Hypothalamic-pituitary-adrenal axis in WBN/Kob rats with non-insulin dependent diabetes mellitus.

Abstract:

:In an attempt to define the hypothalamic-pituitary-adrenal (HPA) axis in non-insulin dependent diabetic rats (WBN/Kob), we measured plasma corticotropin releasing factor (CRF), as well as arginine vasopressin (AVP), ACTH, and corticosterone (B), CRF concentrations in the median eminence (ME), the remainder of the hypothalamus (rHY) and the neurointermediate lobe of the pituitary (NIL). We also measured Iodine-125-labeled ovine CRF ([125I]oCRF) binding in the brain and peripheral tissues. Body and thymus weight in WBN/Kob rats were significantly lower than in control Wistar rats, but adrenal weight was higher in WBN/Kob rats. Plasma ACTH levels were significantly higher in WBN/Kob rats than in the control rats. However, plasma CRF, AVP and B levels in WBN/Kob rats were not different from those in the control rats. The CRF concentration was significantly decreased in the ME of the diabetic rats, compared with control rats, but CRF concentrations in the rHY and NIL were unchanged in the two groups. A significant reduction in [125I]oCRF binding in the anterior pituitary was demonstrated in WBN/Kob rats, but no significant difference between the diabetic and control rats in CRF binding was observed in the frontal cortex, spleen or adrenal gland. These findings suggest that the HPA axis is chronically stimulated in the non-insulin dependent diabetic rats.

journal_name

Endocr J

journal_title

Endocrine journal

authors

Tojo C,Takao T,Nishioka T,Numata Y,Suemaru S,Hashimoto K

doi

10.1507/endocrj.43.233

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

233-9

issue

2

eissn

0918-8959

issn

1348-4540

journal_volume

43

pub_type

杂志文章
  • Pathophysiology and treatment of subclinical Cushing's disease and pituitary silent corticotroph adenomas [Review].

    abstract::Pituitary adrenocorticotropic hormone (ACTH)-secreting tumor presents with a variety of clinical features. We outlined the features of ACTH release and characteristics of corticotroph adenoma cells. We especially focused on the corticotroph adenomas in patients with no clinical features of Cushing's disease. Subclinic...

    journal_title:Endocrine journal

    pub_type: 杂志文章,评审

    doi:10.1507/endocrj.ej14-0120

    authors: Kageyama K,Oki Y,Nigawara T,Suda T,Daimon M

    更新日期:2014-01-01 00:00:00

  • Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: a pilot study.

    abstract::Sirtuin1 (SIRT1) is activated during calorie restriction and appears to be related to energy balance through glucose or lipid metabolism and insulin signaling. These findings suggest that SIRT1 may play a role in the pathophysiology of visceral obesity. Therefore, we investigated the relationship between SIRT1 gene ex...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.ej13-0207

    authors: Lee H,Chu SH,Park JY,Park HK,Im JA,Lee JW

    更新日期:2013-01-01 00:00:00

  • Role of copper ion in the pathogenesis of type 2 diabetes.

    abstract::Reactive oxygen species (ROS) are induced under diabetic conditions and are likely associated with the development of type 2 diabetes. It is also known that ROS production is facilitated in the presence of copper ion through the Fenton reaction. The aim of this study was to examine the involvement of copper ion in the...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k09e-051

    authors: Tanaka A,Kaneto H,Miyatsuka T,Yamamoto K,Yoshiuchi K,Yamasaki Y,Shimomura I,Matsuoka TA,Matsuhisa M

    更新日期:2009-01-01 00:00:00

  • Relationship between metabolic syndrome categorized by newly recommended by International Diabetes Federation criteria with plasma homocysteine concentration.

    abstract::Plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease and increased tHcy levels have been reported to be a novel risk factor of atherosclerotic disease. The aim of this study was to assess the association of the metabolic syndrome components with plasma (tHcy) level. Total 722 parti...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k07e-018

    authors: Rhee EJ,Hwang ST,Lee WY,Yoon JH,Kim BJ,Kim BS,Kang JH,Lee MH,Park JR,Sung KC

