Abstract:
:We report a rare case of ACTH-independent macronodular adrenal hyperplasia (AIMAH) with primary hyperparathyroidism (PHPT). A 57-year-old woman was admitted to our hospital for further examination of secondary hypertension and bilateral adrenal macrotumors. Midnight serum cortisol elevation with undetectable plasma ACTH, increased 24-hour urinary free cortisol excretion, and loss of the normal circadian rhythm in cortisol secretion established the diagnosis of Cushing's syndrome. Total resection of the enlarged left adrenal gland was performed with subsequent steroid replacement. Her general condition improved but serum calcium level increased 3 weeks after surgery. PHPT was diagnosed on the basis of endocrinological examination, although imaging studies failed to detect parathyroid lesion. In summary, we believe this to be the first report of a case of AIMAH with PHPT.
journal_name
Endocr Jjournal_title
Endocrine journalauthors
Sato M,Soma M,Nakayama T,Kosuge K,Suzuki R,Okada K,Komatsu K,Sugitani M,Matsumoto Kdoi
10.1507/endocrj.53.111subject
Has Abstractpub_date
2006-02-01 00:00:00pages
111-7issue
1eissn
0918-8959issn
1348-4540pii
JST.JSTAGE/endocrj/53.111journal_volume
53pub_type
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