Intact sex determining region Y (SRY) in a patient with XY pure gonadal dysgenesis and a twin brother.

abstract：:A nationwide epidemiologic survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases was conducted in 2010 to clarify the prevalence and the clinical presentations of the disorders. A questionnaire inquiring the experience of patients with these diseases was sent to randomly selected hospitals th...

journal_title：Endocrine journal

authors： Endo I,Fukumoto S,Ozono K,Namba N,Inoue D,Okazaki R,Yamauchi M,Sugimoto T,Minagawa M,Michigami T,Nagai M,Matsumoto T

更新日期：2015-01-01 00:00:00

abstract：:Studies on resveratrol in a wide range of concentrations on obese mice and adipose cells are necessary to comprehend its range of diverse and contradictory effects. In this study, we examined the anti-obesity effects of resveratrol on high-fat diet (HFD)-induced obese mice at dosages ranging from 1 to 30 mg/kg treatme...

journal_title：Endocrine journal

authors： Chang CC,Lin KY,Peng KY,Day YJ,Hung LM

更新日期：2016-01-01 00:00:00

abstract：:We assessed the incidence of elderly patients in Japanese acromegalics and the characteristics of their clinical presentation. We also evaluated the safety and efficacy of transsphenoidal surgery (TSS) in this patient group. During the 28-year period from 1980 to 2007 we treated 290 patients with acromegaly at our hos...

journal_title：Endocrine journal

authors： Arita K,Hirano H,Yunoue S,Fujio S,Tominaga A,Sakoguchi T,Sugiyama K,Kurisu K

更新日期：2008-10-01 00:00:00

abstract：:Differentiated thyroid carcinoma (DTC) is generally indolent in nature and, even though it metastasizes to distant organs, the prognosis is normally excellent. In contrast, the overall survival (OS) of patients with radioactive iodine (RAI)-refractory and progressive metastases is dire, because no effective therapies ...

journal_title：Endocrine journal

authors： Ito Y,Suzuki S,Ito K,Imai T,Okamoto T,Kitano H,Sugitani I,Sugino K,Tsutsui H,Hara H,Yoshida A,Shimizu K

更新日期：2016-07-30 00:00:00

abstract：:Since there is increasing evidence that postprandial hyperglycemia is a risk factor for the development of macrovascular complications, it is important to predict postprandial hyperglycemia in the early stages of glucose intolerance, and routine medical checkups provide a good opportunity to do so. The aim of this stu...

journal_title：Endocrine journal

authors： Goto M,Yamamoto-Honda R,Shimbo T,Goto A,Terauchi Y,Kanazawa Y,Noda M

更新日期：2011-01-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) may mimic mixed medullary and follicular thyroid carcinoma (MMFTC). MTC originates from para-follicular cells, while MMFTC is an uncommon tumor characterized by coexistence of follicular and para-follicular cell-derived tumor populations. A 35-year-old woman was diagnosed with MTC but...

journal_title：Endocrine journal

authors： Takeshima K,Ariyasu H,Uraki S,Morita S,Furukawa Y,Inaba H,Iwakura H,Doi A,Warigaya K,Murata SI,Enomoto K,Hotomi M,Akamizu T

更新日期：2020-10-28 00:00:00

abstract：:It has been suggested that metabolic syndrome (MetS) overlaps prediabetes and type 2 diabetes and that it is not necessary to consider it as a separate clinical entity. In the present study, patients with normoglycemia and dysglycemia were compared in terms of MetS frequency and MetS criteria characteristics, in order...

journal_title：Endocrine journal

authors： Uzunlulu M,Oguz A

更新日期：2007-12-01 00:00:00

abstract：:PRL surges in female rats have dual effects of luteal function: either inducing luteolysis during the estrous cycle or rescuing and maintaining luteal function during pseudopregnancy. We analyzed these apparent contradictory effects in relation to apoptosis. The detection of fragmented DNA and in situ 3'-end labeling ...

journal_title：Endocrine journal

authors： Kanuka H,Matsuyama S,Ohnishi M,Matsumoto Y,Nishihara M,Takahashi M

更新日期：1997-02-01 00:00:00

abstract：:Administration of monosodium L-glutamate (MSG) to neonatal mice produces a hypothalamic syndrome consisting of stunted growth and later development of obesity. We assayed plasma insulin (IRI), thyroxine (T4) and insulin-like growth factor-I (IGF-I) to investigate their roles in the growth of the mice. Two mg/g body we...

journal_title：Endocrine journal

authors： Yamamoto T,Matsuo S,Ueshima Y,Inoue F,Kinugasa A,Sawada T

更新日期：1993-08-01 00:00:00

abstract：:We here describe two patients with empty sella syndrome who had variable and abnormal ACTH and cortisol secretory profiles. The patients are a 58-year old male and a 41-year old female, both of whom were neurotic. In both cases, low-dose dexamethasone suppression tests (1 mg, p.o., overnight) caused variable responses...

