Investigation of the pronounced erythropoietin-induced reduction in hyperglycemia in type 1-like diabetic rats.

Abstract:

:Erythropoietin (EPO) is known to stimulate erythropoiesis after binding with its specific receptor. In clinics, EPO is widely used in hemodialyzed patients with diabetes. However, changes in the expression of the erythropoietin receptor (EPOR) under diabetic conditions are still unclear. Therefore, we investigated EPOR expression both in vivo and in vitro. Streptozotocin-induced type 1-like diabetic rats (STZ rats) were used to evaluate the blood glucose-lowering effects of EPO. The expression and activity of the transducer and activator of transcription 3 (STAT3), the potential signaling molecule, was investigated in cultured rat skeletal myoblast (L6) cells incubated in high-glucose (HG) medium to mimic the in vivo changes. The EPO-induced reduction in hyperglycemia was more pronounced in diabetic rats. The increased EPOR expression in the soleus muscle of diabetic rats was reversed by the reduction in hyperglycemia. Glucose uptake was also increased in high-glucose (HG)-treated L6 cells. Western blotting results indicated that the EPO-induced hyperglycemic activity was enhanced mainly through an increase in EPOR expression. Increased EPOR expression was associated with the enhanced nuclear expression of STAT3 in HG-exposed L6 cells. In addition, treatment with siRNA specific to STAT3 reversed the increased expression of EPOR observed in these cells. Treatment with Stattic at a dose sufficient to inhibit STAT3 reduced the expression level of EPOR in STZ rats. In conclusion, the increased expression of EPOR by hyperglycemia is mainly associated with an augmented expression of nuclear STAT3, which was identified both in vivo and in vitro in the present study.

journal_name

Endocr J

journal_title

Endocrine journal

authors

Kuo SC,Li Y,Cheng KC,Niu CS,Cheng JT,Niu HS

doi

10.1507/endocrj.EJ17-0353

subject

Has Abstract

pub_date

2018-02-26 00:00:00

pages

181-191

issue

2

eissn

0918-8959

issn

1348-4540

journal_volume

65

pub_type

杂志文章
  • Anti-alpha-enolase antibodies in pituitary disease.

    abstract::A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pitu...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.50.697

    authors: Tanaka S,Tatsumi KI,Takano T,Murakami Y,Takao T,Yamakita N,Tahara S,Teramoto A,Hashimoto K,Kato Y,Amino N

    更新日期:2003-12-01 00:00:00

  • Follicular thyroid carcinoma: From diagnosis to treatment.

    abstract::Unusual presentations with bone, lung or soft tissue metastases in initial diagnosis of follicular thyroid carcinoma have been reported occasionally. This implies how difficult it is to diagnosis this type of cancer at the pre-operative or intra-operative stage of treatment. Fine needle aspiration cytology has been sh...

    journal_title:Endocrine journal

    pub_type: 杂志文章,评审

    doi:10.1507/endocrj.kr-77

    authors: Lin JD,Chao TC

    更新日期:2006-08-01 00:00:00

  • Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests.

    abstract::Since there is increasing evidence that postprandial hyperglycemia is a risk factor for the development of macrovascular complications, it is important to predict postprandial hyperglycemia in the early stages of glucose intolerance, and routine medical checkups provide a good opportunity to do so. The aim of this stu...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k10e-224

    authors: Goto M,Yamamoto-Honda R,Shimbo T,Goto A,Terauchi Y,Kanazawa Y,Noda M

    更新日期:2011-01-01 00:00:00

  • Aggressive thyroid carcinoma showing thymic-like differentiation (CASTLE): case report and review of the literature.

    abstract::Carcinoma showing thymic-like differentiation (CASTLE) is a rare tumour of the thyroid, which arises from ectopic thymic tissue or remnants of branchial pouches. A systematic review of English literature evidences less than thirty cases; from them, it clearly appears that CASTLE is considered an indolent slow-growing ...

