Comparison of glycated albumin (GA) and glycated hemoglobin (HbA1c) in type 2 diabetic patients: usefulness of GA for evaluation of short-term changes in glycemic control.


:We studied the cross-sectional relationship between GA and HbA1c in 142 type 2 diabetic patients who had an HbA1c level < 7.5% for at least one year without fluctuation by more than 0.5%. We also followed the changes of GA and HbA1c in 18 type 2 diabetic patients for 16 weeks as they progressed from untreated severe hyperglycemia (HbA1c > or = 9.0%) to good glycemic control (HbA1c < or = 6.5%) by intensive insulin treatment. The annual mean levels of GA and HbA1c in the stably controlled patients showed a weak, but significant, correlation (r = 0.23, p<0.001) in the 142 diabetic patients. However, the GA/HbA1c ratio ranged widely from 2.0 to 4.0 showing a normal distribution (2.9 +/- 0.34, M +/- SE), although patients with conditions affecting albumin turnover or RBC lifespan were excluded from the study. The GA/HbA1c ratio was significantly higher when patients were in hyperglycemic than when glycemic control was good (3.5 +/- 0.15 vs. 2.9 +/- 0.07, M +/- SE, p<0.01). GA decreased more rapidly than HbA1c during intensive insulin therapy, but the percent reduction of HbA1c eventually corresponded with that of GA by 16 weeks after the start of treatment. These results demonstrate that, although unknown influences on GA or HbA1c may exist, GA may be a useful marker for monitoring short-term variations of glycemic control during treatment of diabetic patients.


Endocr J


Endocrine journal


Takahashi S,Uchino H,Shimizu T,Kanazawa A,Tamura Y,Sakai K,Watada H,Hirose T,Kawamori R,Tanaka Y




Has Abstract


2007-02-01 00:00:00














  • The effect of calcium-sensing receptor gene polymorphisms on serum calcium levels: a familial hypocalciuric hypercalcemia family without mutation in the calcium-sensing receptor gene.

    abstract::Familial hypocalciuric hypercalcemia (FHH) is a benign syndrome with elevated levels of serum calcium, relative hypocalciuria, and non-suppressed serum parathyroid hormone (PTH) levels. FHH usually occurs by a heterozygous mutation of the calcium sensing receptor (Casr), but some FHH patients show no mutations of the ...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kanazawa H,Tanaka H,Kodama S,Moriwake A,Kobayashi M,Seino Y

    更新日期:2000-02-01 00:00:00

  • Primary granulomatous hypophysitis: a case report and literature review.

    abstract::Primary granulomatous hypophysitis (PGH) is a rarely occurred inflammatory disease of unknown etiology. We retrospective review a case of PGH treated by microsurgical transsphenoidal approach and review the appropriately documented cases of PGH collected from the literatures. The patient was a 56-year-old female who p...

    journal_title:Endocrine journal

    pub_type: 杂志文章,评审


    authors: Su SB,Zhang DJ,Yue SY,Zhang JN

    更新日期:2011-01-01 00:00:00

  • Low plasma corticotropin-releasing hormone (CRH) levels in patients with non-insulin dependent diabetes mellitus (NIDDM).

    abstract::Plasma CRH levels were measured in patients with non-insulin dependent diabetes mellitus (NIDDM) as the pituitary-adrenal abnormalities have been reported in NIDDM. They were also measured after oral administration of 75 g glucose to examine whether glucose increased plasma CRH along with insulin secretion. The baseli...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Hashimoto K,Nishioka T,Takao T,Numata Y

    更新日期:1993-12-01 00:00:00

  • Long-term effects of thyroid hormone on lymphocyte subsets in spleens and thymuses of mice.

    abstract::We examined the effects of the long-term administration to mice of thyroid hormone or propylthiouracil (PTU) on lymphocyte subsets in spleens, and thymuses to clarify whether hyperthyroxinemia itself causes the changes in lymphocyte subsets, such as the marked increase in CD5+ B cells and decrease in natural killer (N...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Watanabe K,Iwatani Y,Hidaka Y,Watanabe M,Amino N

    更新日期:1995-10-01 00:00:00

  • Expression of Fas/Fas-ligand, Bcl-2 protein and apoptosis in extravillous trophoblast along invasion to the decidua in human term placenta.

    abstract::There are two local subtypes of extravillous trophoblast (EVT): one is the proliferative phenotype of EVT, which primarily consists of proximal cells and the other is the invasive phenotype of EVT, which is composed mainly of distal cells of cell columns. The mechanism of invasion of EVT to the decidua remains obscure...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Murakoshi H,Matsuo H,Laoag-Fernandez JB,Samoto T,Maruo T

