Proposal of diagnostic criteria for IgG4-related thyroid disease.

abstract：:Studies on resveratrol in a wide range of concentrations on obese mice and adipose cells are necessary to comprehend its range of diverse and contradictory effects. In this study, we examined the anti-obesity effects of resveratrol on high-fat diet (HFD)-induced obese mice at dosages ranging from 1 to 30 mg/kg treatme...

journal_title：Endocrine journal

authors： Chang CC,Lin KY,Peng KY,Day YJ,Hung LM

更新日期：2016-01-01 00:00:00

abstract：:Therapeutic blocking antibodies against programmed death 1 (PD1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) are applied for advanced cancer therapy, but induce a wide range of immune-related adverse events. In our recent case of a 52-year-old female doctor suffering from breast cancer having metastasized to the lung...

journal_title：Endocrine journal

authors： Okahata S,Sakamoto K,Mitsumatsu T,Kondo Y,Noso S,Ikegami H,Shiba T

更新日期：2019-04-25 00:00:00

abstract：:Genetic linkage analyses have traced the loci for multiple endocrine neoplasia type 2A (MEN 2A) to an interval on chromosome 10q11.2. This region encompasses the RET proto-oncogene, a receptor tyrosine kinase gene expressed in medullary thyroid carcinoma (MTC) and pheochromocytoma. By means of genomic polymerase chain...

journal_title：Endocrine journal

authors： Oishi S,Sato T,Takiguchi-Shirahama S,Nakamura Y

更新日期：1995-08-01 00:00:00

abstract：:The mechanisms of paradoxical TRH response in human somatotroph adenoma cells were investigated using intracellular calcium measurement and static incubation assay. Intracellular calcium measurement revealed that TRH induces a biphasic response: a transient increase followed by a sustained plateau. The transient phase...

journal_title：Endocrine journal

authors： Okinaga H,Takano K,Hayashi S,Yasufuku-Takano J,Teramoto A,Fujita T

更新日期：2005-12-01 00:00:00

abstract：:The aim of this study was to assess the changes in insulin secretion and insulin sensitivity in relation to fasting and 2-hour plasma glucose (PG) levels and to assess the independent contributions of their impairments to non-diabetic hyperglycemia. A total of 2157 Japanese workers (mean age 52.6±7.3 years and mean B...

journal_title：Endocrine journal

authors： Oka R,Yagi K,Sakurai M,Nakamura K,Moriuchi T,Miyamoto S,Nohara A,Kawashiri MA,Takeda Y,Yamagishi M

更新日期：2012-01-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN 1) is rarely reported in Japanese and other oriental populations. To examine if there is a racial difference in the prevalence of MEN 1, we initiated extensive work on patients with endocrine tumors for additional lesions, and annual screening of family members of affected pati...

journal_title：Endocrine journal

authors： Katai M,Sakurai A,Itakura Y,Ikeo Y,Nakajima K,Hara M,Iijima S,Kaneko T,Kobayashi M,Ichikawa K,Aizawa T,Hashizume K

更新日期：1997-12-01 00:00:00

abstract：:Although subacute thyroiditis (de Quervain's thyroiditis) is presumed to be caused by a viral infection, only 2 familial occurrences of subacute thyroiditis have been reported in the literature. Typical and severe subacute thyroiditis was diagnosed in an older sister who was hospitalized for 8 days. During this period...

journal_title：Endocrine journal

authors： Kabalak T,Ozgen AG

更新日期：2002-04-01 00:00:00

abstract：:While patients with large goitrous thyroid diseases often have a relatively high serum free triiodothyronine (FT3)/free thyroxine (FT4) ratio, athyreotic patients have a relatively low FT3/FT4 ratio. Here we investigated the relationship between thyroid hormone status and thyroid volume (TV) among a large number of eu...

journal_title：Endocrine journal

authors： Kawasaki M,Ito M,Danno H,Kousaka K,Nakamura T,Yoshioka W,Kasahara T,Kudo T,Nishihara E,Fukata S,Nishikawa M,Nakamura H,Toyoda N,Miyauchi A

更新日期：2019-09-28 00:00:00

abstract：:Nesfatin-1 is a polypeptide derived from the posttranslational processing of the N-terminal fragment of nucleobindin 2 (NUCB2), that was originally identified as an anorexigenic hypothalamic neuropeptide. A number of reports have recently shown that NUCB2/nesfatin-1 is widely expressed in various peripheral tissues, i...

journal_title：Endocrine journal

authors： Cao X,Liu XM,Zhou LH

更新日期：2013-01-01 00:00:00

abstract：:Methylenetetrahydrofolate reductase plays an important role in folate metabolism. Individuals who are type 2 diabetes mellitus have greatest risk for the development of vascular complications. The results of studies which assessed the association between MTHFR C677T polymorphism and T2DM with vascular complications we...

