Classification of thyroid follicular cell tumors: with special reference to borderline lesions.

abstract：:Following the accident at the Fukushima Daiichi Nuclear Power Station which occurred on March 11, 2011 due to the Eastern Japan Great Earthquake (the Accident), there have been concerns over elevation of the risk of thyroid cancer among children due to internal exposure to radioactive iodine. In Fukushima Prefecture, ...

journal_title：Endocrine journal

authors： Iwaku K,Noh JY,Sasaki E,Suzuki N,Kameda T,Kobayashi S,Yoshihara A,Ohye H,Watanabe N,Suzuki M,Matsumoto M,Kunii Y,Mukasa K,Sugino K,Ito K

更新日期：2014-01-01 00:00:00

abstract：:Nesfatin-1 is a polypeptide derived from the posttranslational processing of the N-terminal fragment of nucleobindin 2 (NUCB2), that was originally identified as an anorexigenic hypothalamic neuropeptide. A number of reports have recently shown that NUCB2/nesfatin-1 is widely expressed in various peripheral tissues, i...

journal_title：Endocrine journal

authors： Cao X,Liu XM,Zhou LH

更新日期：2013-01-01 00:00:00

abstract：:We examined the effects of the long-term administration to mice of thyroid hormone or propylthiouracil (PTU) on lymphocyte subsets in spleens, and thymuses to clarify whether hyperthyroxinemia itself causes the changes in lymphocyte subsets, such as the marked increase in CD5+ B cells and decrease in natural killer (N...

journal_title：Endocrine journal

authors： Watanabe K,Iwatani Y,Hidaka Y,Watanabe M,Amino N

更新日期：1995-10-01 00:00:00

abstract：:Hypertension and norepinephrine hypersecretion in a 59-year-old woman suffering from malignant pheochromocytoma with multiple metastases were appropriately controlled with alpha- and beta- blockers, and alpha-methyltyrosine (alpha-MT), a catecholamine-synthesis inhibitor. Metastasized vertebrae were treated with exter...

journal_title：Endocrine journal

authors： Teno S,Tanabe A,Nomura K,Demura H

更新日期：1996-10-01 00:00:00

abstract：:Thyroid nodules (TN) are common in the general population, and the clinical importance of diagnosing thyroid nodules is based on excluding the possibility of thyroid cancer, which occurs in 7-15% of cases. The thyroid gland, owing to its superficial location, is easily accessible via thermography, a noninvasive method...

journal_title：Endocrine journal

authors： Damião CP,Montero JRG,Moran MBH,de Oliveira Marçal E Silva Carvalho ME,de Farias CG,Brito IB,Saad MAN,Fontes CAP,Fainstein C,Rodrigues MFO,Palombo A,Conci A,da Cruz Filho RA,Lima GAB

更新日期：2021-01-21 00:00:00

abstract：:The physiology of insulin signaling under normal and disease conditions is well studied in classical insulin target tissues, but not in podocytes. To examine insulin stimulation of podocyte GLUT4 translocation, we established a protocol involving treatment with the PPARα agonist fenofibrate to induce E11 podocyte diff...

journal_title：Endocrine journal

authors： Saito T,Yamada E,Okada S,Shimoda Y,Tagaya Y,Hashimoto K,Satoh T,Mori M,Okada J,Pessin JE,Yamada M

更新日期：2014-01-01 00:00:00

abstract：:The present study was aimed to examine the possible functional relationship between melatonin and hypothalamic transmitters, endogenous opioids and excitatory amino acids in controlling gonadotropin secretion in ovariectomized estrogen-primed rats. An intravenous injection of naloxone (mu opioid receptor antagonist), ...

