Activin A as a critical mediator of capillary formation: interaction with the fibroblast growth factor action.

abstract：:Circulating human GH (hGH) consists of several molecular isoforms. It was previously reported that the proportion of 20 kilodalton hGH (20K-hGH) was elevated in the serum of patients with active acromegaly. In this study, we investigated the effects of octreotide and transsphenoidal adenomectomy on the proportion of 2...

journal_title：Endocrine journal

authors： Murakami Y,Shimizu T,Yamamoto M,Kato Y

更新日期：2004-06-01 00:00:00

abstract：:Thyrotropin levels are outside normal reference range in subclinical thyroid disease. Metabolic syndrome (MetS) involves clustered cardiovascular risk factors, including abnormal lipids, insulin resistance, and hypertension. This study aimed to investigate associations between subclinical thyroid disease, thyrotropi...

journal_title：Endocrine journal

authors： Wang CY,Chang TC,Chen MF

更新日期：2012-01-01 00:00:00

abstract：:Sodium-glucose co-transporter-2 inhibitors are newly established anti-diabetic agents with a unique glucose-lowering mechanism. In the present study, we investigated the efficacy and safety of the sodium-glucose co-transporter-2 inhibitor ipragliflozin (Ipra) for metabolic markers and cardiovascular parameters in Japa...

journal_title：Endocrine journal

authors： Nomiyama T,Shimono D,Horikawa T,Fujimura Y,Ohsako T,Terawaki Y,Fukuda T,Motonaga R,Tanabe M,Yanase T,Collaborators of Fukuoka Study of Ipragliflozin (FUSION) trial.

更新日期：2018-08-27 00:00:00

abstract：:Genetic linkage analyses have traced the loci for multiple endocrine neoplasia type 2A (MEN 2A) to an interval on chromosome 10q11.2. This region encompasses the RET proto-oncogene, a receptor tyrosine kinase gene expressed in medullary thyroid carcinoma (MTC) and pheochromocytoma. By means of genomic polymerase chain...

journal_title：Endocrine journal

authors： Oishi S,Sato T,Takiguchi-Shirahama S,Nakamura Y

更新日期：1995-08-01 00:00:00

abstract：:We recently reported three cases of severe hypertriglyceridemia caused by tamoxifen-treatment after breast cancer surgery. In that report we showed that one of the three patients had apo E3/3 and another had E4/2 phenotype. There are few data about the relationship between apoprotein E phenotype, one of modifiers of l...

journal_title：Endocrine journal

authors： Hozumi Y,Kawano M,Saito T,Miyata M

更新日期：1998-04-01 00:00:00

abstract：:Administration of monosodium L-glutamate (MSG) to neonatal mice produces a hypothalamic syndrome consisting of stunted growth and later development of obesity. We assayed plasma insulin (IRI), thyroxine (T4) and insulin-like growth factor-I (IGF-I) to investigate their roles in the growth of the mice. Two mg/g body we...

journal_title：Endocrine journal

authors： Yamamoto T,Matsuo S,Ueshima Y,Inoue F,Kinugasa A,Sawada T

更新日期：1993-08-01 00:00:00

abstract：:The common phenotype of nuclear receptor superfamily 5, group A, member 1 (NR5A1) gene mutations in 46,XY is gonadal dysgenesis without adrenal deficiency. Though the phenotype of gonadal dysgenesis is variable, ranging from complete female to normal male genitalia, an asymptomatic 46,XY male is rare. Preserved fertil...

journal_title：Endocrine journal

authors： Yagi H,Takagi M,Kon M,Igarashi M,Fukami M,Hasegawa Y

更新日期：2015-01-01 00:00:00

abstract：:Immunoglobulin G4-related disease (IgG4-RD) is characterized by elevated serum IgG4 levels, IgG4-positive plasmacytes, and lymphocyte infiltration into multiple organs. IgG4 thyroiditis is a subset of patients with Hashimoto's thyroiditis (HT) who exhibited histopathological features of IgG4-RD; its source of serum Ig...

journal_title：Endocrine journal

authors： Takeshima K,Ariyasu H,Inaba H,Inagaki Y,Yamaoka H,Furukawa Y,Doi A,Furuta H,Nishi M,Akamizu T

更新日期：2015-01-01 00:00:00

abstract：:We assessed the significance of recommendations from the international consensus on continuous glucose monitoring (CGM)-derived metrics in Japanese children and adolescents with type 1 diabetes. Eighty-five patients (age, 13.5 ± 4.7 years) who wore the FreeStyle® Libre for a 28-day period were enrolled in this study. ...

journal_title：Endocrine journal

authors： Urakami T,Yoshida K,Kuwabara R,Mine Y,Aoki M,Suzuki J,Morioka I

更新日期：2020-10-28 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) and its agonists have been known to directly affect steroid hormone production in human granulosa cells. In this study, we examined effects of GnRH on Ca2+ mobilization, protein kinase C activity and steroidogenesis of human granulosa cells. Human granulosa cells were harvested by...