    更新日期:2003-04-01 00:00:00

  • Changes in pediatric thyroid sonograms in or nearby the Kanto region before and after the accident at the Fukushima Daiichi nuclear power plant.

    abstract::Following the accident at the Fukushima Daiichi Nuclear Power Station which occurred on March 11, 2011 due to the Eastern Japan Great Earthquake (the Accident), there have been concerns over elevation of the risk of thyroid cancer among children due to internal exposure to radioactive iodine. In Fukushima Prefecture, ...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Iwaku K,Noh JY,Sasaki E,Suzuki N,Kameda T,Kobayashi S,Yoshihara A,Ohye H,Watanabe N,Suzuki M,Matsumoto M,Kunii Y,Mukasa K,Sugino K,Ito K

    更新日期:2014-01-01 00:00:00

  • TSH receptor antibody titers measured with a third-generation assay did not reflect the activity of Graves' ophthalmopathy in untreated Japanese Graves' disease patients.

    abstract::TSH receptor antibody (TRAb) titer has been reported to be correlated with Graves' ophthalmopathy (GO). However, the correlation between GO activity and TRAb titer assessed with a third-generation assay has not been reported. We enrolled 238 untreated Graves' disease patients who came to the outpatient clinic of Ito H...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Mukasa K,Yoshimura Noh J,Kouzaki A,Ohye H,Kunii Y,Watanabe N,Yoshihara A,Matsumoto M,Suzuki M,Ito K

    更新日期:2016-01-01 00:00:00

  • Proposal of diagnostic criteria for IgG4-related thyroid disease.

    abstract::Patients with IgG4-related disease (IgG4-RD) are diagnosed in Japan by comprehensive or organ-specific diagnostic criteria. To date, organ-specific criteria have been established for several organs, but not for the thyroid. We attempted to establish diagnostic criteria for IgG4-related thyroid disease (IgG4-RTD) based...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Takeshima K,Li Y,Kakudo K,Hirokawa M,Nishihara E,Shimatsu A,Takahashi Y,Akamizu T

    更新日期:2021-01-28 00:00:00

  • Short term effects of atorvastatin on endothelial functions and oxidized LDL levels in patients with type 2 diabetes.

    abstract:OBJECTIVE:This study was designed in order to investigate the short term effects of atorvastatin on endothelial function and oxidized LDL (oxLDL) levels and to evaluate the association of endothelial dysfunction to oxLDL levels and inflammatory markers in type 2 diabetic patients. MATERIAL AND METHODS:Thirty type 2 di...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Akalin A,Temiz G,Akcar N,Sensoy B

    更新日期:2008-10-01 00:00:00

  • Syndrome of inappropriate antidiuresis seen twice in eight years.

    abstract::We present a rare case of a 66-year-old woman with the syndrome of inappropriate antidiuresis (SIAD) accompanied by an empty sella whose symptoms were seen twice in the eight years after the administration of non-steroidal anti-inflammatory drugs (NSAID) or prochlorperazine. No diuresis or suppression of the plasma le...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Shimada T,Higashi K,Kimura K,Shido T,Tomita K

    更新日期:1995-04-01 00:00:00

  • Prognosis of patients with papillary carcinoma showing anaplastic transformation in regional lymph nodes that were curatively resected.

    abstract::Anaplastic carcinoma arises from differentiated carcinoma and generally shows a dire prognosis. Anaplastic transformation may occur not only in primary tumors but also in metastatic lymph nodes. We encountered 5 cases of papillary carcinoma showing anaplastic transformation in lymph nodes that were curatively resected...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Ito Y,Higashiyama T,Hirokawa M,Fukushima M,Inoue H,Yabuta T,Tomoda C,Uruno T,Kihara M,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Miyauchi A

    更新日期:2008-12-01 00:00:00

  • Simvastatin rescues homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by decreasing the expressions of NADPH oxidase 1 and 2.

    abstract::Clinical studies have shown that hyperhomocysteinemia is associated with bone fragility. Homocysteine (Hcy) induces apoptosis of osteoblastic cell lineage by increasing oxidative stress, which may contribute to Hcy-induced bone fragility. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, ameliorate ...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Takeno A,Kanazawa I,Tanaka K,Notsu M,Yokomoto-Umakoshi M,Sugimoto T

    更新日期:2016-04-25 00:00:00

  • Influence of thyroid dysfunction on brain natriuretic peptide level in health examination participants.