journal_title：Endocrine journal

authors： Akema T,Ikeda T,Chiba A,Sugiyama H,Sato I,Kimura F,Toyoda J

更新日期：1999-12-01 00:00:00

abstract：:The objective of this study was to investigate the effect of administration of recombinant human growth hormone (hGH) in patients with Noonan syndrome. hGH was administered (0.5 IU/kg/week) to 15 patients with Noonan syndrome over a 2 year period. Average patient age prior to therapy was 7.5 +/- 2.5 (mean +/- SD) yr, ...

journal_title：Endocrine journal

authors： Ogawa M,Moriya N,Ikeda H,Tanae A,Tanaka T,Ohyama K,Mori O,Yazawa T,Fujita K,Seino Y,Kubo T,Tanaka H,Nishi Y,Yoshimoto M

更新日期：2004-02-01 00:00:00

abstract：:Interferon-tau (IFNtau) is produced by the trophectoderm of ruminant ungulates and its gene transactivation in vitro has so far been achieved only in human choriocarcinoma cells, JAR and JEG3. To examine if ovine IFNtau gene transactivation could be induced in cells other than JAR or JEG3 cells and its activation coul...

journal_title：Endocrine journal

authors： Yamaguchi H,Ikeda Y,Taylor A,Katsumura M,Miyazawa T,Takahashi E,Imakawa K,Sakai S

更新日期：1999-06-01 00:00:00

abstract：:Troglitazone (T) and d-chiroinositol (DCI) have been reported to improve insulin resistance associated with obesity and NIDDM. We tested whether these compounds counteract the insulin antagonistic effects of recombinant human GH. Male Wistar rats were allocated to 4 different treatment groups, rhGH (n=8), rhGH+T (n=7)...

journal_title：Endocrine journal

authors： Sugimoto M,Takeda N,Hattori J,Yoshino K,Nakashima K,Okumura S,Ishimori M,Yasuda K

更新日期：1999-03-01 00:00:00

abstract：:Thyroid disease is known to be associated with pulmonary arterial hypertension (PAH). We investigated the prevalence of thyroid disease in patients with idiopathic PAH (IPAH) or heritable PAH (HPAH), and the factors affecting the pathogenesis of thyroid disease. We retrospectively evaluated 59 patients with IPAH or HP...

journal_title：Endocrine journal

authors： Satoh M,Aso K,Nakayama T,Saji T

更新日期：2017-12-28 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN 1) is rarely reported in Japanese and other oriental populations. To examine if there is a racial difference in the prevalence of MEN 1, we initiated extensive work on patients with endocrine tumors for additional lesions, and annual screening of family members of affected pati...

journal_title：Endocrine journal

authors： Katai M,Sakurai A,Itakura Y,Ikeo Y,Nakajima K,Hara M,Iijima S,Kaneko T,Kobayashi M,Ichikawa K,Aizawa T,Hashizume K

更新日期：1997-12-01 00:00:00

abstract：:A 19-year-old girl presented at our emergency room with hypokalemic periodic paralysis. She had a thyrotoxic goiter and had experienced three paralytic attacks during the previous 2 years on occasions when she stopped taking antithyroid drugs. In addition to thyrotoxic periodic paralysis (TPP), she had metabolic acido...

journal_title：Endocrine journal

authors： Im EJ,Lee JM,Kim JH,Chang SA,Moon SD,Ahn YB,Son HS,Cha BY,Lee KW,Son HY

更新日期：2010-01-01 00:00:00

abstract：:We assessed the incidence of elderly patients in Japanese acromegalics and the characteristics of their clinical presentation. We also evaluated the safety and efficacy of transsphenoidal surgery (TSS) in this patient group. During the 28-year period from 1980 to 2007 we treated 290 patients with acromegaly at our hos...

journal_title：Endocrine journal

authors： Arita K,Hirano H,Yunoue S,Fujio S,Tominaga A,Sakoguchi T,Sugiyama K,Kurisu K

更新日期：2008-10-01 00:00:00

abstract：:Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension. The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium...