journal_title：Endocrine journal

authors： Sakaguchi H,Inoue D,Kataoka K,Koshiyama H,Aoki N,Nakao K

更新日期：1996-08-01 00:00:00

abstract：:Patients with adrenal insufficiency require appropriate glucocorticoid replacement therapy; however, reliable biological parameters for optimizing glucocorticoid supplementation are limited. The physician has to rely primarily on clinical judgment, carefully taking into account signs and symptoms potentially suggestiv...

journal_title：Endocrine journal

authors： Watanabe T,Ozawa A,Ishii S,Tomaru T,Shibusawa N,Saito T,Yamada E,Horiguchi K,Nakajima Y,Matsumoto S,Yoshino S,Katano-Toki A,Hashimoto K,Mori M,Okada S,Satoh T,Yamada M

更新日期：2018-05-28 00:00:00

abstract：:Type 2 diabetes is a serious threat to human health all over the world. It is particularly important to look for the pathogenesis of type 2 diabetes. Researchers have found that obesity was associated with a broad chronic inflammatory response and type 2 diabetes. And tumor necrosis factor alpha (TNF-α) is one of the ...

journal_title：Endocrine journal

authors： Wu S,Dong K,Wang J,Bi Y

更新日期：2018-06-27 00:00:00

abstract：:Although sitagliptin and repaglinide monotherapies improve postprandial hyperglycemia, the long-term effects and safety of their combination has not been examined. In this randomized 24-week trial of Japanese patients with poor control (HbA1c 7.0-8.5%) by sitagliptin, we divided 40 patients randomly into two equal gro...

journal_title：Endocrine journal

authors： Nishimura A,Usui S,Kumashiro N,Uchino H,Yamato A,Yasuda D,Nagasawa K,Okubo M,Mori Y,Hirose T

更新日期：2016-12-30 00:00:00

abstract：:The anti-programmed cell death-1 monoclonal antibody (mab), nivolumab has recently been approved for the treatment of unresectable or metastatic malignant melanoma and non-small-cell lung cancers in Japan. Ipilimumab, an anti-cytotoxic T lymphocyte antigen-4 mab for malignant melanoma that was approved earlier than ni...

journal_title：Endocrine journal

authors： Okano Y,Satoh T,Horiguchi K,Toyoda M,Osaki A,Matsumoto S,Tomaru T,Nakajima Y,Ishii S,Ozawa A,Shibusawa N,Shimada T,Higuchi T,Chikamatsu K,Yamada M

更新日期：2016-10-29 00:00:00

abstract：:In an attempt to define the hypothalamic-pituitary-adrenal (HPA) axis in non-insulin dependent diabetic rats (WBN/Kob), we measured plasma corticotropin releasing factor (CRF), as well as arginine vasopressin (AVP), ACTH, and corticosterone (B), CRF concentrations in the median eminence (ME), the remainder of the hypo...

journal_title：Endocrine journal

authors： Tojo C,Takao T,Nishioka T,Numata Y,Suemaru S,Hashimoto K

更新日期：1996-04-01 00:00:00

abstract：:Pseudohypoaldosteronism type 1 (PHA1) is a rare genetic disease characterized by resistance to aldosterone, and the renal form of PHA1 is associated with heterozygous inactivating mutations in NR3C2, which encodes mineralocorticoid receptor (MR). Here we report a case of renal PHA1 due to a novel frameshift mutation i...

journal_title：Endocrine journal

authors： Kawashima Sonoyama Y,Tajima T,Fujimoto M,Hasegawa A,Miyahara N,Nishimura R,Hashida Y,Hayashi A,Hanaki K,Kanzaki S

更新日期：2017-01-30 00:00:00

abstract：:We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m(2)), were genotyped for four haplotype-tagged single nucleotide po...

journal_title：Endocrine journal

authors： Zheng J,Chen LL,Xiao F,Hu X,Deng X,Li H

更新日期：2012-01-01 00:00:00

abstract：:Sodium-glucose co-transporter-2 inhibitors are newly established anti-diabetic agents with a unique glucose-lowering mechanism. In the present study, we investigated the efficacy and safety of the sodium-glucose co-transporter-2 inhibitor ipragliflozin (Ipra) for metabolic markers and cardiovascular parameters in Japa...

journal_title：Endocrine journal

authors： Nomiyama T,Shimono D,Horikawa T,Fujimura Y,Ohsako T,Terawaki Y,Fukuda T,Motonaga R,Tanabe M,Yanase T,Collaborators of Fukuoka Study of Ipragliflozin (FUSION) trial.

