Mutation of RET proto-oncogene in Japanese patients with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.

abstract：:Cushing's disease rarely appears as a consequence of hereditary disease. However, familial diseases with diminished glucocorticoid feedback are associated with secondary hypercorticotropinism and have been shown to give rise to pituitary adenomas. We here describe the rare case of a 30-year old female patient with con...

journal_title：Endocrine journal

authors： Haase M,Schott M,Kaminsky E,Lüdecke DK,Saeger W,Fritzen R,Schinner S,Scherbaum WA,Willenberg HS

更新日期：2011-01-01 00:00:00

abstract：:We aimed to explore whether common allelic variations in the SIRT1 gene were associated with excess body weight in a Chinese cohort. Using standard molecular techniques 820 non-diabetic individuals, some of who were classified as overweight (> 23 Kg/m(2)), were genotyped for four haplotype-tagged single nucleotide po...

journal_title：Endocrine journal

authors： Zheng J,Chen LL,Xiao F,Hu X,Deng X,Li H

更新日期：2012-01-01 00:00:00

abstract：:X-linked hypophosphatemic rickets (XLH) is one of the most common causes of rickets in infancy and childhood. Combination therapy of vitamin D and phosphate is generally used for patients with XLH. Effect of treatment of vitamin D and phosphate during childhood on final height of XLH has to be elucidated in Japanese. ...

journal_title：Endocrine journal

authors： Miyamoto J,Koto S,Hasegawa Y

更新日期：2000-04-01 00:00:00

abstract：:Serum C-reactive protein (CRP) concentrations have been reported to be associated with body fat, especially visceral fat accumulation, but most studies up to now have been conducted on non-diabetic subjects. In this study, we investigated the association between the serum CRP concentrations and parameters of adiposity...

journal_title：Endocrine journal

authors： Iwasaki T,Nakajima A,Yoneda M,Terauchi Y

更新日期：2006-06-01 00:00:00

abstract：:Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-ol...

journal_title：Endocrine journal

authors： Aoyama M,Takizawa H,Tsuboi M,Nakagawa Y,Tangoku A

更新日期：2017-12-28 00:00:00

abstract：:The effect of a synthetic steroidal anti-androgen, TZP-4238, on steroid-induced rat prostatic hyperplasia was investigated. Male Wistar rats were divided into four experimental groups. Group 1 consisted of intact controls. The other animals were castrated. The castrated animals were treated for 7 weeks with 1) testost...

journal_title：Endocrine journal

authors： Murakoshi M,Tagawa M,Inada R,Suzuki M,Mizokami A,Watanabe K

更新日期：1993-08-01 00:00:00

abstract：:We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4...

journal_title：Endocrine journal

authors： Oita M,Miyoshi H,Ono K,Nakamura A,Cho KY,Nomoto H,Yamamoto K,Omori K,Manda N,Kurihara Y,Aoki S,Atsumi T

更新日期：2018-02-26 00:00:00

abstract：:Defects in insulin receptor function have been associated with insulin resistant states such as obesity and type 2 diabetes mellitus. Several types of mutations in the insulin receptor gene have been identified in patients with genetic syndromes of extreme insulin resistance. We have studied a 10-year-old Japanese gir...

journal_title：Endocrine journal

authors： Hashiramoto M,Osawa H,Ando M,Murakami A,Nishimiya T,Nakano M,Nishida W,Onuma H,Makino H

更新日期：2005-08-01 00:00:00

abstract：:Glucagon dysfunction as well as insulin dysfunction is associated with the pathogenesis of type 2 diabetes (T2DM). However, it is still unclear whether the measurement of plasma glucagon levels is useful in understanding the pathophysiology of T2DM. We recently reported that sandwich ELISA provides more accurate plasm...

journal_title：Endocrine journal

authors： Kobayashi M,Satoh H,Matsuo T,Kusunoki Y,Tokushima M,Watada H,Namba M,Kitamura T

更新日期：2020-09-28 00:00:00

abstract：:It has been demonstrated the involvement of branched-chain amino acids (BCAA) on obesity and related metabolic disorder. We investigated the effects of branched-chain amino acids (BCAA) on obesity and on glucose/fat homeostasis in mice fed on a high-fat (45%) diet. BCAA was dissolved in 0.5% methylcellulose and added ...

journal_title：Endocrine journal

authors： Arakawa M,Masaki T,Nishimura J,Seike M,Yoshimatsu H

更新日期：2011-01-01 00:00:00

abstract：:We evaluated the concentration of epidermal growth factor (EGF) in platelets, serum and plasma obtained from 47 patients with Graves' disease, 7 with hypothyroidism and 20 healthy subjects. The platelets of the subjects were collected from platelet rich plasma and lysed by freezing and thawing. Subsequently the platel...

