Simvastatin rescues homocysteine-induced apoptosis of osteocytic MLO-Y4 cells by decreasing the expressions of NADPH oxidase 1 and 2.

abstract：:Patients with growth hormone (GH) deficiency (GHD) have a clinical feature of visceral adiposity and it has been reported that these patients have an increased active cortisol (F)/inactive cortisone (E) metabolite ratio. 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an enzyme expressed in liver and adipo...

journal_title：Endocrine journal

authors： Morita J,Hakuno F,Hizuka N,Takahashi S,Takano K

更新日期：2009-01-01 00:00:00

abstract：:We report on two siblings with classic simple virilizing 21-hydroxylase deficiency whose neonatal screening for serum 17alpha-hydroxyprogesterone (17-OHP) gave normal results. The proband, a girl with clitoromegaly whose screening 17-OHP value had been 9.2 ng/ml, was diagnosed at the age of 6 months, and her elder bro...

journal_title：Endocrine journal

authors： Shinohara O,Ishiguro H,Shinagawa T,Kubota C

更新日期：1998-06-01 00:00:00

abstract：:The purpose of this study was to determine whether polycystic ovary syndrome (PCOS) and nonclassic 21-hydroxylase deficiency (CAH) are related to hyperhomocysteinemia, and to investigate if there is a correlation between homocysteine levels and insulin sensitivity in women with PCOS and CAH. Fifty patients with PCOS, ...

journal_title：Endocrine journal

authors： Bayraktar F,Dereli D,Ozgen AG,Yilmaz C

更新日期：2004-12-01 00:00:00

abstract：:It has been suggested that metabolic syndrome (MetS) overlaps prediabetes and type 2 diabetes and that it is not necessary to consider it as a separate clinical entity. In the present study, patients with normoglycemia and dysglycemia were compared in terms of MetS frequency and MetS criteria characteristics, in order...

journal_title：Endocrine journal

authors： Uzunlulu M,Oguz A

更新日期：2007-12-01 00:00:00

abstract：:We report a de novo heterozygous 5,013,940 bp terminal deletion of chromosome 15q26 in a 13 9/12 -year-old Japanese girl with short stature (-3.9 SD), mild mental retardation, and ventricular septal defect (VSD). This terminal deletion involved IGF1R but not NR2F2, and was associated with an addition of telomere repea...

journal_title：Endocrine journal

authors： Dateki S,Fukami M,Tanaka Y,Sasaki G,Moriuchi H,Ogata T

更新日期：2011-01-01 00:00:00

abstract：:Hypertension and norepinephrine hypersecretion in a 59-year-old woman suffering from malignant pheochromocytoma with multiple metastases were appropriately controlled with alpha- and beta- blockers, and alpha-methyltyrosine (alpha-MT), a catecholamine-synthesis inhibitor. Metastasized vertebrae were treated with exter...

journal_title：Endocrine journal

authors： Teno S,Tanabe A,Nomura K,Demura H

更新日期：1996-10-01 00:00:00

abstract：:Congenital adrenal hyperplasia (CAH) due to steroid 21-hydroxylase (21-OH) deficiency (21-OHD) is an autosomal recessive disorder, in which CYP21A2 mutations or deletions result in underproduction of glucocorticoid and mineralocorticoid, and overproduction of androgens. Patients with CAH are treated with oral steroid ...

journal_title：Endocrine journal

authors： Naiki Y,Miyado M,Horikawa R,Katsumata N,Onodera M,Pang S,Ogata T,Fukami M

更新日期：2016-10-29 00:00:00

abstract：:Aerobic (sub lactate threshold; sub-LT) exercise training facilitates oxidative phosphorylation and glycolysis of skeletal muscle. Thyroid hormone (TH) also facilitates such metabolic events. Thus, we studied whether TH signaling pathway is activated by treadmill training. Male adult rats received 30 min/day treadmill...

journal_title：Endocrine journal

authors： Lesmana R,Iwasaki T,Iizuka Y,Amano I,Shimokawa N,Koibuchi N

更新日期：2016-08-31 00:00:00

abstract：:Anaplastic carcinoma arises from differentiated carcinoma and generally shows a dire prognosis. Anaplastic transformation may occur not only in primary tumors but also in metastatic lymph nodes. We encountered 5 cases of papillary carcinoma showing anaplastic transformation in lymph nodes that were curatively resected...

journal_title：Endocrine journal

authors： Ito Y,Higashiyama T,Hirokawa M,Fukushima M,Inoue H,Yabuta T,Tomoda C,Uruno T,Kihara M,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Miyauchi A

更新日期：2008-12-01 00:00:00

abstract：:Metabolic disorders, such as PCOS (polycystic ovarian syndrome) and T2DM (type 2 diabetes mellitus), are associated with menstrual dysfunction, anovulation, infertility, and early pregnancy loss. Ovarian dysfunction is not only related to low pregnancy rates but also to the increased risk of miscarriage. Women with PC...

