Relationship between the serum concentrations of C-reactive protein and parameters of adiposity and insulin resistance in patients with type 2 diabetes mellitus.


:Serum C-reactive protein (CRP) concentrations have been reported to be associated with body fat, especially visceral fat accumulation, but most studies up to now have been conducted on non-diabetic subjects. In this study, we investigated the association between the serum CRP concentrations and parameters of adiposity and insulin resistance in both Japanese type 2 diabetes patients and non-diabetic subjects. A total of 248 Japanese subjects (140 type 2 diabetes patients and 108 non-diabetic subjects) were enrolled for the study. The degree of insulin resistance was estimated by the homeostasis model assessment (HOMA-R) method. Fat accumulation was evaluated by measuring visceral and subcutaneous fat areas at the level of the umbilicus in abdominal CT scans. To assess hepatic fat content, the ratio of CT attenuation value of the liver to that of the spleen (L/S ratio) was calculated. Serum CRP was found to be significantly correlated with various indices of adiposity, including L/S ratio, visceral fat area (VFA), subcutaneous fat area (SFA), and HOMA-R, in both the diabetic patients and the non-diabetic subjects. After adjustment for five variables (age, gender, serum CRP, HbA1c, and smoking), serum CRP was still significantly correlated with L/S ratio, VFA, SFA, and HOMA-R in the diabetic patients. We also found that changes in serum CRP concentrations were correlated with changes in the VFA and SFA at 1 year after the baseline in 24 diabetic patients. We conclude that serum CRP may be closely related to the degree of liver steatosis and visceral fat accumulation in Japanese type 2 diabetes mellitus patients.


Endocr J


Endocrine journal


Iwasaki T,Nakajima A,Yoneda M,Terauchi Y




Has Abstract


2006-06-01 00:00:00














  • Improvement of lymph node recurrence rate, but not distant recurrence and carcinoma death rates, in patients with papillary thyroid carcinoma after disease-free survival for 5 years.

    abstract::In this study, we investigated the difference in lymph node-recurrence free survival (LN-RFS), distant recurrence-free survival (DRFS), and cause-specific survival (CSS) between patients with papillary thyroid carcinoma (PTC) in the entire group (Group I) and those with lymph node- and distant-recurrence-free survival...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Ito Y,Kudo T,Kihara M,Takamura Y,Kobayashi K,Miya A,Miyauchi A

    更新日期:2012-01-01 00:00:00

  • Ultrasonographic features of parathyroid carcinoma.

    abstract::Although several authors have reported single cases illustrative of some ultrasonographic characteristic of parathyroid carcinoma, the value of ultrasonography for diagnosing this entity remains to be determined. The purpose of our study was to investigate the ultrasonographic features of parathyroid carcinoma in a la...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Hara H,Igarashi A,Yano Y,Yashiro T,Ueno E,Aiyoshi Y,Ito K,Obara T

    更新日期:2001-04-01 00:00:00

  • Association between severity of obstructive sleep apnea and glycated hemoglobin level in Japanese individuals with and without diabetes.

    abstract::Aim of this study was to examine the association between the severity of obstructive sleep apnea (OSA) and dysglycemia in Japanese individuals with and without type 2 diabetes (T2DM). We enrolled 115 individuals diagnosed with OSA with an apnea hypopnea-index (AHI) ≥ 20 in whom continuous positive airway pressure (CPA...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kurosawa H,Saisho Y,Fukunaga K,Haraguchi M,Yamasawa W,Kurihara I,Betsuyaku T,Itoh H

    更新日期:2018-01-30 00:00:00

  • Characterization of plasma brain natriuretic peptide level in patients with type 2 diabetes.

    abstract::This study investigates whether the plasma brain natriuretic peptide (BNP) level is increased by the clinical traits of diabetes, including its complications, and whether these levels are affected by the presence of other combined diseases such as hypertension, hyperlipidemia, and coronary heart disease (CHD) in patie...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Igarashi M,Jimbu Y,Hirata A,Tominaga M