journal_title：Endocrine journal

authors： Hori H,Uemura T,Minaguchi H

更新日期：1998-04-01 00:00:00

abstract：:In this review, we focused on the patient age as an indicator of tumor growth and prognostic significance in both clinical papillary thyroid carcinoma (PTC) and subclinical papillary microcarcinoma (PMC: PTC ≤ 1 cm). In clinical PTC, young age (< 30 years) and old age (≥ 60 years) significantly affected the disease-fr...

journal_title：Endocrine journal

authors： Ito Y,Miyauchi A,Kobayashi K,Miya A

更新日期：2014-01-01 00:00:00

abstract：:The amounts of immunoreactive proinsulin (IRP), immunoreactive insulin (IRI), and C-peptidelike immunoreactivity (CPR) in six insulinomas and one nesidioblastosis lesion were determined together with those in the surrounding pancreatic tissue. Four non-insulinoma and nondiabetic human pancreases were used as the contr...

journal_title：Endocrine journal

authors： Tasaka Y,Nakaya F,Matsumoto H,Odagiri R,Ohgawara H,Omori Y

更新日期：1993-04-01 00:00:00

abstract：:A 73-year-old Japanese woman was referred for examination of right flank pain and progressive hypertension. Abdominal CT incidentally detected a right adrenal mass 8 cm in size. The tumor exhibited isodensity by CT and contained high-intense lesion by T2-weighted MRI. Scintigraphy with (131) I-metaiodobenzylguanidine ...

journal_title：Endocrine journal

authors： Goto J,Otsuka F,Kodera R,Miyoshi T,Kinomura M,Otani H,Mimura Y,Ogura T,Yanai H,Nasu Y,Makino H

更新日期：2008-03-01 00:00:00

abstract：:Triple A syndrome, also known as Allgrove syndrome, is a rare autosomal recessive disorder characterized by adrenal insufficiency, achalasia and alacrima. It has recently been reported that this syndrome is caused by mutations in the AAAS gene. In the present study, we analyzed the AAAS gene in a Japanese patient with...

journal_title：Endocrine journal

authors： Katsumata N,Hirose H,Kagami M,Tanaka T

更新日期：2002-02-01 00:00:00

abstract：:To evaluate the prevalence of lymphocytic infiltrate in a large series of pituitary adenomas, we retrospectively studied tumor tissues from 1400 patients. Based on immunocytochemical data, tumors were classified as PRL (n=411), multihormonal (n=310), immunonegative (n=275), ACTH (n=166), GH (n=137), alpha subunit (n=4...

journal_title：Endocrine journal

authors： Heshmati HM,Kujas M,Casanova S,Wollan PC,Racadot J,Van Effenterre R,Derome PJ,Turpin G

更新日期：1998-06-01 00:00:00

abstract：:We report the case of a 7-year-old patient of short stature who had normal GH secretion, but a very low serum IGF-I level. On admittance, his height and weight were 102.2 cm (-3.8S.D.) and 15.7 kg (-1.8S.D.), respectively. His bone age was 2 years and 8 months. The serum GH responses to insulin, glucagon and L-dopa we...

journal_title：Endocrine journal

authors： Mochizuki D,Kodama H,Kubota K,Mori Y,Nakamoto N,Kobayashi M,Yanagawa Y,Kaji M

更新日期：2000-03-01 00:00:00

abstract：:KRN568 is a calcimimetic compound which acts on the calcium sensing receptors (CaR) on the parathyroid gland to suppress secretion of PTH. A recent report has demonstrated that CaRs are expressed on cultured human antral gastrin cells and that gastrin secretion is stimulated by an increase in extracellular calcium lev...

journal_title：Endocrine journal

authors： Igarashi T,Ogata E,Maruyama K,Fukuda T

更新日期：2000-10-01 00:00:00

abstract：:To evaluate the clinical usefulness of serum soluble Fas (sFas) and sFas ligand as a prognostic factor and for monitoring the regression and progression of metastatic prostate cancer treated with endocrine therapy, sFas and sFas ligand were measured in sera collected from 30 patients with untreated metastatic prostate...

journal_title：Endocrine journal

authors： Furuya Y,Nagakawa O,Fuse H

更新日期：2003-10-01 00:00:00

abstract：:To determine whether patients with medullary thyroid carcinoma (MTC) develop other endocrine neoplasms or their relatives develop MTC, we investigated the mutations in the RET proto-oncogene in patients with multiple endocrine neoplasia type 2B (MEN 2B, N = 1) and sporadic MTC (N = 6). DNA from MTC tissue and the peri...

journal_title：Endocrine journal

authors： Migita M,Hiromatsu Y,Sato M,Yang D,Kameo J,Jimi A,Nonaka K

更新日期：1997-08-01 00:00:00

abstract：:We studied the cross-sectional relationship between GA and HbA1c in 142 type 2 diabetic patients who had an HbA1c level < 7.5% for at least one year without fluctuation by more than 0.5%. We also followed the changes of GA and HbA1c in 18 type 2 diabetic patients for 16 weeks as they progressed from untreated severe h...

journal_title：Endocrine journal

authors： Takahashi S,Uchino H,Shimizu T,Kanazawa A,Tamura Y,Sakai K,Watada H,Hirose T,Kawamori R,Tanaka Y