    更新日期:2007-12-01 00:00:00

  • Serum sialic acid levels in the diagnosis and follow-up of subacute granulomatous thyroiditis.

    abstract::To evaluate the usefulness of monitoring serum sialic acid (SA) levels for diagnosis and follow-up of subacute granulomatous thyroiditis (SAT), 43 patients were studied at our clinic. In the acute phase of the disease their SA levels averaged 104.9 +/- 19.7 mg/dl (normal 44-69 mg/dl). In the recovery phase SA levels r...

    journal_title:Endocrine journal

    pub_type: 临床试验,杂志文章

    doi:10.1507/endocrj.40.83

    authors: Tajiri J,Noguchi S,Morita M,Tamaru M,Murakami T,Murakami N

    更新日期:1993-02-01 00:00:00

  • SGLT2 inhibitors provide an effective therapeutic option for diabetes complicated with insulin antibodies.

    abstract::Diabetes mellitus complicated with insulin antibodies is rare in clinical practice but usually difficult to control. A high amount of insulin antibodies, especially with low affinity and high binding capacity, leads to unstable glycemic control characterized by hyperglycemia unresponsive to large volume of insulin and...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ15-0523

    authors: Hayashi A,Takano K,Kawai S,Shichiri M

    更新日期:2016-01-01 00:00:00

  • The association between thyroid hormone balance and thyroid volume in patients with Hashimoto thyroiditis.

    abstract::While patients with large goitrous thyroid diseases often have a relatively high serum free triiodothyronine (FT3)/free thyroxine (FT4) ratio, athyreotic patients have a relatively low FT3/FT4 ratio. Here we investigated the relationship between thyroid hormone status and thyroid volume (TV) among a large number of eu...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ19-0063

    authors: Kawasaki M,Ito M,Danno H,Kousaka K,Nakamura T,Yoshioka W,Kasahara T,Kudo T,Nishihara E,Fukata S,Nishikawa M,Nakamura H,Toyoda N,Miyauchi A

    更新日期:2019-09-28 00:00:00

  • Inappropriate elevation of intact PTH in the presence of normocalcemia after successful surgery for primary hyperparathyroidism.

    abstract::We describe here a patient with primary hyperparathyroidism who had high serum intact PTH levels for over 16 months after parathyroidectomy without signs of recurrence or persistence of the disease. The patient was a 48-year-old female who appeared well nourished (body mass index, 23.7). She was received subtotal gast...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.45.609

    authors: Mimura Y,Kanauchi H,Ogawa T,Ohkura F,Kaminishi M

    更新日期:1998-10-01 00:00:00

  • Active form of vitamin D ameliorates non-alcoholic fatty liver disease by alleviating oxidative stress in a high-fat diet rat model.

    abstract::The purpose of this study was to determine whether treatment using the active form of vitamin D (1,25(OH)2D3) could protect against high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) in rats and ameliorate oxidative stress. Male Sprague-Dawley rats were divided into three groups and treated with sta...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ16-0542

    authors: Zhu CG,Liu YX,Wang H,Wang BP,Qu HQ,Wang BL,Zhu M

    更新日期:2017-07-28 00:00:00

  • Is metabolic syndrome a condition independent of prediabetes and type 2 diabetes mellitus? A report from Turkey.

    abstract::It has been suggested that metabolic syndrome (MetS) overlaps prediabetes and type 2 diabetes and that it is not necessary to consider it as a separate clinical entity. In the present study, patients with normoglycemia and dysglycemia were compared in terms of MetS frequency and MetS criteria characteristics, in order...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k07-036

    authors: Uzunlulu M,Oguz A

    更新日期:2007-12-01 00:00:00

  • Regulation of immunoreactive activin A secretion from cultured rat anterior pituitary cells.