    journal_title:Endocrine journal

    pub_type: 杂志文章,评审

    doi:10.1507/endocrj.k07e-147

    authors: Cappelli C,Tironi A,Marchetti GP,Pirola I,De Martino E,Delbarba A,Castellano M,Rosei EA

    更新日期:2008-08-01 00:00:00

  • Effects of PMA and transcription factors on ovine interferon-tau transactivation in various cell lines.

    abstract::Interferon-tau (IFNtau) is produced by the trophectoderm of ruminant ungulates and its gene transactivation in vitro has so far been achieved only in human choriocarcinoma cells, JAR and JEG3. To examine if ovine IFNtau gene transactivation could be induced in cells other than JAR or JEG3 cells and its activation coul...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.46.383

    authors: Yamaguchi H,Ikeda Y,Taylor A,Katsumura M,Miyazawa T,Takahashi E,Imakawa K,Sakai S

    更新日期:1999-06-01 00:00:00

  • Efficacy and safety of repaglinide added to sitagliptin in Japanese patients with type 2 diabetes: A randomized 24-week open-label clinical trial.

    abstract::Although sitagliptin and repaglinide monotherapies improve postprandial hyperglycemia, the long-term effects and safety of their combination has not been examined. In this randomized 24-week trial of Japanese patients with poor control (HbA1c 7.0-8.5%) by sitagliptin, we divided 40 patients randomly into two equal gro...

    journal_title:Endocrine journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1507/endocrj.EJ16-0291

    authors: Nishimura A,Usui S,Kumashiro N,Uchino H,Yamato A,Yasuda D,Nagasawa K,Okubo M,Mori Y,Hirose T

    更新日期:2016-12-30 00:00:00

  • Hypothyroidism results in small dense LDL independent of IRS traits and hypertriglyceridemia.

    abstract::There is evidence of an association between hypothyroidism and coronary heart disease. We decided to look at the relationship between hypothyroidism and LDL subclasses' pattern including small, dense LDL to define a biochemical basis for better management of the CHD risk of these patients. We utilized a case-control d...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k07e-065

    authors: Abbas JM,Chakraborty J,Akanji AO,Doi SA

    更新日期:2008-05-01 00:00:00

  • Manifestation of subclinical diabetes insipidus due to pituitary tumor during pregnancy.

    abstract::We describe a case of diabetes insipidus (DI) due to a pituitary tumor in a 33-year-old pregnant woman who developed a sudden onset of polyuria (over 8 l/day) and polydipsia at 30 weeks of gestation. Her plasma concentration of vasopressin (AVP) was low compared with high serum osmolality (298 mOsm/kg), and her urine ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.43.577

    authors: Hashimoto M,Ogura T,Otsuka F,Yamauchi T,Mimura Y,Hayakawa N,Makino H,Ota Z,Seki N,Hiramatsu Y,Kudo N

    更新日期:1996-10-01 00:00:00

  • MRI detection of suprasellar germinoma causing central diabetes insipidus.

    abstract::This is a case report of an 18-year-old man with central diabetes incipidus (DI). An MRI done three months after the onset of the DI did not disclose a responsible lesion. Four months later, a second MRI showed the location of the tumor origin at the upper pituitary stalk and median eminence. Eight months later, the t...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.46.263

    authors: Saeki N,Uchida D,Tatsuno I,Saito Y,Yamaura A

    更新日期:1999-04-01 00:00:00

  • Influence of thyroid dysfunction on brain natriuretic peptide level in health examination participants.

    abstract::The tissue-specific circulating markers of thyroid hormone action on cardiac function have not been established. Although the relationship between thyroid function and plasma brain natriuretic peptide (BNP) levels has been evaluated in patients with thyroid disorders, the relationship between these parameters in the g...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ19-0380

    authors: Ohba K,Okada E,Goto Y,Suzuki S,Machii M,Nonaka D,Matsushita A,Sasaki S,Suda T,Oki Y,Takase H

    更新日期:2020-04-28 00:00:00

  • Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes.