journal_title：Endocrine journal

authors： Ohtsuka H,Komiya I,Aizawa T,Yamada T

更新日期：1995-12-01 00:00:00

abstract：:Pseudohypoparathyroidism (PHP) is associated with compromised signal transductions via PTH receptor (PTH-R) and other G-protein-coupled receptors including GHRH-R. To date, while GH deficiency (GHD) has been reported in multiple patients with PHP-Ia caused by mutations on the maternally expressed GNAS coding regions a...

journal_title：Endocrine journal

authors： Sano S,Iwata H,Matsubara K,Fukami M,Kagami M,Ogata T

更新日期：2015-01-01 00:00:00

abstract：:Although several authors have reported single cases illustrative of some ultrasonographic characteristic of parathyroid carcinoma, the value of ultrasonography for diagnosing this entity remains to be determined. The purpose of our study was to investigate the ultrasonographic features of parathyroid carcinoma in a la...

journal_title：Endocrine journal

authors： Hara H,Igarashi A,Yano Y,Yashiro T,Ueno E,Aiyoshi Y,Ito K,Obara T

更新日期：2001-04-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is known to stimulate the synthesis and secretion of various proinflammatory cytokines in both the peripheral immune cells and the brain. Yet, the relative contribution of peripheral and central cytokines to the LPS-induced activation of the hypothalamo-pituitary-adrenal axis is still poorly u...

journal_title：Endocrine journal

authors： Kakizaki Y,Watanobe H,Kohsaka A,Suda T

更新日期：1999-08-01 00:00:00

abstract：:Betacellulin (BTC) purified from mouse beta cell tumor (betaTC-3) is a new member of the epidermal growth factor (EGF) family which can bind receptor tyrosine kinase, EGF receptor (erbB1) and erbB4. It has been demonstrated that proBTC mRNA was abundantly expressed in human pancreas tissue, and that BTC converted amyl...

journal_title：Endocrine journal

authors： Miyagawa J,Hanafusa O,Sasada R,Yamamoto K,Igarashi K,Yamamori K,Seno M,Tada H,Nammo T,Li M,Yamagata K,Nakajima H,Namba M,Kuwajima M,Matsuzawa Y

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVES:To evaluate the effect of atorvastatin on bone mass and markers of bone remodeling in patients with acute coronary syndrome according to the Lys656Asn leptin receptor gene polymorphism. METHODS:Sixty-two patients with acute coronary syndrome were included. Patients were allocated to low and high doses of at...

journal_title：Endocrine journal

authors： Pérez-Castrillón JL,Vega G,Abad L,Sanz-Cantalapiedra A,Sagredo MG,De Luis D,Duenas-Laita A

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Surgical removal of growth hormone-producing pituitary adenomas (GHomas) becomes difficult when they invade the cavernous sinus (CS). We investigated the relation among tumor proliferative potential, tumor volume and invasion of GHomas to CS. MATERIALS & METHODS:15 patients with GHoma aged 20-59 years were enr...

journal_title：Endocrine journal

authors： Iuchi S,Saeki N,Uchino Y,Higuchi Y,Tatsuno I,Nakamura S,Yasuda T,Yamaura A

更新日期：2000-03-01 00:00:00

abstract：:The proteins found in cow milk have been reported to cause systemic inflammation. Endoplasmic reticulum (ER) stress is known to be involved in the development of several metabolic disorders including insulin resistance and non-alcoholic fatty liver disease. However, the effect of thiazolidinediones (TZDs) on ER stress...

journal_title：Endocrine journal

authors： Kang SB,Kim HM,Kim HJ,Seok H,Huh JH,Lee BW,Kang ES,Lee HC,Cha BS

更新日期：2013-01-01 00:00:00

abstract：:Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease characterized by resistance to aldosterone, and the renal form of PHA1 is associated with heterozygous inactivating mutations in NR3C2, which encodes mineralocorticoid receptor (MR). Here we report a case of renal PHA1 due to a novel frameshift mutation i...