journal_title：Endocrine journal

authors： Su Y,Wu J,He J,Liu X,Chen X,Ding Y,Zhang C,Chen W,Wang Y,Gao R

更新日期：2017-06-29 00:00:00

abstract：:Unusual presentations with bone, lung or soft tissue metastases in initial diagnosis of follicular thyroid carcinoma have been reported occasionally. This implies how difficult it is to diagnosis this type of cancer at the pre-operative or intra-operative stage of treatment. Fine needle aspiration cytology has been sh...

journal_title：Endocrine journal

authors： Lin JD,Chao TC

更新日期：2006-08-01 00:00:00

abstract：:This study assessed the dose-dependent efficacy and safety of exenatide over 12 weeks in Japanese patients with type 2 diabetes suboptimally controlled despite therapeutic doses of sulfonylurea (SU), SU plus biguanide, or SU plus thiazolidinedione. Patients were randomly assigned to placebo (N = 40), 2.5 microg (N = 3...

journal_title：Endocrine journal

authors： Kadowaki T,Namba M,Yamamura A,Sowa H,Wolka AM,Brodows RG

更新日期：2009-01-01 00:00:00

abstract：:This study assessed the association of muscle mass with insulin resistance, evaluated from the insulin sensitivity index (ISI), in Japanese patients with gestational diabetes mellitus (GDM). Consecutive patients with GDM (n = 96) admitted to St. Marianna University Hospital between October 2015 and March 2018 for init...

journal_title：Endocrine journal

authors： Kawanabe S,Nagai Y,Nakamura Y,Nishine A,Nakagawa T,Tanaka Y

更新日期：2019-01-28 00:00:00

abstract：:It is known that endoplasmic reticulum (ER) stress is provoked under diabetic conditions and is possibly involved in the development of insulin resistance. In this study, using ER stress-activated indicator (ERAI) transgenic mice which express green fluorescent protein under ER stress conditions, we directly evaluated...

journal_title：Endocrine journal

authors： Yoshiuchi K,Kaneto H,Matsuoka TA,Kasami R,Kohno K,Iwawaki T,Nakatani Y,Yamasaki Y,Shimomura I,Matsuhisa M

更新日期：2009-01-01 00:00:00

abstract：:Thyroid dysfunction has been known to be closely associated with increased vascular events. The aims of the present study included determining the prevalence of subclinical thyroid disease and relationships between normal ranges of thyroid function and internal carotid artery steno-occlusion (ICS) in patients with isc...

journal_title：Endocrine journal

authors： Jeong SK,Seo JY,Nam HS,Park HK

更新日期：2010-01-01 00:00:00

abstract：:Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively. We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation. In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells. Ce...

journal_title：Endocrine journal

authors： Kitamura R,Ogata T,Tanaka Y,Motoyoshi K,Seno M,Takei I,Umezawa K,Kojima I

更新日期：2007-04-01 00:00:00

abstract：:Total thyroidectomy was performed in 455 patients with differentiated thyroid carcinoma between 1978 and 1999. Serum calcitonin (CT) was determined preoperatively in all patients using polyclonal antibodies. Among the subjects, 25 patients showed elevated serum calcitonin levels preoperatively. Pathological diagnoses ...

journal_title：Endocrine journal

authors： Yokoi K,Imai T,Shibata A,Hibi Y,Kikumori T,Funahashi H,Nakao A

更新日期：2003-08-01 00:00:00

abstract：:The management of occult small thyroid nodules found by ultrasonography is sometimes problematic. Self-palpation may be utilized in the follow-up of these nodules. We developed a method of thyroid self-examination (TSE). We examined the size of the nodules palpable by this method by ultrasonography. In 78 patients exa...

journal_title：Endocrine journal

authors： Takano T,Hasegawa Y,Amino N

更新日期：2000-10-01 00:00:00

abstract：:The present study was aimed to examine the possible functional relationship between melatonin and hypothalamic transmitters, endogenous opioids and excitatory amino acids in controlling gonadotropin secretion in ovariectomized estrogen-primed rats. An intravenous injection of naloxone (mu opioid receptor antagonist), ...

journal_title：Endocrine journal

authors： Akema T,Ikeda T,Chiba A,Sugiyama H,Sato I,Kimura F,Toyoda J

更新日期：1999-12-01 00:00:00

abstract：:Exercise is a fundamental component of diabetes management. However, choosing inappropriate type or timing of exercise is associated with mild or severe hypoglycemia either during exercise or several hours after exercise. Several studies have shown that impaired counterregulatory responses triggers hypoglycemia. There...

journal_title：Endocrine journal

authors： Mao Y,Wen S,Zhou M,Zhu S,Zhou L

更新日期：2019-09-28 00:00:00

abstract：:To examine the specific changes in gene expression in thyroid carcinomas, we performed sequence specific-differential display (SS-DD) analysis by using a specific degenerate primer for the superfamily of the small G protein. After subcloning and sequencing analysis, one of the genes that showed decreased expression in...

