the significance of recommendations from the international consensus on continuous glucose monitoring (CGM)-derived metrics in Japanese children and adolescents with type 1 diabetes. Eighty-five patients (age, 13.5 ± 4.7 years) who wore the FreeStyle® Libre for a 28-day period were enrolled in this study. ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ20-0193

    authors: Urakami T,Yoshida K,Kuwabara R,Mine Y,Aoki M,Suzuki J,Morioka I

    更新日期:2020-10-28 00:00:00

  • Plasma levels of insulin-like growth factor-I are reduced at one week of age in monosodium L-glutamate-treated mice.

    abstract::Administration of monosodium L-glutamate (MSG) to neonatal mice produces a hypothalamic syndrome consisting of stunted growth and later development of obesity. We assayed plasma insulin (IRI), thyroxine (T4) and insulin-like growth factor-I (IGF-I) to investigate their roles in the growth of the mice. Two mg/g body we...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.40.461

    authors: Yamamoto T,Matsuo S,Ueshima Y,Inoue F,Kinugasa A,Sawada T

    更新日期:1993-08-01 00:00:00

  • False negatives at neonatal screening for congenital adrenal hyperplasia in two siblings with 21-hydroxylase deficiency.

    abstract::We report on two siblings with classic simple virilizing 21-hydroxylase deficiency whose neonatal screening for serum 17alpha-hydroxyprogesterone (17-OHP) gave normal results. The proband, a girl with clitoromegaly whose screening 17-OHP value had been 9.2 ng/ml, was diagnosed at the age of 6 months, and her elder bro...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.45.427

    authors: Shinohara O,Ishiguro H,Shinagawa T,Kubota C

    更新日期:1998-06-01 00:00:00

  • Pathogenesis of chronic hypernatremia with dehydrated and non-dehydrated states in hypothalamic space-occupying lesions.

    abstract::The present study was undertaken to determine pathophysiology of body water control in hypernatremic subjects with hypothalamic space-occupying lesions. Eight subjects with hypothalamic space-occupying lesions were divided into two groups of hypernatremia in the presence or absence of body water deficit. In 5 dehydrat...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k07e-132

    authors: Hayashi T,Murata M,Saito T,Ikoma A,Tamemoto H,Kawakami M,Ishikawa SE

    更新日期:2008-08-01 00:00:00

  • Impaired β-cell function and decreased insulin sensitivity in subjects with normal oral glucose tolerance but isolated high glycosylated hemoglobin.

    abstract::The pathophysiology is distinct in various state of glucose metabolism abnormalities. As the defect of individuals with normal oral glucose tolerance (NGT) but isolated high glycosylated hemoglobin (HbA1c), i.e. iHH, was ambiguous, we aimed to investigate the insulin sensitivity and β-cell function of iHH. According t...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ17-0325

    authors: Fu Q,Sun M,Wang Z,He W,Duan Y,Yang T

    更新日期:2018-01-30 00:00:00

  • Increased urinary levels of pentosidine, pyrraline and acrolein adduct in type 2 diabetes.

    abstract::This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.50.61

    authors: Daimon M,Sugiyama K,Kameda W,Saitoh T,Oizumi T,Hirata A,Yamaguchi H,Ohnuma H,Igarashi M,Kato T

    更新日期:2003-02-01 00:00:00

  • Improvement of lymph node recurrence rate, but not distant recurrence and carcinoma death rates, in patients with papillary thyroid carcinoma after disease-free survival for 5 years.

    abstract::In this study, we investigated the difference in lymph node-recurrence free survival (LN-RFS), distant recurrence-free survival (DRFS), and cause-specific survival (CSS) between patients with papillary thyroid carcinoma (PTC) in the entire group (Group I) and those with lymph node- and distant-recurrence-free survival...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.ej12-0176

    authors: Ito Y,Kudo T,Kihara M,Takamura Y,Kobayashi K,Miya A,Miyauchi A

    更新日期:2012-01-01 00:00:00

  • The ratio of glycated albumin to hemoglobin A1c measured in IFCC units accurately represents the glycation gap.

    abstract::The glycation gap (G-gap: difference between measured hemoglobin A1c [A1C] and the value predicted by its regression on the fructosamine level) is stable and associated with diabetic complications. Measuring A1C level in International Federation of Clinical Chemistry (IFCC) units (A1C-SI; mmol/mol) and National Glycoh...

    journal_title:Endocrine journal

    pub_type: 杂志文章,多中心研究

    doi:10.1507/endocrj.EJ14-0066

    authors: Akatsuka J,Mochizuki M,Musha I,Ohtake A,Kobayashi K,Kikuchi T,Kikuchi N,Kawamura T,Urakami T,Sugihara S,Hoshino T,Amemiya S,Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes.