journal_title：Endocrine journal

authors： Kawashima Sonoyama Y,Tajima T,Fujimoto M,Hasegawa A,Miyahara N,Nishimura R,Hashida Y,Hayashi A,Hanaki K,Kanzaki S

更新日期：2017-01-30 00:00:00

abstract：:We assessed the significance of recommendations from the international consensus on continuous glucose monitoring (CGM)-derived metrics in Japanese children and adolescents with type 1 diabetes. Eighty-five patients (age, 13.5 ± 4.7 years) who wore the FreeStyle® Libre for a 28-day period were enrolled in this study. ...

journal_title：Endocrine journal

authors： Urakami T,Yoshida K,Kuwabara R,Mine Y,Aoki M,Suzuki J,Morioka I

更新日期：2020-10-28 00:00:00

abstract：:A patient with an apparently normal 46, XY karyotype, suffering from pure gonadal dysgenesis and of short stature was investigated. The patient, who was growth retarded, was a 30-year-old married Japanese woman with a history of primary amenorrhea and infertility with a weight of 42 kg and a height of 146 cm. She has ...

journal_title：Endocrine journal

authors： Tsutsumi O,Iida T,Taketani Y,Sugase M,Nakahori Y,Nakagome Y

更新日期：1994-06-01 00:00:00

abstract：:Patients with adrenal insufficiency require appropriate glucocorticoid replacement therapy; however, reliable biological parameters for optimizing glucocorticoid supplementation are limited. The physician has to rely primarily on clinical judgment, carefully taking into account signs and symptoms potentially suggestiv...

journal_title：Endocrine journal

authors： Watanabe T,Ozawa A,Ishii S,Tomaru T,Shibusawa N,Saito T,Yamada E,Horiguchi K,Nakajima Y,Matsumoto S,Yoshino S,Katano-Toki A,Hashimoto K,Mori M,Okada S,Satoh T,Yamada M

更新日期：2018-05-28 00:00:00

abstract：:In contrast to minimally invasive follicular thyroid carcinoma (FTC), widely invasive FTC is aggressive and is associated with a dire prognosis. However, prognostic factors of widely invasive FTC have not been intensively investigated. In this study, we investigated this issue in a series of 79 widely invasive FTC pat...

journal_title：Endocrine journal

authors： Ito Y,Hirokawa M,Masuoka H,Yabuta T,Fukushima M,Kihara M,Higashiyama T,Takamura Y,Kobayashi K,Miya A,Miyauchi A

更新日期：2013-01-01 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) is a skeletal disorder with progressive heterotopic ossification in skeletal muscle. A mutation causing constitutive activation in a bone morphogenetic protein (BMP) type 1 receptor [ALK2(R206H)] is found in most patients with FOP. However, the details in the heterotopic oss...

journal_title：Endocrine journal

authors： Mao L,Yano M,Kawao N,Tamura Y,Okada K,Kaji H

更新日期：2013-01-01 00:00:00

abstract：:To evaluate the clinical usefulness of serum soluble Fas (sFas) and sFas ligand as a prognostic factor and for monitoring the regression and progression of metastatic prostate cancer treated with endocrine therapy, sFas and sFas ligand were measured in sera collected from 30 patients with untreated metastatic prostate...

journal_title：Endocrine journal

authors： Furuya Y,Nagakawa O,Fuse H

更新日期：2003-10-01 00:00:00

abstract：:The aims of this study were to: 1) determine the prevalence of hyperprolactinaemia in patients with newly diagnosed subclinical and overt hypothyroidism, and 2) investigate the change in PRL levels with treatment. In this observational study, patients with a new diagnosis of hypothyroidism in our endocrinology clinic ...

journal_title：Endocrine journal

authors： Hekimsoy Z,Kafesçiler S,Güçlü F,Ozmen B

更新日期：2010-01-01 00:00:00