    abstract::The tissue-specific circulating markers of thyroid hormone action on cardiac function have not been established. Although the relationship between thyroid function and plasma brain natriuretic peptide (BNP) levels has been evaluated in patients with thyroid disorders, the relationship between these parameters in the g...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Ohba K,Okada E,Goto Y,Suzuki S,Machii M,Nonaka D,Matsushita A,Sasaki S,Suda T,Oki Y,Takase H

    更新日期:2020-04-28 00:00:00

  • Gonadal dysgenesis: associations between clinical features and sex of rearing.

    abstract::The purpose of this study was to review the phenotypic and endocrine features or a series of patients with ambiguous genitalia or sex-reversal due to gonadal dysgenesis (GD) and to analyse the impact of these on the decision about sex of rearing. This study is a retrospective analysis of 22 patients with GD treated be...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Cameron FJ,Montalto J,Byrt EA,Sinclair AH,Warne GL

    更新日期:1997-02-01 00:00:00

  • Efficiency of stem cell based therapy in the treatment of diabetic foot ulcer: a meta-analysis.

    abstract::Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patient. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. Howe...

    journal_title:Endocrine journal

    pub_type: 杂志文章,meta分析


    authors: Shu X,Shu S,Tang S,Yang L,Liu D,Li K,Dong Z,Ma Z,Zhu Z,Din J

    更新日期:2018-04-26 00:00:00

  • Effect of treatment with epoprostenol and endothelin receptor antagonists on the development of thyrotoxicosis in patients with pulmonary arterial hypertension.

    abstract::Thyroid disease is known to be associated with pulmonary arterial hypertension (PAH). We investigated the prevalence of thyroid disease in patients with idiopathic PAH (IPAH) or heritable PAH (HPAH), and the factors affecting the pathogenesis of thyroid disease. We retrospectively evaluated 59 patients with IPAH or HP...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Satoh M,Aso K,Nakayama T,Saji T

    更新日期:2017-12-28 00:00:00

  • A pedigree analysis of two homozygous mutant Gitelman syndrome cases.

    abstract::Gitelman syndrome (GS) is a salt-wasting tubulointerstitial disease of autosomal recessive inheritance (OMIM613395) caused by genic mutation of SLC12A3, which codes thiazide-sensitive Na-Cl cotransporter (NCCT) gene. The gene mutation of the majority of GS patients is compound heterozygous. This study analyzes two cas...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Luo J,Yang X,Liang J,Li W

    更新日期:2015-01-01 00:00:00

  • Cloning and characterization of the 4.2 kb region of the rat thyrotropin receptor promoter.

    abstract::We previously identified an approximately 200 bp "minimal promoter" of the rat TSH receptor (TSHR) gene which is essential for the promoter activity. In the present study, we have cloned and characterized an upstream region of the TSHR promoter to disclose additional functional element(s). We screened a rat genomic li...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Ikuyama S,Ohe K,Takayanagi R,Kohn LD,Nawata H

    更新日期:1997-04-01 00:00:00

  • Sex-related differences in gene expression in neonatal rat hypothalamus assessed by cDNA microarray analysis.

    abstract::Sexual differentiation of the rodent brain is recognized to involve transcriptional activation of multiple genes induced by gonadal steroids at developmental stages. To identify the genes differing in expression level between sexes, we analyzed gene expression in male and female rat hypothalami at postnatal day 5 by m...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Yonehara K,Suzuki M,Nishihara M

    更新日期:2002-04-01 00:00:00

  • The influence of American Society of Anesthesiologists Physical Status on patient morbidity and survival after total thyroidectomy.

    abstract::In cases of thyroid papillary carcinoma, a less aggressive cancer, surgeons may hesitate to perform total thyroidectomy on patients with poor general condition because these may experience longer survival without undergoing surgery. To investigate the influence of general patient condition on the patients' survival wh...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Shinohara S,Kikuchi M,Harada H,Takebayashi S,Yunoki K,Yamazaki K

    更新日期:2016-11-30 00:00:00

  • Fertility preservation in a family with a novel NR5A1 mutation.

    abstract::The common phenotype of nuclear receptor superfamily 5, group A, member 1 (NR5A1) gene mutations in 46,XY is gonadal dysgenesis without adrenal deficiency. Though the phenotype of gonadal dysgenesis is variable, ranging from complete female to normal male genitalia, an asymptomatic 46,XY male is rare. Preserved fertil...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Yagi H,Takagi M,Kon M,Igarashi M,Fukami M,Hasegawa Y

    更新日期:2015-01-01 00:00:00

  • High insulin impaired ovarian function in early pregnant mice and the role of autophagy in this process.