    更新日期:2005-06-01 00:00:00

  • Inhibitory effects of trichostatin A on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT-20 cells.

    abstract::Cushing's disease is primarily caused by adrenocorticotropic hormone (ACTH)-producing pituitary adenomas. Pituitary tumor-transforming gene 1 (PTTG1) expression, a hallmark of pituitary tumors, stimulates pituitary cell proliferation. Histone deacetylases (HDACs) play an important role in regulating gene transcription...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Nakada Y,Kageyama K,Sugiyama A,Desaki R,Takayasu S,Niioka K,Murasawa S,Ishigame N,Asari Y,Iwasaki Y,Daimon M

    更新日期:2015-01-01 00:00:00

  • Classification of thyroid follicular cell tumors: with special reference to borderline lesions.

    abstract::We propose a new classification of thyroid follicular cell tumors which is correlated with patient's prognosis. It is unique as to two new categories: borderline malignancy between benign and malignant, and moderately differentiated adenocarcinoma (MDA) as a differentiation classification to stratify tumor aggressive...

    journal_title:Endocrine journal

    pub_type: 杂志文章,评审


    authors: Kakudo K,Bai Y,Liu Z,Li Y,Ito Y,Ozaki T

    更新日期:2012-01-01 00:00:00

  • Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones.

    abstract::Atrial and brain natriuretic peptides (ANP and BNP, respectively) are cardiac hormones. During cardiac development, their expression is a maker of cardiomyocyte differentiation and is under tight spatiotemporal regulation. After birth, however, their ventricular expression is only up-regulated in response to various c...

    journal_title:Endocrine journal

    pub_type: 杂志文章,评审


    authors: Kuwahara K,Nakao K

    更新日期:2010-01-01 00:00:00

  • Pharmacological treatments for GH-induced insulin resistance.

    abstract::Troglitazone (T) and d-chiroinositol (DCI) have been reported to improve insulin resistance associated with obesity and NIDDM. We tested whether these compounds counteract the insulin antagonistic effects of recombinant human GH. Male Wistar rats were allocated to 4 different treatment groups, rhGH (n=8), rhGH+T (n=7)...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Sugimoto M,Takeda N,Hattori J,Yoshino K,Nakashima K,Okumura S,Ishimori M,Yasuda K

    更新日期:1999-03-01 00:00:00

  • Relationship between metabolic syndrome categorized by newly recommended by International Diabetes Federation criteria with plasma homocysteine concentration.

    abstract::Plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease and increased tHcy levels have been reported to be a novel risk factor of atherosclerotic disease. The aim of this study was to assess the association of the metabolic syndrome components with plasma (tHcy) level. Total 722 parti...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Rhee EJ,Hwang ST,Lee WY,Yoon JH,Kim BJ,Kim BS,Kang JH,Lee MH,Park JR,Sung KC

    更新日期:2007-12-01 00:00:00

  • Circulating activated T lymphocyte subsets in patients with silent thyroiditis.

    abstract::In order to investigate the immunological aspects of silent thyroiditis, T lymphocyte subsets were analyzed by two-color flow cytometry in 10 patients with silent thyroiditis in the thyrotoxic phase, 12 patients with silent thyroiditis in the recovery phase, and 11 healthy volunteers as a control. The percentages of C...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kushima K,Ban Y,Taniyama M,Itoh K

    更新日期:1994-12-01 00:00:00

  • Stage-specific expression of estrogen receptor subtypes and estrogen responsive finger protein in preimplantational mouse embryos.

    abstract::In hope of understanding possible roles of estrogen during early embryogenesis, we examined the expression of both estrogen receptor alpha (ER alpha) and ER beta, a recently cloned novel subtype, in mouse oocytes and preimplantation embryos by means of reverse transcription polymerase chain reaction (RT-PCR). To inves...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Hiroi H,Momoeda M,Inoue S,Tsuchiya F,Matsumi H,Tsutsumi O,Muramatsu M,Taketani Y