更新日期：2018-08-27 00:00:00

abstract：:Glucagon dysfunction as well as insulin dysfunction is associated with the pathogenesis of type 2 diabetes (T2DM). However, it is still unclear whether the measurement of plasma glucagon levels is useful in understanding the pathophysiology of T2DM. We recently reported that sandwich ELISA provides more accurate plasm...

journal_title：Endocrine journal

authors： Kobayashi M,Satoh H,Matsuo T,Kusunoki Y,Tokushima M,Watada H,Namba M,Kitamura T

更新日期：2020-09-28 00:00:00

abstract：:The aim of this study was to assess the effect of the long-term different diabetic therapies on the plasma leptin level in type 2 diabetic subjects. We measured plasma leptin, body fat and fasting plasma insulin in 96 type 2 diabetic male subjects. They had received the same treatment regimen for more than one year (3...

journal_title：Endocrine journal

authors： Huang CC,Lin JD,Chang HY

更新日期：2001-06-01 00:00:00

abstract：:Ketoconazole is an imidazole derivative used to treat systemic and superficial mycoses by inhibiting sterol synthesis in fungi. The drug impairs steroid hormone synthesis by blocking mitochondrial P450-dependent enzyme systems. Because of its potent inhibitory effects on adrenal steroidogenesis, ketoconazole is valuab...

journal_title：Endocrine journal

authors： Chou SC,Lin JD

更新日期：2000-08-01 00:00:00

abstract：:Rickets and osteomalacia are diseases characterized by impaired mineralization of bone matrix. Recent investigations revealed that the causes for rickets and osteomalacia are quite variable. While these diseases can severely impair the quality of life of the affected patients, rickets and osteomalacia can be completel...

journal_title：Endocrine journal

authors： Fukumoto S,Ozono K,Michigami T,Minagawa M,Okazaki R,Sugimoto T,Takeuchi Y,Matsumoto T

更新日期：2015-01-01 00:00:00

abstract：:The cytologic localization and cellular levels of insulin-like growth factor binding protein-4 (IGFBP-4) in follicular and stromal compartments of normal and polycystic ovary syndrome (PCOS) ovaries during follicular growth and regression were investigated by the avidin/biotin immunoperoxidase method with a polyclonal...

journal_title：Endocrine journal

authors： Peng X,Maruo T,Samoto T,Mochizuki M

更新日期：1996-06-01 00:00:00

abstract：:This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the...

journal_title：Endocrine journal

authors： Daimon M,Sugiyama K,Kameda W,Saitoh T,Oizumi T,Hirata A,Yamaguchi H,Ohnuma H,Igarashi M,Kato T

更新日期：2003-02-01 00:00:00

abstract：:This study investigates whether the plasma brain natriuretic peptide (BNP) level is increased by the clinical traits of diabetes, including its complications, and whether these levels are affected by the presence of other combined diseases such as hypertension, hyperlipidemia, and coronary heart disease (CHD) in patie...

journal_title：Endocrine journal

authors： Igarashi M,Jimbu Y,Hirata A,Tominaga M

更新日期：2005-06-01 00:00:00

abstract：:The present study was conducted to elucidate the role of activin A in capillary formation. When bovine aortic endothelial cells (BAEC) were cultured in a collagen gel, basic fibroblast growth factor (FGF-2) induced tube formation. Activin A also induced tube formation and the addition of two factors together was more ...

journal_title：Endocrine journal

authors： Hayashi Y,Maeshima K,Goto F,Kojima I

更新日期：2007-04-01 00:00:00

abstract：:Growth hormone (GH) secreted from the pituitary is essential for postnatal growth in animals. GH exerts its actions by a direct effect on target organs and by stimulating insulin-like growth factor I (IGF-I) production. In the human pituitary, there is a naturally occurring variant protein which has a molecular mass o...

journal_title：Endocrine journal

authors： Yoshizato H,Tanaka M,Fujikawa T,Higashimoto Y,Shimizu A,Nakashima K

更新日期：2000-03-01 00:00:00

abstract：:The two types of prognostic factors of papillary thyroid carcinoma (PTC) are static and dynamic. The following static prognostic factors have been conventionally adopted: age, tumor size, extrathyroid extension, lymph node metastasis, and distant metastasis based on pre-, intra- and post-operative findings. These fact...

journal_title：Endocrine journal

authors： Ito Y,Miyauchi A,Kobayashi K,Kihara M,Miya A

更新日期：2014-01-01 00:00:00

abstract：:A 67-year-old female with hypertension and impaired glucose tolerance was admitted to our hospital because of a typical acromegalic appearance, including large, thickened bulky hands and feet, and a large prominent forehead and tongue. She did not have a Cushingoid appearance, such as a moon-face, buffalo hump, purple...

journal_title：Endocrine journal

authors： Kobayashi Y,Takei M,Ohkubo Y,Kakizawa Y,Matoba H,Kumagai M,Takeda T,Suzuki S,Komatsu M

更新日期：2014-01-01 00:00:00

abstract：:A case of isolated ACTH deficiency who developed autoimmune-mediated hypothyroidism and still showed impaired water diuresis during glucocorticoid replacement therapy is reported. A 45-year-old woman was initially admitted for nausea, vomiting, and general malaise. Her serum sodium and plasma osmolality, ACTH and cort...

journal_title：Endocrine journal

authors： Kageyama Y

更新日期：2000-12-01 00:00:00