    abstract::Immunoreactive activin A (ir-activin A) release from cultured rat anterior pituitary cells was examined by measuring ir-activin A in culture medium by a specific radioimmunoassay. Ir-activin A release into the medium increased over 1-18 days, and reached a maximal level at 12-15 days. The basal levels of ir-activin A ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.43.39

    authors: Liu ZH,Shintani Y,Wakatsuki M,Sakamoto Y,Harada K,Zhang CY,Saito S

    更新日期:1996-02-01 00:00:00

  • Significance of thyroid stimulating antibody and long term follow up in patients with euthyroid Graves' disease.

    abstract::We examined 13 patients with euthyroid Graves' disease suspected ophthalmologically, by comparing them with 20 patients with untreated Graves' disease and by following them up for 5 to 10 years. They had Graves' ophthalmopathy (NOSPECS class II-IV) without other ocular diseases, normal levels of serum thyroid hormones...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.42.405

    authors: Kashiwai T,Tada H,Asahi K,Hidaka Y,Tamaki H,Iwatani Y,Amino N

    更新日期:1995-06-01 00:00:00

  • Characterization of plasma brain natriuretic peptide level in patients with type 2 diabetes.

    abstract::This study investigates whether the plasma brain natriuretic peptide (BNP) level is increased by the clinical traits of diabetes, including its complications, and whether these levels are affected by the presence of other combined diseases such as hypertension, hyperlipidemia, and coronary heart disease (CHD) in patie...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.52.353

    authors: Igarashi M,Jimbu Y,Hirata A,Tominaga M

    更新日期:2005-06-01 00:00:00

  • Absence of mutations at codon 768 of the RET proto-oncogene in sporadic and hereditary pheochromocytomas.

    abstract::Sixteen sporadic pheochromocytomas, 3 pheochromocytomas in neurofibromatosis 1, and 4 pheochromocytomas in multiple endocrine neoplasia (MEN) 2A or 2B were screened for mutations at codon 768 of the RET proto-oncogene by AluI digestion of polymerase chain reaction PCR products and mutations in exon 13 by PCR-single st...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.43.109

    authors: Yoshimoto K,Kimura T,Tanaka C,Moritani M,Iwahana H,Itakura M

    更新日期:1996-02-01 00:00:00

  • Immunolocalization of transforming growth factor-beta1 during follicular development and atresia in the mouse ovary.

    abstract::In each estrous cycle not all follicles recruited grow to ovulate, as some degenerate through the process of atresia. Apoptosis is the mechanism underlying follicle atresia. TGF-beta1 has been implicated in the induction and promotion of apoptosis in many cell types and it is expressed in the ovary. In this study immu...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.47.475

    authors: Christopher B

    更新日期:2000-08-01 00:00:00

  • Final height of Japanese patients with X-linked hypophosphatemic rickets: effect of vitamin D and phosphate therapy.

    abstract::X-linked hypophosphatemic rickets (XLH) is one of the most common causes of rickets in infancy and childhood. Combination therapy of vitamin D and phosphate is generally used for patients with XLH. Effect of treatment of vitamin D and phosphate during childhood on final height of XLH has to be elucidated in Japanese. ...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.47.163

    authors: Miyamoto J,Koto S,Hasegawa Y

    更新日期:2000-04-01 00:00:00

  • Two cases of empty sella syndrome with variable dexamethasone-suppressibility of ACTH and cortisol.

    abstract::We here describe two patients with empty sella syndrome who had variable and abnormal ACTH and cortisol secretory profiles. The patients are a 58-year old male and a 41-year old female, both of whom were neurotic. In both cases, low-dose dexamethasone suppression tests (1 mg, p.o., overnight) caused variable responses...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.43.417

    authors: Sakaguchi H,Inoue D,Kataoka K,Koshiyama H,Aoki N,Nakao K

    更新日期:1996-08-01 00:00:00

  • Pathogenesis of chronic hypernatremia with dehydrated and non-dehydrated states in hypothalamic space-occupying lesions.