    abstract::Aim of this study was to examine the association between the severity of obstructive sleep apnea (OSA) and dysglycemia in Japanese individuals with and without type 2 diabetes (T2DM). We enrolled 115 individuals diagnosed with OSA with an apnea hypopnea-index (AHI) ≥ 20 in whom continuous positive airway pressure (CPA...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ17-0356

    authors: Kurosawa H,Saisho Y,Fukunaga K,Haraguchi M,Yamasawa W,Kurihara I,Betsuyaku T,Itoh H

    更新日期:2018-01-30 00:00:00

  • Effects of GnRH on protein kinase C activity, Ca2+ mobilization and steroidogenesis of human granulosa cells.

    abstract::Gonadotropin-releasing hormone (GnRH) and its agonists have been known to directly affect steroid hormone production in human granulosa cells. In this study, we examined effects of GnRH on Ca2+ mobilization, protein kinase C activity and steroidogenesis of human granulosa cells. Human granulosa cells were harvested by...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.45.175

    authors: Hori H,Uemura T,Minaguchi H

    更新日期:1998-04-01 00:00:00

  • Familial occurrence of subacute thyroiditis.

    abstract::Although subacute thyroiditis (de Quervain's thyroiditis) is presumed to be caused by a viral infection, only 2 familial occurrences of subacute thyroiditis have been reported in the literature. Typical and severe subacute thyroiditis was diagnosed in an older sister who was hospitalized for 8 days. During this period...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.49.207

    authors: Kabalak T,Ozgen AG

    更新日期:2002-04-01 00:00:00

  • An acromegalic patient with pulsatile secretion of growth hormone (GH) coincident with the slow-wave sleep.

    abstract::A 43-year-old woman was admitted to our hospital for further treatment of acromegaly with high plasma GH and IGF-I levels after transsphenoidal adenomectomy and subsequent treatment with bromocriptine. Physical examination and magnetic resonance imaging (MRI) showed an active acromegalic appearance with residual pitui...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.45.687

    authors: Matsuno M,Sohmiya M,Yamamoto H,Kato Y

    更新日期:1998-10-01 00:00:00

  • Application of thermography in the diagnostic investigation of thyroid nodules.

    abstract::Thyroid nodules (TN) are common in the general population, and the clinical importance of diagnosing thyroid nodules is based on excluding the possibility of thyroid cancer, which occurs in 7-15% of cases. The thyroid gland, owing to its superficial location, is easily accessible via thermography, a noninvasive method...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ20-0541

    authors: Damião CP,Montero JRG,Moran MBH,de Oliveira Marçal E Silva Carvalho ME,de Farias CG,Brito IB,Saad MAN,Fontes CAP,Fainstein C,Rodrigues MFO,Palombo A,Conci A,da Cruz Filho RA,Lima GAB

    更新日期:2021-01-21 00:00:00

  • Prevalence of lymphocytic infiltrate in 1400 pituitary adenomas.

    abstract::To evaluate the prevalence of lymphocytic infiltrate in a large series of pituitary adenomas, we retrospectively studied tumor tissues from 1400 patients. Based on immunocytochemical data, tumors were classified as PRL (n=411), multihormonal (n=310), immunonegative (n=275), ACTH (n=166), GH (n=137), alpha subunit (n=4...

    journal_title:Endocrine journal

    pub_type: 杂志文章,多中心研究

    doi:10.1507/endocrj.45.357

    authors: Heshmati HM,Kujas M,Casanova S,Wollan PC,Racadot J,Van Effenterre R,Derome PJ,Turpin G

    更新日期:1998-06-01 00:00:00

  • Final height of Japanese patients with X-linked hypophosphatemic rickets: effect of vitamin D and phosphate therapy.

    abstract::X-linked hypophosphatemic rickets (XLH) is one of the most common causes of rickets in infancy and childhood. Combination therapy of vitamin D and phosphate is generally used for patients with XLH. Effect of treatment of vitamin D and phosphate during childhood on final height of XLH has to be elucidated in Japanese. ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.47.163

    authors: Miyamoto J,Koto S,Hasegawa Y

    更新日期:2000-04-01 00:00:00

  • Bone and calcium metabolism in Werner's syndrome.

