Abstract:
:The relative concentrations of total insulin receptor (IR) mRNA were measured in the epididymal adipose tissue and liver of intact untreated rats, dexamethasone-treated rats, adrenalectomized rats and adrenalectomized rats treated with dexamethasone, using RNA blot assays and a specific IR cDNA probe. Northern blot assays revealed two IR mRNA species of approximately 9.5 and 7.5 kb, in both tissues. Dot-Blot assays followed by densitometry indicated that dexamethasone induced an approximately three-fold increase in IR mRNA in liver, but not in epididymal adipose tissue. By contrast, neither adrenalectomy alone nor the combination of adrenalectomy plus dexamethasone treatment altered the IR mRNA concentrations in liver nor in adipose tissue, which indicates that adrenalectomy was able to prevent the stimulation of IR gene expression caused by dexamethasone in rat liver. These results provide evidence for an "in vivo" tissue-specific regulation of IR gene expression, at the mRNA level, in rats under experimental conditions of an excess or insufficiency of glucocorticoids.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Leal MA,Aller P,Mas A,Carranza MC,Calle Cdoi
10.1507/endocrj.41.737subject
Has Abstractpub_date
1994-12-01 00:00:00pages
737-41issue
6eissn
0918-8959issn
1348-4540journal_volume
41pub_type
杂志文章abstract::The effects of an aqueous extract of Ferula hormonis on social aggression, fertility and some physiological and biochemical parameters were investigated in male mice. The ingestion of 3 mg/kg of aqueous extract of F. hormonis for six weeks clearly inhibited social aggression. Body wet weight and other sex accessory or...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.473
更新日期:2001-08-01 00:00:00
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journal_title:Endocrine journal
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journal_title:Endocrine journal
pub_type: 杂志文章
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更新日期:2020-08-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.11
更新日期:1997-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej11-0306
更新日期:2012-01-01 00:00:00
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journal_title:Endocrine journal
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doi:10.1507/endocrj.EJ15-0033
更新日期:2015-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ17-0155
更新日期:2017-12-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k07e-132
更新日期:2008-08-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ19-0096
更新日期:2020-01-28 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.52.213
更新日期:2005-04-01 00:00:00
abstract::Isolated hypoaldosteronism is a rare and occasionally life-threatening cause of salt wasting in infancy. A 2-month-old Japanese boy of unrelated parents was examined for failure to thrive and poor weight gain. Laboratory findings were hyponatremia, hyperkalemia, high plasma renin and low aldosterone levels. Spot ur...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej12-0248
更新日期:2013-01-01 00:00:00
abstract::Continuous subcutaneous insulin infusion (CSII) therapy using insulin pumps has become widely used in the treatment of type 1 diabetes mellitus (T1DM). This retrospective study aimed to assess the efficacy and safety of long-term insulin pump treatment in patients with T1DM aged ≥50 years. The study included patients ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ19-0188
更新日期:2020-03-28 00:00:00
abstract::Ovarian 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD), which converts progesterone to a derivative devoid of biological activity, plays a crucial role in achieving the short estrous cycle in rats. Although 20alpha-HSD activity has also been demonstrated in the thymus, its molecular nature, function, and regulatio...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.557
更新日期:2001-10-01 00:00:00
abstract::Circulating anti-islet autoantibodies in sera are used as a predictive marker for type 1 diabetes (T1D). We here report two Japanese patients with autoimmune thyroid disease complicated with T1D in whom the time course of anti-islet autoantibodies were observed before the clinical onset of diabetes. Case 1: A woman wh...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k10e-068
更新日期:2010-01-01 00:00:00
abstract::The anti-programmed cell death-1 monoclonal antibody (mab), nivolumab has recently been approved for the treatment of unresectable or metastatic malignant melanoma and non-small-cell lung cancers in Japan. Ipilimumab, an anti-cytotoxic T lymphocyte antigen-4 mab for malignant melanoma that was approved earlier than ni...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0161
更新日期:2016-10-29 00:00:00
abstract::The effect of luteinizing hormone releasing hormone (LHRH) on the neuronal activity of CA1 and CA3 regions of the hippocampus was studied by means of extracellular recordings in the castrated male, intact male, castrated female, and castrated female injected s.c. with 20 micrograms estradiol benzoate (EB) for 3 days. ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.42.251
更新日期:1995-04-01 00:00:00
abstract::Colestimide is a new anion-exchange resin used to lower serum cholesterol in Japan. Because of its excellent compliance, colestimide can replace cholestyramine. To clarify the effect of colestimide on glycemic controls, colestimide (3 g/day) or pravastatin (10 mg) was given orally to patients with type 2 diabetes trea...
journal_title:Endocrine journal
pub_type: 杂志文章,随机对照试验
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更新日期:2007-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.48.25
更新日期:2001-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.47.29
更新日期:2000-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-02-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.suppl_s51
更新日期:1999-03-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.k10e-224
更新日期:2011-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.47.supplmarch_s77
更新日期:2000-03-01 00:00:00
abstract::To measure thyroid-stimulating antibody (TSAb) in sera from patients with Graves' disease, we developed a new assay system with using frozen stocks of CHO-K1 cells. CHO-K1 cells transfected with cloned thyrotropin (TSH) receptor on a 96 well plate were frozen in Cell Banker and stored at -70 degrees C. Three days befo...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.44.431
更新日期:1997-06-01 00:00:00
abstract::Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease characterized by resistance to aldosterone, and the renal form of PHA1 is associated with heterozygous inactivating mutations in NR3C2, which encodes mineralocorticoid receptor (MR). Here we report a case of renal PHA1 due to a novel frameshift mutation i...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ16-0280
更新日期:2017-01-30 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.487
更新日期:1999-08-01 00:00:00
abstract::To examine the specific changes in gene expression in thyroid carcinomas, we performed sequence specific-differential display (SS-DD) analysis by using a specific degenerate primer for the superfamily of the small G protein. After subcloning and sequencing analysis, one of the genes that showed decreased expression in...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.46.459
更新日期:1999-06-01 00:00:00
abstract::There are differences in the susceptibility of rat strains to pituitary growth and lactotroph proliferation caused by long-term treatment with estrogens. To investigate the pituitary mechanism for this strain difference in estrogen-induced lactotroph proliferation, we compared the abilities of 17-β estradiol (E2) and ...
journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.ej13-0245
更新日期:2013-01-01 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.EJ15-0480
更新日期:2016-04-25 00:00:00
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journal_title:Endocrine journal
pub_type: 杂志文章
doi:10.1507/endocrj.47.475
更新日期:2000-08-01 00:00:00