    abstract::Metabolic disorders, such as PCOS (polycystic ovarian syndrome) and T2DM (type 2 diabetes mellitus), are associated with menstrual dysfunction, anovulation, infertility, and early pregnancy loss. Ovarian dysfunction is not only related to low pregnancy rates but also to the increased risk of miscarriage. Women with PC...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Su Y,Wu J,He J,Liu X,Chen X,Ding Y,Zhang C,Chen W,Wang Y,Gao R

    更新日期:2017-06-29 00:00:00

  • Diurnal variation in growth hormone receptor messenger ribonucleic acid in liver and skeletal muscle of lit/+ and lit/lit mice.

    abstract::The present study investigated the diurnal variation in GH receptor (GHR) mRNA in liver and skeletal muscle of 3-month-old GH-deficient and -sufficient mice using quantitative real-time RT-PCR. lit/lit (GH deficient) or lit/+ (GH sufficient) mice were fed ad libitum and lights were on between 0600 and 2000. Tissues we...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Itoh E,Iida K,del Rincon JP,Kim DS,Thorner MO

    更新日期:2004-12-01 00:00:00

  • Collagenous colitis in a patient with Addison's disease: a case report.

    abstract::Diarrhea is a non-specific symptom which may be associated with Addison's disease and several causes had been demonstrated in the aetiology. We describe a patient with Addison's disease who was suffering from chronic diarrhea for three months. She was diagnosed as having collagenous colitis and successfully treated wi...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Unlühizarci K,Bayram F,Ozbakir O,Kirgin A,Patiroglu T,Yücesoy M,Keleştimur F

    更新日期:1998-08-01 00:00:00

  • Vitamin D in Hashimoto's thyroiditis and its relationship with thyroid function and inflammatory status.

    abstract::Several studies have shown the correlation between vitamin D [25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether t...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Botelho IMB,Moura Neto A,Silva CA,Tambascia MA,Alegre SM,Zantut-Wittmann DE

    更新日期:2018-10-29 00:00:00

  • TSH-receptor antibodies determined by the first, second and third generation assays and thyroid-stimulating antibody in pregnant patients with Graves' disease.

    abstract::The measurement of TSH receptor antibody (TRAb) has been recommended to predict the risk of neonatal hyperthyroidism (NH) in pregnant women with Graves' disease (GD). For the first generation TRAb (TRAb1) assay with commercial kit (Brahms, Berlin, Germany; or Cosmic co., Tokyo, Japan) an arbitrary limit of 40 U/l or 5...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kamijo K

    更新日期:2007-08-01 00:00:00

  • Relationship between the serum concentrations of C-reactive protein and parameters of adiposity and insulin resistance in patients with type 2 diabetes mellitus.

    abstract::Serum C-reactive protein (CRP) concentrations have been reported to be associated with body fat, especially visceral fat accumulation, but most studies up to now have been conducted on non-diabetic subjects. In this study, we investigated the association between the serum CRP concentrations and parameters of adiposity...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Iwasaki T,Nakajima A,Yoneda M,Terauchi Y

    更新日期:2006-06-01 00:00:00

  • Metabolic syndrome influencing infarct size and heart failure in patients with acute coronary syndrome: does gender matter?

    abstract::Metabolic syndrome (MetS) is the occurrence of diabetes mellitus/glucose intolerance, arterial hypertension, central obesity, dyslipidemia, and microalbuminuria in the same patient (definition by WHO). Presence of metabolic syndrome is associated with larger myocardial infarction size and complications following acut...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kranjcec D,Altabas V

    更新日期:2012-01-01 00:00:00

  • Intact glucagon-like peptide-1 levels are not decreased in Japanese patients with type 2 diabetes.

    abstract::Impaired secretion of glucagon-like peptide 1 (GLP-1) has been suggested to contribute to the deficient incretin effect in patients with type 2 diabetes mellitus (T2DM). Recent studies, however, have not always supported this notion. Since Japanese patients with T2DM usually have severe impairment in the earlyphase of...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Lee S,Yabe D,Nohtomi K,Takada M,Morita R,Seino Y,Hirano T

    更新日期:2010-01-01 00:00:00

  • A nonsense mutation in the Arg345 of the insulin receptor gene in a Japanese type A insulin-resistant patient.

    abstract::Defects in insulin receptor function have been associated with insulin resistant states such as obesity and type 2 diabetes mellitus. Several types of mutations in the insulin receptor gene have been identified in patients with genetic syndromes of extreme insulin resistance. We have studied a 10-year-old Japanese gir...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Hashiramoto M,Osawa H,Ando M,Murakami A,Nishimiya T,Nakano M,Nishida W,Onuma H,Makino H

    更新日期:2005-08-01 00:00:00