    abstract::The present study was undertaken to determine pathophysiology of body water control in hypernatremic subjects with hypothalamic space-occupying lesions. Eight subjects with hypothalamic space-occupying lesions were divided into two groups of hypernatremia in the presence or absence of body water deficit. In 5 dehydrat...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k07e-132

    authors: Hayashi T,Murata M,Saito T,Ikoma A,Tamemoto H,Kawakami M,Ishikawa SE

    更新日期:2008-08-01 00:00:00

  • Tissue-specific changes in insulin receptor mRNA concentrations in dexamethasone-treated and adrenalectomized rats.

    abstract::The relative concentrations of total insulin receptor (IR) mRNA were measured in the epididymal adipose tissue and liver of intact untreated rats, dexamethasone-treated rats, adrenalectomized rats and adrenalectomized rats treated with dexamethasone, using RNA blot assays and a specific IR cDNA probe. Northern blot as...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.41.737

    authors: Leal MA,Aller P,Mas A,Carranza MC,Calle C

    更新日期:1994-12-01 00:00:00

  • Association between serum ferritin and circulating oxidized low-density lipoprotein levels in patients with type 2 diabetes.

    abstract::The oxidative modification of low-density lipoproteins (LDL) plays a central role in the initiation and acceleration of atherosclerosis. Iron plays a part in the formation of highly toxic free radicals such as hydroxide and superoxide anions, which can induce lipid peroxidation. We investigated whether serum iron stat...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k06-010

    authors: Ikeda Y,Suehiro T,Yamanaka S,Kumon Y,Takata H,Inada S,Ogami N,Osaki F,Inoue M,Arii K,Hashimoto K

    更新日期:2006-10-01 00:00:00

  • Acute hyperglycemia and activation of the beta-adrenergic system do not exhibit synergistic inhibitory actions on thyrotropin-releasing hormone (TRH)-induced thyroid stimulating hormone (TSH) secretion.

    abstract::Thyrotropin-releasing hormone (TRH)-stimulated thyroid stimulating hormone (TSH) response in normal subjects is suppressed by oral glucose administration. Pharmacologic studies indicate that this suppressive action of glucose is mediated by an increase in hypothalamic somatostatin (SRIH) tone. Since activation of the ...

    journal_title:Endocrine journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1507/endocrj.52.69

    authors: Park C,Kim E,Sohn S,Yang I,Koh G,Oh S,Woo J,Kim S,Kim J,Kim Y,Oh K,Park S,Park S

    更新日期:2005-02-01 00:00:00

  • Add-on therapy with the DPP-4 inhibitor sitagliptin improves glycemic control in insulin-treated Japanese patients with type 2 diabetes mellitus.

    abstract::The effect of add-on therapy with sitagliptin on glycemic control was prospectively investigated in patients with type 2 diabetes mellitus (T2DM) receiving insulin alone or insulin combined with oral antidiabetic drugs. Seventy-one patients were evaluated (38 men and 33 women aged 63.9 ± 10.2 years). They were divided...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.ej12-0293

    authors: Katsuno T,Ikeda H,Ida K,Miyagawa J,Namba M

    更新日期:2013-01-01 00:00:00

  • Increased urinary levels of pentosidine, pyrraline and acrolein adduct in type 2 diabetes.

    abstract::This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.50.61

    authors: Daimon M,Sugiyama K,Kameda W,Saitoh T,Oizumi T,Hirata A,Yamaguchi H,Ohnuma H,Igarashi M,Kato T

    更新日期:2003-02-01 00:00:00

  • A novel heterozygous mutation of steroidogenic factor-1 (SF-1/Ad4BP) gene (NR5A1) in a 46, XY disorders of sex development (DSD) patient without adrenal failure.

    abstract::Steroidogenic factor-1 [(SF-1/Ad4BP) (MIM184757)] is a nuclear receptor that regulates multiple genes involved in adrenal and gonadal development, steroidogenesis, reproduction, and other metabolic functions. Initially, mutations of SF-1/Ad4BP gene (NR5A1) in humans were identified in two 46, XY female patients with a...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k08e-380

    authors: Tajima T,Fujiwara F,Fujieda K

    更新日期:2009-01-01 00:00:00

  • Evaluation of salivary cortisol measurements for the diagnosis of subclinical Cushing's syndrome.