    更新日期:1999-02-01 00:00:00

  • Histopathological improvement of acromegalic cardiomyopathy by intermittent subcutaneous infusion of octreotide.

    abstract::We studied functional and histopathological changes in acromegalic cardiomyopathy following intermittent subcutaneous infusion of octreotide. A 68-year-old female patient with acromegaly associated with congestive heart failure due to dilated cardiomyopathy was initially treated with cardioactive medication for three ...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Nishiki M,Murakami Y,Sohmiya M,Koshimura K,Inoue K,Goto Y,Nakamura N,Kato Y

    更新日期:1997-10-01 00:00:00

  • Relationship between prognosis of papillary thyroid carcinoma patient and age: a retrospective single-institution study.

    abstract::Age is an important prognostic factor in papillary thyroid carcinoma (PTC). In this study, we investigated the difference in prognosis of 7 subsets of PTC patients without distant metastasis at presentation or a history of radiation exposure (20 years or younger, 21-30 years, 31-40 years, 41-50 years, 51-60 years, 61...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Ito Y,Miyauchi A,Kihara M,Takamura Y,Kobayashi K,Miya A

    更新日期:2012-01-01 00:00:00

  • Effects of reserpine treatment on pituitary-adrenocortical axis in patients with Cushing's disease.

    abstract::Effects of reserpine treatment, not associated with pituitary irradiation, on the pituitary-adrenocortical axis in a total of 37 untreated patients with Cushing's disease were evaluated. With short-term treatment (2 mg daily for 2 weeks, n = 36), basal excretion of urinary 17-OHCS significantly decreased from 11.2 +/-...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Minamori Y,Yasuda K,Murayama M,Morita H,Yamakita N,Miura K

    更新日期:1993-10-01 00:00:00

  • Clinical outcomes of parathyroidectomy versus cinacalcet in the clinical management of secondary hyperparathyroidism.

    abstract::Parathyroidectomy (PTX) is the standard treatment for secondary hyperparathyroidism (SHPT); however, the administration of cinacalcet has gained prominence as a noninvasive treatment. We aimed to determine whether PTX or cinacalcet is more effective in preventing morbidity and mortality through reviewing follow-up dat...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kim WW,Rhee Y,Kim BS,Kim K,Lee CR,Kang SW,Lee J,Jeong JJ,Nam KH,Chung WY

    更新日期:2019-10-28 00:00:00

  • Association of the muscle/fat mass ratio with insulin resistance in gestational diabetes mellitus.

    abstract::This study assessed the association of muscle mass with insulin resistance, evaluated from the insulin sensitivity index (ISI), in Japanese patients with gestational diabetes mellitus (GDM). Consecutive patients with GDM (n = 96) admitted to St. Marianna University Hospital between October 2015 and March 2018 for init...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kawanabe S,Nagai Y,Nakamura Y,Nishine A,Nakagawa T,Tanaka Y

    更新日期:2019-01-28 00:00:00

  • Adult-onset hypogonadotropic hypogonadism caused by aberrant expression of aromatase in an adrenocortical adenocarcinoma.

    abstract::Estrogen-secreting adrenal cancers are extremely rare, with feminizing symptoms attributed to aromatase expression in the adrenal tumor. We describe a case of hypogonadotropic hypogonadism as a consequence of aberrant aromatase expression in a patient with adrenocortical adenocarcinoma. A 54 year-old man presented wit...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Advani A,Johnson SJ,Nicol MR,Papacleovoulou G,Evans DB,Vaikkakara S,Mason JI,Quinton R

    更新日期:2010-01-01 00:00:00

  • Relapse of Graves' disease in a patient with pheochromocytoma.

