Abstract:
:Anaplastic carcinoma arises from differentiated carcinoma and generally shows a dire prognosis. Anaplastic transformation may occur not only in primary tumors but also in metastatic lymph nodes. We encountered 5 cases of papillary carcinoma showing anaplastic transformation in lymph nodes that were curatively resected. Patient ages ranged from 67 to 85 years. Two of these patients showed anaplastic transformation at the initial surgery and the remaining 3 showed anaplastic transformation after repeated recurrence to the lymph nodes. After resection of anaplastic lesions of the nodes, 2 patients underwent radiation therapy, whereas the remaining 3 did not receive any adjuvant therapy. One patient died of rapid growth of lung metastasis 5 months after the resection. One patient died of carcinoma 63 months after surgery. Two patients have survived to date, 6 and 85 months after resection, respectively. The remaining one patient died of heart failure 11 months after surgery. It is therefore suggested that long-term survival can be expected for patients with differentiated carcinoma showing anaplastic transformation in the lymph node if the lesions can be curatively resected.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Ito Y,Higashiyama T,Hirokawa M,Fukushima M,Inoue H,Yabuta T,Tomoda C,Uruno T,Kihara M,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Miyauchi Adoi
10.1507/endocrj.k08e-148subject
Has Abstractpub_date
2008-12-01 00:00:00pages
985-9issue
6eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/K08E-148journal_volume
55pub_type
杂志文章abstract::Carcinoma showing thymic-like differentiation (CASTLE) is a rare tumour of the thyroid, which arises from ectopic thymic tissue or remnants of branchial pouches. A systematic review of English literature evidences less than thirty cases; from them, it clearly appears that CASTLE is considered an indolent slow-growing ...
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