    更新日期:2015-01-01 00:00:00

  • Ultrasonographic features of parathyroid carcinoma.

    abstract::Although several authors have reported single cases illustrative of some ultrasonographic characteristic of parathyroid carcinoma, the value of ultrasonography for diagnosing this entity remains to be determined. The purpose of our study was to investigate the ultrasonographic features of parathyroid carcinoma in a la...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.48.213

    authors: Hara H,Igarashi A,Yano Y,Yashiro T,Ueno E,Aiyoshi Y,Ito K,Obara T

    更新日期:2001-04-01 00:00:00

  • Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese--the J-MICC Study.

    abstract::We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after inform...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.ej12-0307

    authors: Hishida A,Wakai K,Okada R,Morita E,Hamajima N,Hosono S,Higaki Y,Turin TC,Suzuki S,Motahareh K,Mikami H,Tashiro N,Watanabe I,Katsuura S,Kubo M,Tanaka H,Naito M

    更新日期:2013-01-01 00:00:00

  • Prevalence of lymphocytic infiltrate in 1400 pituitary adenomas.

    abstract::To evaluate the prevalence of lymphocytic infiltrate in a large series of pituitary adenomas, we retrospectively studied tumor tissues from 1400 patients. Based on immunocytochemical data, tumors were classified as PRL (n=411), multihormonal (n=310), immunonegative (n=275), ACTH (n=166), GH (n=137), alpha subunit (n=4...

    journal_title:Endocrine journal

    pub_type: 杂志文章,多中心研究

    doi:10.1507/endocrj.45.357

    authors: Heshmati HM,Kujas M,Casanova S,Wollan PC,Racadot J,Van Effenterre R,Derome PJ,Turpin G

    更新日期:1998-06-01 00:00:00

  • High insulin impaired ovarian function in early pregnant mice and the role of autophagy in this process.

    abstract::Metabolic disorders, such as PCOS (polycystic ovarian syndrome) and T2DM (type 2 diabetes mellitus), are associated with menstrual dysfunction, anovulation, infertility, and early pregnancy loss. Ovarian dysfunction is not only related to low pregnancy rates but also to the increased risk of miscarriage. Women with PC...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ16-0494

    authors: Su Y,Wu J,He J,Liu X,Chen X,Ding Y,Zhang C,Chen W,Wang Y,Gao R

    更新日期:2017-06-29 00:00:00

  • Erdheim-Chester disease: report of a case with PCR-based analysis of the expression of osteopontin and survivin in Xanthogranulomas following glucocorticoid treatment.

    abstract::Erdheim-Chester disease (ECD) is a form of non-Langerhans histiocytosis. In this report, we show a case of ECD presenting diabetes insipidus and multiple xanthogranulomas received glucocorticoid treatment over a year. During this period, xanthogranulomas improved in response to the glucocorticoid therapy. Furthermore,...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k07e-044

    authors: Taguchi T,Iwasaki Y,Asaba K,Yoshida T,Takao T,Ikeno F,Nakajima H,Kodama H,Hashimoto K

    更新日期:2008-03-01 00:00:00

  • A nitric oxide synthesis inhibitor prevents the ACTH-stimulated production of aldosterone in rat adrenal gland.

    abstract::The synthesis of nitric oxide (NO) has been demonstrated in the vascular endothelial cells and other tissues including in rat and bovine adrenal gland. To determine whether NO mediates aldosterone production in the adrenals, we evaluated the basal production of aldosterone, and the ACTH or angiotensin II (A II)-stimul...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.43.157

    authors: Nakayama T,Izumi Y,Soma M,Kanmatsuse K

    更新日期:1996-04-01 00:00:00

  • Diagnosis and treatment of autoimmune and IgG4-related hypophysitis: clinical guidelines of the Japan Endocrine Society.

    abstract::Hypophysitis, which is often accompanied by pituitary dysfunction, is classified into several subtypes based on the cause, histology, and the location of inflammation in the pituitary gland. A definitive diagnosis requires pituitary biopsy, which is invasive, and the process is limited to specialized clinical settings...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ19-0569

    authors: Takagi H,Iwama S,Sugimura Y,Takahashi Y,Oki Y,Akamizu T,Arima H

    更新日期:2020-04-28 00:00:00