journal_title：Endocrine journal

authors： Zhang D,Zhou Y,Han L,Ji H,Li J

更新日期：2014-01-01 00:00:00

abstract：:This study investigates whether urinary levels of pentosidine, pyrraline and acrolein adduct are increased in type 2 diabetes (DM), and whether these levels are correlated with glycemic control and clinical traits. Urinary levels of pentosidine, pyrraline and acrolein adduct in DM patients (n = 100) recruited from the...

journal_title：Endocrine journal

authors： Daimon M,Sugiyama K,Kameda W,Saitoh T,Oizumi T,Hirata A,Yamaguchi H,Ohnuma H,Igarashi M,Kato T

更新日期：2003-02-01 00:00:00

abstract：:The serum T3 to T4 ratio is a useful indicator for differentiating destruction-induced thyrotoxicosis from Graves' thyrotoxicosis. However, the usefulness of the serum free T3 (FT3) to free T4 (FT4) ratio is controversial. We therefore systematically evaluated the usefulness of this ratio, based on measurements made u...

journal_title：Endocrine journal

authors： Yoshimura Noh J,Momotani N,Fukada S,Ito K,Miyauchi A,Amino N

更新日期：2005-10-01 00:00:00

abstract：:Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patient. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. Howe...

journal_title：Endocrine journal

authors： Shu X,Shu S,Tang S,Yang L,Liu D,Li K,Dong Z,Ma Z,Zhu Z,Din J

更新日期：2018-04-26 00:00:00

abstract：:Fibrodysplasia ossificans progressiva (FOP) is a skeletal disorder with progressive heterotopic ossification in skeletal muscle. A mutation causing constitutive activation in a bone morphogenetic protein (BMP) type 1 receptor [ALK2(R206H)] is found in most patients with FOP. However, the details in the heterotopic oss...

journal_title：Endocrine journal

authors： Mao L,Yano M,Kawao N,Tamura Y,Okada K,Kaji H

更新日期：2013-01-01 00:00:00

abstract：:Inflammatory lesions of the pituitary gland are rarely encountered. Recently, the concept of immunoglobulin G4 (IgG4)-related systemic disease was proposed in Japan, and more than 20 cases have been reported as possibly associated with infundibulo-hypophysitis since 2000. We herein review such case reports in the publ...

journal_title：Endocrine journal

authors： Shimatsu A,Oki Y,Fujisawa I,Sano T

更新日期：2009-01-01 00:00:00

abstract：:We report a rare case of ACTH-independent macronodular adrenal hyperplasia (AIMAH) with primary hyperparathyroidism (PHPT). A 57-year-old woman was admitted to our hospital for further examination of secondary hypertension and bilateral adrenal macrotumors. Midnight serum cortisol elevation with undetectable plasma AC...

journal_title：Endocrine journal

authors： Sato M,Soma M,Nakayama T,Kosuge K,Suzuki R,Okada K,Komatsu K,Sugitani M,Matsumoto K

更新日期：2006-02-01 00:00:00

abstract：:We previously developed a radioreceptor assay which is presumably specific for detection of blocking-type anti-TSH receptor (TSHR) antibodies using unsolubilized porcine TSHR. Employing this assay, we measured blocking TSH-binding inhibitory immunoglobulin (TBII) in the sera from 30 untreated Graves' patients and comp...

journal_title：Endocrine journal

authors： Tada H,Izumi Y,Watanabe Y,Takano T,Fukata S,Kuma K,Hidaka Y,Amino N

更新日期：2001-12-01 00:00:00

abstract：:A 77-year-old man was diagnosed as having hypothyroidism. An electrocardiogram obtained at the time of the first examination revealed Brugada electrocardiographic waveforms in leads V1 to V3. When pilsicainide hydrochloride loading changed the waveforms of the electrocardiographic ST segment, this result suggested an ...

journal_title：Endocrine journal

authors： Kitahara A,Hirai R,Matsui Y,Ikeda Y,Nakamura H

更新日期：2008-07-01 00:00:00

abstract：:Hypophysitis, which is often accompanied by pituitary dysfunction, is classified into several subtypes based on the cause, histology, and the location of inflammation in the pituitary gland. A definitive diagnosis requires pituitary biopsy, which is invasive, and the process is limited to specialized clinical settings...

journal_title：Endocrine journal

authors： Takagi H,Iwama S,Sugimura Y,Takahashi Y,Oki Y,Akamizu T,Arima H

更新日期：2020-04-28 00:00:00

abstract：:Pathogenesis of pseudohypoparathyroidism type 1b (PHP-1b) is related to the loss of methylation at the GNAS exon A/B region, which is combined with epigenetic defects at other differentially methylated GNAS regions in most sporadic cases. In this study, we established a method for evaluating the methylation status of...