journal_title：Endocrine journal

authors： Okada M,Kamiya Y,Ito J,Yoshimata T,Kawaguchi M,Shibata H,Fujinami T

更新日期：1998-02-01 00:00:00

abstract：:The aims of this study were to: 1) determine the prevalence of hyperprolactinaemia in patients with newly diagnosed subclinical and overt hypothyroidism, and 2) investigate the change in PRL levels with treatment. In this observational study, patients with a new diagnosis of hypothyroidism in our endocrinology clinic ...

journal_title：Endocrine journal

authors： Hekimsoy Z,Kafesçiler S,Güçlü F,Ozmen B

更新日期：2010-01-01 00:00:00

abstract：:This study assessed the association of muscle mass with insulin resistance, evaluated from the insulin sensitivity index (ISI), in Japanese patients with gestational diabetes mellitus (GDM). Consecutive patients with GDM (n = 96) admitted to St. Marianna University Hospital between October 2015 and March 2018 for init...

journal_title：Endocrine journal

authors： Kawanabe S,Nagai Y,Nakamura Y,Nishine A,Nakagawa T,Tanaka Y

更新日期：2019-01-28 00:00:00

abstract：:Gitelman syndrome (GS) is a salt-wasting tubulointerstitial disease of autosomal recessive inheritance (OMIM613395) caused by genic mutation of SLC12A3, which codes thiazide-sensitive Na-Cl cotransporter (NCCT) gene. The gene mutation of the majority of GS patients is compound heterozygous. This study analyzes two cas...

journal_title：Endocrine journal

authors： Luo J,Yang X,Liang J,Li W

更新日期：2015-01-01 00:00:00

abstract：:Interferon-tau (IFNtau) is produced by the trophectoderm of ruminant ungulates and its gene transactivation in vitro has so far been achieved only in human choriocarcinoma cells, JAR and JEG3. To examine if ovine IFNtau gene transactivation could be induced in cells other than JAR or JEG3 cells and its activation coul...

journal_title：Endocrine journal

authors： Yamaguchi H,Ikeda Y,Taylor A,Katsumura M,Miyazawa T,Takahashi E,Imakawa K,Sakai S

更新日期：1999-06-01 00:00:00

abstract：:In this study, nine patients with Graves' ophthalmopathy with positive clinical activity score (CAS), who were either unresponsive or not suitable for glucocorticoid treatment, were given 100 microg of octreotide three times daily, subcutaneously, for three months. The mean age was 49+/-13 years. All patients were und...

journal_title：Endocrine journal

authors： Uysal AR,Corapçioğlu D,Tonyukuk VC,Güllü S,Sav H,Kamel N,Erdoğan G

更新日期：1999-08-01 00:00:00

abstract：:Thyrotropin levels are outside normal reference range in subclinical thyroid disease. Metabolic syndrome (MetS) involves clustered cardiovascular risk factors, including abnormal lipids, insulin resistance, and hypertension. This study aimed to investigate associations between subclinical thyroid disease, thyrotropi...

journal_title：Endocrine journal

authors： Wang CY,Chang TC,Chen MF

更新日期：2012-01-01 00:00:00

abstract：:The two types of prognostic factors of papillary thyroid carcinoma (PTC) are static and dynamic. The following static prognostic factors have been conventionally adopted: age, tumor size, extrathyroid extension, lymph node metastasis, and distant metastasis based on pre-, intra- and post-operative findings. These fact...

journal_title：Endocrine journal

authors： Ito Y,Miyauchi A,Kobayashi K,Kihara M,Miya A

更新日期：2014-01-01 00:00:00

abstract：:We assessed the significance of recommendations from the international consensus on continuous glucose monitoring (CGM)-derived metrics in Japanese children and adolescents with type 1 diabetes. Eighty-five patients (age, 13.5 ± 4.7 years) who wore the FreeStyle® Libre for a 28-day period were enrolled in this study. ...

journal_title：Endocrine journal

authors： Urakami T,Yoshida K,Kuwabara R,Mine Y,Aoki M,Suzuki J,Morioka I

更新日期：2020-10-28 00:00:00

abstract：:Plasma CRH levels were measured in patients with non-insulin dependent diabetes mellitus (NIDDM) as the pituitary-adrenal abnormalities have been reported in NIDDM. They were also measured after oral administration of 75 g glucose to examine whether glucose increased plasma CRH along with insulin secretion. The baseli...

journal_title：Endocrine journal

authors： Hashimoto K,Nishioka T,Takao T,Numata Y

更新日期：1993-12-01 00:00:00

abstract：:Differentiated thyroid carcinoma (DTC) is generally indolent in nature and, even though it metastasizes to distant organs, the prognosis is normally excellent. In contrast, the overall survival (OS) of patients with radioactive iodine (RAI)-refractory and progressive metastases is dire, because no effective therapies ...