    abstract::In order to compare the bone aging process in Werner's syndrome, a disease characterized by premature aging, and that in natural aging, we have assessed the bone status in a total of 19 cases (11 males and eight postmenopausal females) with Werner's syndrome. The spinal deformity index was determined for a total of 87...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.45.505

    authors: Shiraki M,Aoki C,Goto M

    更新日期:1998-08-01 00:00:00

  • The effect of calcium-sensing receptor gene polymorphisms on serum calcium levels: a familial hypocalciuric hypercalcemia family without mutation in the calcium-sensing receptor gene.

    abstract::Familial hypocalciuric hypercalcemia (FHH) is a benign syndrome with elevated levels of serum calcium, relative hypocalciuria, and non-suppressed serum parathyroid hormone (PTH) levels. FHH usually occurs by a heterozygous mutation of the calcium sensing receptor (Casr), but some FHH patients show no mutations of the ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.47.29

    authors: Kanazawa H,Tanaka H,Kodama S,Moriwake A,Kobayashi M,Seino Y

    更新日期:2000-02-01 00:00:00

  • Concentration of the n-octanoylated active form of ghrelin in fetal and neonatal circulation.

    abstract::The octanoylation of Ser3 is essential for the biological function of ghrelin. We examined the concentrations of the n-octanoylated active-form ghrelin in cord and neonatal blood using an RIA system that specifically recognized n-octanoylated ghrelin, as well as a system that measured the total ghrelin concentration. ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.52.271

    authors: Yokota I,Kitamura S,Hosoda H,Kotani Y,Kangawa K

    更新日期:2005-04-01 00:00:00

  • Tyrosine-kinase inhibitors to treat radioiodine-refracted, metastatic, or recurred and progressive differentiated thyroid carcinoma [Review].

    abstract::Differentiated thyroid carcinoma (DTC) is generally indolent in nature and, even though it metastasizes to distant organs, the prognosis is normally excellent. In contrast, the overall survival (OS) of patients with radioactive iodine (RAI)-refractory and progressive metastases is dire, because no effective therapies ...

    journal_title:Endocrine journal

    pub_type: 杂志文章,评审

    doi:10.1507/endocrj.EJ16-0064

    authors: Ito Y,Suzuki S,Ito K,Imai T,Okamoto T,Kitano H,Sugitani I,Sugino K,Tsutsui H,Hara H,Yoshida A,Shimizu K

    更新日期:2016-07-30 00:00:00

  • Ratio of serum free triiodothyronine to free thyroxine in Graves' hyperthyroidism and thyrotoxicosis caused by painless thyroiditis.

    abstract::The serum T3 to T4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T3 (FT3) to free T4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made u...

    journal_title:Endocrine journal

    pub_type: 杂志文章,多中心研究

    doi:10.1507/endocrj.52.537

    authors: Yoshimura Noh J,Momotani N,Fukada S,Ito K,Miyauchi A,Amino N

    更新日期:2005-10-01 00:00:00

  • A case of McCune-Albright syndrome associated with Gs alpha mutation in the bone tissue.

    abstract::The syndrome of McCune-Albright syndrome (MAS) is clasically defined as a triad presentation with the findings of polyostotic fibrous dysplasia, café-au-lait spots, and sexual precocity. However, not all patients present with complete symptoms. A 52-year-old man was diagnosed as having a variant of McCune-Albright syn...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.53.35

    authors: Sargin H,Gozu H,Bircan R,Sargin M,Avsar M,Ekinci G,Yayla A,Gulec I,Bozbuga M,Cirakoglu B,Tanakol R

    更新日期:2006-02-01 00:00:00

  • Effects of exenatide and liraglutide on 24-hour glucose fluctuations in type 2 diabetes.