    abstract::We describe a patient with right adrenal tumor detected incidentally. The tumor was diagnosed as pheochromocytoma by endocrinological and radiological studies, and was removed surgically. Graves' disease, which had been in remission for more than two decades after discontinuation of antithyroid drug treatment, relapse...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Abe M,Mori K,Nagai K,Ito S

    更新日期:2003-12-01 00:00:00

  • Intraventricular injection of melatonin inhibits naloxone-induced, but not NMDA- or LHRH-induced LH release in ovariectomized estrogen-primed rats.

    abstract::The present study was aimed to examine the possible functional relationship between melatonin and hypothalamic transmitters, endogenous opioids and excitatory amino acids in controlling gonadotropin secretion in ovariectomized estrogen-primed rats. An intravenous injection of naloxone (mu opioid receptor antagonist), ...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Akema T,Ikeda T,Chiba A,Sugiyama H,Sato I,Kimura F,Toyoda J

    更新日期:1999-12-01 00:00:00

  • Comparison of glycated albumin (GA) and glycated hemoglobin (HbA1c) in type 2 diabetic patients: usefulness of GA for evaluation of short-term changes in glycemic control.

    abstract::We studied the cross-sectional relationship between GA and HbA1c in 142 type 2 diabetic patients who had an HbA1c level < 7.5% for at least one year without fluctuation by more than 0.5%. We also followed the changes of GA and HbA1c in 18 type 2 diabetic patients for 16 weeks as they progressed from untreated severe h...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Takahashi S,Uchino H,Shimizu T,Kanazawa A,Tamura Y,Sakai K,Watada H,Hirose T,Kawamori R,Tanaka Y

    更新日期:2007-02-01 00:00:00

  • The effect of calcium-sensing receptor gene polymorphisms on serum calcium levels: a familial hypocalciuric hypercalcemia family without mutation in the calcium-sensing receptor gene.

    abstract::Familial hypocalciuric hypercalcemia (FHH) is a benign syndrome with elevated levels of serum calcium, relative hypocalciuria, and non-suppressed serum parathyroid hormone (PTH) levels. FHH usually occurs by a heterozygous mutation of the calcium sensing receptor (Casr), but some FHH patients show no mutations of the ...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kanazawa H,Tanaka H,Kodama S,Moriwake A,Kobayashi M,Seino Y

    更新日期:2000-02-01 00:00:00

  • A case of nonfunctioning pituitary adenoma resembling so-called silent corticotroph adenoma.

    abstract::It has been indicated that some subsets of clinically nonfunctioning pituitary adenoma exhibit immunohistochemical and ultrastructural features of somatotroph or corticotroph cells, which are described as silent somatotroph and corticotroph adenomas, respectively. We here describe a 70-year-old woman with nonfunctioni...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Sakaguchi H,Koshiyama H,Sano T,Inoue D,Hashimoto N,Aoki N,Nakao K

    更新日期:1997-04-01 00:00:00

  • Tyrosine-kinase inhibitors to treat radioiodine-refracted, metastatic, or recurred and progressive differentiated thyroid carcinoma [Review].

    abstract::Differentiated thyroid carcinoma (DTC) is generally indolent in nature and, even though it metastasizes to distant organs, the prognosis is normally excellent. In contrast, the overall survival (OS) of patients with radioactive iodine (RAI)-refractory and progressive metastases is dire, because no effective therapies ...

    journal_title:Endocrine journal

    pub_type: 杂志文章,评审


    authors: Ito Y,Suzuki S,Ito K,Imai T,Okamoto T,Kitano H,Sugitani I,Sugino K,Tsutsui H,Hara H,Yoshida A,Shimizu K

    更新日期:2016-07-30 00:00:00

  • HLA-associated cellular response to GAD in type 2 diabetes with antibodies to GAD.

