Abstract:
:It has been demonstrated the involvement of branched-chain amino acids (BCAA) on obesity and related metabolic disorder. We investigated the effects of branched-chain amino acids (BCAA) on obesity and on glucose/fat homeostasis in mice fed on a high-fat (45%) diet. BCAA was dissolved in 0.5% methylcellulose and added to the drinking water (BCAA-treated group). A high-fat diet was provided for 6 weeks and BCAA was given for 2 weeks. The BCAA-treated group gained almost 7% less body weight and had less epididymal adipose tissue (WAT) mass than the control group (p<0.05). BCAA supplementation also reduced the hepatic and skeletal muscle triglyceride (TG) concentrations (p<0.05). The hepatic levels of PPAR-alpha and uncoupling protein (UCP) 2, and the level of PPAR-alpha and UCP3 in the skeletal muscle were greater in the BCAA-treated group than in the control mice (p<0.05). These results demonstrate that the liver and muscle TG concentration are less in BCAA-treated group. BCAA affects PPAR-alpha and UCP expression in muscle and liver tissue.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Arakawa M,Masaki T,Nishimura J,Seike M,Yoshimatsu Hdoi
10.1507/endocrj.k10e-221subject
Has Abstractpub_date
2011-01-01 00:00:00pages
161-70issue
3eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/K10E-221journal_volume
58pub_type
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