journal_title：Endocrine journal

authors： Kinoshita K,Minagawa M,Takatani T,Takatani R,Ohashi M,Kohno Y

更新日期：2011-01-01 00:00:00

abstract：:The antidiabetic effects of Lactobacillus casei (LC) on a non-insulin-dependent diabetes mellitus (NIDDM) model, KK-Ay mice, were investigated. The oral administration of LC to male 4-week-old KK-Ay mice, or raising the mice on a 0.05% LC-containing diet significantly decreased the plasma glucose at 8 to 10 weeks of a...

journal_title：Endocrine journal

authors： Matsuzaki T,Yamazaki R,Hashimoto S,Yokokura T

更新日期：1997-06-01 00:00:00

abstract：:Following the accident at the Fukushima Daiichi Nuclear Power Station which occurred on March 11, 2011 due to the Eastern Japan Great Earthquake (the Accident), there have been concerns over elevation of the risk of thyroid cancer among children due to internal exposure to radioactive iodine. In Fukushima Prefecture, ...

journal_title：Endocrine journal

authors： Iwaku K,Noh JY,Sasaki E,Suzuki N,Kameda T,Kobayashi S,Yoshihara A,Ohye H,Watanabe N,Suzuki M,Matsumoto M,Kunii Y,Mukasa K,Sugino K,Ito K

更新日期：2014-01-01 00:00:00

abstract：:Serum C-reactive protein (CRP) concentrations have been reported to be associated with body fat, especially visceral fat accumulation, but most studies up to now have been conducted on non-diabetic subjects. In this study, we investigated the association between the serum CRP concentrations and parameters of adiposity...

journal_title：Endocrine journal

authors： Iwasaki T,Nakajima A,Yoneda M,Terauchi Y

更新日期：2006-06-01 00:00:00

abstract：:Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension. The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium...

journal_title：Endocrine journal

authors： Ohtsuka H,Komiya I,Aizawa T,Yamada T

更新日期：1995-12-01 00:00:00

abstract：:In this study we confirmed our previous findings on the importance of IgE in Graves' disease and further investigated the relationships existing among Graves' disease, IgE, and interleukin-4. Two hundred and thirty-two newly diagnosed Graves' disease patients were treated with methimazole for 2 years, and were classif...

journal_title：Endocrine journal

authors： Yamada T,Komiya I,Miyahara Y,Komatsu M,Shima I,Inazawa T,Aizawa T

更新日期：2006-12-01 00:00:00

abstract：:Progression to overt hypothyroidism and the associated adverse effects on lipid metabolism and the cardiovascular system are major concerns for patients diagnosed with subclinical hypothyroidism (SCH). No consensus regarding the clinical parameters associated with prognosis for this mild thyroid dysfunction has yet be...

journal_title：Endocrine journal

authors： Shin DY,Kim EK,Lee EJ

更新日期：2010-01-01 00:00:00

abstract：:We recently reported three cases of severe hypertriglyceridemia caused by tamoxifen-treatment after breast cancer surgery. In that report we showed that one of the three patients had apo E3/3 and another had E4/2 phenotype. There are few data about the relationship between apoprotein E phenotype, one of modifiers of l...

journal_title：Endocrine journal

authors： Hozumi Y,Kawano M,Saito T,Miyata M

更新日期：1998-04-01 00:00:00

abstract：:Unusual presentations with bone, lung or soft tissue metastases in initial diagnosis of follicular thyroid carcinoma have been reported occasionally. This implies how difficult it is to diagnosis this type of cancer at the pre-operative or intra-operative stage of treatment. Fine needle aspiration cytology has been sh...

journal_title：Endocrine journal

authors： Lin JD,Chao TC

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess the rate of malignancy in thyroid nodules incidentally detected at sonography and to determine the diagnostic value of ultrasonography-guided fine needle aspiration cytology (USgFNAC) in thyroid nodules. METHODS:Five hundred patients (84 men and 416 women) who had thyr...

journal_title：Endocrine journal

authors： Kim DL,Song KH,Kim SK

更新日期：2008-03-01 00:00:00

abstract：:Recent studies indicate that succinate dehydrogenase (SDH) genes B, C, or D are, at least partly, involved in the pathogenesis of pheochromocytoma or paraganglioma. Of these three genes, the SDHD gene mutation is most closely related with paragangliomas of the neck. Here we describe a case of an SDHD-related paragangl...

journal_title：Endocrine journal

authors： Yamashita R,Usui T,Hashimoto S,Suzuki H,Takahashi M,Honkura K,Iwamoto K,Kodama E,Tagami T,Naruse M,Shimatsu A,Kaise K

更新日期：2009-01-01 00:00:00