    abstract::Proliferative response of peripheral blood mononuclear cells (PBMC) to glutamic acid decarboxylase (GAD), which has been reported in patients with type 1 diabetes, was measured in type 2 diabetes, especially in patients with antibodies to GAD initially diagnosed as having type 2 diabetes (anti-GAD+ type 2 diabetes). W...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Fukui M,Nakamura N,Nakano K,Kajiyama S,Matsuo S,Obayashi H,Ohta M,Shigeta M,Shigeta H,Kitagawa Y,Kondo M

    更新日期:2000-12-01 00:00:00

  • Hormone replacement therapy and vascular risk disorders in adult hypopituitarism.

    abstract::Adult patients with hypopituitarism are treated by the replacement of deficient hormones, although GH has not been substituted until March 2006 in Japan except for clinical trial. This study examines which hormonal status influences the prevalence of vascular risk disorders in hypopituitary adults. A sample of 263 adu...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Kaji H,Iida K,Takahashi Y,Okimura Y,Chihara K

    更新日期:2007-04-01 00:00:00

  • Serum irisin and its regulation by hyperinsulinemia in women with polycystic ovary syndrome.

    abstract::Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance. The aim of the present study was to determine the relationship between serum irisin concentration and ...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Adamska A,Karczewska-Kupczewska M,Lebkowska A,Milewski R,Górska M,Otziomek E,Nikolajuk A,Wolczynski S,Kowalska I

    更新日期:2016-12-30 00:00:00

  • Novel SLC12A1 (NKCC2) mutations in two families with Bartter syndrome type 1.

    abstract::Bartter syndrome (BS) type 1, also referred to antenatal BS, is a genetic tubulopathy with hypokalemic metabolic alkalosis and prenatal onset of polyuria leading to polyhydramnios. It has been shown that BS type 1 is caused by mutations in the SLC12A1 gene encoding bumetanide-sensitive Na-K-2Cl (-) cotransporter (NKCC...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Adachi M,Asakura Y,Sato Y,Tajima T,Nakajima T,Yamamoto T,Fujieda K

    更新日期:2007-12-01 00:00:00

  • Intact glucagon-like peptide-1 levels are not decreased in Japanese patients with type 2 diabetes.

    abstract::Impaired secretion of glucagon-like peptide 1 (GLP-1) has been suggested to contribute to the deficient incretin effect in patients with type 2 diabetes mellitus (T2DM). Recent studies, however, have not always supported this notion. Since Japanese patients with T2DM usually have severe impairment in the earlyphase of...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Lee S,Yabe D,Nohtomi K,Takada M,Morita R,Seino Y,Hirano T

    更新日期:2010-01-01 00:00:00

  • Nonclassic steroid 21-hydroxylase deficiency due to a homozygous V281L mutation in CYP21A2 detected by the neonatal mass-screening program in Japan.

    abstract::Since 1989, neonatal mass screening for congenital adrenal hyperplasia (CAH) has been carried out in Japan. The mass screening has detected not only the patients with the classic form of steroid 21-hydroxylase deficiency (21-OHD), but also those with the nonclassic (NC) form of 21-OHD, and the molecular basis in these...

    journal_title:Endocrine journal

    pub_type: 杂志文章


    authors: Shinagawa T,Horikawa R,Isojima T,Naiki Y,Tanaka T,Katsumata N

    更新日期:2007-12-01 00:00:00

  • Efficacy of combined therapy of goserelin and letrozole on very young women with advanced breast cancer as first-line endocrine therapy.

    abstract::Breast cancer in young women younger than 35 years old is rare, aggressive and associated with a poor prognosis. Endocrine therapy is a preferred treatment modality in hormone receptor-positive early stage and advanced breast cancer, combined therapy of goserelin and letrozole presents an option for premenopausal wome...

    journal_title:Endocrine journal

    pub_type: 临床试验,杂志文章


    authors: Liu X,Qu H,Cao W,Wang Y,Ma Z,Li F,Wang H

    更新日期:2013-01-01 00:00:00