Anti-alpha-enolase antibodies in pituitary disease.

Abstract:

:A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pituitary non-functioning adenoma (n = 13), other pituitary diseases (n = 17) and other autoimmune diseases (n = 30), and compared to healthy controls (n = 46). Autoantibodies were found in 41.2%, 46.2%, 23.5%, 20.0% and 4.3%, respectively. Our findings indicate that detection of anti-alpha-enolase antibodies is not suitable for specific diagnosis of lymphocytic hypophysitis.

journal_name

Endocr J

journal_title

Endocrine journal

authors

Tanaka S,Tatsumi KI,Takano T,Murakami Y,Takao T,Yamakita N,Tahara S,Teramoto A,Hashimoto K,Kato Y,Amino N

doi

10.1507/endocrj.50.697

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

697-702

issue

6

eissn

0918-8959

issn

1348-4540

journal_volume

50

pub_type

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