journal_title：Endocrine journal

authors： Ito Y,Suzuki S,Ito K,Imai T,Okamoto T,Kitano H,Sugitani I,Sugino K,Tsutsui H,Hara H,Yoshida A,Shimizu K

更新日期：2016-07-30 00:00:00

abstract：:Estrogen has been shown to stimulate lactotroph proliferation and expression of the prolactin (PRL) gene. Recently it has been established that Pit-1, a pituitary-specific transcription factor, is required for lactotroph proliferation. Furthermore, in vitro studies showed that an increase in the PRL promoter activity ...

journal_title：Endocrine journal

authors： Tsukahara S,Kambe F,Suganuma N,Tomoda Y,Seo H

更新日期：1994-10-01 00:00:00

abstract：:Bartter syndrome (BS) type 1, also referred to antenatal BS, is a genetic tubulopathy with hypokalemic metabolic alkalosis and prenatal onset of polyuria leading to polyhydramnios. It has been shown that BS type 1 is caused by mutations in the SLC12A1 gene encoding bumetanide-sensitive Na-K-2Cl (-) cotransporter (NKCC...

journal_title：Endocrine journal

authors： Adachi M,Asakura Y,Sato Y,Tajima T,Nakajima T,Yamamoto T,Fujieda K

更新日期：2007-12-01 00:00:00

abstract：:Cushing's disease is primarily caused by adrenocorticotropic hormone (ACTH)-producing pituitary adenomas. Pituitary tumor-transforming gene 1 (PTTG1) expression, a hallmark of pituitary tumors, stimulates pituitary cell proliferation. Histone deacetylases (HDACs) play an important role in regulating gene transcription...

journal_title：Endocrine journal

authors： Nakada Y,Kageyama K,Sugiyama A,Desaki R,Takayasu S,Niioka K,Murasawa S,Ishigame N,Asari Y,Iwasaki Y,Daimon M

更新日期：2015-01-01 00:00:00

abstract：:The risk factors for impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) have yet to be established. Our aim was to elucidate the predisposing factors for IFG and IGT in Japanese subjects with normal glucose tolerance (NGT). Using a 75 g oral glucose tolerance test (OGTT), we analyzed 604 adults with t...

journal_title：Endocrine journal

authors： Oka R,Yagi K,Hayashi K,Kawashiri MA,Yamagishi M,Yamada M,Fumisawa Y,Yamauchi K,Aizawa T

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study is to explore beta cell dysfunction and its clinical significance in gestational diabetes mellitus (GDM). We assessed insulin sensitivity and insulin secretion in a total of 277 Japanese women between 24 and 27 weeks of pregnancy who underwent a 2 h, 75 g oral glucose tolerance test (OGTT) becaus...

journal_title：Endocrine journal

authors： Saisho Y,Miyakoshi K,Tanaka M,Shimada A,Ikenoue S,Kadohira I,Yoshimura Y,Itoh H

更新日期：2010-01-01 00:00:00

abstract：:The objective of this study was to investigate the effect of administration of recombinant human growth hormone (hGH) in patients with Noonan syndrome. hGH was administered (0.5 IU/kg/week) to 15 patients with Noonan syndrome over a 2 year period. Average patient age prior to therapy was 7.5 +/- 2.5 (mean +/- SD) yr, ...

journal_title：Endocrine journal

authors： Ogawa M,Moriya N,Ikeda H,Tanae A,Tanaka T,Ohyama K,Mori O,Yazawa T,Fujita K,Seino Y,Kubo T,Tanaka H,Nishi Y,Yoshimoto M

更新日期：2004-02-01 00:00:00

abstract：:Antipituitary antibody (APA) has been reported to be detected in patients with autoimmune thyroid disease. Type 2 iodothyronine deiodinase (D2) is expressed in both pituitary gland and thyroid gland. We studied the association of APA and D2 peptide antibody in patients with autoimmune thyroid disease. Rat pituitary gl...

journal_title：Endocrine journal

authors： Nakahara R,Tsunekawa K,Yabe S,Nara M,Seki K,Kasahara T,Ogiwara T,Nishino M,Kobayashi I,Murakami M

更新日期：2005-12-01 00:00:00

abstract：:Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patient. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. Howe...

journal_title：Endocrine journal

authors： Shu X,Shu S,Tang S,Yang L,Liu D,Li K,Dong Z,Ma Z,Zhu Z,Din J

更新日期：2018-04-26 00:00:00

abstract：:The present study was aimed to examine the possible functional relationship between melatonin and hypothalamic transmitters, endogenous opioids and excitatory amino acids in controlling gonadotropin secretion in ovariectomized estrogen-primed rats. An intravenous injection of naloxone (mu opioid receptor antagonist), ...

journal_title：Endocrine journal

authors： Akema T,Ikeda T,Chiba A,Sugiyama H,Sato I,Kimura F,Toyoda J

更新日期：1999-12-01 00:00:00