    abstract::We evaluated the influence of short-term treatment with exenatide twice daily or liraglutide once daily on daily blood glucose fluctuations in 40 patients with type 2 diabetes inadequately controlled by sulfonylureas. The patients in a multicenter, open-label trial were randomly assigned to receive add-on exenatide (1...

    journal_title:Endocrine journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1507/endocrj.EJ15-0500

    authors: Nagakura J,Yamakawa T,Taguri M,Tsuchiya H,Shigematsu E,Suzuki J,Morita S,Kadonosono K,Terauchi Y

    更新日期:2016-01-01 00:00:00

  • Diurnal variation in growth hormone receptor messenger ribonucleic acid in liver and skeletal muscle of lit/+ and lit/lit mice.

    abstract::The present study investigated the diurnal variation in GH receptor (GHR) mRNA in liver and skeletal muscle of 3-month-old GH-deficient and -sufficient mice using quantitative real-time RT-PCR. lit/lit (GH deficient) or lit/+ (GH sufficient) mice were fed ad libitum and lights were on between 0600 and 2000. Tissues we...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.51.529

    authors: Itoh E,Iida K,del Rincon JP,Kim DS,Thorner MO

    更新日期:2004-12-01 00:00:00

  • Growth of an aggressive tumor during pregnancy in an acromegalic patient.

    abstract::Pregnancy in acromegalic patients is a rare event, but is usually uneventful, with stable GH and IGF-I levels and no tumor enlargement. Medical treatment can usually be withdrawn without problems and although no major adverse event has been reported, the suspension of drug treatments is generally recommended. No cas...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.ej11-0306

    authors: Kasuki L,Neto LV,Takiya CM,Gadelha MR

    更新日期:2012-01-01 00:00:00

  • Is metabolic syndrome a condition independent of prediabetes and type 2 diabetes mellitus? A report from Turkey.

    abstract::It has been suggested that metabolic syndrome (MetS) overlaps prediabetes and type 2 diabetes and that it is not necessary to consider it as a separate clinical entity. In the present study, patients with normoglycemia and dysglycemia were compared in terms of MetS frequency and MetS criteria characteristics, in order...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k07-036

    authors: Uzunlulu M,Oguz A

    更新日期:2007-12-01 00:00:00

  • Relation between apolipoprotein e phenotype and the changes in lipids during tamoxifen treatment.

    abstract::We recently reported three cases of severe hypertriglyceridemia caused by tamoxifen-treatment after breast cancer surgery. In that report we showed that one of the three patients had apo E3/3 and another had E4/2 phenotype. There are few data about the relationship between apoprotein E phenotype, one of modifiers of l...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.45.255

    authors: Hozumi Y,Kawano M,Saito T,Miyata M

    更新日期:1998-04-01 00:00:00

  • Increased epinephrine-induced cAMP response in severely diabetic BB/W rat liver.

    abstract::The effect of prolonged diabetes on epinephrine-induced adenosine 3',5'-monophosphate (cAMP) response in the liver was examined in diabetes-prone BB/W rats. Basal and 1 microM epinephrine-induced cAMP release from isolated perfused liver was similar in non-diabetic and diabetic BB/W rats with preserved adipose tissue....

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.44.725

    authors: Yamatani K,Saito K,Ohnuma H,Ikezawa Y,Seino T,Manaka Y,Daimon M,Takahashi K,Sasaki H

    更新日期:1997-10-01 00:00:00

  • Emergence of anti-islet autoantibodies in Japanese patients with type 1 diabetes.

    abstract::Circulating anti-islet autoantibodies in sera are used as a predictive marker for type 1 diabetes (T1D). We here report two Japanese patients with autoimmune thyroid disease complicated with T1D in whom the time course of anti-islet autoantibodies were observed before the clinical onset of diabetes. Case 1: A woman wh...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k10e-068

    authors: Horie I,Kawasaki E,Shimomura A,Satoh T,Ueki I,Kuwahara H,Ando T,Abiru N,Usa T,Eguchi K

    更新日期:2010-01-01 00:00:00