更新日期：2007-02-01 00:00:00

abstract：:We examined the effects of the long-term administration to mice of thyroid hormone or propylthiouracil (PTU) on lymphocyte subsets in spleens, and thymuses to clarify whether hyperthyroxinemia itself causes the changes in lymphocyte subsets, such as the marked increase in CD5+ B cells and decrease in natural killer (N...

journal_title：Endocrine journal

authors： Watanabe K,Iwatani Y,Hidaka Y,Watanabe M,Amino N

更新日期：1995-10-01 00:00:00

abstract：:The present study set forth the reference values for penile size and determined the prevalence of buried penis in Japanese full-term newborns. The stretched penile length was measured and the presence of buried penis was assessed at 1-7 days of age in 547 Japanese full-term newborn infants born between 2008 and 2012 i...

journal_title：Endocrine journal

authors： Matsuo N,Ishii T,Takayama JI,Miwa M,Hasegawa T

更新日期：2014-01-01 00:00:00

abstract：:In order to investigate the immunological aspects of silent thyroiditis, T lymphocyte subsets were analyzed by two-color flow cytometry in 10 patients with silent thyroiditis in the thyrotoxic phase, 12 patients with silent thyroiditis in the recovery phase, and 11 healthy volunteers as a control. The percentages of C...

journal_title：Endocrine journal

authors： Kushima K,Ban Y,Taniyama M,Itoh K

更新日期：1994-12-01 00:00:00

abstract：:Previously, we reported that short-term continuous glucose monitoring (CGM) with the professional iPro2© CGM device is a good clinical indicator of glycated hemoglobin (HbA1c) levels. However, there was no significant correlation between CGM and HbA1c levels when HbA1c levels were >8.0%. To further investigate this is...

journal_title：Endocrine journal

authors： Yamada M,Okada S,Oda H,Nakajima Y,C Bastie C,Kasai Y,Osaki A,Shimoda Y,Shibusawa R,Uehara R,Saito T,Ozawa A,Yamada E

更新日期：2020-05-28 00:00:00

abstract：:Components of cyclinD1/cyclin-dependent kinase 4 (CDK4)/p16INK4a/pRb pathway are the frequent target of many tumor types. We examined the role of retinoblastoma susceptibility gene (RB1) and the CDK4 gene in human pituitary tumorigenesis. For the RB1 gene, pRb expression and loss of heterozygosity (LOH) on 13q in pitu...

journal_title：Endocrine journal

authors： Honda S,Tanaka-Kosugi C,Yamada S,Sano T,Matsumoto T,Itakura M,Yoshimoto K

更新日期：2003-06-01 00:00:00

abstract：:The present study investigated the diurnal variation in GH receptor (GHR) mRNA in liver and skeletal muscle of 3-month-old GH-deficient and -sufficient mice using quantitative real-time RT-PCR. lit/lit (GH deficient) or lit/+ (GH sufficient) mice were fed ad libitum and lights were on between 0600 and 2000. Tissues we...

journal_title：Endocrine journal

authors： Itoh E,Iida K,del Rincon JP,Kim DS,Thorner MO

更新日期：2004-12-01 00:00:00

abstract：:The octanoylation of Ser3 is essential for the biological function of ghrelin. We examined the concentrations of the n-octanoylated active-form ghrelin in cord and neonatal blood using an RIA system that specifically recognized n-octanoylated ghrelin, as well as a system that measured the total ghrelin concentration. ...

journal_title：Endocrine journal

authors： Yokota I,Kitamura S,Hosoda H,Kotani Y,Kangawa K

更新日期：2005-04-01 00:00:00

abstract：:The proteins found in cow milk have been reported to cause systemic inflammation. Endoplasmic reticulum (ER) stress is known to be involved in the development of several metabolic disorders including insulin resistance and non-alcoholic fatty liver disease. However, the effect of thiazolidinediones (TZDs) on ER stress...

journal_title：Endocrine journal

authors： Kang SB,Kim HM,Kim HJ,Seok H,Huh JH,Lee BW,Kang ES,Lee HC,Cha BS

更新日期：2013-01-01 00:00:00

abstract：:The mechanism of onset of hypoglycemia in patients with carnitine deficiency has yet to be determined. Using mice with systemic carnitine deficiency (JVS mice), we examined this mechanism, focusing on the weaning period (days 14-28 postpartum). For normal mice, the survival rate was 100%, and no hypoglycemia was obser...

journal_title：Endocrine journal

authors： Kuwajima M,Fujihara H,Sei H,Umehara A,Sei M,Tsuda TT,Sukeno A,Okamoto T,Inubushi A,Ueta Y,Doi T,Kido H

更新日期：2007-12-01 00:00:00

abstract：:Unusual presentations with bone, lung or soft tissue metastases in initial diagnosis of follicular thyroid carcinoma have been reported occasionally. This implies how difficult it is to diagnosis this type of cancer at the pre-operative or intra-operative stage of treatment. Fine needle aspiration cytology has been sh...

journal_title：Endocrine journal

authors： Lin JD,Chao TC

更新日期：2006-08-01 00:00:00