    abstract::Late-night salivary cortisol (NSC) has been recognized as a sensitive and easy-to-perform screening test for the diagnosis of overt Cushing's syndrome (CS). However, there have been few reports on the diagnostic utility of salivary cortisol (SC) measurement in the diagnosis of subclinical Cushing's syndrome (SCS). T...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.ej11-0204

    authors: Tateishi Y,Kouyama R,Mihara M,Doi M,Yoshimoto T,Hirata Y

    更新日期:2012-01-01 00:00:00

  • Application of thermography in the diagnostic investigation of thyroid nodules.

    abstract::Thyroid nodules (TN) are common in the general population, and the clinical importance of diagnosing thyroid nodules is based on excluding the possibility of thyroid cancer, which occurs in 7-15% of cases. The thyroid gland, owing to its superficial location, is easily accessible via thermography, a noninvasive method...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.EJ20-0541

    authors: Damião CP,Montero JRG,Moran MBH,de Oliveira Marçal E Silva Carvalho ME,de Farias CG,Brito IB,Saad MAN,Fontes CAP,Fainstein C,Rodrigues MFO,Palombo A,Conci A,da Cruz Filho RA,Lima GAB

    更新日期:2021-01-21 00:00:00

  • Effect of methimazole treatment for 2 years on circulating IL-4, IgE, TBII, and TSAb in patients with hyperthyroid Graves' disease.

    abstract::In this study we confirmed our previous findings on the importance of IgE in Graves' disease and further investigated the relationships existing among Graves' disease, IgE, and interleukin-4. Two hundred and thirty-two newly diagnosed Graves' disease patients were treated with methimazole for 2 years, and were classif...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.k06-054

    authors: Yamada T,Komiya I,Miyahara Y,Komatsu M,Shima I,Inazawa T,Aizawa T

    更新日期:2006-12-01 00:00:00

  • Induction of ovulation by Sairei-to for polycystic ovary syndrome patients.

    abstract::In anovulatory patients ovulation is usually induced by clomiphene citrate (CC) or gonadotropin therapy, but in the case of polycystic ovary syndrome (PCOS), diagnosed by the presence of several micropolycysts in the ovaries and a high LH/FSH ratio in the serum, CC is only minimally effective, and side effects are oft...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.46.217

    authors: Sakai A,Kondo Z,Kamei K,Izumi S,Sumi K

    更新日期:1999-02-01 00:00:00

  • A somatotropin-producing pituitary adenoma with an isolated adrenocorticotropin-producing pituitary adenoma in a female patient with acromegaly, subclinical Cushing's disease and a left adrenal tumor.

    abstract::A 67-year-old female with hypertension and impaired glucose tolerance was admitted to our hospital because of a typical acromegalic appearance, including large, thickened bulky hands and feet, and a large prominent forehead and tongue. She did not have a Cushingoid appearance, such as a moon-face, buffalo hump, purple...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.ej14-0093

    authors: Kobayashi Y,Takei M,Ohkubo Y,Kakizawa Y,Matoba H,Kumagai M,Takeda T,Suzuki S,Komatsu M

    更新日期:2014-01-01 00:00:00

  • 20 kDa human growth hormone (20K hGH) stimulates insulin-like growth factor-I (IGF-I) gene expression at lower concentrations than 22K hGH in hGH receptor-expressing Ba/F3 cells.

    abstract::Growth hormone (GH) secreted from the pituitary is essential for postnatal growth in animals. GH exerts its actions by a direct effect on target organs and by stimulating insulin-like growth factor I (IGF-I) production. In the human pituitary, there is a naturally occurring variant protein which has a molecular mass o...

    journal_title:Endocrine journal

    pub_type: 杂志文章

    doi:10.1507/endocrj.47.supplmarch_s37

    authors: Yoshizato H,Tanaka M,Fujikawa T,Higashimoto Y,Shimizu A,Nakashima K

    更新日期:2000-03-01 00:00:00