journal_title：Endocrine journal

authors： Liu G,Takano T,Matsuzuka F,Higashiyama T,Kuma K,Amino N

更新日期：1999-06-01 00:00:00

abstract：:We saw a 57-yr-old female non-insulin dependent diabetes mellitus (NIDDM) patient with antiinsulin antibody, in whom insulin-like growth factor-I (IGF-I) was shown to be effective as a blood glucose-lowering agent. Due to the presence of the antibody, the patient suffered from postprandial hyperglycemia and frequent h...

journal_title：Endocrine journal

authors： Kajimoto Y,Kawamori R,Fujitani Y,Kishimoto M,Kubota M,Yamasaki Y,Morishima T,Kamada T

更新日期：1995-02-01 00:00:00

abstract：:Glucagon dysfunction as well as insulin dysfunction is associated with the pathogenesis of type 2 diabetes (T2DM). However, it is still unclear whether the measurement of plasma glucagon levels is useful in understanding the pathophysiology of T2DM. We recently reported that sandwich ELISA provides more accurate plasm...

journal_title：Endocrine journal

authors： Kobayashi M,Satoh H,Matsuo T,Kusunoki Y,Tokushima M,Watada H,Namba M,Kitamura T

更新日期：2020-09-28 00:00:00

abstract：:A series of chimeric TSH-LH/CG receptors were constructed by substituting homologous segments of the extracellular domain of the rat TSH receptor with corresponding segments of rat LH/CG receptor: C1 (amino acids 37-123 substituted), C2 (91-112), C3 (173-234), C4 (233-266), C5 (268-304), C6 (112-305) and C7 (36-404). ...

journal_title：Endocrine journal

authors： Akamizu T,Inoue D,Kosugi S,Ban T,Kohn LD,Imura H,Mori T

更新日期：1993-06-01 00:00:00

abstract：:The objective of this study was to assess the potential predictive factors for follicle growth, ovulation, and pregnancy rate in patients with primary ovarian insufficiency/premature ovarian failure (POI/POF). We enrolled 25 POI patients with desired fertility who were treated and monitored for a minimum of 7 months b...

journal_title：Endocrine journal

authors： Miyazaki K,Miki F,Uchida S,Masuda H,Uchida H,Maruyama T

更新日期：2015-01-01 00:00:00

abstract：:The syndrome of inappropriate secretion of thyrotropin (SITSH) is defined as the inappropriate non-suppression of serum TSH in the presence of elevated free thyroid hormone; TSH-secreting pituitary adenomas and the syndrome of resistance to thyroid hormone are the main etiologies of SITSH. In addition, erroneous thyro...

journal_title：Endocrine journal

authors： Ohba K,Noh JY,Unno T,Satoh T,Iwahara K,Matsushita A,Sasaki S,Oki Y,Nakamura H

更新日期：2012-01-01 00:00:00

abstract：:Effects of prolactin and bromocriptine on neutral and phospholipids of liver, adipose tissue and serum were studied in mature male bonnet monkeys. Hyperprolactinemia (ovine prolactin, 250 micrograms/kg body weight/day, i.p. for 30 days) elevated hepatic total lipids and phospholipids and decreased total and free chole...

journal_title：Endocrine journal

authors： Aruldhas MM,Thampi LT,Kumari TM,Govindarajulu P

更新日期：1994-04-01 00:00:00

abstract：:Geographic differences have been reported to affect the morphological and molecular features of papillary thyroid carcinomas (PTCs). The area around Chernobyl is well-known to be iodine-deficient in contrast to Japan, an iodine-rich country. We reviewed histological differences in adult PTC between Ukraine and Japan. ...

journal_title：Endocrine journal

authors： Ito M,Bogdanova T,Zurnadzhy L,Saenko V,Rogounovitch T,Mitsutake N,Kondo H,Maeda S,Nakashima M,Tronko M,Yamashita S

更新日期：2014-01-01 00:00:00

abstract：:We evaluated the concentration of epidermal growth factor (EGF) in platelets, serum and plasma obtained from 47 patients with Graves' disease, 7 with hypothyroidism and 20 healthy subjects. The platelets of the subjects were collected from platelet rich plasma and lysed by freezing and thawing. Subsequently the platel...

journal_title：Endocrine journal

authors： Okada M,Kamiya Y,Ito J,Yoshimata T,Kawaguchi M,Shibata H,Fujinami T

更新日期：1998-02-01 00:00:00

abstract：:Since there is increasing evidence that postprandial hyperglycemia is a risk factor for the development of macrovascular complications, it is important to predict postprandial hyperglycemia in the early stages of glucose intolerance, and routine medical checkups provide a good opportunity to do so. The aim of this stu...

journal_title：Endocrine journal

authors： Goto M,Yamamoto-Honda R,Shimbo T,Goto A,Terauchi Y,Kanazawa Y,Noda M

更新日期：2011-01-01 00:00:00